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The map label for this gene is ntdR [H]

Identifier: 56963337

GI number: 56963337

Start: 1693932

End: 1694939

Strand: Direct

Name: ntdR [H]

Synonym: ABC1572

Alternate gene names: 56963337

Gene position: 1693932-1694939 (Clockwise)

Preceding gene: 56963336

Following gene: 56963338

Centisome position: 39.36

GC content: 46.43

Gene sequence:

>1008_bases
ATGCCCACAATTAAAGATGTGGCCCTTCGTGCTGGTGTGTCACGGTCAACGGTTTCCCGTGTAATGAACAATCAGCCTTA
TGTGGATGAGGAAAAACGGAAAGCCGTCAAACAAGCAATGAAGGAGCTGGGCTATTTACCGAATTCATCGGCTCAACGCC
TTAGGGGAACAGAAACACGGACAATTGCTGTCCTTGTTTCACGAATCGTAAACCCTTTTTTTAGTGCAATTGTAGACGCG
ATGGACGAGGTCGCTGCTGAACAGTCGTATAGGCTTATTTTATGCAACACAAGAGGTTCTGCAAACCAAGAGCTCCATTT
CTTGCAGCTTTTGCGAACCAAACAAGTCGATGGCCTTATTCTTGCTTCGCTCGTTAATGATTGGGAAACGATTGCCCCCT
ATACGGATTATGGGCCCATTGTCATTTGCAATGAATATCCACGGCAGTCTGATGGAGTACCAGTAGTGACAATTGACCAG
AGTAAAGCGATGTACGAAGCAACTGTCCATTTGTTAAAAAAAGGTTATAAGCAAATTGCTTATTGCAATCCGATCACAAA
AACGGAATCCGATGCCGTTATTTCGCCACTTGCCCAAGATCGTTATTTAGGGTTTTGTCAGGCAATGGAAGAAGCCGGGA
TGCACATGTATGGCGAATGTTTGTTTTTGGGACATTCCCTTGAGGACGGCAGAAATATATTCAAACAAATGGTGTGCTTA
GCTAACCGGCCTGATGCCATTTTGACAGGAAGCGATGAAGTGGCAGCTGGAATAATCGCTGAGGCAAAAGCTGCTGGCTG
GAAAATCCCTGATGACTTAGCGATTGTCGGCTTTGACAATCAACCGCATGCTACTTTGATTGAACCCGAGTTGACGACGA
TTCACCAGCCTGTGCAGGAAATGGGCAGGGCAGCAATGGAACGTATGCTCGCTTTGTTGCGAAAAGAGAGTCCACCACCG
TTAGCGACATATTTGGAGGCGCCGCTGTTGGCGCGGAAATCAACTTAA

Upstream 100 bases:

>100_bases
CCAGTTGGCAGGCTCTTTTTTATAAATGAAGGTTGACATGAAGGGAGAAACAAGTACAATAAAAGTGAAATGAGAACGTT
TTCAATAAAGGAGTGGATCA

Downstream 100 bases:

>100_bases
CGATTACTGGGAACGATTCCAGGAAGGGGAAATACAATGAATGTAACCATTTGGAATGAATTTAGGCATGAACAAAAAGA
TGAAGCTGTGCGCAGCGTTT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPTIKDVALRAGVSRSTVSRVMNNQPYVDEEKRKAVKQAMKELGYLPNSSAQRLRGTETRTIAVLVSRIVNPFFSAIVDA
MDEVAAEQSYRLILCNTRGSANQELHFLQLLRTKQVDGLILASLVNDWETIAPYTDYGPIVICNEYPRQSDGVPVVTIDQ
SKAMYEATVHLLKKGYKQIAYCNPITKTESDAVISPLAQDRYLGFCQAMEEAGMHMYGECLFLGHSLEDGRNIFKQMVCL
ANRPDAILTGSDEVAAGIIAEAKAAGWKIPDDLAIVGFDNQPHATLIEPELTTIHQPVQEMGRAAMERMLALLRKESPPP
LATYLEAPLLARKST

Sequences:

>Translated_335_residues
MPTIKDVALRAGVSRSTVSRVMNNQPYVDEEKRKAVKQAMKELGYLPNSSAQRLRGTETRTIAVLVSRIVNPFFSAIVDA
MDEVAAEQSYRLILCNTRGSANQELHFLQLLRTKQVDGLILASLVNDWETIAPYTDYGPIVICNEYPRQSDGVPVVTIDQ
SKAMYEATVHLLKKGYKQIAYCNPITKTESDAVISPLAQDRYLGFCQAMEEAGMHMYGECLFLGHSLEDGRNIFKQMVCL
ANRPDAILTGSDEVAAGIIAEAKAAGWKIPDDLAIVGFDNQPHATLIEPELTTIHQPVQEMGRAAMERMLALLRKESPPP
LATYLEAPLLARKST
>Mature_334_residues
PTIKDVALRAGVSRSTVSRVMNNQPYVDEEKRKAVKQAMKELGYLPNSSAQRLRGTETRTIAVLVSRIVNPFFSAIVDAM
DEVAAEQSYRLILCNTRGSANQELHFLQLLRTKQVDGLILASLVNDWETIAPYTDYGPIVICNEYPRQSDGVPVVTIDQS
KAMYEATVHLLKKGYKQIAYCNPITKTESDAVISPLAQDRYLGFCQAMEEAGMHMYGECLFLGHSLEDGRNIFKQMVCLA
NRPDAILTGSDEVAAGIIAEAKAAGWKIPDDLAIVGFDNQPHATLIEPELTTIHQPVQEMGRAAMERMLALLRKESPPPL
ATYLEAPLLARKST

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=34.3283582089552, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=33.5347432024169, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787948, Length=341, Percent_Identity=29.9120234604106, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788474, Length=345, Percent_Identity=32.1739130434783, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI48994940, Length=320, Percent_Identity=27.5, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789202, Length=338, Percent_Identity=28.698224852071, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789068, Length=339, Percent_Identity=25.3687315634218, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787580, Length=325, Percent_Identity=27.0769230769231, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=25.4716981132075, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786540, Length=347, Percent_Identity=26.8011527377522, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790715, Length=318, Percent_Identity=21.0691823899371, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787906, Length=221, Percent_Identity=26.2443438914027, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789456, Length=344, Percent_Identity=23.2558139534884, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786268, Length=343, Percent_Identity=23.3236151603499, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37069; Mature: 36938

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIKDVALRAGVSRSTVSRVMNNQPYVDEEKRKAVKQAMKELGYLPNSSAQRLRGTETR
CCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHH
TIAVLVSRIVNPFFSAIVDAMDEVAAEQSYRLILCNTRGSANQELHFLQLLRTKQVDGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHH
LASLVNDWETIAPYTDYGPIVICNEYPRQSDGVPVVTIDQSKAMYEATVHLLKKGYKQIA
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
YCNPITKTESDAVISPLAQDRYLGFCQAMEEAGMHMYGECLFLGHSLEDGRNIFKQMVCL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCHHHHHHHHHHHHHH
ANRPDAILTGSDEVAAGIIAEAKAAGWKIPDDLAIVGFDNQPHATLIEPELTTIHQPVQE
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHH
MGRAAMERMLALLRKESPPPLATYLEAPLLARKST
HHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCC
>Mature Secondary Structure 
PTIKDVALRAGVSRSTVSRVMNNQPYVDEEKRKAVKQAMKELGYLPNSSAQRLRGTETR
CCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHH
TIAVLVSRIVNPFFSAIVDAMDEVAAEQSYRLILCNTRGSANQELHFLQLLRTKQVDGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHH
LASLVNDWETIAPYTDYGPIVICNEYPRQSDGVPVVTIDQSKAMYEATVHLLKKGYKQIA
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
YCNPITKTESDAVISPLAQDRYLGFCQAMEEAGMHMYGECLFLGHSLEDGRNIFKQMVCL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCHHHHHHHHHHHHHH
ANRPDAILTGSDEVAAGIIAEAKAAGWKIPDDLAIVGFDNQPHATLIEPELTTIHQPVQE
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHH
MGRAAMERMLALLRKESPPPLATYLEAPLLARKST
HHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]