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The map label for this gene is glyA [H]

Identifier: 55981493

GI number: 55981493

Start: 1449266

End: 1450489

Strand: Direct

Name: glyA [H]

Synonym: TTHA1524

Alternate gene names: 55981493

Gene position: 1449266-1450489 (Clockwise)

Preceding gene: 55981489

Following gene: 55981494

Centisome position: 78.35

GC content: 68.3

Gene sequence:

>1224_bases
ATGGTGAGCACCCTCAAGCGGGACGAGGCCCTCTTTGAGCTCATCGCCTTAGAGGAGAAAAGGCAGCGGGAAGGCCTGGA
GCTCATCGCCAGCGAAAACTTCGTCTCCAAGCAGGTGCGGGAGGCGGTGGGGAGCGTCCTCACCAACAAGTACGCCGAGG
GCTACCCCGGGGCCCGGTACTACGGGGGGTGCGAGGTCATTGACCGGGTGGAGTCCCTGGCCATAGAGCGGGCCAAGGCC
CTCTTCGGGGCGGCCTGGGCCAACGTCCAGCCCCACTCCGGCTCCCAAGCCAACATGGCGGTCTACATGGCCCTGATGGA
GCCGGGGGACACCCTCATGGGCATGGACCTCGCGGCCGGCGGCCACCTCACCCACGGCTCCCGCGTGAACTTCTCCGGGA
AGCTTTACAAGGTGGTCTCCTACGGGGTCCGTCCCGACACGGAGCTCATAGACCTGGAGGAGGTCCGCCGCCTCGCCCTG
GAGCACCGCCCCAAGGTGATCGTGGCCGGGGCCAGCGCCTACCCCCGCTTCTGGGACTTCAAGGCCTTTCGGGAGATCGC
CGACGAGGTGGGGGCCTACCTCGTGGTGGACATGGCCCACTTCGCCGGGCTCGTGGCCGCGGGCCTCCACCCGAACCCCC
TGCCTTACGCCCACGTGGTGACGAGCACCACCCACAAAACCCTCCGGGGCCCGAGGGGCGGCCTCATCCTCTCCAACGAC
CCCGAGCTCGGCAAGAGGATTGACAAGCTCATCTTCCCCGGGATCCAGGGAGGGCCCTTGGAGCACGTGATCGCCGGGAA
GGCCGTGGCCTTCTTTGAGGCCCTACAGCCCGAGTTCAAGGAGTACAGCCGCCTGGTGGTGGAAAACGCCAAGCGCCTGG
CGGAGGAGCTTGCCCGCCGGGGCTACCGCATCGTCACCGGGGGGACGGACAACCACCTCTTCCTCGTGGACCTGCGCCCC
AAAGGCCTCACCGGGAAGGAGGCGGAGGAGAGGCTGGACGCCGTGGGGATCACGGTGAACAAGAACGCCATCCCCTTTGA
CCCCAAGCCCCCCCGGGTCACCTCGGGGATCCGCATCGGCACCCCGGCCATCACCACCCGGGGCTTCACCCCCGAGGAGA
TGCCCCTCGTCGCCGAGCTCATAGACCGGGCCCTTCTGGAGGGCCCCTCGGAGGCCCTGCGGGAAGAGGTGCGCAGGCTC
GCCCTGGCCCACCCCATGCCCTGA

Upstream 100 bases:

>100_bases
GCACCAAGAGGACGAGGGCCCCGAAGAGGACCAGGGCCCAGCGCAGCCCGGTTTGCGCCTTCTCCCTCATGCCGCGATTT
TACCCGGCTATAATCGCCCT

Downstream 100 bases:

>100_bases
AGGCCCCCGCGGCACCCCCTTAAAATGGGGGGGATGCTCCGCCGCCTCGAGGTCCAGAACCTCGCCGTCATCCGCGAGGC
CGCCTTGGACTTCGCCCCCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARYYGGCEVIDRVESLAIERAKA
LFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAGGHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLAL
EHRPKVIVAGASAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSND
PELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARRGYRIVTGGTDNHLFLVDLRP
KGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRL
ALAHPMP

Sequences:

>Translated_407_residues
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARYYGGCEVIDRVESLAIERAKA
LFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAGGHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLAL
EHRPKVIVAGASAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSND
PELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARRGYRIVTGGTDNHLFLVDLRP
KGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRL
ALAHPMP
>Mature_407_residues
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARYYGGCEVIDRVESLAIERAKA
LFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAGGHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLAL
EHRPKVIVAGASAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSND
PELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARRGYRIVTGGTDNHLFLVDLRP
KGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRL
ALAHPMP

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=448, Percent_Identity=45.7589285714286, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI261862352, Length=448, Percent_Identity=45.7589285714286, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI261862350, Length=448, Percent_Identity=45.7589285714286, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI261862348, Length=448, Percent_Identity=45.7589285714286, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=45.0892857142857, Blast_Score=352, Evalue=2e-97,
Organism=Homo sapiens, GI22547186, Length=450, Percent_Identity=45.7777777777778, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI22547189, Length=436, Percent_Identity=43.5779816513761, Blast_Score=310, Evalue=1e-84,
Organism=Escherichia coli, GI1788902, Length=393, Percent_Identity=61.0687022900763, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI25144732, Length=398, Percent_Identity=49.4974874371859, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25144729, Length=398, Percent_Identity=49.4974874371859, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=48.1296758104738, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=46.8827930174564, Blast_Score=348, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24640005, Length=403, Percent_Identity=50.1240694789082, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221329721, Length=403, Percent_Identity=50.1240694789082, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44620; Mature: 44620

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YGGCEVIDRVESLAIERAKALFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEECEEECCC
GHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLALEHRPKVIVAGASAYPRFWDF
CCCCCCCEECCCCCEEEEEECCCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCHHHH
KAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSND
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCHHHHHCCCCCCEEECCC
PELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
GYRIVTGGTDNHLFLVDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIG
CEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEC
TPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRLALAHPMP
CCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YGGCEVIDRVESLAIERAKALFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCEECEEECCC
GHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLALEHRPKVIVAGASAYPRFWDF
CCCCCCCEECCCCCEEEEEECCCCCCCCEECHHHHHHHHHHCCCCEEEECCCCCCCHHHH
KAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSND
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCHHHHHCCCCCCEEECCC
PELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
GYRIVTGGTDNHLFLVDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIG
CEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEC
TPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRLALAHPMP
CCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA