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The map label for this gene is 55981834

Identifier: 55981834

GI number: 55981834

Start: 1747449

End: 1748822

Strand: Reverse

Name: 55981834

Synonym: TTHA1865

Alternate gene names: NA

Gene position: 1748822-1747449 (Counterclockwise)

Preceding gene: 55981835

Following gene: 55981830

Centisome position: 94.54

GC content: 68.12

Gene sequence:

>1374_bases
GTGAGGAGGTGGAGCTGGATTCTCCTGGTGACGTTGGCCGCCTGCGGCGGCCCGGGGCTGCCTTCCCACGGGGGCAAGGA
CCCCTTCCCCCCTTCTGCCCTGGTCCTCGGTTATGAGACGGAGGCCCAGGTGGAGGCCGCCGCCCAGGCCCTAGGGGCAA
GGGAGGTGGTCTGGCTTGAGACCCTTCGGGCCGCCCGGTTGGGGCTTCCACGTGCCCTTCCTTTGGCCGAGGCCAAGGAG
CGGCTCCGCCCCTTGGGGCTGCGGTACGTGGAGGAGGAGGGTCAAAGGGACTACCGGCCCCTCCCAGAGGGCCTGCAGCC
CCAGGGGGTGAGCCCCTACGCCTGGCACCTGGAGGCGGTGCGGGCGGAGGAGGCCTGGGGGGTCTCCACCGGGGCCGGGG
TACAGGTGGCGGTGTTGGACACGGGGGTAGACGCCACCCACCCCGCCCTTCGGGGGCGGGTGCTGGAGGGTTTGGACGCG
GCCACGGGCCTGCCCCTTCCGCCGGACGCCGATGAGAGTCTTGGAGAGATGCACGGGACCCACGTGGCCGGGCTGGCGGT
GGGGGAGGGCGTGGGGGTGGCCCCGGAGGCCCTCCTTCGCCCGGTGCGGGTCTTCTCCCCGAACTACGTCGGGGACTTCC
GGGTGGCCCAGGCCATCGTTTGGGCCGTGGACCAGGGGGCAAGGGTCATCAACCTCTCCTTCGGGGGCACCGCCTATTCG
TACCTACTTCATGAGGCCATTAACTACGCCCTGGAGCGTCAGGTGGTGGTGGTGGCCGCCGCGGGCAACCAGGGGAGTGT
GGCCCGCTTTTATCCTGCGGGCCTTCCCGGGGTGATCGCCGTGGGGGCGGCGGACGGCCAGGGCAGGCCGGCCTGGTTTA
GTAACCGGGGGTCCTGGGTAGGTGTGTGGGCCCCGGGGGTGCGGATCTACTCGGCCGTTCCGGGAGGAGGGTATAGCCTC
CTTAGCGGGACCTCCATGGCCAGCCCCATCGTGAGCGGGATCGCGGCCCTCATCAAAGCCCGCAACTCCTTTATGGAACC
TTTTCACGTGTATCAGGCCCTAAAGGCCGGCTCTGGGCCGGATGCCCTTTTGGCCCTTCAGGCTTCCTATTCTCAGCGGC
CTGCCTGCCTCTATCTGCGGGTGTCCTGGGAGGGTGTGCCCGCCTCGGATGTGGACGTGACCCTCGTGGGACCCGTGGCC
TTTTTCGCGAGGACCAACGCTCAAGGGGAGGCAAGGTTGCTTCAACTGCCCCCAGGGGACTACAAGCTCACCCTCGCCCT
TTCTACCCCTCAGGGAAGGTGGTTTCTGGAGCAAAGCTTAAGCCTGACTCCGGGCTTCTCTTGCCTTCTTCCCCTGACCT
TTTCTCTGCCCTAG

Upstream 100 bases:

>100_bases
ACCCGGAAAATCCCAGGGCCTACAGCGTGGCCGCCGATCGGCAGGGGAGCCTTTCGGGGATCGCCGTTCCGGGGCCCAGC
GTGAACTTTGAGGTGAGGCC

Downstream 100 bases:

>100_bases
GGATTTGCTTAGAGCCGCAGGGCCAGGCCGAAAGCTATGGTGGAGCGCTGGCTGGCCTGGCTGTCAAAGAGGTAGCGCTG
GTGGCCTTCCAGGAAGAGGC

Product: serine protease

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRRWSWILLVTLAACGGPGLPSHGGKDPFPPSALVLGYETEAQVEAAAQALGAREVVWLETLRAARLGLPRALPLAEAKE
RLRPLGLRYVEEEGQRDYRPLPEGLQPQGVSPYAWHLEAVRAEEAWGVSTGAGVQVAVLDTGVDATHPALRGRVLEGLDA
ATGLPLPPDADESLGEMHGTHVAGLAVGEGVGVAPEALLRPVRVFSPNYVGDFRVAQAIVWAVDQGARVINLSFGGTAYS
YLLHEAINYALERQVVVVAAAGNQGSVARFYPAGLPGVIAVGAADGQGRPAWFSNRGSWVGVWAPGVRIYSAVPGGGYSL
LSGTSMASPIVSGIAALIKARNSFMEPFHVYQALKAGSGPDALLALQASYSQRPACLYLRVSWEGVPASDVDVTLVGPVA
FFARTNAQGEARLLQLPPGDYKLTLALSTPQGRWFLEQSLSLTPGFSCLLPLTFSLP

Sequences:

>Translated_457_residues
MRRWSWILLVTLAACGGPGLPSHGGKDPFPPSALVLGYETEAQVEAAAQALGAREVVWLETLRAARLGLPRALPLAEAKE
RLRPLGLRYVEEEGQRDYRPLPEGLQPQGVSPYAWHLEAVRAEEAWGVSTGAGVQVAVLDTGVDATHPALRGRVLEGLDA
ATGLPLPPDADESLGEMHGTHVAGLAVGEGVGVAPEALLRPVRVFSPNYVGDFRVAQAIVWAVDQGARVINLSFGGTAYS
YLLHEAINYALERQVVVVAAAGNQGSVARFYPAGLPGVIAVGAADGQGRPAWFSNRGSWVGVWAPGVRIYSAVPGGGYSL
LSGTSMASPIVSGIAALIKARNSFMEPFHVYQALKAGSGPDALLALQASYSQRPACLYLRVSWEGVPASDVDVTLVGPVA
FFARTNAQGEARLLQLPPGDYKLTLALSTPQGRWFLEQSLSLTPGFSCLLPLTFSLP
>Mature_457_residues
MRRWSWILLVTLAACGGPGLPSHGGKDPFPPSALVLGYETEAQVEAAAQALGAREVVWLETLRAARLGLPRALPLAEAKE
RLRPLGLRYVEEEGQRDYRPLPEGLQPQGVSPYAWHLEAVRAEEAWGVSTGAGVQVAVLDTGVDATHPALRGRVLEGLDA
ATGLPLPPDADESLGEMHGTHVAGLAVGEGVGVAPEALLRPVRVFSPNYVGDFRVAQAIVWAVDQGARVINLSFGGTAYS
YLLHEAINYALERQVVVVAAAGNQGSVARFYPAGLPGVIAVGAADGQGRPAWFSNRGSWVGVWAPGVRIYSAVPGGGYSL
LSGTSMASPIVSGIAALIKARNSFMEPFHVYQALKAGSGPDALLALQASYSQRPACLYLRVSWEGVPASDVDVTLVGPVA
FFARTNAQGEARLLQLPPGDYKLTLALSTPQGRWFLEQSLSLTPGFSCLLPLTFSLP

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=265, Percent_Identity=33.9622641509434, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI31317307, Length=240, Percent_Identity=32.0833333333333, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319893, Length=241, Percent_Identity=34.4398340248963, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324576, Length=272, Percent_Identity=31.25, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320775, Length=226, Percent_Identity=34.5132743362832, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45550681, Length=253, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 48251; Mature: 48251

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRWSWILLVTLAACGGPGLPSHGGKDPFPPSALVLGYETEAQVEAAAQALGAREVVWLE
CCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHH
TLRAARLGLPRALPLAEAKERLRPLGLRYVEEEGQRDYRPLPEGLQPQGVSPYAWHLEAV
HHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RAEEAWGVSTGAGVQVAVLDTGVDATHPALRGRVLEGLDAATGLPLPPDADESLGEMHGT
HHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHCCC
HVAGLAVGEGVGVAPEALLRPVRVFSPNYVGDFRVAQAIVWAVDQGARVINLSFGGTAYS
EEEEEEECCCCCCCHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
YLLHEAINYALERQVVVVAAAGNQGSVARFYPAGLPGVIAVGAADGQGRPAWFSNRGSWV
HHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCCEEEEECCCCCCCCCEECCCCCEE
GVWAPGVRIYSAVPGGGYSLLSGTSMASPIVSGIAALIKARNSFMEPFHVYQALKAGSGP
EEECCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
DALLALQASYSQRPACLYLRVSWEGVPASDVDVTLVGPVAFFARTNAQGEARLLQLPPGD
CEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEECCEEEEEECCCCCCEEEEECCCCC
YKLTLALSTPQGRWFLEQSLSLTPGFSCLLPLTFSLP
EEEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRWSWILLVTLAACGGPGLPSHGGKDPFPPSALVLGYETEAQVEAAAQALGAREVVWLE
CCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHH
TLRAARLGLPRALPLAEAKERLRPLGLRYVEEEGQRDYRPLPEGLQPQGVSPYAWHLEAV
HHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RAEEAWGVSTGAGVQVAVLDTGVDATHPALRGRVLEGLDAATGLPLPPDADESLGEMHGT
HHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHCCC
HVAGLAVGEGVGVAPEALLRPVRVFSPNYVGDFRVAQAIVWAVDQGARVINLSFGGTAYS
EEEEEEECCCCCCCHHHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
YLLHEAINYALERQVVVVAAAGNQGSVARFYPAGLPGVIAVGAADGQGRPAWFSNRGSWV
HHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCCEEEEECCCCCCCCCEECCCCCEE
GVWAPGVRIYSAVPGGGYSLLSGTSMASPIVSGIAALIKARNSFMEPFHVYQALKAGSGP
EEECCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
DALLALQASYSQRPACLYLRVSWEGVPASDVDVTLVGPVAFFARTNAQGEARLLQLPPGD
CEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEECCEEEEEECCCCCCEEEEECCCCC
YKLTLALSTPQGRWFLEQSLSLTPGFSCLLPLTFSLP
EEEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]