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The map label for this gene is mmgD [H]

Identifier: 56963570

GI number: 56963570

Start: 1922467

End: 1923588

Strand: Direct

Name: mmgD [H]

Synonym: ABC1805

Alternate gene names: 56963570

Gene position: 1922467-1923588 (Clockwise)

Preceding gene: 56963569

Following gene: 56963571

Centisome position: 44.67

GC content: 45.63

Gene sequence:

>1122_bases
ATGCAAGTTGAACAAACGTATCATCCAGGATTGGACGGAGTGATTGCGGCAGAAACCGATTTATCTTTTCTCGACACGGA
ACAAGGACAAATCATCATCCACGGTTACGACTTGATTCAATTATCAAAAACAAATGGCTATTTGGATATTGTCCACTTAT
TGTTAAAGGGTGAATTGCCGTCGGAACAAGAACGGCTAGCATTAGCAGAACGTTTAAGCGGTTCGTATGACTTGCCTGAA
GCTGTTTTGGACGTTTTAAAACGGCTACCTGCATCGACACACCCAATGGATGCACTGCGGACGGGCGTTTCTGTGCTAGG
GGGTTTTGATACACGGCTAGATGACCGCAGTGAAGAGGCAAACCGTGAACGAGCCTATGAATTACTGGCCAAGCTGCCGG
CGGTTGTTGCTAACAGTTACCGCATCCTTGAGAAGAAACAAGTGTTAACGCCAAAAGATTCCCTTTCCTATAGCGCCAAT
TTCTTATACATGATTACAGGAAATGTGCCAAGTGAATTAGAAGAGCGTGTGTTCGACCAATCGCTGTTGCTCTATTCTGA
GCATGAAATGCCTAACTCCACTTTTGCAGCGCGAGTCATTGCCTCCACGCTTTCAGATATGTACGGCGCCTTAACGGGGG
CAGTCGCTTCTTTGAAAGGGCATTTGCACGGCGGCGCCAATGAAGCAGTTATGTATATGCTCCTTGATGCAAACTCACCT
GAAGAGTTTGAAACACTTCTATCGAATAAGTTAAAGAAAAAAGAAAAAATAATGGGATTTGGCCACCGAGTGTATATGAA
AAAAATCGACCCTCGGGCTCTTATTATGAAAGAAGCGCTTGCTGAACTTTCACAAGCTGCTGGAGATGACAGACTCCTGC
AAATGTGCGAGGCGGGAGAGGCTCTTATGGCTAAAGAGAAGGGGCTTTATCCTAATTTAGACTATTATGCTGCCCCGGTA
TACTGGATGTTAGGCATCCCAATCAGCTTGTATACCCCGATTTTCTTTTCGTCCCGGACAGCCGGGCTAAGTGCCCACGT
AATCGAGCAACATCGAAACAACAAGCTATTTAGGCCTCGGGTTAAGTATACAGGGCCACGTTATACATCTGTACAGAAAT
GA

Upstream 100 bases:

>100_bases
GTCGTAGACGGCAGTTGGAGGTGAGTTTCGTCGAATTATGTAAGCGCTTTATTTAATTAGACTTATCGTTTTACTCGGAA
AAAGAAAAAGGAGGGATCGC

Downstream 100 bases:

>100_bases
AGGGACAACGGAGGTTTTTTGCATGGACTTGAAAACGGATACAAGAAAAACAGACTTGCTTTTAGAGGAAATTGCTGAGT
ATGTGCTAAAAAAGGAGATT

Product: citrate synthase 3

Products: NA

Alternate protein names: Citrate synthase 3; Citrate synthase III; Methylcitrate synthase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MQVEQTYHPGLDGVIAAETDLSFLDTEQGQIIIHGYDLIQLSKTNGYLDIVHLLLKGELPSEQERLALAERLSGSYDLPE
AVLDVLKRLPASTHPMDALRTGVSVLGGFDTRLDDRSEEANRERAYELLAKLPAVVANSYRILEKKQVLTPKDSLSYSAN
FLYMITGNVPSELEERVFDQSLLLYSEHEMPNSTFAARVIASTLSDMYGALTGAVASLKGHLHGGANEAVMYMLLDANSP
EEFETLLSNKLKKKEKIMGFGHRVYMKKIDPRALIMKEALAELSQAAGDDRLLQMCEAGEALMAKEKGLYPNLDYYAAPV
YWMLGIPISLYTPIFFSSRTAGLSAHVIEQHRNNKLFRPRVKYTGPRYTSVQK

Sequences:

>Translated_373_residues
MQVEQTYHPGLDGVIAAETDLSFLDTEQGQIIIHGYDLIQLSKTNGYLDIVHLLLKGELPSEQERLALAERLSGSYDLPE
AVLDVLKRLPASTHPMDALRTGVSVLGGFDTRLDDRSEEANRERAYELLAKLPAVVANSYRILEKKQVLTPKDSLSYSAN
FLYMITGNVPSELEERVFDQSLLLYSEHEMPNSTFAARVIASTLSDMYGALTGAVASLKGHLHGGANEAVMYMLLDANSP
EEFETLLSNKLKKKEKIMGFGHRVYMKKIDPRALIMKEALAELSQAAGDDRLLQMCEAGEALMAKEKGLYPNLDYYAAPV
YWMLGIPISLYTPIFFSSRTAGLSAHVIEQHRNNKLFRPRVKYTGPRYTSVQK
>Mature_373_residues
MQVEQTYHPGLDGVIAAETDLSFLDTEQGQIIIHGYDLIQLSKTNGYLDIVHLLLKGELPSEQERLALAERLSGSYDLPE
AVLDVLKRLPASTHPMDALRTGVSVLGGFDTRLDDRSEEANRERAYELLAKLPAVVANSYRILEKKQVLTPKDSLSYSAN
FLYMITGNVPSELEERVFDQSLLLYSEHEMPNSTFAARVIASTLSDMYGALTGAVASLKGHLHGGANEAVMYMLLDANSP
EEFETLLSNKLKKKEKIMGFGHRVYMKKIDPRALIMKEALAELSQAAGDDRLLQMCEAGEALMAKEKGLYPNLDYYAAPV
YWMLGIPISLYTPIFFSSRTAGLSAHVIEQHRNNKLFRPRVKYTGPRYTSVQK

Specific function: Catalyzes the synthesis of citrate from acetyl-CoA and oxaloacetate. The genomic context suggests that this protein probably functions as a 2-methylcitrate synthase, i.e. catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=373, Percent_Identity=27.0777479892761, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786527, Length=357, Percent_Identity=37.2549019607843, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1786939, Length=375, Percent_Identity=32, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17555174, Length=377, Percent_Identity=29.1777188328912, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=394, Percent_Identity=26.9035532994924, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319850, Length=405, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325257, Length=334, Percent_Identity=26.0479041916168, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640124, Length=378, Percent_Identity=27.5132275132275, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24640126, Length=378, Percent_Identity=27.5132275132275, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21356863, Length=321, Percent_Identity=24.2990654205607, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5; =2.3.3.1 [H]

Molecular weight: Translated: 41638; Mature: 41638

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVEQTYHPGLDGVIAAETDLSFLDTEQGQIIIHGYDLIQLSKTNGYLDIVHLLLKGELP
CCCCCCCCCCCCCEEEECCCCHHEECCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCC
SEQERLALAERLSGSYDLPEAVLDVLKRLPASTHPMDALRTGVSVLGGFDTRLDDRSEEA
CHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
NRERAYELLAKLPAVVANSYRILEKKQVLTPKDSLSYSANFLYMITGNVPSELEERVFDQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
SLLLYSEHEMPNSTFAARVIASTLSDMYGALTGAVASLKGHLHGGANEAVMYMLLDANSP
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCH
EEFETLLSNKLKKKEKIMGFGHRVYMKKIDPRALIMKEALAELSQAAGDDRLLQMCEAGE
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
ALMAKEKGLYPNLDYYAAPVYWMLGIPISLYTPIFFSSRTAGLSAHVIEQHRNNKLFRPR
HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCHHHCCCCCCCCHHHHHHHHCCCCCCCCC
VKYTGPRYTSVQK
CCCCCCCCCCCCC
>Mature Secondary Structure
MQVEQTYHPGLDGVIAAETDLSFLDTEQGQIIIHGYDLIQLSKTNGYLDIVHLLLKGELP
CCCCCCCCCCCCCEEEECCCCHHEECCCCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCC
SEQERLALAERLSGSYDLPEAVLDVLKRLPASTHPMDALRTGVSVLGGFDTRLDDRSEEA
CHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
NRERAYELLAKLPAVVANSYRILEKKQVLTPKDSLSYSANFLYMITGNVPSELEERVFDQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
SLLLYSEHEMPNSTFAARVIASTLSDMYGALTGAVASLKGHLHGGANEAVMYMLLDANSP
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCH
EEFETLLSNKLKKKEKIMGFGHRVYMKKIDPRALIMKEALAELSQAAGDDRLLQMCEAGE
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
ALMAKEKGLYPNLDYYAAPVYWMLGIPISLYTPIFFSSRTAGLSAHVIEQHRNNKLFRPR
HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCHHHCCCCCCCCHHHHHHHHCCCCCCCCC
VKYTGPRYTSVQK
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]