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The map label for this gene is mepA [H]

Identifier: 56963018

GI number: 56963018

Start: 1358755

End: 1360107

Strand: Direct

Name: mepA [H]

Synonym: ABC1246

Alternate gene names: 56963018

Gene position: 1358755-1360107 (Clockwise)

Preceding gene: 56963017

Following gene: 56963024

Centisome position: 31.57

GC content: 43.02

Gene sequence:

>1353_bases
GTGAGTACACAACATACACAAAATCCTTTAGACACACAACCAATAGGGAAAATATTTCTCCGTTATTTAATCCCATCATT
AGTTGGGATGATTTTAATGGCTGTCAACTTGGCGGTTGATGGAATTATGGTCGGAAATAAATTGGGCCCAGTCGCTCTTG
CTGGCGTTAATATTGCTGGACCGGTATACACCGTGTTTGTCGCAATGTCCCTTTGGCTTGGCATTGGCGGTGCGACCTTG
TACTCTCAGAGCATGGGGCGAAAAGAGCCCGAGCGTGCCCGATTTATTTTTACCCATTCTTTAGTCTTAATTGGGTCAGG
CACACTGATCATTGGCTTCATTGCTTGGATGTTCCATGAACCGCTCGTTTATGCGCTGGGCGCCAATGATGAAACGGCTC
CGTTTGCCGCTGATTATATGAATGTATTTTTAGTGTTTGGCTTTGTTTTCACATTGGAAAATGCGTTTAGCATTTTTGTA
CGCAATGACGGCAATCCAAACTTGGCGATGGCAGCGCTTGTAACAACCGCTTTTTCCAATGTAGGGATCAACTATATGAT
TTTATATGTGTTTGATATGGGGGTTCGTGAAATTGCGTTTGGCACGATTTTGGCGGCAACATTAGGGTTGCTTGTGCTCA
CTACCCATTTTTTTACGAAGAAAAGCAATCTCAAACTTGTTCCATTTAGATTTGAAAAGCCTTTAACGGTCAAAGCGTTT
ACATTTGGCTTCCCAAGTTTTCTTGCTGAAGTAGGCATTTCTGTATTTACGATTTCACATAACATTATGTTTGCCCGTTT
AGCGGGCACAGTGGGCGTAGCGGCTTTTTCTGTTTTAAATTATGTTCATGGCGTCATGTTGCTTATGTTCTTAGGAATGG
GATCGGCGATTCAGCCGATCATCAGCTACTTCCACGGAGCAGATGAAACCGCGAAAAAACGGGCGATTATGCGAATCGCT
ATAAGGACTGCTTTTATCGCTGGGGCGGCTTGCTTCTTAATTGGCCAAGTGGCAGCTACACCGATTGTCCATTTATTTGG
TGATTTTCCCACTGAAGTAAAGGAAATGGCTACCCTTGGGATACGCTTGTTTTTCATTGCTTATTTTGTCATGGGGATTA
ATTTTGTCTTAATGAGTTATTTTCAATCAATTGGTTCTGTGGCAGTAGCGACGTGGATTACCGCAGGCAGAGAGATTTTT
TTTATGCTACTGTTTCTTCTTACCATCCCGTTTGTGTTTGGCGCCAATGCGATCTGGCTATCCATTCCGTTCGCCGAACT
AGCAGTATTGGCATTTATCCTCGTTTATTTAAAGCGGAACCGGATTGTTTTTAGGGAGGATAAAGGACTTTAA

Upstream 100 bases:

>100_bases
CTATTGAGCTCGTGTATGGGGCAGATAAAGAAAGAATCAAGAAAAAGACGGCTGCTGGCTGGGCCGTTTTTTGGCGAGGA
ATTATGGCAGGTGAAGATAC

Downstream 100 bases:

>100_bases
TGGTACCGTCACGTTAAAAAGAGTGCATAAAAACCGCTGATAACAGTGTTTGCTATCAGCGGTTTTTCGTTCATTTATAG
GCCGCTTTCTAAAAAGATCC

Product: Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSTQHTQNPLDTQPIGKIFLRYLIPSLVGMILMAVNLAVDGIMVGNKLGPVALAGVNIAGPVYTVFVAMSLWLGIGGATL
YSQSMGRKEPERARFIFTHSLVLIGSGTLIIGFIAWMFHEPLVYALGANDETAPFAADYMNVFLVFGFVFTLENAFSIFV
RNDGNPNLAMAALVTTAFSNVGINYMILYVFDMGVREIAFGTILAATLGLLVLTTHFFTKKSNLKLVPFRFEKPLTVKAF
TFGFPSFLAEVGISVFTISHNIMFARLAGTVGVAAFSVLNYVHGVMLLMFLGMGSAIQPIISYFHGADETAKKRAIMRIA
IRTAFIAGAACFLIGQVAATPIVHLFGDFPTEVKEMATLGIRLFFIAYFVMGINFVLMSYFQSIGSVAVATWITAGREIF
FMLLFLLTIPFVFGANAIWLSIPFAELAVLAFILVYLKRNRIVFREDKGL

