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The map label for this gene is atpA [H]

Identifier: 55981242

GI number: 55981242

Start: 1214862

End: 1216598

Strand: Reverse

Name: atpA [H]

Synonym: TTHA1273

Alternate gene names: 55981242

Gene position: 1216598-1214862 (Counterclockwise)

Preceding gene: 55981243

Following gene: 55981241

Centisome position: 65.77

GC content: 68.05

Gene sequence:

>1737_bases
ATGATCCAAGGGGTGATCCAGAAGATCGCGGGCCCGGCGGTGATCGCCAAGGGCATGCTCGGGGCCCGCATGTACGACAT
CTGCAAGGTGGGCGAAGAGGGCCTCGTGGGCGAGATCATCCGCCTGGACGGGGACACGGCCTTCGTCCAGGTCTACGAGG
ACACCTCGGGCCTAAAGGTGGGGGAGCCCGTGGTCTCCACGGGGCTTCCCTTGGCGGTGGAGCTCGGCCCCGGGATGCTG
AACGGCATCTACGACGGCATCCAGCGCCCCCTGGAGCGCATCCGGGAGAAGACGGGGATCTACATCACCCGGGGCGTGGT
GGTCCACGCCCTGGACCGGGAGAAGAAGTGGGCCTGGACGCCCATGGTCAAGCCCGGGGACGAGGTGCGGGGGGGTATGG
TCCTGGGCACGGTGCCCGAGTTCGGCTTCACCCACAAGATCCTGGTACCCCCGGACGTGCGGGGCCGGGTCAAGGAGGTG
AAGCCCGCCGGGGAGTACACCGTGGAGGAGCCGGTGGTGGTCCTCGAGGACGGCACCGAGCTCAAGATGTACCACACCTG
GCCCGTTCGCCGGGCGAGGCCCGTGCAAAGGAAGCTTGACCCCAACACCCCCTTCCTCACGGGGATGCGCATCCTGGACG
TCCTCTTCCCCGTGGCCATGGGGGGCACCGCCGCCATCCCTGGGCCCTTCGGCAGCGGCAAGACCGTGACCCAGCAGTCC
CTGGCCAAGTGGTCCAACGCCGACGTGGTGGTCTACGTGGGCTGCGGGGAGCGGGGGAACGAGATGACCGACGTGCTCGT
GGAGTTCCCCGAGCTCACCGACCCCAAGACGGGGGGGCCCTTGATGCACCGCACCGTCCTCATCGCCAACACCTCCAACA
TGCCCGTGGCCGCCCGCGAGGCCAGCATCTACGTGGGCGTGACCATCGCCGAGTACTTCCGCGACCAGGGCTTCTCCGTG
GCCCTCATGGCCGACTCCACGAGCCGCTGGGCCGAGGCTTTGCGCGAGATCTCTAGCCGCCTCGAGGAGATGCCCGCCGA
GGAGGGCTACCCGCCCTACCTCGCCGCCAGGCTCGCCGCCTTCTACGAGCGGGCGGGCAAGGTCATCACCCTGGGCGGCG
AGGAGGGGGCGGTGACCATCGTGGGGGCCGTCTCCCCGCCGGGCGGCGACATGTCCGAGCCCGTGACCCAGTCCACCTTG
AGGATCGTGGGGGCCTTCTGGCGGCTTGACGCCTCCCTGGCCTTCCGCCGCCACTTCCCCGCCATCAACTGGAACGGCTC
CTACAGCCTCTTCACCTCCGCCCTTGACCCCTGGTACCGGGAGAACGTGGCCGAGGACTACCCCGAGCTCCGCGACGCCA
TCTCCGAGCTTTTGCAGCGGGAGGCGGGCCTCCAGGAGATCGTCCAGCTCGTGGGGCCGGACGCCCTCCAGGACGCCGAG
CGCCTCGTCATTGAGGTGGGCCGGATCATCCGCGAGGACTTCCTGCAGCAGAACGCCTACCACGAGGTGGACGCCTACTG
CTCCATGAAGAAGGCCTACGGGATCATGAAGATGATCCTCGCCTTCTACAAGGAGGCGGAGGCGGCCATCAAGCGGGGGG
TTTCCATAGACGAGATCCTGCAGCTCCCCGTTCTGGAGCGCATCGGCCGCGCCCGCTACGTGAGCGAGGAGGAGTTCCCC
GCCTACTTTGAGGAGGCCATGAAGGAGATCCAGGGGGCCTTCAAGGCCCTGGCCTAA

Upstream 100 bases:

>100_bases
GCTGAAGGAGGCCTTCCAGGGGCACGACGTGGAAGGCTACATGCGGGAGCTGGTGAGGAAGACCATCGGCTTTGACATCA
AGCTGTAGAATGGAGGGACG

Downstream 100 bases:

>100_bases
AGGGGGAGAGATGGACCTTCTGAAGAAGGAGTACACGGGCATCACCTACATCTCGGGGCCTCTTCTCTTCGTGGAGAACG
CCAAGGACCTGGCCTACGGG

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MIQGVIQKIAGPAVIAKGMLGARMYDICKVGEEGLVGEIIRLDGDTAFVQVYEDTSGLKVGEPVVSTGLPLAVELGPGML
NGIYDGIQRPLERIREKTGIYITRGVVVHALDREKKWAWTPMVKPGDEVRGGMVLGTVPEFGFTHKILVPPDVRGRVKEV
KPAGEYTVEEPVVVLEDGTELKMYHTWPVRRARPVQRKLDPNTPFLTGMRILDVLFPVAMGGTAAIPGPFGSGKTVTQQS
LAKWSNADVVVYVGCGERGNEMTDVLVEFPELTDPKTGGPLMHRTVLIANTSNMPVAAREASIYVGVTIAEYFRDQGFSV
ALMADSTSRWAEALREISSRLEEMPAEEGYPPYLAARLAAFYERAGKVITLGGEEGAVTIVGAVSPPGGDMSEPVTQSTL
RIVGAFWRLDASLAFRRHFPAINWNGSYSLFTSALDPWYRENVAEDYPELRDAISELLQREAGLQEIVQLVGPDALQDAE
RLVIEVGRIIREDFLQQNAYHEVDAYCSMKKAYGIMKMILAFYKEAEAAIKRGVSIDEILQLPVLERIGRARYVSEEEFP
AYFEEAMKEIQGAFKALA

Sequences:

>Translated_578_residues
MIQGVIQKIAGPAVIAKGMLGARMYDICKVGEEGLVGEIIRLDGDTAFVQVYEDTSGLKVGEPVVSTGLPLAVELGPGML
NGIYDGIQRPLERIREKTGIYITRGVVVHALDREKKWAWTPMVKPGDEVRGGMVLGTVPEFGFTHKILVPPDVRGRVKEV
KPAGEYTVEEPVVVLEDGTELKMYHTWPVRRARPVQRKLDPNTPFLTGMRILDVLFPVAMGGTAAIPGPFGSGKTVTQQS
LAKWSNADVVVYVGCGERGNEMTDVLVEFPELTDPKTGGPLMHRTVLIANTSNMPVAAREASIYVGVTIAEYFRDQGFSV
ALMADSTSRWAEALREISSRLEEMPAEEGYPPYLAARLAAFYERAGKVITLGGEEGAVTIVGAVSPPGGDMSEPVTQSTL
RIVGAFWRLDASLAFRRHFPAINWNGSYSLFTSALDPWYRENVAEDYPELRDAISELLQREAGLQEIVQLVGPDALQDAE
RLVIEVGRIIREDFLQQNAYHEVDAYCSMKKAYGIMKMILAFYKEAEAAIKRGVSIDEILQLPVLERIGRARYVSEEEFP
AYFEEAMKEIQGAFKALA
>Mature_578_residues
MIQGVIQKIAGPAVIAKGMLGARMYDICKVGEEGLVGEIIRLDGDTAFVQVYEDTSGLKVGEPVVSTGLPLAVELGPGML
NGIYDGIQRPLERIREKTGIYITRGVVVHALDREKKWAWTPMVKPGDEVRGGMVLGTVPEFGFTHKILVPPDVRGRVKEV
KPAGEYTVEEPVVVLEDGTELKMYHTWPVRRARPVQRKLDPNTPFLTGMRILDVLFPVAMGGTAAIPGPFGSGKTVTQQS
LAKWSNADVVVYVGCGERGNEMTDVLVEFPELTDPKTGGPLMHRTVLIANTSNMPVAAREASIYVGVTIAEYFRDQGFSV
ALMADSTSRWAEALREISSRLEEMPAEEGYPPYLAARLAAFYERAGKVITLGGEEGAVTIVGAVSPPGGDMSEPVTQSTL
RIVGAFWRLDASLAFRRHFPAINWNGSYSLFTSALDPWYRENVAEDYPELRDAISELLQREAGLQEIVQLVGPDALQDAE
RLVIEVGRIIREDFLQQNAYHEVDAYCSMKKAYGIMKMILAFYKEAEAAIKRGVSIDEILQLPVLERIGRARYVSEEEFP
AYFEEAMKEIQGAFKALA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=598, Percent_Identity=51.1705685618729, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI32189394, Length=379, Percent_Identity=28.4960422163588, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI19913426, Length=417, Percent_Identity=25.1798561151079, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI19913428, Length=395, Percent_Identity=25.0632911392405, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI50345984, Length=255, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4757810, Length=255, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790170, Length=321, Percent_Identity=30.2180685358255, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788251, Length=248, Percent_Identity=33.4677419354839, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790172, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=554, Percent_Identity=53.6101083032491, Blast_Score=584, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI25144756, Length=305, Percent_Identity=29.8360655737705, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=240, Percent_Identity=28.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17570191, Length=240, Percent_Identity=27.0833333333333, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988080, Length=261, Percent_Identity=27.2030651340996, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71988063, Length=261, Percent_Identity=27.2030651340996, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71988074, Length=261, Percent_Identity=27.2030651340996, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320016, Length=352, Percent_Identity=49.1477272727273, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6322581, Length=308, Percent_Identity=31.1688311688312, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319370, Length=244, Percent_Identity=28.6885245901639, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583988, Length=597, Percent_Identity=50.9212730318258, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583986, Length=597, Percent_Identity=50.9212730318258, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583984, Length=597, Percent_Identity=50.9212730318258, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583992, Length=597, Percent_Identity=50.7537688442211, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI20129479, Length=540, Percent_Identity=52.7777777777778, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI28574560, Length=302, Percent_Identity=31.1258278145695, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24638766, Length=302, Percent_Identity=29.1390728476821, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281361666, Length=398, Percent_Identity=23.8693467336683, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646341, Length=398, Percent_Identity=23.8693467336683, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136796, Length=398, Percent_Identity=23.8693467336683, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24658560, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 63633; Mature: 63633

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQGVIQKIAGPAVIAKGMLGARMYDICKVGEEGLVGEIIRLDGDTAFVQVYEDTSGLKV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCCCCC
GEPVVSTGLPLAVELGPGMLNGIYDGIQRPLERIREKTGIYITRGVVVHALDREKKWAWT
CCCHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCEEEC
PMVKPGDEVRGGMVLGTVPEFGFTHKILVPPDVRGRVKEVKPAGEYTVEEPVVVLEDGTE
CCCCCCCHHCCCEEEECCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCEEEEECCCE
LKMYHTWPVRRARPVQRKLDPNTPFLTGMRILDVLFPVAMGGTAAIPGPFGSGKTVTQQS
EEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LAKWSNADVVVYVGCGERGNEMTDVLVEFPELTDPKTGGPLMHRTVLIANTSNMPVAARE
HHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEEEEEEEECCCCCEEEEC
ASIYVGVTIAEYFRDQGFSVALMADSTSRWAEALREISSRLEEMPAEEGYPPYLAARLAA
CEEEEEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FYERAGKVITLGGEEGAVTIVGAVSPPGGDMSEPVTQSTLRIVGAFWRLDASLAFRRHFP
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AINWNGSYSLFTSALDPWYRENVAEDYPELRDAISELLQREAGLQEIVQLVGPDALQDAE
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHH
RLVIEVGRIIREDFLQQNAYHEVDAYCSMKKAYGIMKMILAFYKEAEAAIKRGVSIDEIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QLPVLERIGRARYVSEEEFPAYFEEAMKEIQGAFKALA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQGVIQKIAGPAVIAKGMLGARMYDICKVGEEGLVGEIIRLDGDTAFVQVYEDTSGLKV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEECCCCCCC
GEPVVSTGLPLAVELGPGMLNGIYDGIQRPLERIREKTGIYITRGVVVHALDREKKWAWT
CCCHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCEEEC
PMVKPGDEVRGGMVLGTVPEFGFTHKILVPPDVRGRVKEVKPAGEYTVEEPVVVLEDGTE
CCCCCCCHHCCCEEEECCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCEEEEECCCE
LKMYHTWPVRRARPVQRKLDPNTPFLTGMRILDVLFPVAMGGTAAIPGPFGSGKTVTQQS
EEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LAKWSNADVVVYVGCGERGNEMTDVLVEFPELTDPKTGGPLMHRTVLIANTSNMPVAARE
HHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEEEEEEEECCCCCEEEEC
ASIYVGVTIAEYFRDQGFSVALMADSTSRWAEALREISSRLEEMPAEEGYPPYLAARLAA
CEEEEEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FYERAGKVITLGGEEGAVTIVGAVSPPGGDMSEPVTQSTLRIVGAFWRLDASLAFRRHFP
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AINWNGSYSLFTSALDPWYRENVAEDYPELRDAISELLQREAGLQEIVQLVGPDALQDAE
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHH
RLVIEVGRIIREDFLQQNAYHEVDAYCSMKKAYGIMKMILAFYKEAEAAIKRGVSIDEIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QLPVLERIGRARYVSEEEFPAYFEEAMKEIQGAFKALA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA