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The map label for this gene is mrdA [H]

Identifier: 55981160

GI number: 55981160

Start: 1136681

End: 1138408

Strand: Direct

Name: mrdA [H]

Synonym: TTHA1191

Alternate gene names: 55981160

Gene position: 1136681-1138408 (Clockwise)

Preceding gene: 55981159

Following gene: 55981161

Centisome position: 61.45

GC content: 70.72

Gene sequence:

>1728_bases
ATGACCGGGAGGATCCACGCCCTGGCCCTGTTCTTCGCCCTGGCCCTCTTCCTCCTCGGGCTTCGGGCGTGGCAGCTCCA
GGTCCTGGAGTACGAGCGCTACGCCCTGCGAAGCCAGGGAAACTACCTGAAGACCGAGGACATCCCCGCCCCCCGGGGCA
AGATCCTGGACCGGAAGGGGCGGGTCCTGGCCCAGGACCGGCTGGTGGTGGACCTCGTCTACACCGGGGGGGAGGTGGCC
TTCAAGGAGAGGCTCCTCCCCCTCCTGGGCCTGGAAGACCTTCCCCAGGTCACGGAGCCCACGGTCCTGAAAGCCGGCGT
CCCCGAGGCCCTAAGGCCCACCCTGGAGGAGCTCACCGCCGGGCAGAAGAACCTCTACCTCCGGGAAAGGATTGAGCGGT
ACTACCCGAACCCCATCTCCGGCCCCGTCATGGGGTACGTCCTCCGGGCGAACGCCGCCCAGGTAAAGCAGGGGTACAGC
CCCGAGGAGGAGGTGGGGCAGGCGGGCCTCGAGGCCGCTTTGGAGCCCTACCTCCGGGGCAAGCGGGGGGTGCGGGCGGT
GGAGGTGAACGTCCGGGGGGAGAGGCTTCGGGAGACCGTCCTGGAGGAGCCCACCCCGGGGCAGGACGTGGTCCTCACCC
TGGACCTCGCCCTCCAGCGGGCCGCAGAAAAGGCCCTGGAGGAGGCCCTCGCCGACATCAACGCCGGGAGAAGGCTGAAC
GGCCTGCCCGAGGAAAAGCAGGTGAAGGGGGCCATCGTGGCCTTGGACCCCACCACGGGGGAGGTCTTGGCCATGGCCAG
CGCCCCTTCCTTTGACCCCAACCTCTTCGCCAAGCGCCCCGTCCCGGAGGAGGCGAAGGCGCTCCTTGAGGACAAGAACC
TCCCCCTCCTCAACCGGGCGGTCCAGCCCTACACCCCGGGGTCCACCTTCAAGCTGGCCACGAGCTACGCCCTCCTGGAG
GAGGGGTACGTGACCCCGGCGACCACCTACCGCTGCAGCCCCTACATCGTCTTCGGCGGCCAGGTGCGGCGCAACTGGGC
GAGCCGGGACATGGGCCCCATGACGGTCCGGGAGGCCATCGCCTGGAGCTGCAACACCTGGTACTACCAGGCGGTGGCCC
AGGACCCCCTGGGCTTCGTGGACCGCCTGGCGAGGCGGGCCCGGCTTTTGGGCCTGGGGGAGGCCACGGGGCTCGAGGTG
GCGGAGAAGACGGGCCTCCTCCCCACCCGGGCCTGGAAGCGGGAGGCCCTGGGCGAGCCCTGGTACCCCGGGGAGACCCT
CTCCGTGGCCATCGGCCAGGGGGCCGTCCTCGCCACCCCCGCCCAGATCGCCCGCATGCTCGCCACCATCGCCACCGGGG
GAAACAAGCCCGCCCTCCACCTGGTGAAGGCCATCGGGGGCGTTCCCGTCCAGCCCCGGTGGGAAAAGGTCCCCGGACGG
TACTGGAAGGTCCTCCAGGAGGGCCTGCGCAAGACGGTGAGCGAGGGGACCGCCCGCTTCGTCCTAGGGGAGTTCCCCGT
GCCCACGGGGGGCAAGACGGGCACCGCCGAAACCCCGGGGAAGCGCCGCGGCCTGGAGCACGCCTGGTACATGGGCTACG
GCCCCACCGACGGGAGCCCCTACCCGCCCCTCGTCGTGGTGGCCTTCTTTGAGAACGGCGGGGAGGGCAGCCGGGTGGCC
TTGCCCGCGGTCCGCAAGGTGATGGCCGCCTACTGGGGGATAAAATAG

Upstream 100 bases:

>100_bases
ACCTGCCCGCCCTCTTCCCCTGGCTTCCCCTCGGGGAGGGCCTCCTCTCCCTGGCCTTCTTCTGGCCCCTTAGGCCCAAG
GCGCGGGAGGAACCGAAGGC

Downstream 100 bases:

>100_bases
CGCCATGCGCCTCCGCGCCACGCCCAAGGCCCTGGCCCTCCGCCTAGACGGCGGCGAGACGCCCGAGGACGTGCGCCGCT
TAAGCCTCCCCGAGGGGCTT

Product: penicillin-binding protein 2/cell division protein FtsI

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTGRIHALALFFALALFLLGLRAWQLQVLEYERYALRSQGNYLKTEDIPAPRGKILDRKGRVLAQDRLVVDLVYTGGEVA
FKERLLPLLGLEDLPQVTEPTVLKAGVPEALRPTLEELTAGQKNLYLRERIERYYPNPISGPVMGYVLRANAAQVKQGYS
PEEEVGQAGLEAALEPYLRGKRGVRAVEVNVRGERLRETVLEEPTPGQDVVLTLDLALQRAAEKALEEALADINAGRRLN
GLPEEKQVKGAIVALDPTTGEVLAMASAPSFDPNLFAKRPVPEEAKALLEDKNLPLLNRAVQPYTPGSTFKLATSYALLE
EGYVTPATTYRCSPYIVFGGQVRRNWASRDMGPMTVREAIAWSCNTWYYQAVAQDPLGFVDRLARRARLLGLGEATGLEV
AEKTGLLPTRAWKREALGEPWYPGETLSVAIGQGAVLATPAQIARMLATIATGGNKPALHLVKAIGGVPVQPRWEKVPGR
YWKVLQEGLRKTVSEGTARFVLGEFPVPTGGKTGTAETPGKRRGLEHAWYMGYGPTDGSPYPPLVVVAFFENGGEGSRVA
LPAVRKVMAAYWGIK

Sequences:

>Translated_575_residues
MTGRIHALALFFALALFLLGLRAWQLQVLEYERYALRSQGNYLKTEDIPAPRGKILDRKGRVLAQDRLVVDLVYTGGEVA
FKERLLPLLGLEDLPQVTEPTVLKAGVPEALRPTLEELTAGQKNLYLRERIERYYPNPISGPVMGYVLRANAAQVKQGYS
PEEEVGQAGLEAALEPYLRGKRGVRAVEVNVRGERLRETVLEEPTPGQDVVLTLDLALQRAAEKALEEALADINAGRRLN
GLPEEKQVKGAIVALDPTTGEVLAMASAPSFDPNLFAKRPVPEEAKALLEDKNLPLLNRAVQPYTPGSTFKLATSYALLE
EGYVTPATTYRCSPYIVFGGQVRRNWASRDMGPMTVREAIAWSCNTWYYQAVAQDPLGFVDRLARRARLLGLGEATGLEV
AEKTGLLPTRAWKREALGEPWYPGETLSVAIGQGAVLATPAQIARMLATIATGGNKPALHLVKAIGGVPVQPRWEKVPGR
YWKVLQEGLRKTVSEGTARFVLGEFPVPTGGKTGTAETPGKRRGLEHAWYMGYGPTDGSPYPPLVVVAFFENGGEGSRVA
LPAVRKVMAAYWGIK
>Mature_574_residues
TGRIHALALFFALALFLLGLRAWQLQVLEYERYALRSQGNYLKTEDIPAPRGKILDRKGRVLAQDRLVVDLVYTGGEVAF
KERLLPLLGLEDLPQVTEPTVLKAGVPEALRPTLEELTAGQKNLYLRERIERYYPNPISGPVMGYVLRANAAQVKQGYSP
EEEVGQAGLEAALEPYLRGKRGVRAVEVNVRGERLRETVLEEPTPGQDVVLTLDLALQRAAEKALEEALADINAGRRLNG
LPEEKQVKGAIVALDPTTGEVLAMASAPSFDPNLFAKRPVPEEAKALLEDKNLPLLNRAVQPYTPGSTFKLATSYALLEE
GYVTPATTYRCSPYIVFGGQVRRNWASRDMGPMTVREAIAWSCNTWYYQAVAQDPLGFVDRLARRARLLGLGEATGLEVA
EKTGLLPTRAWKREALGEPWYPGETLSVAIGQGAVLATPAQIARMLATIATGGNKPALHLVKAIGGVPVQPRWEKVPGRY
WKVLQEGLRKTVSEGTARFVLGEFPVPTGGKTGTAETPGKRRGLEHAWYMGYGPTDGSPYPPLVVVAFFENGGEGSRVAL
PAVRKVMAAYWGIK

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=30.2931596091205, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1786272, Length=543, Percent_Identity=26.3351749539595, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62925; Mature: 62794

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRIHALALFFALALFLLGLRAWQLQVLEYERYALRSQGNYLKTEDIPAPRGKILDRKG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCC
RVLAQDRLVVDLVYTGGEVAFKERLLPLLGLEDLPQVTEPTVLKAGVPEALRPTLEELTA
CEEECCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHC
GQKNLYLRERIERYYPNPISGPVMGYVLRANAAQVKQGYSPEEEVGQAGLEAALEPYLRG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
KRGVRAVEVNVRGERLRETVLEEPTPGQDVVLTLDLALQRAAEKALEEALADINAGRRLN
CCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLPEEKQVKGAIVALDPTTGEVLAMASAPSFDPNLFAKRPVPEEAKALLEDKNLPLLNRA
CCCCHHHHCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHC
VQPYTPGSTFKLATSYALLEEGYVTPATTYRCSPYIVFGGQVRRNWASRDMGPMTVREAI
CCCCCCCCCEEHHHHHHHHHCCCCCCCCEECCCCEEEECCHHHHHHHCCCCCCHHHHHHH
AWSCNTWYYQAVAQDPLGFVDRLARRARLLGLGEATGLEVAEKTGLLPTRAWKREALGEP
HHCCCCCEEHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHCCCC
WYPGETLSVAIGQGAVLATPAQIARMLATIATGGNKPALHLVKAIGGVPVQPRWEKVPGR
CCCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHCCHH
YWKVLQEGLRKTVSEGTARFVLGEFPVPTGGKTGTAETPGKRRGLEHAWYMGYGPTDGSP
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCC
YPPLVVVAFFENGGEGSRVALPAVRKVMAAYWGIK
CCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGRIHALALFFALALFLLGLRAWQLQVLEYERYALRSQGNYLKTEDIPAPRGKILDRKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCC
RVLAQDRLVVDLVYTGGEVAFKERLLPLLGLEDLPQVTEPTVLKAGVPEALRPTLEELTA
CEEECCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHC
GQKNLYLRERIERYYPNPISGPVMGYVLRANAAQVKQGYSPEEEVGQAGLEAALEPYLRG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
KRGVRAVEVNVRGERLRETVLEEPTPGQDVVLTLDLALQRAAEKALEEALADINAGRRLN
CCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLPEEKQVKGAIVALDPTTGEVLAMASAPSFDPNLFAKRPVPEEAKALLEDKNLPLLNRA
CCCCHHHHCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHC
VQPYTPGSTFKLATSYALLEEGYVTPATTYRCSPYIVFGGQVRRNWASRDMGPMTVREAI
CCCCCCCCCEEHHHHHHHHHCCCCCCCCEECCCCEEEECCHHHHHHHCCCCCCHHHHHHH
AWSCNTWYYQAVAQDPLGFVDRLARRARLLGLGEATGLEVAEKTGLLPTRAWKREALGEP
HHCCCCCEEHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHCCCC
WYPGETLSVAIGQGAVLATPAQIARMLATIATGGNKPALHLVKAIGGVPVQPRWEKVPGR
CCCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHCCHH
YWKVLQEGLRKTVSEGTARFVLGEFPVPTGGKTGTAETPGKRRGLEHAWYMGYGPTDGSP
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCC
YPPLVVVAFFENGGEGSRVALPAVRKVMAAYWGIK
CCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]