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The map label for this gene is ispB [H]

Identifier: 55981624

GI number: 55981624

Start: 1570133

End: 1571071

Strand: Reverse

Name: ispB [H]

Synonym: TTHA1655

Alternate gene names: 55981624

Gene position: 1571071-1570133 (Counterclockwise)

Preceding gene: 55981625

Following gene: 55981623

Centisome position: 84.93

GC content: 70.5

Gene sequence:

>939_bases
GTGACCGATCTCGAGGCCCCCCTCCGCCGCTTTGAAGAGGCCCTTTCCGAGCTCGTCCAGTCCGACGTCCTCTTCATCCG
CCTCATCCACCAGGACCTGGTGACGGCGGGGGGGAAGCGCATCCGGCCCAGGCTCGTCTTTCTGGCCTCGAGGGCCTTAG
GGGGGGCGCCCTTTGAGCTGGAGCTCGCCCTGGCGGTGGAGCTCCTCCACTCCGCCACCCTCCTCCACGACGACCTCATT
GACGACGCCGAGACCAGGCGGGGCAAGGAGGCGGCCTTCCGCAAGTACGGGAACGCCGTTTCCGTGCTTTCCGGGGACTT
CCTCCTCTCAAGGCTCCTTCACGTCATCGCCAAGACGGGGCGGATGGAGCTCGTGGAGCGGTTCGCCGAGGTGGCCAAGA
CCCTCTCCGAAGGCGAGGTCCTCCAGTTCCAGGTGGCGGCCCTCGAGGACTACTCCCTGGAGAACTACGAGCGGATCATT
ACCGCCAAGACGGCAGTCCTCATGGCCCTCGCCACGGAGGGCCCCGCCCTTCTTCTCGGGGCGGAAAGCGGGGTGCGGGA
GGCCCTTTACCGCTACGGCCTCCTCTACGGCCAGGCCTTCCAGATGCGGGACGATTACCTGGACCTCATGGGGACGCCGG
AGGTCCTAGGCAAGCCCGTGGGCGGGGACCTGCGGGAGGGCAAGGCCACCCTCATCCCCCTCCTCCTCATGGAGCGCTAC
CCCGAGGTGCGGGAGGTGCTCAGGCGCCGGGCCCGGGAGGCCGGGGACCTGGAACGGGTGCGGGCCCTGGCCCGGGAGAG
CGGGGCGGCCGAGGAGGCGGTGCGCCGCATCCGGGAGCGGGCCGAGGCCGCGGCCCAGGCCCTGGAGGCCCTGCCTCCGA
GCCCCTTCCGGGAGGCCTTGCGGGAGCTCGCCCTGAAGGAGGCGGAGCGGGTCCGCTAG

Upstream 100 bases:

>100_bases
GTGCAGGCGGTGAAGTACCGGACCATTTCGGCCAACGGGCAGTCCAAGGTGGTCCCCCTGAACGCCACGATAGAGCTCTA
CTAGGGCTATACTGGGGGGC

Downstream 100 bases:

>100_bases
GGTATGCTTAGGGGGATGAAGGTGGTCCTGGCCACCGGCAACCCCGGGAAGGTGCGGGAGCTCAAGGAGGGCCTCGCCCC
CTTGGGCTGGACCCTCCTCA

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTDLEAPLRRFEEALSELVQSDVLFIRLIHQDLVTAGGKRIRPRLVFLASRALGGAPFELELALAVELLHSATLLHDDLI
DDAETRRGKEAAFRKYGNAVSVLSGDFLLSRLLHVIAKTGRMELVERFAEVAKTLSEGEVLQFQVAALEDYSLENYERII
TAKTAVLMALATEGPALLLGAESGVREALYRYGLLYGQAFQMRDDYLDLMGTPEVLGKPVGGDLREGKATLIPLLLMERY
PEVREVLRRRAREAGDLERVRALARESGAAEEAVRRIRERAEAAAQALEALPPSPFREALRELALKEAERVR

Sequences:

>Translated_312_residues
MTDLEAPLRRFEEALSELVQSDVLFIRLIHQDLVTAGGKRIRPRLVFLASRALGGAPFELELALAVELLHSATLLHDDLI
DDAETRRGKEAAFRKYGNAVSVLSGDFLLSRLLHVIAKTGRMELVERFAEVAKTLSEGEVLQFQVAALEDYSLENYERII
TAKTAVLMALATEGPALLLGAESGVREALYRYGLLYGQAFQMRDDYLDLMGTPEVLGKPVGGDLREGKATLIPLLLMERY
PEVREVLRRRAREAGDLERVRALARESGAAEEAVRRIRERAEAAAQALEALPPSPFREALRELALKEAERVR
>Mature_311_residues
TDLEAPLRRFEEALSELVQSDVLFIRLIHQDLVTAGGKRIRPRLVFLASRALGGAPFELELALAVELLHSATLLHDDLID
DAETRRGKEAAFRKYGNAVSVLSGDFLLSRLLHVIAKTGRMELVERFAEVAKTLSEGEVLQFQVAALEDYSLENYERIIT
AKTAVLMALATEGPALLLGAESGVREALYRYGLLYGQAFQMRDDYLDLMGTPEVLGKPVGGDLREGKATLIPLLLMERYP
EVREVLRRRAREAGDLERVRALARESGAAEEAVRRIRERAEAAAQALEALPPSPFREALRELALKEAERVR

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=275, Percent_Identity=32, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI209571582, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503685, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI209571584, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4758430, Length=260, Percent_Identity=26.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI83700220, Length=260, Percent_Identity=26.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789578, Length=306, Percent_Identity=39.8692810457516, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786623, Length=289, Percent_Identity=30.1038062283737, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505681, Length=306, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17508563, Length=234, Percent_Identity=28.6324786324786, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319475, Length=292, Percent_Identity=29.7945205479452, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322294, Length=190, Percent_Identity=27.8947368421053, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651612, Length=276, Percent_Identity=31.1594202898551, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17137582, Length=270, Percent_Identity=25.1851851851852, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 34730; Mature: 34598

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLEAPLRRFEEALSELVQSDVLFIRLIHQDLVTAGGKRIRPRLVFLASRALGGAPFEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
ELALAVELLHSATLLHDDLIDDAETRRGKEAAFRKYGNAVSVLSGDFLLSRLLHVIAKTG
HHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
RMELVERFAEVAKTLSEGEVLQFQVAALEDYSLENYERIITAKTAVLMALATEGPALLLG
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AESGVREALYRYGLLYGQAFQMRDDYLDLMGTPEVLGKPVGGDLREGKATLIPLLLMERY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCC
PEVREVLRRRAREAGDLERVRALARESGAAEEAVRRIRERAEAAAQALEALPPSPFREAL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RELALKEAERVR
HHHHHHHHHHCC
>Mature Secondary Structure 
TDLEAPLRRFEEALSELVQSDVLFIRLIHQDLVTAGGKRIRPRLVFLASRALGGAPFEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
ELALAVELLHSATLLHDDLIDDAETRRGKEAAFRKYGNAVSVLSGDFLLSRLLHVIAKTG
HHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
RMELVERFAEVAKTLSEGEVLQFQVAALEDYSLENYERIITAKTAVLMALATEGPALLLG
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AESGVREALYRYGLLYGQAFQMRDDYLDLMGTPEVLGKPVGGDLREGKATLIPLLLMERY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCC
PEVREVLRRRAREAGDLERVRALARESGAAEEAVRRIRERAEAAAQALEALPPSPFREAL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RELALKEAERVR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]