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The map label for this gene is era

Identifier: 56963446

GI number: 56963446

Start: 1809663

End: 1810574

Strand: Direct

Name: era

Synonym: ABC1681

Alternate gene names: 56963446

Gene position: 1809663-1810574 (Clockwise)

Preceding gene: 56963445

Following gene: 56963447

Centisome position: 42.05

GC content: 43.31

Gene sequence:

>912_bases
ATGAAGCAAAAAACAACAACATTTAAATCAGGGTTTGTGTCCATTATTGGCAGGCCAAATGTTGGAAAGTCAACCCTTTT
AAACCGGGTGATTGGCCAGAAAATTGCCATTATGTCAGACAAGCCGCAAACAACACGGAATAAAGTGCAAGGCGTGTTGA
CACGAGACGACGCGCAACTTGTCTTTATGGACACGCCTGGCATTCACAAACCGAAACACCGGCTAGGCGACTTTATGATG
AAAGTCGCAAAAAATACGCTCCGCGAAGTGGATTTGATTTTATACGTGGTGGAAGCGGATGCGAAATTCGGCCCTGGTGA
ACAGTATATTATCGAACGACTTCAGGAAACGAAAACACCGGTGTTTTTATTGATTAACAAAATTGATAAAGTTTCTCCAG
AAGAATTGCTTAAAGTGATTGATTTGTACAAAGATCGTTATCCATTTGCAGAAATTATCCCGATTTCCGCATTGGAAGGG
AATAATGTGCCAACGCTTGTCGAACAAATTGTGGAGCACATGGAAGAAGGGCCGCAATATTACCCGGCAGACCAAGTGAC
GGACCACCCAGAACGGTTTATAATTGCTGAGCTTATTCGCGAGAAAGTGCTTCATTTGACGAAGGAAGAAATTCCACATT
CTGTCGCTGTAGTCATTGAACAAATCAAAAAGCGGGACAATGGCAAAGTATATGTTGGCGCCACTGTCATCGTCGAGCGT
TCGTCGCAAAAAGGCATTATCATTGGCAAACATGGTGCCATGCTAAAAGAAGTCGGCCAGCTTGCCCGAAGCGACATTGA
AGCGCTGCTTGGTTCTAGCGTCTATTTGGAACTGTGGGTGAAAGTCCAAAAAGACTGGCGTAACCGACCGTCTCAATTAA
AGGATTATGGTTTTAATGAAAATGAATATTAA

Upstream 100 bases:

>100_bases
CCACCAGAAATGCCTGTGTATTTATGTAACTTAAAAGGAAATGTGAAACAAACAACAGTGGAAGAATTGCTGCCTGGATT
TTTTAAAGCGGAGGATTTAT

Downstream 100 bases:

>100_bases
CTGGGAAAACAATGGGTTCAAACTGGGCGTTTGACCATTGTTTTTTTATGTCGCCTGATTTATGATTAAACAAACAATCT
GATAAAATTAACCAAATTAA

Product: Era, Era/TrmE family GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKQKTTTFKSGFVSIIGRPNVGKSTLLNRVIGQKIAIMSDKPQTTRNKVQGVLTRDDAQLVFMDTPGIHKPKHRLGDFMM
KVAKNTLREVDLILYVVEADAKFGPGEQYIIERLQETKTPVFLLINKIDKVSPEELLKVIDLYKDRYPFAEIIPISALEG
NNVPTLVEQIVEHMEEGPQYYPADQVTDHPERFIIAELIREKVLHLTKEEIPHSVAVVIEQIKKRDNGKVYVGATVIVER
SSQKGIIIGKHGAMLKEVGQLARSDIEALLGSSVYLELWVKVQKDWRNRPSQLKDYGFNENEY

Sequences:

