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The map label for this gene is aroD

Identifier: 56963403

GI number: 56963403

Start: 1769227

End: 1770054

Strand: Direct

Name: aroD

Synonym: ABC1638

Alternate gene names: 56963403

Gene position: 1769227-1770054 (Clockwise)

Preceding gene: 56963402

Following gene: 56963404

Centisome position: 41.11

GC content: 47.71

Gene sequence:

>828_bases
ATGACCCGCCAATTTGGTTTAATTGGTCATCCACTAGGCCATAGCAAAAGCCCAGTCATGCATGAAGCAGCCTACAAAGA
TATGGGGTTAGACGCTGTTTATTGTGCCTATGACATTTCTCCTCAGGAATTGGGAAATGCTATACGTACAATGAAAGCGC
AAGGCATCGACGGGTTTAACGTAACCATTCCCCATAAAGTCGCAATCATCGACTATTTAGACGAAATTGATGAAGATGCC
GAAGCGATGGGGGCGGTCAATACAGTCGTTTGTCAGGACGGCCGTTGGGTCGGCAAAAACACAGATGCGGATGGTTACAT
CGAATCCCTTCTGCCGGTTGTAAGCGACCAATCGCTTACAGGAAGGCGTGTGCTTGTCATTGGTGCAGGAGGCGCGGCGA
GGGCTGTAATCCACGCCCTCGGCAAACAACGTGCCACTATTTCTGTTTCAAACCGGACGGCGGAAAAAGCCCAGGAGCTG
GCGCAGCTGTTTAGCCATTTGACTATTGAGGCAATCCCGCTTAACGAGGCGGAATCAACGCTCGGAACATACGACGTATT
AATTAATACGACTTCAGTCGGTATGTACCCTGATACGAGCAAACAGCCGATCGCTTTAGACCGTCTTAAGCAAGCAACGA
TTGTTAGTGATTTAATTTATAACCCATATGAGACAGCGCTTTTGCAAGAAGCGAAACAAAGAGGAAACCGGATTTTAAAT
GGCATTGGCATGTTTGTCAATCAAGGAGCGTTGTCCATTGAACACTGGACAGGGCGCAAACCAAACCGCAAATGCATGGA
ACGCGTTGTTCGTATGCATTTGACTTAA

Upstream 100 bases:

>100_bases
AGACGGAAGGCGCCATCGTTGAAGCACACGCCCCAAAAGAAGTCGGCGTAGCGATTCGCCGTTCTATCCATACGTAAAAA
GGGAGCAGGAGGTGGAGGAA

Downstream 100 bases:

>100_bases
TGGGAGAGGTACTAGCAAATGTTAACAAATAAACAGAAGCGGTTTTTACGGGCCAAGTCACATGCGGTCCAGCCGATTTT
TCAAGTCGGCAAAGGGGGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MTRQFGLIGHPLGHSKSPVMHEAAYKDMGLDAVYCAYDISPQELGNAIRTMKAQGIDGFNVTIPHKVAIIDYLDEIDEDA
EAMGAVNTVVCQDGRWVGKNTDADGYIESLLPVVSDQSLTGRRVLVIGAGGAARAVIHALGKQRATISVSNRTAEKAQEL
AQLFSHLTIEAIPLNEAESTLGTYDVLINTTSVGMYPDTSKQPIALDRLKQATIVSDLIYNPYETALLQEAKQRGNRILN
GIGMFVNQGALSIEHWTGRKPNRKCMERVVRMHLT

Sequences:

>Translated_275_residues
MTRQFGLIGHPLGHSKSPVMHEAAYKDMGLDAVYCAYDISPQELGNAIRTMKAQGIDGFNVTIPHKVAIIDYLDEIDEDA
EAMGAVNTVVCQDGRWVGKNTDADGYIESLLPVVSDQSLTGRRVLVIGAGGAARAVIHALGKQRATISVSNRTAEKAQEL
AQLFSHLTIEAIPLNEAESTLGTYDVLINTTSVGMYPDTSKQPIALDRLKQATIVSDLIYNPYETALLQEAKQRGNRILN
GIGMFVNQGALSIEHWTGRKPNRKCMERVVRMHLT
>Mature_274_residues
TRQFGLIGHPLGHSKSPVMHEAAYKDMGLDAVYCAYDISPQELGNAIRTMKAQGIDGFNVTIPHKVAIIDYLDEIDEDAE
AMGAVNTVVCQDGRWVGKNTDADGYIESLLPVVSDQSLTGRRVLVIGAGGAARAVIHALGKQRATISVSNRTAEKAQELA
QLFSHLTIEAIPLNEAESTLGTYDVLINTTSVGMYPDTSKQPIALDRLKQATIVSDLIYNPYETALLQEAKQRGNRILNG
IGMFVNQGALSIEHWTGRKPNRKCMERVVRMHLT

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=263, Percent_Identity=33.4600760456274, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787983, Length=270, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=290, Percent_Identity=28.6206896551724, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_BACSK (Q5WHI2)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175134.1
- HSSP:   Q58484
- ProteinModelPortal:   Q5WHI2
- SMR:   Q5WHI2
- STRING:   Q5WHI2
- EnsemblBacteria:   EBBACT00000049359
- GeneID:   3201724
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1638
- NMPDR:   fig|66692.3.peg.1600
- eggNOG:   COG0169
- GeneTree:   EBGT00050000000826
- HOGENOM:   HBG553408
- OMA:   GMHPRVE
- BioCyc:   BCLA66692:ABC1638-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30046; Mature: 29915

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQFGLIGHPLGHSKSPVMHEAAYKDMGLDAVYCAYDISPQELGNAIRTMKAQGIDGFN
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCE
VTIPHKVAIIDYLDEIDEDAEAMGAVNTVVCQDGRWVGKNTDADGYIESLLPVVSDQSLT
EECCCHHHHHHHHHHHCHHHHHHCCHHEEEECCCEEECCCCCCHHHHHHHHHHHCCCCCC
GRRVLVIGAGGAARAVIHALGKQRATISVSNRTAEKAQELAQLFSHLTIEAIPLNEAEST
CCEEEEEECCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCHHHH
LGTYDVLINTTSVGMYPDTSKQPIALDRLKQATIVSDLIYNPYETALLQEAKQRGNRILN
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GIGMFVNQGALSIEHWTGRKPNRKCMERVVRMHLT
HHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TRQFGLIGHPLGHSKSPVMHEAAYKDMGLDAVYCAYDISPQELGNAIRTMKAQGIDGFN
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCE
VTIPHKVAIIDYLDEIDEDAEAMGAVNTVVCQDGRWVGKNTDADGYIESLLPVVSDQSLT
EECCCHHHHHHHHHHHCHHHHHHCCHHEEEECCCEEECCCCCCHHHHHHHHHHHCCCCCC
GRRVLVIGAGGAARAVIHALGKQRATISVSNRTAEKAQELAQLFSHLTIEAIPLNEAEST
CCEEEEEECCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCHHHH
LGTYDVLINTTSVGMYPDTSKQPIALDRLKQATIVSDLIYNPYETALLQEAKQRGNRILN
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GIGMFVNQGALSIEHWTGRKPNRKCMERVVRMHLT
HHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA