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The map label for this gene is blt [H]

Identifier: 56963730

GI number: 56963730

Start: 2080092

End: 2081303

Strand: Direct

Name: blt [H]

Synonym: ABC1965

Alternate gene names: 56963730

Gene position: 2080092-2081303 (Clockwise)

Preceding gene: 56963729

Following gene: 56963731

Centisome position: 48.33

GC content: 49.01

Gene sequence:

>1212_bases
ATGAAGGCATTGGCAACAAGAAACAGAGGGGCTATTTTATTGCTCATGTTTAATATCTTTATAGGATTTGTAGGCGTTGG
CTTGGTTATCCCGATTATGCCGACATATATGAACGTCCTTGGCATCTCTGGAACGATCGTTGGCCTGCTGGTCGCTGTAT
TTTCATTAACTCAATTTCTAGTGGCGCCTTATGCAGGCAGTTGGTCTGATCGTTATGGGCGAAAGTGGATCATTGTCGCC
GGTCTGCTGCTTTTTGCTGTATCCGAGCTGCTTTTTGGCCTGGCTACGAATGCAGTCTTGCTGTTTATCTCAAGACTGCT
TGGCGGTGTATCCGTTGCCTTTATTATGCCCGCCGTCATGGCCTACGTCGTTGATATTACGACAGAAGAGGATCGGGGAA
TGGGAATGGGCTGGATTAATGCGGCGATTTCCACAGGTTTTATCATCGGTCCGGCGATCGGTGGTTTTTTAGTCGAGTAC
GGTATGCGAGTGCCTTTCTTCGCCGCAGCTGGAGCTGCCGCCTTATCCGCTGTCGTTTCAATGAGTATTTTGCCAGAGTC
ACTGGATAAAAACAAGTTGCCTGCTCCAGAGGCACGTATGGACCGAAAAGAGTCTCAACTCGCACAGCTTGCCAAATCTT
ATCGCACCCCTTATTTTACAGGGCTGTTGATCATCTTGATCACTTCGCTCGGATTGTCCCAATTTGAGACGGTGTTAGGA
CTTTTTGTTGACCATAAGTACAGCTATACGCCTAATGAAATTGCCTGGTTAATCATGATCGGGGCGATCGTTGGCGCTGT
GATGCAGCTGACGCTCTTCGGGCGGCTGATCAATTGGATTGGGGAGAAGAAGCTGACGGTCTATTGCTTATTAGTGATGG
CTGTTTTTATGGTTGCGACCATCTTTTCGGCCCAATATTGGATGATGGTTGTATCGGTCACGCTTGTTTTTCTGGCAGTT
GATTTTGTACGCCCGGCGATTAGCACTTATTTTTCCAGAATTGCCGGCAACGAACAGGGGCTTGTTGCCGGTTTGAATGC
TTCCTATACGAGTCTAGGGAACATCGGCGGCCCGATCCTTGCCGGGGCCTTGTTTGATGTTCAAATCAACTCCCCATTCC
TGGTCGGCAGTCTGATCGCTTTAGGCGGCTGGATCCTTAGTCTGCGCTGGATGCGCAAACAAACGGAACGGTCTCCAGGC
ACGACCGTTTAA

Upstream 100 bases:

>100_bases
TGCCACTGAACAAACCATTAAATCGGGCGCCGATTTTAAAGCTGGAAAACTATCCAGAGTATAGATAGTCATGAGAGAAG
AATTCGGAGGAATTTGTAGA

Downstream 100 bases:

>100_bases
TAGACCGTTTTGGCTGTCCAACTTTTAATTGGTTTTATTTAATAATATTCAAATAAAGAAATGTTCAAGTGAGAGGCATT
CAATGAACTGCCGGATCCAT

Product: major facilitator superfamily multidrug resistance protein

Products: NA

Alternate protein names: Multidrug-efflux transporter 2 [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKALATRNRGAILLLMFNIFIGFVGVGLVIPIMPTYMNVLGISGTIVGLLVAVFSLTQFLVAPYAGSWSDRYGRKWIIVA
GLLLFAVSELLFGLATNAVLLFISRLLGGVSVAFIMPAVMAYVVDITTEEDRGMGMGWINAAISTGFIIGPAIGGFLVEY
GMRVPFFAAAGAAALSAVVSMSILPESLDKNKLPAPEARMDRKESQLAQLAKSYRTPYFTGLLIILITSLGLSQFETVLG
LFVDHKYSYTPNEIAWLIMIGAIVGAVMQLTLFGRLINWIGEKKLTVYCLLVMAVFMVATIFSAQYWMMVVSVTLVFLAV
DFVRPAISTYFSRIAGNEQGLVAGLNASYTSLGNIGGPILAGALFDVQINSPFLVGSLIALGGWILSLRWMRKQTERSPG
TTV

Sequences:

>Translated_403_residues
MKALATRNRGAILLLMFNIFIGFVGVGLVIPIMPTYMNVLGISGTIVGLLVAVFSLTQFLVAPYAGSWSDRYGRKWIIVA
GLLLFAVSELLFGLATNAVLLFISRLLGGVSVAFIMPAVMAYVVDITTEEDRGMGMGWINAAISTGFIIGPAIGGFLVEY
GMRVPFFAAAGAAALSAVVSMSILPESLDKNKLPAPEARMDRKESQLAQLAKSYRTPYFTGLLIILITSLGLSQFETVLG
LFVDHKYSYTPNEIAWLIMIGAIVGAVMQLTLFGRLINWIGEKKLTVYCLLVMAVFMVATIFSAQYWMMVVSVTLVFLAV
DFVRPAISTYFSRIAGNEQGLVAGLNASYTSLGNIGGPILAGALFDVQINSPFLVGSLIALGGWILSLRWMRKQTERSPG
TTV
>Mature_403_residues
MKALATRNRGAILLLMFNIFIGFVGVGLVIPIMPTYMNVLGISGTIVGLLVAVFSLTQFLVAPYAGSWSDRYGRKWIIVA
GLLLFAVSELLFGLATNAVLLFISRLLGGVSVAFIMPAVMAYVVDITTEEDRGMGMGWINAAISTGFIIGPAIGGFLVEY
GMRVPFFAAAGAAALSAVVSMSILPESLDKNKLPAPEARMDRKESQLAQLAKSYRTPYFTGLLIILITSLGLSQFETVLG
LFVDHKYSYTPNEIAWLIMIGAIVGAVMQLTLFGRLINWIGEKKLTVYCLLVMAVFMVATIFSAQYWMMVVSVTLVFLAV
DFVRPAISTYFSRIAGNEQGLVAGLNASYTSLGNIGGPILAGALFDVQINSPFLVGSLIALGGWILSLRWMRKQTERSPG
TTV

Specific function: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally div

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=413, Percent_Identity=24.2130750605327, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI39753965, Length=325, Percent_Identity=27.0769230769231, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI94721311, Length=358, Percent_Identity=27.3743016759777, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI87081738, Length=368, Percent_Identity=24.7282608695652, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787291, Length=349, Percent_Identity=22.3495702005731, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71996331, Length=348, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551570, Length=162, Percent_Identity=32.7160493827161, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17738085, Length=337, Percent_Identity=25.8160237388724, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357569, Length=364, Percent_Identity=27.4725274725275, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161080926, Length=364, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161080924, Length=364, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656463, Length=364, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656468, Length=364, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43490; Mature: 43490

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7608059; 8969508; 9384377 [H]