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The map label for this gene is sdhA [H]

Identifier: 55981423

GI number: 55981423

Start: 1381742

End: 1383475

Strand: Reverse

Name: sdhA [H]

Synonym: TTHA1454

Alternate gene names: 55981423

Gene position: 1383475-1381742 (Counterclockwise)

Preceding gene: 55981424

Following gene: 55981422

Centisome position: 74.79

GC content: 67.24

Gene sequence:

>1734_bases
ATGGCGCACAGGCACGAGGTCATCGTGGTGGGTGCGGGCGGGGCGGGCCTCACGGCCGCCCTCTACGCGGCCAAGGAAGG
CGCGGACGTGGCGGTGGTCTCCAAGCTCTACCCCACGCGGAGCCACACCGGGGCGGCCCAGGGGGGGATAGGGGCCGCCC
TCGGCAACGTGGAGGAGGACCACTGGGAATGGCACATGTTTGACACGGTCAAGGGGGGGGACTACCTCACGGACCAGGAC
GCCGCCGAGGTCTTCGCCAAGGAAGTGATTGAGGCGGTGATTGAGCTGGAGCACATGGGCCTCCCCTTTGACCGGCTCCC
GAACGGCAAGATCGCCCAGCGCCGCTTCGGGGGGCACACCAAGGAGTGGGGCAAGGCCCCGGTGCACCGGGCGGCCCACG
CCGCCGACCGCACCGGGCACATGATCCTCCAGACCCTCTACCAGCAGTGCGTCAAGCACAACATCACCTTCTACAACGAG
TTCCACGTCACCGACGTCATCATTGAGGACGGGGTGGCCAAGGGCCTGGTGGCCCTGGAGCTCGCCACCGGGGAGCTCCA
CCTCTTTGAGGCCAAGGCCATCGTCATCGCCTCCGGGGGGTTCGGGCGGATCTACAAGGTGACCTCCAACGCCTACACCC
TCACCGGGGACCTGCAGGCCATCCTCTACCGCAAGGGGCTTCCCCTCGAGGACATGGAGTTCTACCAGTTCCACCCCACG
GGCCTTTACCCCCTGGGCATCCTCCTCACCGAGGGGGCCCGGGGCGAGGGGGGGATCCTCCGGAACGCCCTCGGGGAGCG
GTTCATGGAGCGCTACGCCCCCACCATCAAGGACCTTGCCCCAAGGGACCTCGTCTCCCGGGCCATGTACCTGGAGGTGC
GGGAGGGGCGGGGTTGCGGCCCCAAGAAGGACCACGTCCTCCTGGACCTCACCCACCTGCCCCCCGAGATCATTGAGAAG
AAGCTCCCGGACATCACCGAGTTCAGCCGCATCTACCTGGGGGTGGACCCCCTGAAGGAGCCCGTGCCGGTGATGCCCAC
GGCCCACTACGCCATGGGGGGGATCCCCACCACCCTCTGGGGCCAGGTGATCAAGGACGAGAAGAACACCGTGGTCCCCG
GGCTCTACGCCGCCGGGGAGGCCGCCTGCGTGAGCCTCCACGGGGCGAACCGCCTGGGGACGAACTCCTTGGGGGACCTC
GTGGTCTTCGGACGCCGGGCCGGGATCCACGCCGCCCGCTTCGCCCGGGACGCCGACTACCACGAGCTCACCGAGGAGCA
CCTCGGGGAGAGCCGGGAGCGCATTGAGCGCATCAAGAACTCCACCGGTAAGGAGAAGGTGGCGGCCCTTAGGGCCGAGC
TGCAGCAGTCCATGATGGACAACGCCTCCGTCTTCCGCACCGGGGAGCTTCTTAAAAAGCAGGTGGAGATCCTCAAGGAG
CTCATGGACCGGTACAAGCGGATCTCCATTGACGACAAGGGGGACGCCTACAACACCGAGCTCGTGGAGGCTTTGGAGCT
CGGTTACCTCCTCGAGGTCTCCGAGGCCCTGGTCCACTCCGCCCTAAACCGCACCGAGTCCCGCGGGGCCCACGCCCGGG
AGGACTACCCCGAGCGGGACGACGAGAACTGGCTCAAGCACACCCTGGCCTACAAGGTGGAAGACGGCAAGGTTTGCTTC
CGCTACAAGCCCGTGGTCCTGGGCCGCTTTGAGCCCAAGCCCCGGACCTACTAG

Upstream 100 bases:

>100_bases
AAGCGCTTCTGGACCAAGGTGGTGGTCTACAGCCTTTTGGCCTTTCTCTTCTTCCTGGGGAGCCTTTCCCTCTTTAACCA
CGACTTCGGGGTGAACTAGT

Downstream 100 bases:

>100_bases
GAGGGAGGCATGCAGGTCACGCTGAAGGTCCTCCGCTTTGACCCCGCCAAGGACAAGAAGCCCCGCTGGGAGACCTACCA
GGTGGAGGCCGAGCCCTGGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MAHRHEVIVVGAGGAGLTAALYAAKEGADVAVVSKLYPTRSHTGAAQGGIGAALGNVEEDHWEWHMFDTVKGGDYLTDQD
AAEVFAKEVIEAVIELEHMGLPFDRLPNGKIAQRRFGGHTKEWGKAPVHRAAHAADRTGHMILQTLYQQCVKHNITFYNE
FHVTDVIIEDGVAKGLVALELATGELHLFEAKAIVIASGGFGRIYKVTSNAYTLTGDLQAILYRKGLPLEDMEFYQFHPT
GLYPLGILLTEGARGEGGILRNALGERFMERYAPTIKDLAPRDLVSRAMYLEVREGRGCGPKKDHVLLDLTHLPPEIIEK
KLPDITEFSRIYLGVDPLKEPVPVMPTAHYAMGGIPTTLWGQVIKDEKNTVVPGLYAAGEAACVSLHGANRLGTNSLGDL
VVFGRRAGIHAARFARDADYHELTEEHLGESRERIERIKNSTGKEKVAALRAELQQSMMDNASVFRTGELLKKQVEILKE
LMDRYKRISIDDKGDAYNTELVEALELGYLLEVSEALVHSALNRTESRGAHAREDYPERDDENWLKHTLAYKVEDGKVCF
RYKPVVLGRFEPKPRTY

Sequences:

>Translated_577_residues
MAHRHEVIVVGAGGAGLTAALYAAKEGADVAVVSKLYPTRSHTGAAQGGIGAALGNVEEDHWEWHMFDTVKGGDYLTDQD
AAEVFAKEVIEAVIELEHMGLPFDRLPNGKIAQRRFGGHTKEWGKAPVHRAAHAADRTGHMILQTLYQQCVKHNITFYNE
FHVTDVIIEDGVAKGLVALELATGELHLFEAKAIVIASGGFGRIYKVTSNAYTLTGDLQAILYRKGLPLEDMEFYQFHPT
GLYPLGILLTEGARGEGGILRNALGERFMERYAPTIKDLAPRDLVSRAMYLEVREGRGCGPKKDHVLLDLTHLPPEIIEK
KLPDITEFSRIYLGVDPLKEPVPVMPTAHYAMGGIPTTLWGQVIKDEKNTVVPGLYAAGEAACVSLHGANRLGTNSLGDL
VVFGRRAGIHAARFARDADYHELTEEHLGESRERIERIKNSTGKEKVAALRAELQQSMMDNASVFRTGELLKKQVEILKE
LMDRYKRISIDDKGDAYNTELVEALELGYLLEVSEALVHSALNRTESRGAHAREDYPERDDENWLKHTLAYKVEDGKVCF
RYKPVVLGRFEPKPRTY
>Mature_576_residues
AHRHEVIVVGAGGAGLTAALYAAKEGADVAVVSKLYPTRSHTGAAQGGIGAALGNVEEDHWEWHMFDTVKGGDYLTDQDA
AEVFAKEVIEAVIELEHMGLPFDRLPNGKIAQRRFGGHTKEWGKAPVHRAAHAADRTGHMILQTLYQQCVKHNITFYNEF
HVTDVIIEDGVAKGLVALELATGELHLFEAKAIVIASGGFGRIYKVTSNAYTLTGDLQAILYRKGLPLEDMEFYQFHPTG
LYPLGILLTEGARGEGGILRNALGERFMERYAPTIKDLAPRDLVSRAMYLEVREGRGCGPKKDHVLLDLTHLPPEIIEKK
LPDITEFSRIYLGVDPLKEPVPVMPTAHYAMGGIPTTLWGQVIKDEKNTVVPGLYAAGEAACVSLHGANRLGTNSLGDLV
VFGRRAGIHAARFARDADYHELTEEHLGESRERIERIKNSTGKEKVAALRAELQQSMMDNASVFRTGELLKKQVEILKEL
MDRYKRISIDDKGDAYNTELVEALELGYLLEVSEALVHSALNRTESRGAHAREDYPERDDENWLKHTLAYKVEDGKVCFR
YKPVVLGRFEPKPRTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=565, Percent_Identity=48.8495575221239, Blast_Score=550, Evalue=1e-156,
Organism=Escherichia coli, GI1786942, Length=581, Percent_Identity=51.8072289156626, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1790597, Length=567, Percent_Identity=42.5044091710758, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=33.5701598579041, Blast_Score=234, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=585, Percent_Identity=46.6666666666667, Blast_Score=530, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17505833, Length=583, Percent_Identity=46.3121783876501, Blast_Score=515, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322701, Length=571, Percent_Identity=49.9124343257443, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322416, Length=571, Percent_Identity=49.5621716287215, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320788, Length=481, Percent_Identity=28.0665280665281, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137288, Length=587, Percent_Identity=50.0851788756388, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24655642, Length=587, Percent_Identity=50.0851788756388, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24655647, Length=587, Percent_Identity=50.0851788756388, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=46.1285008237232, Blast_Score=511, Evalue=1e-145,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64024; Mature: 63893

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRHEVIVVGAGGAGLTAALYAAKEGADVAVVSKLYPTRSHTGAAQGGIGAALGNVEED
CCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCHHHHCCCCCC
HWEWHMFDTVKGGDYLTDQDAAEVFAKEVIEAVIELEHMGLPFDRLPNGKIAQRRFGGHT
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCC
KEWGKAPVHRAAHAADRTGHMILQTLYQQCVKHNITFYNEFHVTDVIIEDGVAKGLVALE
CHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHCCEEEEE
LATGELHLFEAKAIVIASGGFGRIYKVTSNAYTLTGDLQAILYRKGLPLEDMEFYQFHPT
EECCCEEEEEEEEEEEECCCCCEEEEEECCCEEEECHHHHHHHHCCCCCCCCCCEEECCC
GLYPLGILLTEGARGEGGILRNALGERFMERYAPTIKDLAPRDLVSRAMYLEVREGRGCG
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHEEEEECCCCCC
PKKDHVLLDLTHLPPEIIEKKLPDITEFSRIYLGVDPLKEPVPVMPTAHYAMGGIPTTLW
CCCCCEEEEECCCCHHHHHHCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHCCCCHHHH
GQVIKDEKNTVVPGLYAAGEAACVSLHGANRLGTNSLGDLVVFGRRAGIHAARFARDADY
HHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCH
HELTEEHLGESRERIERIKNSTGKEKVAALRAELQQSMMDNASVFRTGELLKKQVEILKE
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LMDRYKRISIDDKGDAYNTELVEALELGYLLEVSEALVHSALNRTESRGAHAREDYPERD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENWLKHTLAYKVEDGKVCFRYKPVVLGRFEPKPRTY
CHHHHHHHHEEEECCCCEEEEECCEEEECCCCCCCCC
>Mature Secondary Structure 
AHRHEVIVVGAGGAGLTAALYAAKEGADVAVVSKLYPTRSHTGAAQGGIGAALGNVEED
CCCCEEEEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCHHHHCCCCCC
HWEWHMFDTVKGGDYLTDQDAAEVFAKEVIEAVIELEHMGLPFDRLPNGKIAQRRFGGHT
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCC
KEWGKAPVHRAAHAADRTGHMILQTLYQQCVKHNITFYNEFHVTDVIIEDGVAKGLVALE
CHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHCCEEEEE
LATGELHLFEAKAIVIASGGFGRIYKVTSNAYTLTGDLQAILYRKGLPLEDMEFYQFHPT
EECCCEEEEEEEEEEEECCCCCEEEEEECCCEEEECHHHHHHHHCCCCCCCCCCEEECCC
GLYPLGILLTEGARGEGGILRNALGERFMERYAPTIKDLAPRDLVSRAMYLEVREGRGCG
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHEEEEECCCCCC
PKKDHVLLDLTHLPPEIIEKKLPDITEFSRIYLGVDPLKEPVPVMPTAHYAMGGIPTTLW
CCCCCEEEEECCCCHHHHHHCCCCHHHHHHHEECCCCCCCCCCCCCCCHHHHCCCCHHHH
GQVIKDEKNTVVPGLYAAGEAACVSLHGANRLGTNSLGDLVVFGRRAGIHAARFARDADY
HHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCH
HELTEEHLGESRERIERIKNSTGKEKVAALRAELQQSMMDNASVFRTGELLKKQVEILKE
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LMDRYKRISIDDKGDAYNTELVEALELGYLLEVSEALVHSALNRTESRGAHAREDYPERD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DENWLKHTLAYKVEDGKVCFRYKPVVLGRFEPKPRTY
CHHHHHHHHEEEECCCCEEEEECCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA