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The map label for this gene is yhaU [H]

Identifier: 55981445

GI number: 55981445

Start: 1406186

End: 1407334

Strand: Reverse

Name: yhaU [H]

Synonym: TTHA1476

Alternate gene names: 55981445

Gene position: 1407334-1406186 (Counterclockwise)

Preceding gene: 55981446

Following gene: 55981444

Centisome position: 76.08

GC content: 70.58

Gene sequence:

>1149_bases
ATGCACCCTTCCCTCGAGGCCTTCGCCCTGGCCGCGGGGCTTCTGGCCCTGGGTGCGGCCCTGGTGCACCGCTTCGGCTT
CCCTCCCCTCCCCGTCTACCTCCTCACGGGGCTTGTGGTGGGGGAGAGGCTTCCCGTGGAGGATCTGGAGCCCCTCCCCT
CCTTGGGGCTTTTGCTCCTCCTCTTCTCCGTGGGGCTGGAGTTCGGCCCGGACCGGCTTCGGGAGCTTTCGGGGAAGGCC
CTGCGGGCGGGGTTTTTTGACGCCCTGGCCCTCCCCCTGGGCTTCCTCCTCGGCCTCCTCGCCGGGCTGGACCTGAGGGG
GGCCCTCCTCCTCGCCGGGGTGATCTACATCAGCTCCAGCGCCGTCATCGTCAAGCTCATCATTGACCTGCGCCGCGCCG
CCAACCCCGAAAGCGAGGTGGTCCTCGGGGTCTTGGTCCTGGAGGACCTCGTCATCGCCCTCCTCCTTGCCCTCCTGGGC
GGCCAGGGGCCTGCGGGCTTCCTCGGGGGGGTGGCCTTGGCCCTCGCCTACTTCCTCTTCGCCCGCTTCCTGGGCCCGAG
GCTCGTCCGCTTCATGGAGGGGCTTTCCGACGAGCTCGTCCTCCTCCTCGGGGCCGCCTTCACCGCGGGCACCGCCCTCC
TCTTCCACGCCGTGGGGGCCTCGGAGGGGGTGGGGGCCTTCCTCTCCGGGGTCATCGCCGCGGGGCTTGGCCTCAGGGAG
AGGTTTGAGCACCTCTTCGGGCCGGTGCGGGACCTGGGGGTGGCCCTCTTCTTCCTCGTGGTGGGGGCGGAGGCCCTAGG
CCTCCTTCGTGGGCTTACCCCCTGGGCGGTGGGGCTTGTCCTCCTGGGCCTCCTTCTCAAGCTCCCCCTGAACCACCTGG
GCGGGGCGAGGGCGGGCCTCGGCCGGAAGCGGCGGCTCTACAGCGCCCTCTACCTCGTGCCCCGGGGCGAGTTCAACCTG
GTGCTTGGGGCCTTGGCCTTAGGCCAGGGCTACCCCCTGGTGGCCCAGGTGGCCGTGCTCCTGGTCCTGGTCTCCATTCC
CTTGGGGGCCCTCCTCATCCGCTACGCCCCCGAGATCGCCCAGGCCCTCTACCCGGAGGCGCGCCCCAGGAAGAGGGCGA
AGAGGGCTGAAGGAAGCCCTGTAAAATGA

Upstream 100 bases:

>100_bases
TCATCCCCCACCCCGGCCCGGACGTGGTCTTAGAGGTGGGGGACACCCTGGTGGTGGCGGGGAGCCGGGAGGCGGTGGAG
GCCCTGAAGGGGAGCTTCTG

Downstream 100 bases:

>100_bases
CCTTGCCGGAGGTGAGGCATGGACATCTTTTTCCAGCTCTTTTGGCTCTTCTTCATCCTCTCCGTCCTCTCCCCCTACTT
CCAGCAGCAGTGGCTCCTCG

Product: Na(+)/H(+) antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MHPSLEAFALAAGLLALGAALVHRFGFPPLPVYLLTGLVVGERLPVEDLEPLPSLGLLLLLFSVGLEFGPDRLRELSGKA
LRAGFFDALALPLGFLLGLLAGLDLRGALLLAGVIYISSSAVIVKLIIDLRRAANPESEVVLGVLVLEDLVIALLLALLG
GQGPAGFLGGVALALAYFLFARFLGPRLVRFMEGLSDELVLLLGAAFTAGTALLFHAVGASEGVGAFLSGVIAAGLGLRE
RFEHLFGPVRDLGVALFFLVVGAEALGLLRGLTPWAVGLVLLGLLLKLPLNHLGGARAGLGRKRRLYSALYLVPRGEFNL
VLGALALGQGYPLVAQVAVLLVLVSIPLGALLIRYAPEIAQALYPEARPRKRAKRAEGSPVK

Sequences:

>Translated_382_residues
MHPSLEAFALAAGLLALGAALVHRFGFPPLPVYLLTGLVVGERLPVEDLEPLPSLGLLLLLFSVGLEFGPDRLRELSGKA
LRAGFFDALALPLGFLLGLLAGLDLRGALLLAGVIYISSSAVIVKLIIDLRRAANPESEVVLGVLVLEDLVIALLLALLG
GQGPAGFLGGVALALAYFLFARFLGPRLVRFMEGLSDELVLLLGAAFTAGTALLFHAVGASEGVGAFLSGVIAAGLGLRE
RFEHLFGPVRDLGVALFFLVVGAEALGLLRGLTPWAVGLVLLGLLLKLPLNHLGGARAGLGRKRRLYSALYLVPRGEFNL
VLGALALGQGYPLVAQVAVLLVLVSIPLGALLIRYAPEIAQALYPEARPRKRAKRAEGSPVK
>Mature_382_residues
MHPSLEAFALAAGLLALGAALVHRFGFPPLPVYLLTGLVVGERLPVEDLEPLPSLGLLLLLFSVGLEFGPDRLRELSGKA
LRAGFFDALALPLGFLLGLLAGLDLRGALLLAGVIYISSSAVIVKLIIDLRRAANPESEVVLGVLVLEDLVIALLLALLG
GQGPAGFLGGVALALAYFLFARFLGPRLVRFMEGLSDELVLLLGAAFTAGTALLFHAVGASEGVGAFLSGVIAAGLGLRE
RFEHLFGPVRDLGVALFFLVVGAEALGLLRGLTPWAVGLVLLGLLLKLPLNHLGGARAGLGRKRRLYSALYLVPRGEFNL
VLGALALGQGYPLVAQVAVLLVLVSIPLGALLIRYAPEIAQALYPEARPRKRAKRAEGSPVK

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 40013; Mature: 40013

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPSLEAFALAAGLLALGAALVHRFGFPPLPVYLLTGLVVGERLPVEDLEPLPSLGLLLL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHH
LFSVGLEFGPDRLRELSGKALRAGFFDALALPLGFLLGLLAGLDLRGALLLAGVIYISSS
HHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
AVIVKLIIDLRRAANPESEVVLGVLVLEDLVIALLLALLGGQGPAGFLGGVALALAYFLF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ARFLGPRLVRFMEGLSDELVLLLGAAFTAGTALLFHAVGASEGVGAFLSGVIAAGLGLRE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
RFEHLFGPVRDLGVALFFLVVGAEALGLLRGLTPWAVGLVLLGLLLKLPLNHLGGARAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCCHHCC
GRKRRLYSALYLVPRGEFNLVLGALALGQGYPLVAQVAVLLVLVSIPLGALLIRYAPEIA
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALYPEARPRKRAKRAEGSPVK
HHHCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MHPSLEAFALAAGLLALGAALVHRFGFPPLPVYLLTGLVVGERLPVEDLEPLPSLGLLLL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHH
LFSVGLEFGPDRLRELSGKALRAGFFDALALPLGFLLGLLAGLDLRGALLLAGVIYISSS
HHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
AVIVKLIIDLRRAANPESEVVLGVLVLEDLVIALLLALLGGQGPAGFLGGVALALAYFLF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ARFLGPRLVRFMEGLSDELVLLLGAAFTAGTALLFHAVGASEGVGAFLSGVIAAGLGLRE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
RFEHLFGPVRDLGVALFFLVVGAEALGLLRGLTPWAVGLVLLGLLLKLPLNHLGGARAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCCHHCC
GRKRRLYSALYLVPRGEFNLVLGALALGQGYPLVAQVAVLLVLVSIPLGALLIRYAPEIA
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALYPEARPRKRAKRAEGSPVK
HHHCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]