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The map label for this gene is yqjC [H]

Identifier: 56963517

GI number: 56963517

Start: 1875294

End: 1875707

Strand: Direct

Name: yqjC [H]

Synonym: ABC1752

Alternate gene names: 56963517

Gene position: 1875294-1875707 (Clockwise)

Preceding gene: 56963516

Following gene: 56963518

Centisome position: 43.57

GC content: 45.65

Gene sequence:

>414_bases
ATGGACCATTTTCAAATTGACCATATTGCTATCGCCGTTCCTTCCTTAAACACCAGCCTTCCTTTGTTTGAACAAGCGCT
TCAAGCGACTGCCAGCCATGAGGAAAGGCTGCCACACCATCATATTAATGCTGTTTTTATTAATGGGAGGGGAGTGGGGT
ATGAACTGATTGAACCTCATCCTAGCAACGTATCGTTGCAACGCTTTCTAGCGAAACAAAACAATCGACCTGCTTTTCAC
CACATTGCTTTTTCGGTTGCTAATATAGAGACGGCCATAGGAATGTTGAAAGAAAAGCACGTCCGCTTGACGAGTGAGTT
GCCGCTTATCGGTAGCTTCGGACGGAAGGTTGCTTTTATTCATCCGAGCAGTACAGGCGGTTTGCTCGTTGAACTTTGTG
AGGGAAAAACGTGA

Upstream 100 bases:

>100_bases
ACTATCAAGCGCTGGAATTTACGCGGCATCTCCATTCCTCCCCAAATCAACTACTTTTTAGTTTACCCGAAGAAAACACA
AGCAATCAAGGGGTGTTTTT

Downstream 100 bases:

>100_bases
AATCAATTAGCAAATCAGCTATAGTAAAAAGGAAATGGAAAAGCAGCGATGGAGTGATGACGTGTATTCAAGAGTAGTCG
AAGAGTTTTTGGAACTTGTG

Product: lactoylglutathione lyase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MDHFQIDHIAIAVPSLNTSLPLFEQALQATASHEERLPHHHINAVFINGRGVGYELIEPHPSNVSLQRFLAKQNNRPAFH
HIAFSVANIETAIGMLKEKHVRLTSELPLIGSFGRKVAFIHPSSTGGLLVELCEGKT

Sequences:

>Translated_137_residues
MDHFQIDHIAIAVPSLNTSLPLFEQALQATASHEERLPHHHINAVFINGRGVGYELIEPHPSNVSLQRFLAKQNNRPAFH
HIAFSVANIETAIGMLKEKHVRLTSELPLIGSFGRKVAFIHPSSTGGLLVELCEGKT
>Mature_137_residues
MDHFQIDHIAIAVPSLNTSLPLFEQALQATASHEERLPHHHINAVFINGRGVGYELIEPHPSNVSLQRFLAKQNNRPAFH
HIAFSVANIETAIGMLKEKHVRLTSELPLIGSFGRKVAFIHPSSTGGLLVELCEGKT

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=128, Percent_Identity=38.28125, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17506387, Length=128, Percent_Identity=35.9375, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 15128; Mature: 15128

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFQIDHIAIAVPSLNTSLPLFEQALQATASHEERLPHHHINAVFINGRGVGYELIEPH
CCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
PSNVSLQRFLAKQNNRPAFHHIAFSVANIETAIGMLKEKHVRLTSELPLIGSFGRKVAFI
CCCHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHHHHHHHEEECCCCCCEECCCCEEEEE
HPSSTGGLLVELCEGKT
CCCCCCCEEEEECCCCC
>Mature Secondary Structure
MDHFQIDHIAIAVPSLNTSLPLFEQALQATASHEERLPHHHINAVFINGRGVGYELIEPH
CCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
PSNVSLQRFLAKQNNRPAFHHIAFSVANIETAIGMLKEKHVRLTSELPLIGSFGRKVAFI
CCCHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHHHHHHHEEECCCCCCEECCCCEEEEE
HPSSTGGLLVELCEGKT
CCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]