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The map label for this gene is argF [H]

Identifier: 55981168

GI number: 55981168

Start: 1143166

End: 1144071

Strand: Reverse

Name: argF [H]

Synonym: TTHA1199

Alternate gene names: 55981168

Gene position: 1144071-1143166 (Counterclockwise)

Preceding gene: 55981169

Following gene: 55981167

Centisome position: 61.85

GC content: 67.88

Gene sequence:

>906_bases
ATGGGGGGAGAGGCCCTGACCCTGCCCAAGGACCTTCTGGACTTTTCCGGCTACGGCCCCAAGGAGCTTCAGGCCCTTCT
GGACCTGGCGGAGCAGCTAAAGCGGGAGCGCTACCGGGGGGAGGACCTCAAAGGGAAGGTCCTCGCCCTCCTCTTTGAGA
AGCCCTCCTTGCGCACCCGGACGACCCTCGAGGTGGCCATGGTCCACCTGGGGGGGCACGCCGTTTACCTGGACCAGAAG
CAGGTGGGCATCGGGGAGAGGGAGCCCGTGAGGGACGTGGCCAAGAACCTGGAGCGCTTCGTGGAGGGGATCGCCGCCCG
GGTCTTTCGCCACGAGACGGTGGAGGCCCTGGCCCGCCACGCCAAGGTCCCCGTGGTGAACGCCCTCTCCGACCGCGCCC
ACCCCCTCCAGGCCCTGGCGGACCTCCTCACCCTGAAGGAGGTTTTTGGGGGGCTTGCGGGCCTCGAGGTGGCCTGGGTG
GGGGACGGAAACAACGTCCTGAACTCCCTTCTTGAGGTGGCTCCCCTGGCGGGCCTTAAGGTGCGGGTCGCGACCCCCAA
GGGCTACGAGCCCGACCCTGGCCTTCTCAAGCGGGCGAACGCCTTCTTCACCCACGACCCCAAGGAGGCCGCCTTGGGCG
CCCACGCCCTCTACACCGACGTCTGGACCAGCATGGGGCAGGAGGCGGAAAGGGAGAAGCGCCTCCGGGACTTCCAGGGC
TTCCAGGTGAACGGGGAGTTGCTCAAGCTCCTCCGCCCGGAGGGTGTCTTCCTCCACTGCCTCCCCGCCCACTACGGGGA
GGAGACCACGGAGGAGGCGGTCCACGGGCCGCGGAGCCGGGTCTTTGACCAGGCGGAAAACCGCCTCCACACCGCCAAGG
CCGTGCTTCTTACCTTGCTAAAGTAG

Upstream 100 bases:

>100_bases
GCCGAGCCTTTCGTAAGCCCTCTTCCCGTGCTTTACGTGCCCTGGTCCCGGGCCTAGGCCCTTGCATAAGTTTGCGGGCA
CAGGGTATGCTTAAGGCCTC

Downstream 100 bases:

>100_bases
GGGTATGGTCCGGCCCTACCGCTTTAGCCTGGAGGAGTTCCTGAAGCTTCCCCTTCCCGAGCGGGGGGTGGAGCTTCTAG
AGGGAGAGATCTACCAGATG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTC; OTCase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MGGEALTLPKDLLDFSGYGPKELQALLDLAEQLKRERYRGEDLKGKVLALLFEKPSLRTRTTLEVAMVHLGGHAVYLDQK
QVGIGEREPVRDVAKNLERFVEGIAARVFRHETVEALARHAKVPVVNALSDRAHPLQALADLLTLKEVFGGLAGLEVAWV
GDGNNVLNSLLEVAPLAGLKVRVATPKGYEPDPGLLKRANAFFTHDPKEAALGAHALYTDVWTSMGQEAEREKRLRDFQG
FQVNGELLKLLRPEGVFLHCLPAHYGEETTEEAVHGPRSRVFDQAENRLHTAKAVLLTLLK

Sequences:

>Translated_301_residues
MGGEALTLPKDLLDFSGYGPKELQALLDLAEQLKRERYRGEDLKGKVLALLFEKPSLRTRTTLEVAMVHLGGHAVYLDQK
QVGIGEREPVRDVAKNLERFVEGIAARVFRHETVEALARHAKVPVVNALSDRAHPLQALADLLTLKEVFGGLAGLEVAWV
GDGNNVLNSLLEVAPLAGLKVRVATPKGYEPDPGLLKRANAFFTHDPKEAALGAHALYTDVWTSMGQEAEREKRLRDFQG
FQVNGELLKLLRPEGVFLHCLPAHYGEETTEEAVHGPRSRVFDQAENRLHTAKAVLLTLLK
>Mature_300_residues
GGEALTLPKDLLDFSGYGPKELQALLDLAEQLKRERYRGEDLKGKVLALLFEKPSLRTRTTLEVAMVHLGGHAVYLDQKQ
VGIGEREPVRDVAKNLERFVEGIAARVFRHETVEALARHAKVPVVNALSDRAHPLQALADLLTLKEVFGGLAGLEVAWVG
DGNNVLNSLLEVAPLAGLKVRVATPKGYEPDPGLLKRANAFFTHDPKEAALGAHALYTDVWTSMGQEAEREKRLRDFQGF
QVNGELLKLLRPEGVFLHCLPAHYGEETTEEAVHGPRSRVFDQAENRLHTAKAVLLTLLK

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=304, Percent_Identity=41.7763157894737, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI18105007, Length=301, Percent_Identity=24.2524916943522, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=40, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1786469, Length=324, Percent_Identity=39.8148148148148, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI48994908, Length=355, Percent_Identity=25.9154929577465, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367364, Length=161, Percent_Identity=34.7826086956522, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=283, Percent_Identity=36.3957597173145, Blast_Score=198, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=302, Percent_Identity=23.5099337748344, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642586, Length=310, Percent_Identity=27.741935483871, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 33236; Mature: 33104

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGEALTLPKDLLDFSGYGPKELQALLDLAEQLKRERYRGEDLKGKVLALLFEKPSLRTR
CCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCHH
TTLEVAMVHLGGHAVYLDQKQVGIGEREPVRDVAKNLERFVEGIAARVFRHETVEALARH
HHHHHHHHHCCCEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVPVVNALSDRAHPLQALADLLTLKEVFGGLAGLEVAWVGDGNNVLNSLLEVAPLAGLK
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCEEEEECCCHHHHHHHHHHHCCCCCE
VRVATPKGYEPDPGLLKRANAFFTHDPKEAALGAHALYTDVWTSMGQEAEREKRLRDFQG
EEEECCCCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
FQVNGELLKLLRPEGVFLHCLPAHYGEETTEEAVHGPRSRVFDQAENRLHTAKAVLLTLL
CCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure 
GGEALTLPKDLLDFSGYGPKELQALLDLAEQLKRERYRGEDLKGKVLALLFEKPSLRTR
CCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCHH
TTLEVAMVHLGGHAVYLDQKQVGIGEREPVRDVAKNLERFVEGIAARVFRHETVEALARH
HHHHHHHHHCCCEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVPVVNALSDRAHPLQALADLLTLKEVFGGLAGLEVAWVGDGNNVLNSLLEVAPLAGLK
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCEEEEECCCHHHHHHHHHHHCCCCCE
VRVATPKGYEPDPGLLKRANAFFTHDPKEAALGAHALYTDVWTSMGQEAEREKRLRDFQG
EEEECCCCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
FQVNGELLKLLRPEGVFLHCLPAHYGEETTEEAVHGPRSRVFDQAENRLHTAKAVLLTLL
CCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346304 [H]