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The map label for this gene is drrB [H]

Identifier: 56963246

GI number: 56963246

Start: 1600097

End: 1600936

Strand: Direct

Name: drrB [H]

Synonym: ABC1481

Alternate gene names: 56963246

Gene position: 1600097-1600936 (Clockwise)

Preceding gene: 56963245

Following gene: 56963247

Centisome position: 37.18

GC content: 47.98

Gene sequence:

>840_bases
ATGAACAAGGCAACGGAAGGAAATAAACAAGAACAAAGCATGCAATTAGCGGATGCGATTGCCAAAAGCAGGCGCCCGCC
TCGCCCGAGCCCACTCGCTGCGTCAATGGCATTCGCGACTAGGGCACTGCTGCGGATTAAGCACATTCCTGAACAAATGT
TTGATGTGACAGTTTTTCCAGTTATTTTCCTGTTGATGTTCACTTATTTATTTGGCGGTGCGATTTCTGGCTCCACAAAT
GAATATTTGCAATTCCTCCTGCCAGGGATTCTTGTCATGACCGTCGCGCAAATTACGATGTATACTGGACTTGATTTAAA
CAACGATATTCGAAAAGGCATCTTCGACCGTTTCCGAACGTTGCCACTCTGGCTGCCTTCGGCCCTGATCGGCTCGTTGC
TGGTAGATACAGTCCGCTATACAATGGCATCGGCGATCATGATTATACTTGGCCTTATTCTGGGGTTCCGTCCAGAAGGG
GGAGCGCTTGGCGTCATTGCCGCCGTTGCGCTAATCTTGCTTTTCTGCTTCAGTTTATCGTGGATTTGGACGACGCTTGG
CCTTATTATGCGTTCTGATAAGTCGCTCATGATGGTCAGTATGATGGTGCTGTTTCCGCTCACTTTTGTCAGCAATGTCT
TCGTCGATCCAGGAACACTGCCATCGTGGCTCCAAGTTTTTGTCGACATCAATCCAATCTCCTTATTAGTCGATGCCGTT
CGTGGCTTCATGCATGGAACGGCTACTGGTGAACAGGTAGGCTGGGTAGTAGCTGTATCGTTTTTGATTGCAGCTGTTTT
TGCTCCGCTCACGATGTATTTGTACCGGAATAAGAAATGA

Upstream 100 bases:

>100_bases
TCCGTACTTTCTCCCTTGGGCAGCCGAGTCTAGATGAAGTCTTTTTGACGCTGACTGGTGAAATGGTGCAAACCCCAGAG
GAAGAAAGGGAGGGAAGTGA

Downstream 100 bases:

>100_bases
AACAAGACGACCAGCAGTCAGGTATTTGCTGGTCTTTTGCTGTTTTCAGTGTCTGTTGGCTGTTTCATCAATTGTTTTGG
CGCTATGTTTTTGATGACTC

Product: multidrug ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNKATEGNKQEQSMQLADAIAKSRRPPRPSPLAASMAFATRALLRIKHIPEQMFDVTVFPVIFLLMFTYLFGGAISGSTN
EYLQFLLPGILVMTVAQITMYTGLDLNNDIRKGIFDRFRTLPLWLPSALIGSLLVDTVRYTMASAIMIILGLILGFRPEG
GALGVIAAVALILLFCFSLSWIWTTLGLIMRSDKSLMMVSMMVLFPLTFVSNVFVDPGTLPSWLQVFVDINPISLLVDAV
RGFMHGTATGEQVGWVVAVSFLIAAVFAPLTMYLYRNKK

Sequences:

>Translated_279_residues
MNKATEGNKQEQSMQLADAIAKSRRPPRPSPLAASMAFATRALLRIKHIPEQMFDVTVFPVIFLLMFTYLFGGAISGSTN
EYLQFLLPGILVMTVAQITMYTGLDLNNDIRKGIFDRFRTLPLWLPSALIGSLLVDTVRYTMASAIMIILGLILGFRPEG
GALGVIAAVALILLFCFSLSWIWTTLGLIMRSDKSLMMVSMMVLFPLTFVSNVFVDPGTLPSWLQVFVDINPISLLVDAV
RGFMHGTATGEQVGWVVAVSFLIAAVFAPLTMYLYRNKK
>Mature_279_residues
MNKATEGNKQEQSMQLADAIAKSRRPPRPSPLAASMAFATRALLRIKHIPEQMFDVTVFPVIFLLMFTYLFGGAISGSTN
EYLQFLLPGILVMTVAQITMYTGLDLNNDIRKGIFDRFRTLPLWLPSALIGSLLVDTVRYTMASAIMIILGLILGFRPEG
GALGVIAAVALILLFCFSLSWIWTTLGLIMRSDKSLMMVSMMVLFPLTFVSNVFVDPGTLPSWLQVFVDINPISLLVDAV
RGFMHGTATGEQVGWVVAVSFLIAAVFAPLTMYLYRNKK

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 30824; Mature: 30824

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]