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The map label for this gene is helD [H]

Identifier: 56963024

GI number: 56963024

Start: 1365029

End: 1367056

Strand: Direct

Name: helD [H]

Synonym: ABC1252

Alternate gene names: 56963024

Gene position: 1365029-1367056 (Clockwise)

Preceding gene: 56963018

Following gene: 56963025

Centisome position: 31.72

GC content: 47.63

Gene sequence:

>2028_bases
ATGTCCATATTTGAAGCCGAAGAGGCGCAGTTGCAGGCGACGCTTGCCCGACTGGATGAACTAGGCGATAAGCTGGAGCA
GGTGCCGCGCTACCGCGGGAGCGATTTTACGGAACAAGTGCTGGAAGATAGGCGTGAGCATTTACGTACAGCGCTTCATT
CAGCCAGACAAGAACCGTATTTTGGCAGGCTCGACTTTTGTGAATGGGACCAGGAAACAAAAGCGCTCTATATTGGAAAA
GTCGGCGTTCACGATGAAGACAGCGGCGATCCGTTCGTAATTGATTGGCGCGCACCGGTTGCCTCACTGTTTTATTCGTT
TACAGGAAGTGAGGAAGATGTTTTTTATCAATCACCGGAAGGCATAGTCGAAGGTGAAATTTTGCTGAAGCGAAACATTG
TGATTCGAAATCGCCGTCTGCAGCGGGTCGTGGATAGCTATGCGAAAGGGCAAGAAATGAGCGGCGGCGATGAATTTTTG
TTATATAAGTTAAGCGAGCAAAAAGACAACAAATTGAAAGACATTGTCGCGACCATTCAAGCAGAACAAAACGCGATCAT
TCGCCATGCAATCAAAGAACCGCTTATTATCCAAGGAGCTGCTGGAAGCGGGAAAACGACAGTCGCCTTGCATCGCCTTG
CCTATTTGTTGTATGAATTCCGCGAGCAGCTACGAGCTGAGAAAATGGTGATTTTTGCGCCAAACGCGATGTTTCTCGAT
TATATTTCACACGTCCTGCCGGAGCTCGGAGTAGGAACGATTGCCCAAAGTACATTTGCCAACTGGGGGTTGTCGGTGCT
TGGTTCTTCTTATCAGCTTTATGACACGAAAAAACGCTTGGCCAATCAATTTGAATCGAAACTTGAACAGCAGTCAGAAG
ATGTGCTTGCTTATAAAGGCTCGCTTGCATGCCAAAAGCAAATGCGTCGTTTTATTGATGCTTATGTAGGGGAAAGGGTG
CCCAAAAAAGATTTTTGCCCGTGGGACGGCTGCGTGCTGAACAAAGAAACAATGAAACAGTGGATTGAGCAGGATTTTGC
CGCTTCGCCGCCAATGAAACGGCGGGAGCGCTTTCATGCCCGCGCGAAACGATGGATTGAGATCGAAGCAAAGCGCTTTG
AAGACAAAAAAGAACAACAGGCTTTTAAGTCGGAAGCGCTTAAACGTTTGCGCTCCTTTCTTTCCTACTGGTCCAAGCCT
GATCTTGCTAAGTTGTACACCGCTTTTTTAAAAGAACAGCAACTGCCAGTGCCTGCTAGTCTGAAAGAGAAGCGGTTAGG
CTACGAAGATATAGCTCCACTTGTGTACATGCACCAACAGCTTTACGGAATTGAGCGCGACGCTCGCTTCGACCATGTTG
TTATCGATGAAGCGCAAGATGTATCCCCTTTTATGCTAGCTGTTTTAAAAGAGCGGACGCGCGCAGGAGGATTTACGATA
TTAGGGGATCTAGCCCAAGGGATTCACGGAGACGAAGGAATTTCGAACTGGGCTGCCTTTGAAGAGGTATTTGCCAACAA
CGTTTCCTATGTACAAATGGAGCGGAGTTACCGGTCAACGATGGAAATTATTGAATTTTCGAACCGGATCCTTCAGCAAA
TGGCTTTCGCTCCTGCGCCAGCAAAACCTGTTTTTCGCAGCGGGCAAGACGTGGTTGTGGAACAGAGGCCGACGGAACAT
GTGGCGCACTGGGTAAAGGCGATGCAGGATAAACAAACACAAACCATCGCCGTTCTTACACGTACAGAAAAAGCTAGCAC
AGCCATTTGCAGGCAGCTACAAGCAGCGGGCTTTGATGCCCATTTGCTTATAGCAGGAGGAGAAAGGTATGAGGGCGGCA
TTTCTGTTTTGCCTGTTTATCTTTCAAAAGGATTTGAATTTGATGCTGTCTTACTAACTGATGTAACAAACGACCATTAC
CCTTGTGATGAACTCCATAAAAAACTATTGTATGTGGGTTGCACACGGGCCCTTCATGAACTGACTGTTTGGTATGACGG
TGCGTTGTCCCCGATCTTGGCTCCTTGA

Upstream 100 bases:

>100_bases
ACTTGAACTATATAAAGCTTACCAAAACGAAAAGAAAAAGTCTATTCTTTTTTTTCGTTTTTCGCGACAATAGAGAAGAA
CTTTTAGGAGGAGTGATACG

Downstream 100 bases:

>100_bases
TTGTCAATGAGCTGACACCTCGTCTTTTTTGCAAAAATATTTCAGTAGGAAAGCAGGTGTCTTGCTCATTTTAAAGATGT
TCACATACAATCTTCCTGTT

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MSIFEAEEAQLQATLARLDELGDKLEQVPRYRGSDFTEQVLEDRREHLRTALHSARQEPYFGRLDFCEWDQETKALYIGK
VGVHDEDSGDPFVIDWRAPVASLFYSFTGSEEDVFYQSPEGIVEGEILLKRNIVIRNRRLQRVVDSYAKGQEMSGGDEFL
LYKLSEQKDNKLKDIVATIQAEQNAIIRHAIKEPLIIQGAAGSGKTTVALHRLAYLLYEFREQLRAEKMVIFAPNAMFLD
YISHVLPELGVGTIAQSTFANWGLSVLGSSYQLYDTKKRLANQFESKLEQQSEDVLAYKGSLACQKQMRRFIDAYVGERV
PKKDFCPWDGCVLNKETMKQWIEQDFAASPPMKRRERFHARAKRWIEIEAKRFEDKKEQQAFKSEALKRLRSFLSYWSKP
DLAKLYTAFLKEQQLPVPASLKEKRLGYEDIAPLVYMHQQLYGIERDARFDHVVIDEAQDVSPFMLAVLKERTRAGGFTI
LGDLAQGIHGDEGISNWAAFEEVFANNVSYVQMERSYRSTMEIIEFSNRILQQMAFAPAPAKPVFRSGQDVVVEQRPTEH
VAHWVKAMQDKQTQTIAVLTRTEKASTAICRQLQAAGFDAHLLIAGGERYEGGISVLPVYLSKGFEFDAVLLTDVTNDHY
PCDELHKKLLYVGCTRALHELTVWYDGALSPILAP

Sequences:

>Translated_675_residues
MSIFEAEEAQLQATLARLDELGDKLEQVPRYRGSDFTEQVLEDRREHLRTALHSARQEPYFGRLDFCEWDQETKALYIGK
VGVHDEDSGDPFVIDWRAPVASLFYSFTGSEEDVFYQSPEGIVEGEILLKRNIVIRNRRLQRVVDSYAKGQEMSGGDEFL
LYKLSEQKDNKLKDIVATIQAEQNAIIRHAIKEPLIIQGAAGSGKTTVALHRLAYLLYEFREQLRAEKMVIFAPNAMFLD
YISHVLPELGVGTIAQSTFANWGLSVLGSSYQLYDTKKRLANQFESKLEQQSEDVLAYKGSLACQKQMRRFIDAYVGERV
PKKDFCPWDGCVLNKETMKQWIEQDFAASPPMKRRERFHARAKRWIEIEAKRFEDKKEQQAFKSEALKRLRSFLSYWSKP
DLAKLYTAFLKEQQLPVPASLKEKRLGYEDIAPLVYMHQQLYGIERDARFDHVVIDEAQDVSPFMLAVLKERTRAGGFTI
LGDLAQGIHGDEGISNWAAFEEVFANNVSYVQMERSYRSTMEIIEFSNRILQQMAFAPAPAKPVFRSGQDVVVEQRPTEH
VAHWVKAMQDKQTQTIAVLTRTEKASTAICRQLQAAGFDAHLLIAGGERYEGGISVLPVYLSKGFEFDAVLLTDVTNDHY
PCDELHKKLLYVGCTRALHELTVWYDGALSPILAP
>Mature_674_residues
SIFEAEEAQLQATLARLDELGDKLEQVPRYRGSDFTEQVLEDRREHLRTALHSARQEPYFGRLDFCEWDQETKALYIGKV
GVHDEDSGDPFVIDWRAPVASLFYSFTGSEEDVFYQSPEGIVEGEILLKRNIVIRNRRLQRVVDSYAKGQEMSGGDEFLL
YKLSEQKDNKLKDIVATIQAEQNAIIRHAIKEPLIIQGAAGSGKTTVALHRLAYLLYEFREQLRAEKMVIFAPNAMFLDY
ISHVLPELGVGTIAQSTFANWGLSVLGSSYQLYDTKKRLANQFESKLEQQSEDVLAYKGSLACQKQMRRFIDAYVGERVP
KKDFCPWDGCVLNKETMKQWIEQDFAASPPMKRRERFHARAKRWIEIEAKRFEDKKEQQAFKSEALKRLRSFLSYWSKPD
LAKLYTAFLKEQQLPVPASLKEKRLGYEDIAPLVYMHQQLYGIERDARFDHVVIDEAQDVSPFMLAVLKERTRAGGFTIL
GDLAQGIHGDEGISNWAAFEEVFANNVSYVQMERSYRSTMEIIEFSNRILQQMAFAPAPAKPVFRSGQDVVVEQRPTEHV
AHWVKAMQDKQTQTIAVLTRTEKASTAICRQLQAAGFDAHLLIAGGERYEGGISVLPVYLSKGFEFDAVLLTDVTNDHYP
CDELHKKLLYVGCTRALHELTVWYDGALSPILAP

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77117; Mature: 76985

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFEAEEAQLQATLARLDELGDKLEQVPRYRGSDFTEQVLEDRREHLRTALHSARQEPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
FGRLDFCEWDQETKALYIGKVGVHDEDSGDPFVIDWRAPVASLFYSFTGSEEDVFYQSPE
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCC
GIVEGEILLKRNIVIRNRRLQRVVDSYAKGQEMSGGDEFLLYKLSEQKDNKLKDIVATIQ
CCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
AEQNAIIRHAIKEPLIIQGAAGSGKTTVALHRLAYLLYEFREQLRAEKMVIFAPNAMFLD
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
YISHVLPELGVGTIAQSTFANWGLSVLGSSYQLYDTKKRLANQFESKLEQQSEDVLAYKG
HHHHHHHHCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
SLACQKQMRRFIDAYVGERVPKKDFCPWDGCVLNKETMKQWIEQDFAASPPMKRRERFHA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHH
RAKRWIEIEAKRFEDKKEQQAFKSEALKRLRSFLSYWSKPDLAKLYTAFLKEQQLPVPAS
HHHHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
LKEKRLGYEDIAPLVYMHQQLYGIERDARFDHVVIDEAQDVSPFMLAVLKERTRAGGFTI
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEE
LGDLAQGIHGDEGISNWAAFEEVFANNVSYVQMERSYRSTMEIIEFSNRILQQMAFAPAP
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AKPVFRSGQDVVVEQRPTEHVAHWVKAMQDKQTQTIAVLTRTEKASTAICRQLQAAGFDA
CCHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCCE
HLLIAGGERYEGGISVLPVYLSKGFEFDAVLLTDVTNDHYPCDELHKKLLYVGCTRALHE
EEEEECCCCCCCCCEEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTVWYDGALSPILAP
HHHHCCCCCCCCCCC
>Mature Secondary Structure 
SIFEAEEAQLQATLARLDELGDKLEQVPRYRGSDFTEQVLEDRREHLRTALHSARQEPY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
FGRLDFCEWDQETKALYIGKVGVHDEDSGDPFVIDWRAPVASLFYSFTGSEEDVFYQSPE
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEECCC
GIVEGEILLKRNIVIRNRRLQRVVDSYAKGQEMSGGDEFLLYKLSEQKDNKLKDIVATIQ
CCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
AEQNAIIRHAIKEPLIIQGAAGSGKTTVALHRLAYLLYEFREQLRAEKMVIFAPNAMFLD
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
YISHVLPELGVGTIAQSTFANWGLSVLGSSYQLYDTKKRLANQFESKLEQQSEDVLAYKG
HHHHHHHHCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
SLACQKQMRRFIDAYVGERVPKKDFCPWDGCVLNKETMKQWIEQDFAASPPMKRRERFHA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHH
RAKRWIEIEAKRFEDKKEQQAFKSEALKRLRSFLSYWSKPDLAKLYTAFLKEQQLPVPAS
HHHHHEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
LKEKRLGYEDIAPLVYMHQQLYGIERDARFDHVVIDEAQDVSPFMLAVLKERTRAGGFTI
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEE
LGDLAQGIHGDEGISNWAAFEEVFANNVSYVQMERSYRSTMEIIEFSNRILQQMAFAPAP
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AKPVFRSGQDVVVEQRPTEHVAHWVKAMQDKQTQTIAVLTRTEKASTAICRQLQAAGFDA
CCHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCCE
HLLIAGGERYEGGISVLPVYLSKGFEFDAVLLTDVTNDHYPCDELHKKLLYVGCTRALHE
EEEEECCCCCCCCCEEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTVWYDGALSPILAP
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]