Sequences:

>Translated_450_residues
MSTQHTQNPLDTQPIGKIFLRYLIPSLVGMILMAVNLAVDGIMVGNKLGPVALAGVNIAGPVYTVFVAMSLWLGIGGATL
YSQSMGRKEPERARFIFTHSLVLIGSGTLIIGFIAWMFHEPLVYALGANDETAPFAADYMNVFLVFGFVFTLENAFSIFV
RNDGNPNLAMAALVTTAFSNVGINYMILYVFDMGVREIAFGTILAATLGLLVLTTHFFTKKSNLKLVPFRFEKPLTVKAF
TFGFPSFLAEVGISVFTISHNIMFARLAGTVGVAAFSVLNYVHGVMLLMFLGMGSAIQPIISYFHGADETAKKRAIMRIA
IRTAFIAGAACFLIGQVAATPIVHLFGDFPTEVKEMATLGIRLFFIAYFVMGINFVLMSYFQSIGSVAVATWITAGREIF
FMLLFLLTIPFVFGANAIWLSIPFAELAVLAFILVYLKRNRIVFREDKGL
>Mature_449_residues
STQHTQNPLDTQPIGKIFLRYLIPSLVGMILMAVNLAVDGIMVGNKLGPVALAGVNIAGPVYTVFVAMSLWLGIGGATLY
SQSMGRKEPERARFIFTHSLVLIGSGTLIIGFIAWMFHEPLVYALGANDETAPFAADYMNVFLVFGFVFTLENAFSIFVR
NDGNPNLAMAALVTTAFSNVGINYMILYVFDMGVREIAFGTILAATLGLLVLTTHFFTKKSNLKLVPFRFEKPLTVKAFT
FGFPSFLAEVGISVFTISHNIMFARLAGTVGVAAFSVLNYVHGVMLLMFLGMGSAIQPIISYFHGADETAKKRAIMRIAI
RTAFIAGAACFLIGQVAATPIVHLFGDFPTEVKEMATLGIRLFFIAYFVMGINFVLMSYFQSIGSVAVATWITAGREIFF
MLLFLLTIPFVFGANAIWLSIPFAELAVLAFILVYLKRNRIVFREDKGL

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49299; Mature: 49168

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQHTQNPLDTQPIGKIFLRYLIPSLVGMILMAVNLAVDGIMVGNKLGPVALAGVNIAG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECCCCCH
PVYTVFVAMSLWLGIGGATLYSQSMGRKEPERARFIFTHSLVLIGSGTLIIGFIAWMFHE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHEEEEEEEEEEECCHHHHHHHHHHHCC
PLVYALGANDETAPFAADYMNVFLVFGFVFTLENAFSIFVRNDGNPNLAMAALVTTAFSN
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHH
VGINYMILYVFDMGVREIAFGTILAATLGLLVLTTHFFTKKSNLKLVPFRFEKPLTVKAF
CCHHEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEE
TFGFPSFLAEVGISVFTISHNIMFARLAGTVGVAAFSVLNYVHGVMLLMFLGMGSAIQPI
ECCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ISYFHGADETAKKRAIMRIAIRTAFIAGAACFLIGQVAATPIVHLFGDFPTEVKEMATLG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IRLFFIAYFVMGINFVLMSYFQSIGSVAVATWITAGREIFFMLLFLLTIPFVFGANAIWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEE
SIPFAELAVLAFILVYLKRNRIVFREDKGL
ECCHHHHHHHHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure 
STQHTQNPLDTQPIGKIFLRYLIPSLVGMILMAVNLAVDGIMVGNKLGPVALAGVNIAG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECCCCCH
PVYTVFVAMSLWLGIGGATLYSQSMGRKEPERARFIFTHSLVLIGSGTLIIGFIAWMFHE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHEEEEEEEEEEECCHHHHHHHHHHHCC
PLVYALGANDETAPFAADYMNVFLVFGFVFTLENAFSIFVRNDGNPNLAMAALVTTAFSN
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHH
VGINYMILYVFDMGVREIAFGTILAATLGLLVLTTHFFTKKSNLKLVPFRFEKPLTVKAF
CCHHEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEE
TFGFPSFLAEVGISVFTISHNIMFARLAGTVGVAAFSVLNYVHGVMLLMFLGMGSAIQPI
ECCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ISYFHGADETAKKRAIMRIAIRTAFIAGAACFLIGQVAATPIVHLFGDFPTEVKEMATLG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IRLFFIAYFVMGINFVLMSYFQSIGSVAVATWITAGREIFFMLLFLLTIPFVFGANAIWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEE
SIPFAELAVLAFILVYLKRNRIVFREDKGL
ECCHHHHHHHHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA