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The map label for this gene is hbd [H]

Identifier: 55981231

GI number: 55981231

Start: 1203165

End: 1204037

Strand: Reverse

Name: hbd [H]

Synonym: TTHA1262

Alternate gene names: 55981231

Gene position: 1204037-1203165 (Counterclockwise)

Preceding gene: 55981232

Following gene: 55981230

Centisome position: 65.09

GC content: 66.9

Gene sequence:

>873_bases
ATGGAGGTCAAGCGGATCGGCGTGGTGGGCGCGGGGCAGATGGGAAGCGGCATCGCCCAGGTGGCGGCAAGCGCAGGCTA
CGAGGTGGTCCTCGTGGACGTGGCGGAAAGCTTCCTGGAAAGGGGCCTCGCCGCCATAAGGCGCTCTTTGGGCAAGTTCC
TGGAGAAGGGAAAGATCACCCAGGAGGCCCACGATGAGGCCCTGGGGCGGATCCGGACGAGCCTAAGCCTCGAGGACCTC
AAAGACGCCGACCTCATCGTGGAGGCCATCGTGGAGGACGAGGGGGAGAAGCGGAGGCTCTTTGAGCGCCTGGGGGCCCT
GGCCAAGCCCGAGGCCATCCTCGCGAGCAACACCAGCTCCATCCCCATCACCGCCCTCGCCCGCTACTCGGGGCGGCCGG
AGCGCTTCATCGGCATGCACTTCTTCAACCCCGTGCCCCTCATGCAGCTCGTGGAGGTGATCCGGGGGGAGCTCACCTCC
GAGGCAACCCGGGACGTGGTGGTGGAGGTGGCGAGGCGCATGGGGAAGACCCCCCTCGAGGTCCAGGACTACCCCGGCTT
CATCTCCAACCGCCTCCTCATGCCCATGATCAACGAGGCCATAGAGGCCCTCCGCGAGGGGGTGGCCACCAAGGAGGCCA
TTGACGGCATCATGCGCCTGGGGATGAACCACCCCATGGGGCCCTTGGAGCTCGCCGACTTCATCGGCCTGGACACCTGC
CTCGCCATCATGGAGGTCCTCCACCGGGGCTTTGGGGACGACAAGTACCGGCCTTCGCCCCTCCTCCGCCGCATGGTGCA
GGCGGGGCTTTTGGGCCGCAAGGCGGGCCGGGGGTTTTACACCTACGACGAGAAGGGGAACAAGGTGGGCTGA

Upstream 100 bases:

>100_bases
GGGAGGTGCCCTCCCCCCTCTCCCTCCTGGGCGGGGGACTCGCCCTCCTCGGGGTCCTCCTGGTGAACCTCAGGGCGTAG
AATGGGCCGGGGTGAACGCC

Downstream 100 bases:

>100_bases
GTGCCCCGCGCTGGCCCAAGCCCGCGCGGGGGCCCCGAAACCGCTTCGCCCTGGAAACTCTTCCAAGCCCCGGGGGTATA
CTGGGGCCATGGAGCTTCCC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEVKRIGVVGAGQMGSGIAQVAASAGYEVVLVDVAESFLERGLAAIRRSLGKFLEKGKITQEAHDEALGRIRTSLSLEDL
KDADLIVEAIVEDEGEKRRLFERLGALAKPEAILASNTSSIPITALARYSGRPERFIGMHFFNPVPLMQLVEVIRGELTS
EATRDVVVEVARRMGKTPLEVQDYPGFISNRLLMPMINEAIEALREGVATKEAIDGIMRLGMNHPMGPLELADFIGLDTC
LAIMEVLHRGFGDDKYRPSPLLRRMVQAGLLGRKAGRGFYTYDEKGNKVG

Sequences:

>Translated_290_residues
MEVKRIGVVGAGQMGSGIAQVAASAGYEVVLVDVAESFLERGLAAIRRSLGKFLEKGKITQEAHDEALGRIRTSLSLEDL
KDADLIVEAIVEDEGEKRRLFERLGALAKPEAILASNTSSIPITALARYSGRPERFIGMHFFNPVPLMQLVEVIRGELTS
EATRDVVVEVARRMGKTPLEVQDYPGFISNRLLMPMINEAIEALREGVATKEAIDGIMRLGMNHPMGPLELADFIGLDTC
LAIMEVLHRGFGDDKYRPSPLLRRMVQAGLLGRKAGRGFYTYDEKGNKVG
>Mature_290_residues
MEVKRIGVVGAGQMGSGIAQVAASAGYEVVLVDVAESFLERGLAAIRRSLGKFLEKGKITQEAHDEALGRIRTSLSLEDL
KDADLIVEAIVEDEGEKRRLFERLGALAKPEAILASNTSSIPITALARYSGRPERFIGMHFFNPVPLMQLVEVIRGELTS
EATRDVVVEVARRMGKTPLEVQDYPGFISNRLLMPMINEAIEALREGVATKEAIDGIMRLGMNHPMGPLELADFIGLDTC
LAIMEVLHRGFGDDKYRPSPLLRRMVQAGLLGRKAGRGFYTYDEKGNKVG

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=44.9477351916376, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=42.4342105263158, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=38.0281690140845, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=32.312925170068, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=32.312925170068, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=30.0429184549356, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=39.5759717314488, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=37.9699248120301, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788682, Length=268, Percent_Identity=34.3283582089552, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=43.0555555555556, Blast_Score=236, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=41.4634146341463, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.2822299651568, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=35.7388316151203, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=35.7388316151203, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=35.7388316151203, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=291, Percent_Identity=34.7079037800687, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=31.7241379310345, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=288, Percent_Identity=29.1666666666667, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=198, Percent_Identity=28.2828282828283, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=198, Percent_Identity=28.2828282828283, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=39.5759717314488, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=39.5759717314488, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=39.5759717314488, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI20129993, Length=243, Percent_Identity=27.5720164609054, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=27.3858921161826, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31779; Mature: 31779

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKRIGVVGAGQMGSGIAQVAASAGYEVVLVDVAESFLERGLAAIRRSLGKFLEKGKIT
CCCCCCCEEECCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QEAHDEALGRIRTSLSLEDLKDADLIVEAIVEDEGEKRRLFERLGALAKPEAILASNTSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCC
IPITALARYSGRPERFIGMHFFNPVPLMQLVEVIRGELTSEATRDVVVEVARRMGKTPLE
CCHHHHHHHCCCCHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VQDYPGFISNRLLMPMINEAIEALREGVATKEAIDGIMRLGMNHPMGPLELADFIGLDTC
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAIMEVLHRGFGDDKYRPSPLLRRMVQAGLLGRKAGRGFYTYDEKGNKVG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure
MEVKRIGVVGAGQMGSGIAQVAASAGYEVVLVDVAESFLERGLAAIRRSLGKFLEKGKIT
CCCCCCCEEECCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QEAHDEALGRIRTSLSLEDLKDADLIVEAIVEDEGEKRRLFERLGALAKPEAILASNTSS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCC
IPITALARYSGRPERFIGMHFFNPVPLMQLVEVIRGELTSEATRDVVVEVARRMGKTPLE
CCHHHHHHHCCCCHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VQDYPGFISNRLLMPMINEAIEALREGVATKEAIDGIMRLGMNHPMGPLELADFIGLDTC
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAIMEVLHRGFGDDKYRPSPLLRRMVQAGLLGRKAGRGFYTYDEKGNKVG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]