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The map label for this gene is hisS

Identifier: 56963341

GI number: 56963341

Start: 1698546

End: 1699826

Strand: Direct

Name: hisS

Synonym: ABC1576

Alternate gene names: 56963341

Gene position: 1698546-1699826 (Clockwise)

Preceding gene: 56963340

Following gene: 56963342

Centisome position: 39.47

GC content: 47.38

Gene sequence:

>1281_bases
ATGTCGATTCAGCTGCCACGGGGGACGCAAGATATTTTGCCAGATGACGCAGCAATTTGGCAGTACATTGAACAAGTTGC
TAAGGAAACATGCGAAACATACCATTATCAAGAAATCCGTACGCCGATCTTTGAACATACCGAAATTTTTTCACGGGGTG
TAGGCGATACGACCGATATTGTTCAAAAAGAAATGTATACCTTTTCGGACCGCGGCGGTCGCAGCTTAACACTAAGGCCT
GAGGGAACGGCGGCAGTCGTTCGTTCTTATGTCAACCATAAACTGTATGCATCCCCAGCACAGCCAACGAAGTTGTACTA
CACAGGGCCGATGTTTCGTTACGAGCGCCCACAAGCAGGGCGTATGCGTCAATTTGTCCAATTTGGCGTAGAGGCGCTTG
GCAGCGCGAGCCCCCAACTAGATGCGGAAGTGCTAGCATTGCTCATCGCTATCTGCAAAAAACTTGGCCTTGTCAACTTG
AAACTGGTCATCAATTCACTTGGCGATTCGGAAAGCCGTCAGGCACATCGGGAAGCATTAATTGCCCACTTTAAGCCATC
AATTGATGAATTTTGTAGCGACTGCCAAATGCGACTTGAAAAAAATCCATTGCGCATTCTCGATTGCAAAAAGGATAGAG
AGCATCCGCTTATGGCGACAGCACCGTCGATTTTAGATTATTTAAATGAAGAGTCACGTGCGTATTTTCAGTCGCTAAAG
GAAACGCTCGACTTGCTGAACATTCCTTATGTAGTCGATCCAACGCTTGTGCGTGGGTTGGATTATTACAACCATACCGC
ATTTGAATTGCTTAGTACTGCTCCAGGATTCGGAGCAATTACAACGCTATGCGGGGGCGGGCGCTACAATGGACTTGTCC
AGGAATTTGGCGGGCCAGAGACGCCAGGCATCGGATTTGCCTTCAGCATCGAACGCTTTATATTAGCGATGAAAGCGGAG
AATGTCGACTTGCCAGTACCGCAAAGCCTCGATGCGTATGTAGTTACTCTCGGCGATGAAGCAAGCCGCCTAGGGCCACA
ACTGTTGCAACGGTTGCGCGATGGAGGCATTCGTGCTGATAAAGACTACTTAGGCAAAAAAATGAAAGCACAGCTTAAAG
CGGCTGATCGTTATCAAGCGTCTTATACAATTATCATTGGCGAAGACGAAATCGCGAAGCAACAAGCGCTCGTTAAACAA
ATGGCAACTGGAGAACAAACGGTAGTCGCCATTAGCGATTTGACATCATTTTTACAAGAACAGATACGAGGAGGAAACTA
G

Upstream 100 bases:

>100_bases
TTTATGCCTCAATTTGGGTGGTACCACGGGATATGCTCCCGTCCCAGATGATCCGATCATCTGGGACGGGAGTTTTTTTA
TGGAAAAGGAGAGATGAGAG

Downstream 100 bases:

>100_bases
GAGATGAAACGTACACATCATTGTGGCCAACTTGACAAAACACTCGCAGGCCAACAGGTTCAACTAAAAGGGTGGGTGCA
GCGGCGCCGTGATTTAGGCC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase 1; HisRS 1

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSIQLPRGTQDILPDDAAIWQYIEQVAKETCETYHYQEIRTPIFEHTEIFSRGVGDTTDIVQKEMYTFSDRGGRSLTLRP
EGTAAVVRSYVNHKLYASPAQPTKLYYTGPMFRYERPQAGRMRQFVQFGVEALGSASPQLDAEVLALLIAICKKLGLVNL
KLVINSLGDSESRQAHREALIAHFKPSIDEFCSDCQMRLEKNPLRILDCKKDREHPLMATAPSILDYLNEESRAYFQSLK
ETLDLLNIPYVVDPTLVRGLDYYNHTAFELLSTAPGFGAITTLCGGGRYNGLVQEFGGPETPGIGFAFSIERFILAMKAE
NVDLPVPQSLDAYVVTLGDEASRLGPQLLQRLRDGGIRADKDYLGKKMKAQLKAADRYQASYTIIIGEDEIAKQQALVKQ
MATGEQTVVAISDLTSFLQEQIRGGN

Sequences:

>Translated_426_residues
MSIQLPRGTQDILPDDAAIWQYIEQVAKETCETYHYQEIRTPIFEHTEIFSRGVGDTTDIVQKEMYTFSDRGGRSLTLRP
EGTAAVVRSYVNHKLYASPAQPTKLYYTGPMFRYERPQAGRMRQFVQFGVEALGSASPQLDAEVLALLIAICKKLGLVNL
KLVINSLGDSESRQAHREALIAHFKPSIDEFCSDCQMRLEKNPLRILDCKKDREHPLMATAPSILDYLNEESRAYFQSLK
ETLDLLNIPYVVDPTLVRGLDYYNHTAFELLSTAPGFGAITTLCGGGRYNGLVQEFGGPETPGIGFAFSIERFILAMKAE
NVDLPVPQSLDAYVVTLGDEASRLGPQLLQRLRDGGIRADKDYLGKKMKAQLKAADRYQASYTIIIGEDEIAKQQALVKQ
MATGEQTVVAISDLTSFLQEQIRGGN
>Mature_425_residues
SIQLPRGTQDILPDDAAIWQYIEQVAKETCETYHYQEIRTPIFEHTEIFSRGVGDTTDIVQKEMYTFSDRGGRSLTLRPE
GTAAVVRSYVNHKLYASPAQPTKLYYTGPMFRYERPQAGRMRQFVQFGVEALGSASPQLDAEVLALLIAICKKLGLVNLK
LVINSLGDSESRQAHREALIAHFKPSIDEFCSDCQMRLEKNPLRILDCKKDREHPLMATAPSILDYLNEESRAYFQSLKE
TLDLLNIPYVVDPTLVRGLDYYNHTAFELLSTAPGFGAITTLCGGGRYNGLVQEFGGPETPGIGFAFSIERFILAMKAEN
VDLPVPQSLDAYVVTLGDEASRLGPQLLQRLRDGGIRADKDYLGKKMKAQLKAADRYQASYTIIIGEDEIAKQQALVKQM
ATGEQTVVAISDLTSFLQEQIRGGN

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=421, Percent_Identity=42.7553444180523, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71993686, Length=472, Percent_Identity=23.0932203389831, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71993693, Length=472, Percent_Identity=23.0932203389831, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH1_BACSK (Q5WHP4)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175072.1
- ProteinModelPortal:   Q5WHP4
- SMR:   Q5WHP4
- STRING:   Q5WHP4
- EnsemblBacteria:   EBBACT00000046583
- GeneID:   3201289
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1576
- NMPDR:   fig|66692.3.peg.1538
- eggNOG:   COG0124
- GeneTree:   EBGT00050000001169
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   BCLA66692:ABC1576-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47534; Mature: 47403

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQLPRGTQDILPDDAAIWQYIEQVAKETCETYHYQEIRTPIFEHTEIFSRGVGDTTDI
CCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHH
VQKEMYTFSDRGGRSLTLRPEGTAAVVRSYVNHKLYASPAQPTKLYYTGPMFRYERPQAG
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCEECCCCHH
RMRQFVQFGVEALGSASPQLDAEVLALLIAICKKLGLVNLKLVINSLGDSESRQAHREAL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
IAHFKPSIDEFCSDCQMRLEKNPLRILDCKKDREHPLMATAPSILDYLNEESRAYFQSLK
HHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
ETLDLLNIPYVVDPTLVRGLDYYNHTAFELLSTAPGFGAITTLCGGGRYNGLVQEFGGPE
HHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHCCCCC
TPGIGFAFSIERFILAMKAENVDLPVPQSLDAYVVTLGDEASRLGPQLLQRLRDGGIRAD
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC
KDYLGKKMKAQLKAADRYQASYTIIIGEDEIAKQQALVKQMATGEQTVVAISDLTSFLQE
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
QIRGGN
HHCCCC
>Mature Secondary Structure 
SIQLPRGTQDILPDDAAIWQYIEQVAKETCETYHYQEIRTPIFEHTEIFSRGVGDTTDI
CCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHH
VQKEMYTFSDRGGRSLTLRPEGTAAVVRSYVNHKLYASPAQPTKLYYTGPMFRYERPQAG
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCEECCCCHH
RMRQFVQFGVEALGSASPQLDAEVLALLIAICKKLGLVNLKLVINSLGDSESRQAHREAL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
IAHFKPSIDEFCSDCQMRLEKNPLRILDCKKDREHPLMATAPSILDYLNEESRAYFQSLK
HHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
ETLDLLNIPYVVDPTLVRGLDYYNHTAFELLSTAPGFGAITTLCGGGRYNGLVQEFGGPE
HHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHCCCCC
TPGIGFAFSIERFILAMKAENVDLPVPQSLDAYVVTLGDEASRLGPQLLQRLRDGGIRAD
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC
KDYLGKKMKAQLKAADRYQASYTIIIGEDEIAKQQALVKQMATGEQTVVAISDLTSFLQE
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
QIRGGN
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA