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The map label for this gene is aroB

Identifier: 56963658

GI number: 56963658

Start: 2010060

End: 2011136

Strand: Direct

Name: aroB

Synonym: ABC1893

Alternate gene names: 56963658

Gene position: 2010060-2011136 (Clockwise)

Preceding gene: 56963657

Following gene: 56963659

Centisome position: 46.7

GC content: 45.87

Gene sequence:

>1077_bases
ATGTTTGTAGACATTCACACCTCTTCAAAACAATACAAGGCTGAAGTGGGGTCAGGAATTTTGCGGGAGGCAGGCAAAAC
GATTGAAGCGCTTGCCCCGGCTTCTTCCTATTTGATCGTTTCAGATGAAAATGTCGCAAACCGTTATCTTGATGTGTTGG
TTTCTTCTTTTTCAAAGGAGCCTCATACGTTTGTCGTGAAAGCGGGGGAACAATCAAAGTCTTTTCATGTGTATGAGCAG
CTTGCCGCTTTTTGTTTGGAAAAACAGCTTGACCGCCAGTCGGTTATCATCGCTTTTGGAGGCGGCGTTGTTGGCGATTT
GGCCGGGTTTGTAGCGGGGACCTATATGCGTGGCGTTCGCTTTATTCAAGTTCCAACTACTTTGCTTGCCCATGATTCAA
GCGTTGGCGGAAAAGTAGCAGTCAATTTGCCTGCCGCTAAAAATATGATTGGCGTTTTTCATCAGCCTGAAGCTGTCTTG
TTCGACACAGAATTGTTGGCAACTTTGCCGGAACACGAATGGCGTTCTGGTTTTGCAGAAATCGTTAAACTTGGTTTTAT
AGCCGACGCTTCTTTTTTAGCTTGGCTGCGTGAAACAGTGCCTGCACTAACAAGTATAAAAGCAGATAATTTGCAAAAAA
TGGTGGCCAAGGCGATTGCCATCAAAGCCGACATTGTTGGCAAAGATGAAAAAGAGCATGGCATCCGCGCCCATTTGAAC
TTTGGTCATACACTCGCTCATGCGATTGAAGCAGAACTAGGGTATGGAAAGATAACCCATGGCGAAGCGGTGGCAATCGG
CATGCGTTTTGCTTTTCGTCTTAGCCTCCGTTTTACAAAAGAGGATTTGCGGCTTGCCGATTATGAAGAGTGGTTTTCTG
CCCTCGGTTATGACCTTCGTTTGCCAGCAGGGCTTTCAGCACAACGGTTGCTTGCCCGTATGAAAAGCGACAAAAAAACG
AATGCAGGAAAGATTGTCATGGTGTTGCTCGCTCAGCTTGGAGCCGCCTATACAAAAACAGTCGATGAACATTTGCTTTT
AGAGTTGTTAGAAGAAGAACTGGGAGGAAGATCATGA

Upstream 100 bases:

>100_bases
AGTTGCCAATGCCTTGCTTGATACATTTGGTTCTGACCAGCTTCCTCTGATCCAGGCAGCTGTCGAACGTCACCATGCCG
CTTCAAAGGAGTTTTAAACG

Downstream 100 bases:

>100_bases
TTCGTGGCGTCCGAGGTGCAACAACCGTAACAAAAAATGAGGCGCAAGAAATTGAACAGGCTACAGAAACACTCGTGCGG
GAAATGGTCAGTCAAAATGC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MFVDIHTSSKQYKAEVGSGILREAGKTIEALAPASSYLIVSDENVANRYLDVLVSSFSKEPHTFVVKAGEQSKSFHVYEQ
LAAFCLEKQLDRQSVIIAFGGGVVGDLAGFVAGTYMRGVRFIQVPTTLLAHDSSVGGKVAVNLPAAKNMIGVFHQPEAVL
FDTELLATLPEHEWRSGFAEIVKLGFIADASFLAWLRETVPALTSIKADNLQKMVAKAIAIKADIVGKDEKEHGIRAHLN
FGHTLAHAIEAELGYGKITHGEAVAIGMRFAFRLSLRFTKEDLRLADYEEWFSALGYDLRLPAGLSAQRLLARMKSDKKT
NAGKIVMVLLAQLGAAYTKTVDEHLLLELLEEELGGRS

Sequences:

>Translated_358_residues
MFVDIHTSSKQYKAEVGSGILREAGKTIEALAPASSYLIVSDENVANRYLDVLVSSFSKEPHTFVVKAGEQSKSFHVYEQ
LAAFCLEKQLDRQSVIIAFGGGVVGDLAGFVAGTYMRGVRFIQVPTTLLAHDSSVGGKVAVNLPAAKNMIGVFHQPEAVL
FDTELLATLPEHEWRSGFAEIVKLGFIADASFLAWLRETVPALTSIKADNLQKMVAKAIAIKADIVGKDEKEHGIRAHLN
FGHTLAHAIEAELGYGKITHGEAVAIGMRFAFRLSLRFTKEDLRLADYEEWFSALGYDLRLPAGLSAQRLLARMKSDKKT
NAGKIVMVLLAQLGAAYTKTVDEHLLLELLEEELGGRS
>Mature_358_residues
MFVDIHTSSKQYKAEVGSGILREAGKTIEALAPASSYLIVSDENVANRYLDVLVSSFSKEPHTFVVKAGEQSKSFHVYEQ
LAAFCLEKQLDRQSVIIAFGGGVVGDLAGFVAGTYMRGVRFIQVPTTLLAHDSSVGGKVAVNLPAAKNMIGVFHQPEAVL
FDTELLATLPEHEWRSGFAEIVKLGFIADASFLAWLRETVPALTSIKADNLQKMVAKAIAIKADIVGKDEKEHGIRAHLN
FGHTLAHAIEAELGYGKITHGEAVAIGMRFAFRLSLRFTKEDLRLADYEEWFSALGYDLRLPAGLSAQRLLARMKSDKKT
NAGKIVMVLLAQLGAAYTKTVDEHLLLELLEEELGGRS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=345, Percent_Identity=40.2898550724638, Blast_Score=232, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6320332, Length=393, Percent_Identity=35.8778625954198, Blast_Score=196, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_BACSK (Q5WGS7)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175389.1
- ProteinModelPortal:   Q5WGS7
- STRING:   Q5WGS7
- EnsemblBacteria:   EBBACT00000048815
- GeneID:   3201722
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1893
- NMPDR:   fig|66692.3.peg.1937
- eggNOG:   COG0337
- GeneTree:   EBGT00050000002325
- HOGENOM:   HBG632303
- OMA:   EHAIATS
- ProtClustDB:   CLSK2767540
- BioCyc:   BCLA66692:ABC1893-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39101; Mature: 39101

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDIHTSSKQYKAEVGSGILREAGKTIEALAPASSYLIVSDENVANRYLDVLVSSFSKE
CEEEEECCCHHHHHHHCCHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCC
PHTFVVKAGEQSKSFHVYEQLAAFCLEKQLDRQSVIIAFGGGVVGDLAGFVAGTYMRGVR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCEE
FIQVPTTLLAHDSSVGGKVAVNLPAAKNMIGVFHQPEAVLFDTELLATLPEHEWRSGFAE
EEEECHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEECHHHHHHCCCHHHHHHHHH
IVKLGFIADASFLAWLRETVPALTSIKADNLQKMVAKAIAIKADIVGKDEKEHGIRAHLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
FGHTLAHAIEAELGYGKITHGEAVAIGMRFAFRLSLRFTKEDLRLADYEEWFSALGYDLR
CCHHHHHHHHHHCCCCEECCCCEEEEHEEEEEEEEEEECHHHCCCCCHHHHHHHCCCCEE
LPAGLSAQRLLARMKSDKKTNAGKIVMVLLAQLGAAYTKTVDEHLLLELLEEELGGRS
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVDIHTSSKQYKAEVGSGILREAGKTIEALAPASSYLIVSDENVANRYLDVLVSSFSKE
CEEEEECCCHHHHHHHCCHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCC
PHTFVVKAGEQSKSFHVYEQLAAFCLEKQLDRQSVIIAFGGGVVGDLAGFVAGTYMRGVR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCEE
FIQVPTTLLAHDSSVGGKVAVNLPAAKNMIGVFHQPEAVLFDTELLATLPEHEWRSGFAE
EEEECHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEECHHHHHHCCCHHHHHHHHH
IVKLGFIADASFLAWLRETVPALTSIKADNLQKMVAKAIAIKADIVGKDEKEHGIRAHLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
FGHTLAHAIEAELGYGKITHGEAVAIGMRFAFRLSLRFTKEDLRLADYEEWFSALGYDLR
CCHHHHHHHHHHCCCCEECCCCEEEEHEEEEEEEEEEECHHHCCCCCHHHHHHHCCCCEE
LPAGLSAQRLLARMKSDKKTNAGKIVMVLLAQLGAAYTKTVDEHLLLELLEEELGGRS
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA