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The map label for this gene is glnA [H]

Identifier: 55981298

GI number: 55981298

Start: 1268723

End: 1270063

Strand: Direct

Name: glnA [H]

Synonym: TTHA1329

Alternate gene names: 55981298

Gene position: 1268723-1270063 (Clockwise)

Preceding gene: 55981296

Following gene: 55981299

Centisome position: 68.59

GC content: 65.77

Gene sequence:

>1341_bases
ATGGGTTACACAAAGGCCGAGATTTTAAAAGCGCTTAAGGGGGAAAACGTCAAGTTCTTGCGCCTGCAGATCACGGACAT
CCTGGGCGTGGTCAAGAACGTGGAGGTGCCCGAGTCCCAGTTTGAGAAGGCCCTGGACGGGGAGATCATGTTTGACGGCT
CCTCCATTGAGGGCTTCACCCGGATTGAGGAGTCGGACATGCTCCTAAGGCCCGACTACAACACCTTCGTCATCCTCCCC
GACCTGGTGGAAGACCCAAAGCGGGGCCGGGTGGCGCGGCTCATCTGCGACGTCTACTACCCCGACGGCCGCCCCTTTGA
AGGGGACCCCCGCTACGTCCTCAAGCGGCAGATTGAAAGGCTCAAGAAGCTCGGGTTTGACAACCTGTACGCCGGCCCCG
AGCCCGAGTTCTTCCTCTTCCTCAGGACCCCGGAGGGCCTGCCCACCACCGAGACCCACGACCGGGCGGGCTACTTTGAC
CTGGCCCCCATAGACAAGGGGGAGGAGGCGCGCCGCGACATGGTGAACGCCCTGGTGGCCATGGGCTTTGAGATTGAGGC
GGCCCACCACGAGGTGGCCCCGGGGCAGCACGAGATTGACTTCAAGTACGCCGACGCCCTCACCACCGCCGACAACATCG
CCACCTTCAAGTGGGTGGTGAAGCGGATCGCCCTGAACCACGGCCTCCACGCCACCTTCCTGCCCAAGCCCATCCGGGGC
ATCAACGGCAGCGGCATGCACACCCACCTCTCCCTCTTCAAGGACGGGGAGAACGCCTTCTATGACCCCAACGCCGAGTA
CCAGCTCTCCCAGACCGCCCTCCACTTCATCGCTGGGCTCCTGGAGCACGCCGCCGGGATGGTGGCCGTCACCAACCCCT
TGGTGAACTCCTACAAGCGCCTCACCCCCGGGTACGAGGCCCCCACCAACATCGCCTGGTCCGCCTCCAACCGCTCCGCC
ATGATCCGGATCCCGGCGCGCCGGGGCGTGGGCACCCGGGCGGAGCTCAGGATGCCCGACCCCTCCTGCAACCCCTACCT
GGCCCTGGCGGTGATGGCGGCCGCGGGCGCGGACGGGATTGAGCGGAAGCTCCTCCCGCCCCCGCCCATCCAGCGGAACA
TCTACCAGATGACCGTGCGGGAGCGGCGCAAGCACAAGATCCGGGAGCTCCCCGGGACCCTCCGGGAGGCCCTCGAGGCC
CTGAGGAAGGACCCCGTGATCCGGGAGGCCCTGGGCGAGCACGTCTACACCCACTTCCTCCAGGCCAAGCAGATGGAGTG
GGACGACTACCGGGTCACGGTCCACCAGTGGGAGCTGGACCGGTACCTGGCCACCTACTAG

Upstream 100 bases:

>100_bases
CGTCCAAGCTTGACATCTGACCGCATTTGTCGGTACACTCCGCAGCAAGGTCCGGGTAAAACGGCGAAAGCCCGGGACCT
AAAAGGAATGGGAGGCGAAC

Downstream 100 bases:

>100_bases
GCCGCCTGGGGTCAGGGCGCTTATCCTTGCGCCCTGACCCGTTGGTCACGCATAAACCTCAAGGAAAGGCGTTGACAAGA
CGCCCAGCCCCCCCTATAGA

Product: glutamine synthetase

Products: NA

Alternate protein names: Glutamate--ammonia ligase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MGYTKAEILKALKGENVKFLRLQITDILGVVKNVEVPESQFEKALDGEIMFDGSSIEGFTRIEESDMLLRPDYNTFVILP
DLVEDPKRGRVARLICDVYYPDGRPFEGDPRYVLKRQIERLKKLGFDNLYAGPEPEFFLFLRTPEGLPTTETHDRAGYFD
LAPIDKGEEARRDMVNALVAMGFEIEAAHHEVAPGQHEIDFKYADALTTADNIATFKWVVKRIALNHGLHATFLPKPIRG
INGSGMHTHLSLFKDGENAFYDPNAEYQLSQTALHFIAGLLEHAAGMVAVTNPLVNSYKRLTPGYEAPTNIAWSASNRSA
MIRIPARRGVGTRAELRMPDPSCNPYLALAVMAAAGADGIERKLLPPPPIQRNIYQMTVRERRKHKIRELPGTLREALEA
LRKDPVIREALGEHVYTHFLQAKQMEWDDYRVTVHQWELDRYLATY

Sequences:

>Translated_446_residues
MGYTKAEILKALKGENVKFLRLQITDILGVVKNVEVPESQFEKALDGEIMFDGSSIEGFTRIEESDMLLRPDYNTFVILP
DLVEDPKRGRVARLICDVYYPDGRPFEGDPRYVLKRQIERLKKLGFDNLYAGPEPEFFLFLRTPEGLPTTETHDRAGYFD
LAPIDKGEEARRDMVNALVAMGFEIEAAHHEVAPGQHEIDFKYADALTTADNIATFKWVVKRIALNHGLHATFLPKPIRG
INGSGMHTHLSLFKDGENAFYDPNAEYQLSQTALHFIAGLLEHAAGMVAVTNPLVNSYKRLTPGYEAPTNIAWSASNRSA
MIRIPARRGVGTRAELRMPDPSCNPYLALAVMAAAGADGIERKLLPPPPIQRNIYQMTVRERRKHKIRELPGTLREALEA
LRKDPVIREALGEHVYTHFLQAKQMEWDDYRVTVHQWELDRYLATY
>Mature_445_residues
GYTKAEILKALKGENVKFLRLQITDILGVVKNVEVPESQFEKALDGEIMFDGSSIEGFTRIEESDMLLRPDYNTFVILPD
LVEDPKRGRVARLICDVYYPDGRPFEGDPRYVLKRQIERLKKLGFDNLYAGPEPEFFLFLRTPEGLPTTETHDRAGYFDL
APIDKGEEARRDMVNALVAMGFEIEAAHHEVAPGQHEIDFKYADALTTADNIATFKWVVKRIALNHGLHATFLPKPIRGI
NGSGMHTHLSLFKDGENAFYDPNAEYQLSQTALHFIAGLLEHAAGMVAVTNPLVNSYKRLTPGYEAPTNIAWSASNRSAM
IRIPARRGVGTRAELRMPDPSCNPYLALAVMAAAGADGIERKLLPPPPIQRNIYQMTVRERRKHKIRELPGTLREALEAL
RKDPVIREALGEHVYTHFLQAKQMEWDDYRVTVHQWELDRYLATY

Specific function: Unknown

COG id: COG0174

COG function: function code E; Glutamine synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine synthetase family [H]

Homologues:

Organism=Homo sapiens, GI221307485, Length=458, Percent_Identity=26.8558951965066, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790301, Length=472, Percent_Identity=37.0762711864407, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87081870, Length=427, Percent_Identity=27.8688524590164, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 15324 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal medi

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008147
- InterPro:   IPR014746
- InterPro:   IPR008146
- InterPro:   IPR004809
- InterPro:   IPR001637 [H]

Pfam domain/function: PF00120 Gln-synt_C; PF03951 Gln-synt_N [H]

EC number: =6.3.1.2 [H]

Molecular weight: Translated: 50558; Mature: 50426

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00180 GLNA_1 ; PS00181 GLNA_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYTKAEILKALKGENVKFLRLQITDILGVVKNVEVPESQFEKALDGEIMFDGSSIEGFT
CCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCE
RIEESDMLLRPDYNTFVILPDLVEDPKRGRVARLICDVYYPDGRPFEGDPRYVLKRQIER
EECCCCEEECCCCCEEEEECHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHH
LKKLGFDNLYAGPEPEFFLFLRTPEGLPTTETHDRAGYFDLAPIDKGEEARRDMVNALVA
HHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
MGFEIEAAHHEVAPGQHEIDFKYADALTTADNIATFKWVVKRIALNHGLHATFLPKPIRG
HCCEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
INGSGMHTHLSLFKDGENAFYDPNAEYQLSQTALHFIAGLLEHAAGMVAVTNPLVNSYKR
CCCCCCEEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHH
LTPGYEAPTNIAWSASNRSAMIRIPARRGVGTRAELRMPDPSCNPYLALAVMAAAGADGI
CCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCC
ERKLLPPPPIQRNIYQMTVRERRKHKIRELPGTLREALEALRKDPVIREALGEHVYTHFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QAKQMEWDDYRVTVHQWELDRYLATY
HHHCCCCCCEEEEEEEEEHHHHHHCC
>Mature Secondary Structure 
GYTKAEILKALKGENVKFLRLQITDILGVVKNVEVPESQFEKALDGEIMFDGSSIEGFT
CCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCE
RIEESDMLLRPDYNTFVILPDLVEDPKRGRVARLICDVYYPDGRPFEGDPRYVLKRQIER
EECCCCEEECCCCCEEEEECHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHH
LKKLGFDNLYAGPEPEFFLFLRTPEGLPTTETHDRAGYFDLAPIDKGEEARRDMVNALVA
HHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
MGFEIEAAHHEVAPGQHEIDFKYADALTTADNIATFKWVVKRIALNHGLHATFLPKPIRG
HCCEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
INGSGMHTHLSLFKDGENAFYDPNAEYQLSQTALHFIAGLLEHAAGMVAVTNPLVNSYKR
CCCCCCEEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHH
LTPGYEAPTNIAWSASNRSAMIRIPARRGVGTRAELRMPDPSCNPYLALAVMAAAGADGI
CCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCC
ERKLLPPPPIQRNIYQMTVRERRKHKIRELPGTLREALEALRKDPVIREALGEHVYTHFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QAKQMEWDDYRVTVHQWELDRYLATY
HHHCCCCCCEEEEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2906311; 2565853; 9384377; 11719184 [H]