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The map label for this gene is dnaA [H]

Identifier: 55981942

GI number: 55981942

Start: 1848185

End: 1849495

Strand: Direct

Name: dnaA [H]

Synonym: TTHA1973

Alternate gene names: 55981942

Gene position: 1848185-1849495 (Clockwise)

Preceding gene: 55981937

Following gene: NA

Centisome position: 99.92

GC content: 67.43

Gene sequence:

>1311_bases
TTGTCGCACGAGGCCGTCTGGCAACACGTTCTGGAGCACATCCGCCGCAGCATCACCGAGGTGGAGTTCCACACCTGGTT
TGAAAGGATCCGCCCCTTGGGGATCCGGGACGGGGTGCTGGAGCTCGCCGTGCCCACCTCCTTTGCCCTGGACTGGATCC
GGCGCCACTACGCCGGCCTCATCCAGGAGGCCCTCGGCCTCCTCGGGGCCCAGGCGCCCCGGTTTGAGCTCCGGGTGGTG
CCCGGGGTCGTGGTCCAGGAGGACATCTTCCAGGCCGCCCCCGCCGAGGCCCCCCGGCCCAAGCTCAACCCGAAGTACAC
CTTTGAAAACTTCGTGGTGGGGCCCAACAACTCCATGGCCCACGCCGCCGCCGTGGCCGTGGCCGAGTCCCCCGGCCGGG
CCTACAACCCCCTCTTCATCTACGGGGGCGTGGGCCTGGGAAAGACCCACCTGATGCACGCCGTGGGCCACTCCGTGGCC
AAGCGCTTCCCCCACCTGAGGATTGAGTACGTTTCCACGGAAACTTTCACCAACGAGCTCATCAACGCCATCCGCGAGGA
CCGGATGACGGAGTTCCGGGAGCGGTACCGCTCCGTGGACCTCCTGCTGGTGGACGACGTCCAGTTCATCGCCGGAAAGG
AGCGCACCCAGGAGGAGTTTTTCCACACCTTCAACGCCCTTTACGAGGCCCACAAGCAGATCATCCTCTCCTCCGACCGG
CCGCCCAAGGACATCCTCACCCTGGAGGCGCGCCTGCGGAGCCGCTTTGAGTGGGGCCTGATCACCGACATCCAGCCCCC
CGACCTGGAAACCCGGATCGCCATCCTGAAGATGAACGCCGAGCAGCGGGGCCTGAGGATCCCCGAGGACGCCCTGGAGT
ACATCGCCCGGCAGGTCACCTCCAACATCCGGGAGTTGGAAGGGGCCCTCATGCGGGCCATCGCCTTCGCCTCCCTCAAC
GGCGTTGAGCTGACCCGCGCCGTGGCCGCCAAGGCCCTCTCCGACATCTTCGCCCCCAGGGAGCTGGAGGCGGACCCCTT
GGAGATCATCCGCAAAGTGGCGGACCACTTCGGCCTGAAACCGGAGGAGCTCACGGGGAGCGGCCGCAAGAAGGAGGTGG
TCCTCCCCCGGCAGCTCGCCATGTACCTGGTGCGGGAGCTCACCCGGGCCTCCCTGCCCGAGATCGGCCAGCTCTTCGGC
GGCCGGGACCACACCACGGTCCTCTACGCCATCCAGAAGGTCCAGGAGCTCGCGGAAAGCGACCGGGAGGTGCAGGGCCT
CCTCCGCACCCTCCGGGAGGCGTGCACATGA

Upstream 100 bases:

>100_bases
TGGCCCCCTCCCACCACCACCACGTCGTAGCCCGCCATCCCATCTCACTCTAGCGGGTCCCGGGGTTAAAATGGGGGACC
GGGACGACGGAGGGGGAAGG

Downstream 100 bases:

>100_bases
CCCCTGTGGATAACCTGTGGATAACCCTGTGGATAACCGGGCTCAAGCTGTGGATAACCCTGTGGATAACCTGTGGAAAA
CTCCGGGGGGGCCGACCCCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGLIQEALGLLGAQAPRFELRVV
PGVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMAHAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVA
KRFPHLRIEYVSTETFTNELINAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDR
PPKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVTSNIRELEGALMRAIAFASLN
GVELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLKPEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFG
GRDHTTVLYAIQKVQELAESDREVQGLLRTLREACT

Sequences:

>Translated_436_residues
MSHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGLIQEALGLLGAQAPRFELRVV
PGVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMAHAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVA
KRFPHLRIEYVSTETFTNELINAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDR
PPKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVTSNIRELEGALMRAIAFASLN
GVELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLKPEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFG
GRDHTTVLYAIQKVQELAESDREVQGLLRTLREACT
>Mature_435_residues
SHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGLIQEALGLLGAQAPRFELRVVP
GVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMAHAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVAK
RFPHLRIEYVSTETFTNELINAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDRP
PKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVTSNIRELEGALMRAIAFASLNG
VELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLKPEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFGG
RDHTTVLYAIQKVQELAESDREVQGLLRTLREACT

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=43.4408602150538, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI226510964, Length=219, Percent_Identity=26.027397260274, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49388; Mature: 49257

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
IQEALGLLGAQAPRFELRVVPGVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMA
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHH
HAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVAKRFPHLRIEYVSTETFTNEL
HHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
INAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDR
HHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCC
PPKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVT
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHCCCCCCHHHHHHHHHHHH
SNIRELEGALMRAIAFASLNGVELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
PEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFGGRDHTTVLYAIQKVQELAES
CHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DREVQGLLRTLREACT
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHEAVWQHVLEHIRRSITEVEFHTWFERIRPLGIRDGVLELAVPTSFALDWIRRHYAGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
IQEALGLLGAQAPRFELRVVPGVVVQEDIFQAAPAEAPRPKLNPKYTFENFVVGPNNSMA
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHH
HAAAVAVAESPGRAYNPLFIYGGVGLGKTHLMHAVGHSVAKRFPHLRIEYVSTETFTNEL
HHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
INAIREDRMTEFRERYRSVDLLLVDDVQFIAGKERTQEEFFHTFNALYEAHKQIILSSDR
HHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCC
PPKDILTLEARLRSRFEWGLITDIQPPDLETRIAILKMNAEQRGLRIPEDALEYIARQVT
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECHHHCCCCCCHHHHHHHHHHHH
SNIRELEGALMRAIAFASLNGVELTRAVAAKALSDIFAPRELEADPLEIIRKVADHFGLK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
PEELTGSGRKKEVVLPRQLAMYLVRELTRASLPEIGQLFGGRDHTTVLYAIQKVQELAES
CHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DREVQGLLRTLREACT
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA