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The map label for this gene is thrB [H]

Identifier: 55981363

GI number: 55981363

Start: 1329948

End: 1330826

Strand: Direct

Name: thrB [H]

Synonym: TTHA1394

Alternate gene names: 55981363

Gene position: 1329948-1330826 (Clockwise)

Preceding gene: 55981362

Following gene: 55981364

Centisome position: 71.9

GC content: 73.61

Gene sequence:

>879_bases
ATGGACCTCCCCCGCCTCTACGTCCCCGCCACCCTGGCCAACCTGGGCTCGGGCTTTGACGCCTTGGGGGTGGCCCTGGA
CCTCTACCTCGAGGTGGAGGCCCACCCCGCCCCGGAGGACGCCTTCCTCTACGAGGGGGAAGGCCATGTGGAGGGTACAG
ACAACCTGATCCACGAGGGGTACCGGGCCGGGATGCGGGCCCTGGGGCTAGAGCCCTTCCCCTTGCGGGTGCGGGCCTTC
AACCCCATCCCCCTGGCCCGGGGCATGGGAAGCTCCTCCGCCGCCTTAGTGGCCGGGGTGGCCCTGGCGGACCGGCTTTC
CGGGGGGAGGCTTGGGCGGGAGGGGGTCTTCCGGGTGGCGGCGGGGCTCGAGGGCCATCCCGACAACGTGGCCCCGGCGG
TCTACGGGGGCTTCGTGGCCGCCCTGAGCGACCCCCCCTTGGCCATCCCCCTGCCGAGGCCCGAAGGGGTGCGCTTCGTC
CTGGCCGTCCCCCCCTACGAGGTCCCCACCCCCTTGGCCCGGGAGGCCCTGCCCCGGGAGGTGCCCCTGGAGGACGCCAT
CTACAACCTGGCAAGAAGCGCCCTCTGGCCCGCGGCGCTTTCCTCGGGGAGGCTCGAGGCCCTGAGGGAGGCCTGCCGCG
ACCGGCTCCACCAGCCCCACCGGGCCCACCTCATGCCCGGGGTCCTGGAGGCGATAGAAGGCGCGCTAGAGGCCGGGGCC
CTGGCGGCCTTCGTGGGCGGGGCGGGGCCCACCCTGGCCGCCCTGGCGCGCGCCGGGGAGGAAGCCCCCGTGATCCGGGC
CCTTTCCGCCTACCGGGGCCCGGAAGGGCGCACGCTGGTATTGGGCATAGGGGAGGGATACTTTTGGAAGGAGACCTGA

Upstream 100 bases:

>100_bases
GCCCTCCCCCGGGCAAGGAGGCTCCTCCAGGAGGGAAGGGTGCCCCCGGCCTTCTTCCCGCGGTAGCCTGGTATATTCGG
GTGGGGTTTTGCCCGGCGCC

Downstream 100 bases:

>100_bases
AGGCCATCCCCCTGACCGAGGTCCTGGAGCTGGTCCACGCCCATAGGCGCTCCGGGGTCCTGGAGGTGCGCACCGGGCCC
CTTCCCCTCACCCTCCGCTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MDLPRLYVPATLANLGSGFDALGVALDLYLEVEAHPAPEDAFLYEGEGHVEGTDNLIHEGYRAGMRALGLEPFPLRVRAF
NPIPLARGMGSSSAALVAGVALADRLSGGRLGREGVFRVAAGLEGHPDNVAPAVYGGFVAALSDPPLAIPLPRPEGVRFV
LAVPPYEVPTPLAREALPREVPLEDAIYNLARSALWPAALSSGRLEALREACRDRLHQPHRAHLMPGVLEAIEGALEAGA
LAAFVGGAGPTLAALARAGEEAPVIRALSAYRGPEGRTLVLGIGEGYFWKET

Sequences:

>Translated_292_residues
MDLPRLYVPATLANLGSGFDALGVALDLYLEVEAHPAPEDAFLYEGEGHVEGTDNLIHEGYRAGMRALGLEPFPLRVRAF
NPIPLARGMGSSSAALVAGVALADRLSGGRLGREGVFRVAAGLEGHPDNVAPAVYGGFVAALSDPPLAIPLPRPEGVRFV
LAVPPYEVPTPLAREALPREVPLEDAIYNLARSALWPAALSSGRLEALREACRDRLHQPHRAHLMPGVLEAIEGALEAGA
LAAFVGGAGPTLAALARAGEEAPVIRALSAYRGPEGRTLVLGIGEGYFWKET
>Mature_292_residues
MDLPRLYVPATLANLGSGFDALGVALDLYLEVEAHPAPEDAFLYEGEGHVEGTDNLIHEGYRAGMRALGLEPFPLRVRAF
NPIPLARGMGSSSAALVAGVALADRLSGGRLGREGVFRVAAGLEGHPDNVAPAVYGGFVAALSDPPLAIPLPRPEGVRFV
LAVPPYEVPTPLAREALPREVPLEDAIYNLARSALWPAALSSGRLEALREACRDRLHQPHRAHLMPGVLEAIEGALEAGA
LAAFVGGAGPTLAALARAGEEAPVIRALSAYRGPEGRTLVLGIGEGYFWKET

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=278, Percent_Identity=28.4172661870504, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321814, Length=318, Percent_Identity=30.188679245283, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 30690; Mature: 30690

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLPRLYVPATLANLGSGFDALGVALDLYLEVEAHPAPEDAFLYEGEGHVEGTDNLIHEG
CCCCCEEHHHHHHHHCCCHHHHHEEEEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHH
YRAGMRALGLEPFPLRVRAFNPIPLARGMGSSSAALVAGVALADRLSGGRLGREGVFRVA
HHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
AGLEGHPDNVAPAVYGGFVAALSDPPLAIPLPRPEGVRFVLAVPPYEVPTPLAREALPRE
CCCCCCCCCCCHHHHHHHHEECCCCCEEEECCCCCCCEEEEEECCCCCCCCHHHHHCCCC
VPLEDAIYNLARSALWPAALSSGRLEALREACRDRLHQPHRAHLMPGVLEAIEGALEAGA
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LAAFVGGAGPTLAALARAGEEAPVIRALSAYRGPEGRTLVLGIGEGYFWKET
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCC
>Mature Secondary Structure
MDLPRLYVPATLANLGSGFDALGVALDLYLEVEAHPAPEDAFLYEGEGHVEGTDNLIHEG
CCCCCEEHHHHHHHHCCCHHHHHEEEEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHH
YRAGMRALGLEPFPLRVRAFNPIPLARGMGSSSAALVAGVALADRLSGGRLGREGVFRVA
HHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
AGLEGHPDNVAPAVYGGFVAALSDPPLAIPLPRPEGVRFVLAVPPYEVPTPLAREALPRE
CCCCCCCCCCCHHHHHHHHEECCCCCEEEECCCCCCCEEEEEECCCCCCCCHHHHHCCCC
VPLEDAIYNLARSALWPAALSSGRLEALREACRDRLHQPHRAHLMPGVLEAIEGALEAGA
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LAAFVGGAGPTLAALARAGEEAPVIRALSAYRGPEGRTLVLGIGEGYFWKET
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA