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The map label for this gene is comEC [H]

Identifier: 56963413

GI number: 56963413

Start: 1775692

End: 1777998

Strand: Direct

Name: comEC [H]

Synonym: ABC1648

Alternate gene names: 56963413

Gene position: 1775692-1777998 (Clockwise)

Preceding gene: 56963412

Following gene: 56963415

Centisome position: 41.26

GC content: 47.64

Gene sequence:

>2307_bases
ATGAACCGCCTGTGCATCAGTTTGCTCACAGCGAGCGCAGCTGTTGTGTTCGTTTTAAGCAGCCATGTTGGCGTTGCTGT
CGCGTTGTTTATAGGAGCAATCGCTCTCCTGCCCGCGGCTTGGCGGAGCGGCCGGCTAGCAGCGGTGACGGCATTTGTAC
TGCCGTTGCTTCTGTTTGCTAGTGTGGCGACTGTGCACAAAAAAAGCAACGTCAGCATGCTTTCAGGTGAGGAAACGGCG
TTTATTGTAGTGGTAAAAGAAACACCTCGCCTTGATGGAAATCGCTTCCGGGTAGTTGTTGAAACAACGGCCGGGGAGCG
CTTGCAATTAGCAAGCCGTTTGCAATCAGAAAGCGAGCAACGTTTAGGAAAATTATTACCAGGAGACCATTGCCGCGTAA
ATGGAAAGTTGAGCGAGCCAGCGCCTCCGCGCAACCGTTATGCATTTGACTATAGCCGCTATTTATATGAGCAACGAATT
CACTGGCTGTTGGAGGTAGAGTCTGGGTCCTTTGTATGCAAACGCCCGGACGGGCTTTCGTTATTGACCCATTTGCAGGC
ATTTCGAGCACAATTGCTTCACGAGGCGGCTGCTGCCTTTCCAGAAGAAGCAGGAGGCATTGTGTTGGCGCTTACTCTTG
GAGAGCGTTTCTATGTAGAAGAAGACGTGATTGAAGCTTACTCAACGCTTGGCATTATCCACTTGCTAGCGATCTCTGGC
TTGCATGTTGGCTTGGTGACTGGAGCCGCTTTCTTTATCTGTATCCGCATCGGTTTGACGCGTGAGCGTGCCGCACTATT
CATGCTTATTCTCTTGCCTATTTTTGCAATTCTCGCCGGGGCGGCGCCTCCGGTAGTACGCGCGTCCGCAATGGCATTCG
TGTTTTTTCTATTTGCCTTACGCAAATGGCGAATTCACCCCTTATTCGGTTTTGCTACGATCTATTTCCTCTATCTGTTG
TTGGATCCTTACAAACTGTTCCAACTCGGTTTTCAACTTTCGTTTCTCGTATCGTTTGCTCTGATTTTCTCGGCTAAAAC
GATTCAAACCGCAAACGGAGGGTATTTACGGCAAATGTGCACGGTCACAACAATTGCCCAGTTTGCCGGATTGCCGCTTA
TCTTTTTCCATTTCTATGAATGGTCACCTTTCAGCCTTCTCCTCAACCTTGTGTATATTCCACTTGTTTCATTTATCGTT
CTTCCCTTTAGTTTCCTCTCTCTGATTGCGTTTGTATGGCTTCCTGAGCAAGTAAATCTGTTTATTGGATTGCTCGAATC
GCTTTTGACGTTTGTTCATCCAACTCTTCTTAAGCTAAGTGAATCTACTTTTCAGCTTGTGCTTGGGAAACCTCCGGTAT
GGCTTGTAGTCGCAATGTATGGTGCTCTTGCTTTTGCTTTTGTCCATTGGCAGGAACAAAAATGGCCTTTGCCGATCGCT
TTTTTGCCTTTTGTTGCCTGTTTAATCGTTGGAGCTGTTGCGCCTTACGTTCAGTCAAAAGCAGCTGTGACGATGATTGA
TGTCGGCCAAGGCGATAGTTTTTTGATTGAGCTCCCTTACCGAAAAGGGATTTATATGATCGATACTGGGGGAGTGGCAG
TTTATGGCGAGGAAGAAGACTGGCAGCAACGGAAAAACACGTTCGACCCAGGCAGTGATGTCATTGCTCCATTTTTAAAA
GCGAAAGGCATCAGCAAAATAGACATGCTTGTTTTAACACATGGCGATTACGACCATATTGGCGGGGCAACTGGTTTGTT
GAATGAAATCAATGTCGAACAGGTTATTTATCCGAAAGGGCCAGTTGAAAAGGAAACTGAAATTGAGCTCCTCGAAAACA
TTCACGCATCGCCAACCAACCTCCACTTTACGAGAGCAAACGAGGTGCTTGCTGAGAATTGGTATGTGTTGCATCCACCA
GAGGGAGAACACTTTACAGGAAATGACGGTTCTATCGTAATATTTGCTGAAATTGAAGGGGTGACGTTTCTATTCACTGG
AGATTTGGAAGAGACAGGAGAACAGAGGCTTATGCGCTCGTATCCCGGCATACAAGCAGATGTGCTAAAAGTTGGCCATC
ATGGCAGTTTATCGTCTACGACAGAACCGTTTATTAGCCAAGTGGCACCGCGCTATGCATTCATCTCGGCAGGGCCCCAA
AACCGCTTTGGCCACCCTCACCCTGAAGTGGTTGAGCGGCTAGAAAGGGCGAATATGATCGTGTGGCGAACAGATCTACA
TGGAATGGTTGAACTGACGCTTAGCAATGGGGAAATTGAGGCGGTGGAGACGATGCTAAAACCGTGA

Upstream 100 bases:

>100_bases
AAATTGAACGGTTAGGGGCAAGCGAAGAAGAATTGGATGCCTATGTAAAGCGAACAAAGAACTTGTATTTCTCAGCAAGC
AATGATGTGCCAGAAGAGAA

Downstream 100 bases:

>100_bases
ACATAAAAAAGGCAGAAAATAATCTGCCCCAGACTTTATAGGAAAACGCTCGCATCCTTCGTTGTTCCCCTCGGCTGACA
AGCGTTTCCGATCAGTCTGA

Product: late competence protein ComEC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 768

Protein sequence:

>768_residues
MNRLCISLLTASAAVVFVLSSHVGVAVALFIGAIALLPAAWRSGRLAAVTAFVLPLLLFASVATVHKKSNVSMLSGEETA
FIVVVKETPRLDGNRFRVVVETTAGERLQLASRLQSESEQRLGKLLPGDHCRVNGKLSEPAPPRNRYAFDYSRYLYEQRI
HWLLEVESGSFVCKRPDGLSLLTHLQAFRAQLLHEAAAAFPEEAGGIVLALTLGERFYVEEDVIEAYSTLGIIHLLAISG
LHVGLVTGAAFFICIRIGLTRERAALFMLILLPIFAILAGAAPPVVRASAMAFVFFLFALRKWRIHPLFGFATIYFLYLL
LDPYKLFQLGFQLSFLVSFALIFSAKTIQTANGGYLRQMCTVTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIV
LPFSFLSLIAFVWLPEQVNLFIGLLESLLTFVHPTLLKLSESTFQLVLGKPPVWLVVAMYGALAFAFVHWQEQKWPLPIA
FLPFVACLIVGAVAPYVQSKAAVTMIDVGQGDSFLIELPYRKGIYMIDTGGVAVYGEEEDWQQRKNTFDPGSDVIAPFLK
AKGISKIDMLVLTHGDYDHIGGATGLLNEINVEQVIYPKGPVEKETEIELLENIHASPTNLHFTRANEVLAENWYVLHPP
EGEHFTGNDGSIVIFAEIEGVTFLFTGDLEETGEQRLMRSYPGIQADVLKVGHHGSLSSTTEPFISQVAPRYAFISAGPQ
NRFGHPHPEVVERLERANMIVWRTDLHGMVELTLSNGEIEAVETMLKP

Sequences:

>Translated_768_residues
MNRLCISLLTASAAVVFVLSSHVGVAVALFIGAIALLPAAWRSGRLAAVTAFVLPLLLFASVATVHKKSNVSMLSGEETA
FIVVVKETPRLDGNRFRVVVETTAGERLQLASRLQSESEQRLGKLLPGDHCRVNGKLSEPAPPRNRYAFDYSRYLYEQRI
HWLLEVESGSFVCKRPDGLSLLTHLQAFRAQLLHEAAAAFPEEAGGIVLALTLGERFYVEEDVIEAYSTLGIIHLLAISG
LHVGLVTGAAFFICIRIGLTRERAALFMLILLPIFAILAGAAPPVVRASAMAFVFFLFALRKWRIHPLFGFATIYFLYLL
LDPYKLFQLGFQLSFLVSFALIFSAKTIQTANGGYLRQMCTVTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIV
LPFSFLSLIAFVWLPEQVNLFIGLLESLLTFVHPTLLKLSESTFQLVLGKPPVWLVVAMYGALAFAFVHWQEQKWPLPIA
FLPFVACLIVGAVAPYVQSKAAVTMIDVGQGDSFLIELPYRKGIYMIDTGGVAVYGEEEDWQQRKNTFDPGSDVIAPFLK
AKGISKIDMLVLTHGDYDHIGGATGLLNEINVEQVIYPKGPVEKETEIELLENIHASPTNLHFTRANEVLAENWYVLHPP
EGEHFTGNDGSIVIFAEIEGVTFLFTGDLEETGEQRLMRSYPGIQADVLKVGHHGSLSSTTEPFISQVAPRYAFISAGPQ
NRFGHPHPEVVERLERANMIVWRTDLHGMVELTLSNGEIEAVETMLKP
>Mature_768_residues
MNRLCISLLTASAAVVFVLSSHVGVAVALFIGAIALLPAAWRSGRLAAVTAFVLPLLLFASVATVHKKSNVSMLSGEETA
FIVVVKETPRLDGNRFRVVVETTAGERLQLASRLQSESEQRLGKLLPGDHCRVNGKLSEPAPPRNRYAFDYSRYLYEQRI
HWLLEVESGSFVCKRPDGLSLLTHLQAFRAQLLHEAAAAFPEEAGGIVLALTLGERFYVEEDVIEAYSTLGIIHLLAISG
LHVGLVTGAAFFICIRIGLTRERAALFMLILLPIFAILAGAAPPVVRASAMAFVFFLFALRKWRIHPLFGFATIYFLYLL
LDPYKLFQLGFQLSFLVSFALIFSAKTIQTANGGYLRQMCTVTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIV
LPFSFLSLIAFVWLPEQVNLFIGLLESLLTFVHPTLLKLSESTFQLVLGKPPVWLVVAMYGALAFAFVHWQEQKWPLPIA
FLPFVACLIVGAVAPYVQSKAAVTMIDVGQGDSFLIELPYRKGIYMIDTGGVAVYGEEEDWQQRKNTFDPGSDVIAPFLK
AKGISKIDMLVLTHGDYDHIGGATGLLNEINVEQVIYPKGPVEKETEIELLENIHASPTNLHFTRANEVLAENWYVLHPP
EGEHFTGNDGSIVIFAEIEGVTFLFTGDLEETGEQRLMRSYPGIQADVLKVGHHGSLSSTTEPFISQVAPRYAFISAGPQ
NRFGHPHPEVVERLERANMIVWRTDLHGMVELTLSNGEIEAVETMLKP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=622, Percent_Identity=24.5980707395498, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 85124; Mature: 85124

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLCISLLTASAAVVFVLSSHVGVAVALFIGAIALLPAAWRSGRLAAVTAFVLPLLLFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SVATVHKKSNVSMLSGEETAFIVVVKETPRLDGNRFRVVVETTAGERLQLASRLQSESEQ
HHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
RLGKLLPGDHCRVNGKLSEPAPPRNRYAFDYSRYLYEQRIHWLLEVESGSFVCKRPDGLS
HHHHCCCCCCEEECCEECCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEEEECCCCHH
LLTHLQAFRAQLLHEAAAAFPEEAGGIVLALTLGERFYVEEDVIEAYSTLGIIHLLAISG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCC
LHVGLVTGAAFFICIRIGLTRERAALFMLILLPIFAILAGAAPPVVRASAMAFVFFLFAL
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RKWRIHPLFGFATIYFLYLLLDPYKLFQLGFQLSFLVSFALIFSAKTIQTANGGYLRQMC
HHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
TVTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIVLPFSFLSLIAFVWLPEQVNL
HHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FIGLLESLLTFVHPTLLKLSESTFQLVLGKPPVWLVVAMYGALAFAFVHWQEQKWPLPIA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
FLPFVACLIVGAVAPYVQSKAAVTMIDVGQGDSFLIELPYRKGIYMIDTGGVAVYGEEED
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCEEEECCCHH
WQQRKNTFDPGSDVIAPFLKAKGISKIDMLVLTHGDYDHIGGATGLLNEINVEQVIYPKG
HHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHCCCCHHHHHHCCCCEEECCCC
PVEKETEIELLENIHASPTNLHFTRANEVLAENWYVLHPPEGEHFTGNDGSIVIFAEIEG
CCCCCHHHHHHHHCCCCCCCEEEECHHHHHHCCCEEEECCCCCCEECCCCCEEEEEEECC
VTFLFTGDLEETGEQRLMRSYPGIQADVLKVGHHGSLSSTTEPFISQVAPRYAFISAGPQ
EEEEEECCHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCHHHHHHHHCCCEEEEECCCC
NRFGHPHPEVVERLERANMIVWRTDLHGMVELTLSNGEIEAVETMLKP
CCCCCCCHHHHHHHHHCCEEEEEECCCEEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MNRLCISLLTASAAVVFVLSSHVGVAVALFIGAIALLPAAWRSGRLAAVTAFVLPLLLFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SVATVHKKSNVSMLSGEETAFIVVVKETPRLDGNRFRVVVETTAGERLQLASRLQSESEQ
HHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
RLGKLLPGDHCRVNGKLSEPAPPRNRYAFDYSRYLYEQRIHWLLEVESGSFVCKRPDGLS
HHHHCCCCCCEEECCEECCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEEEECCCCHH
LLTHLQAFRAQLLHEAAAAFPEEAGGIVLALTLGERFYVEEDVIEAYSTLGIIHLLAISG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCC
LHVGLVTGAAFFICIRIGLTRERAALFMLILLPIFAILAGAAPPVVRASAMAFVFFLFAL
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RKWRIHPLFGFATIYFLYLLLDPYKLFQLGFQLSFLVSFALIFSAKTIQTANGGYLRQMC
HHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
TVTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIVLPFSFLSLIAFVWLPEQVNL
HHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FIGLLESLLTFVHPTLLKLSESTFQLVLGKPPVWLVVAMYGALAFAFVHWQEQKWPLPIA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
FLPFVACLIVGAVAPYVQSKAAVTMIDVGQGDSFLIELPYRKGIYMIDTGGVAVYGEEED
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCEEEECCCHH
WQQRKNTFDPGSDVIAPFLKAKGISKIDMLVLTHGDYDHIGGATGLLNEINVEQVIYPKG
HHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHCCCCHHHHHHCCCCEEECCCC
PVEKETEIELLENIHASPTNLHFTRANEVLAENWYVLHPPEGEHFTGNDGSIVIFAEIEG
CCCCCHHHHHHHHCCCCCCCEEEECHHHHHHCCCEEEECCCCCCEECCCCCEEEEEEECC
VTFLFTGDLEETGEQRLMRSYPGIQADVLKVGHHGSLSSTTEPFISQVAPRYAFISAGPQ
EEEEEECCHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCHHHHHHHHCCCEEEEECCCC
NRFGHPHPEVVERLERANMIVWRTDLHGMVELTLSNGEIEAVETMLKP
CCCCCCCHHHHHHHHHCCEEEEEECCCEEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]