>Translated_303_residues
MKQKTTTFKSGFVSIIGRPNVGKSTLLNRVIGQKIAIMSDKPQTTRNKVQGVLTRDDAQLVFMDTPGIHKPKHRLGDFMM
KVAKNTLREVDLILYVVEADAKFGPGEQYIIERLQETKTPVFLLINKIDKVSPEELLKVIDLYKDRYPFAEIIPISALEG
NNVPTLVEQIVEHMEEGPQYYPADQVTDHPERFIIAELIREKVLHLTKEEIPHSVAVVIEQIKKRDNGKVYVGATVIVER
SSQKGIIIGKHGAMLKEVGQLARSDIEALLGSSVYLELWVKVQKDWRNRPSQLKDYGFNENEY
>Mature_303_residues
MKQKTTTFKSGFVSIIGRPNVGKSTLLNRVIGQKIAIMSDKPQTTRNKVQGVLTRDDAQLVFMDTPGIHKPKHRLGDFMM
KVAKNTLREVDLILYVVEADAKFGPGEQYIIERLQETKTPVFLLINKIDKVSPEELLKVIDLYKDRYPFAEIIPISALEG
NNVPTLVEQIVEHMEEGPQYYPADQVTDHPERFIIAELIREKVLHLTKEEIPHSVAVVIEQIKKRDNGKVYVGATVIVER
SSQKGIIIGKHGAMLKEVGQLARSDIEALLGSSVYLELWVKVQKDWRNRPSQLKDYGFNENEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=24.5341614906832, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1788919, Length=291, Percent_Identity=38.4879725085911, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI87082120, Length=179, Percent_Identity=30.7262569832402, Blast_Score=95, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323665, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=25.974025974026, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_BACSK (Q5WHD9)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175177.1
- HSSP:   Q9X1F8
- ProteinModelPortal:   Q5WHD9
- SMR:   Q5WHD9
- STRING:   Q5WHD9
- EnsemblBacteria:   EBBACT00000046271
- GeneID:   3202347
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1681
- NMPDR:   fig|66692.3.peg.64
- eggNOG:   COG1159
- GeneTree:   EBGT00070000032135
- HOGENOM:   HBG561652
- OMA:   QNATRRK
- BioCyc:   BCLA66692:ABC1681-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34460; Mature: 34460

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKTTTFKSGFVSIIGRPNVGKSTLLNRVIGQKIAIMSDKPQTTRNKVQGVLTRDDAQL
CCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHEEECCCEE
VFMDTPGIHKPKHRLGDFMMKVAKNTLREVDLILYVVEADAKFGPGEQYIIERLQETKTP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCC
VFLLINKIDKVSPEELLKVIDLYKDRYPFAEIIPISALEGNNVPTLVEQIVEHMEEGPQY
EEEEEHHHCCCCHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCC
YPADQVTDHPERFIIAELIREKVLHLTKEEIPHSVAVVIEQIKKRDNGKVYVGATVIVER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEEE
SSQKGIIIGKHGAMLKEVGQLARSDIEALLGSSVYLELWVKVQKDWRNRPSQLKDYGFNE
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHCCCCC
NEY
CCC
>Mature Secondary Structure
MKQKTTTFKSGFVSIIGRPNVGKSTLLNRVIGQKIAIMSDKPQTTRNKVQGVLTRDDAQL
CCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHEEECCCEE
VFMDTPGIHKPKHRLGDFMMKVAKNTLREVDLILYVVEADAKFGPGEQYIIERLQETKTP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCC
VFLLINKIDKVSPEELLKVIDLYKDRYPFAEIIPISALEGNNVPTLVEQIVEHMEEGPQY
EEEEEHHHCCCCHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCC
YPADQVTDHPERFIIAELIREKVLHLTKEEIPHSVAVVIEQIKKRDNGKVYVGATVIVER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEEE
SSQKGIIIGKHGAMLKEVGQLARSDIEALLGSSVYLELWVKVQKDWRNRPSQLKDYGFNE
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHCCCCC
NEY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA