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The map label for this gene is ubiE [H]

Identifier: 55981823

GI number: 55981823

Start: 1738685

End: 1739347

Strand: Reverse

Name: ubiE [H]

Synonym: TTHA1854

Alternate gene names: 55981823

Gene position: 1739347-1738685 (Counterclockwise)

Preceding gene: 55981826

Following gene: 55981815

Centisome position: 94.03

GC content: 69.38

Gene sequence:

>663_bases
ATGTTCTCGGAGATCGCCCCCCGCTACGACCTCCTGAACCGCCTCCTCTCCTTCGGGGCGGACCTCCGCTGGCGCAGGCG
GGCGGTGGACCTGGCCCTGGAGAAGGCCCCAAGGCGCATCCTGGACCTGGCCACGGGGACGGGGGACCTGGCCCTCATGC
TCAAGGAAAGGGCCCCCGGGGCGGAGGTGGTGGGGGCGGACTTCGCCCCGCCCATGCTGGCGATCGCCCGCAGGAAGGCG
GAGGCGAGGGGCCTCGAGGTCCGCTTCCTCGAGGCGGACGCCCTCGCCCTCCCCTTTCCCGACGGGGCCTTTGACGCGGT
GACCATCGCCTTCGGCTTCCGCAACTTCGCCGATTACGAAAAGGCCCTAAGGGAGCTTTACCGGGTCCTGGCCCCCGGGG
GGAGGCTCGTGGTTCTGGAGTTTCCCCCGCCCCCTAAGGGGGCCTTTGGCCTCGTCTACCGGGTCTACTTCCAGCGGGTC
CTCCCTTTCCTCGGGGGGCTTATTTCGGGGAACTTCGGGGCCTACCGCTACCTTCCGGAAAGCGTGGAGGCCTTCCCCGC
TCCTGAGGCCCTGAAGGCCATGATGGCGGCGGCGGGGTTTTCCGTGCGCTACGAGCTCCTCACCTTCGGGGTGGCGGCCA
TCCACGTGGGGGACAGGCCCTAA

Upstream 100 bases:

>100_bases
CGTCAACACGCGGAGGATTTTACCCTAAGGGGGTGGCCTTTCGTGCTAGACTCCCCTCGTGGCGGCTTCCCCGGAGGAAA
AGGCGAAAAGGGTGCGGCGG

Downstream 100 bases:

>100_bases
AGCCTGGCCGCTTGCCTCAGCTCCTCGTCGCTGGGAAGCCTTCCCTCCTTGAGGGCTTCCACCAGGAAGCGGGCCATCCG
CCCGAGGGCGTCCCGCACCT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MFSEIAPRYDLLNRLLSFGADLRWRRRAVDLALEKAPRRILDLATGTGDLALMLKERAPGAEVVGADFAPPMLAIARRKA
EARGLEVRFLEADALALPFPDGAFDAVTIAFGFRNFADYEKALRELYRVLAPGGRLVVLEFPPPPKGAFGLVYRVYFQRV
LPFLGGLISGNFGAYRYLPESVEAFPAPEALKAMMAAAGFSVRYELLTFGVAAIHVGDRP

Sequences:

>Translated_220_residues
MFSEIAPRYDLLNRLLSFGADLRWRRRAVDLALEKAPRRILDLATGTGDLALMLKERAPGAEVVGADFAPPMLAIARRKA
EARGLEVRFLEADALALPFPDGAFDAVTIAFGFRNFADYEKALRELYRVLAPGGRLVVLEFPPPPKGAFGLVYRVYFQRV
LPFLGGLISGNFGAYRYLPESVEAFPAPEALKAMMAAAGFSVRYELLTFGVAAIHVGDRP
>Mature_220_residues
MFSEIAPRYDLLNRLLSFGADLRWRRRAVDLALEKAPRRILDLATGTGDLALMLKERAPGAEVVGADFAPPMLAIARRKA
EARGLEVRFLEADALALPFPDGAFDAVTIAFGFRNFADYEKALRELYRVLAPGGRLVVLEFPPPPKGAFGLVYRVYFQRV
LPFLGGLISGNFGAYRYLPESVEAFPAPEALKAMMAAAGFSVRYELLTFGVAAIHVGDRP

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=258, Percent_Identity=35.6589147286822, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI48994983, Length=221, Percent_Identity=44.7963800904977, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17557039, Length=225, Percent_Identity=36.4444444444444, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323526, Length=236, Percent_Identity=35.1694915254237, Blast_Score=138, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24641702, Length=234, Percent_Identity=38.4615384615385, Blast_Score=153, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 24177; Mature: 24177

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSEIAPRYDLLNRLLSFGADLRWRRRAVDLALEKAPRRILDLATGTGDLALMLKERAPG
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
AEVVGADFAPPMLAIARRKAEARGLEVRFLEADALALPFPDGAFDAVTIAFGFRNFADYE
CCEECCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHH
KALRELYRVLAPGGRLVVLEFPPPPKGAFGLVYRVYFQRVLPFLGGLISGNFGAYRYLPE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCH
SVEAFPAPEALKAMMAAAGFSVRYELLTFGVAAIHVGDRP
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCC
>Mature Secondary Structure
MFSEIAPRYDLLNRLLSFGADLRWRRRAVDLALEKAPRRILDLATGTGDLALMLKERAPG
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
AEVVGADFAPPMLAIARRKAEARGLEVRFLEADALALPFPDGAFDAVTIAFGFRNFADYE
CCEECCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHH
KALRELYRVLAPGGRLVVLEFPPPPKGAFGLVYRVYFQRVLPFLGGLISGNFGAYRYLPE
HHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCH
SVEAFPAPEALKAMMAAAGFSVRYELLTFGVAAIHVGDRP
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA