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The map label for this gene is polX [H]

Identifier: 55981119

GI number: 55981119

Start: 1095294

End: 1097021

Strand: Reverse

Name: polX [H]

Synonym: TTHA1150

Alternate gene names: 55981119

Gene position: 1097021-1095294 (Counterclockwise)

Preceding gene: 55981120

Following gene: 55981116

Centisome position: 59.31

GC content: 68.23

Gene sequence:

>1728_bases
ATGCGGAACCAGGAGCTCGCCCGGATCTTTGAGGAGATCGGGCTCATGAGCGAGTTCTTGGGGGACAACCCCTTCCGGGT
CCGGGCCTACCACCAGGCGGCCCGAACCCTCTACGACCTGGACACCCCCATAGAGGAGATCGCCGAAAAGGGCAAGGAGG
CCCTCATGGAGCTTCCCGGGGTGGGGCCGGACCTCGCGGAGAAGATCCTGGAGTTCCTCCGCACGGGGAAGGTGAGGAAG
CACGAGGAACTCTCCCGGAAGGTCCCGCGGGGCGTCCTCGAGGTGATGGAGGTCCCCGGCGTGGGCCCCAAGACCGCCCG
CCTCCTCTACGAGGGCCTGGGCATAGACTCCCTGGAGAAGCTTAAAGCGGCCCTGGACCGGGGGGACCTCACCCGGCTCA
AAGGCTTCGGCCCCAAGAGGGCGGAGAGGATCCGGGAAGGCCTCGCCCTCGCCCAGGCGGCGGGAAAGCGGAGGCCCCTG
GGGGCGGTGCTCTCCCTGGCGCGAAGCCTCCTCGAGGCCATAAGGGCCCTACCCGGGGTGGAAAGGGCGGAGCTCTGCGG
CTCGGCGAGGCGCTACAAGGACACCGTGGGGGACCTGGACTTTTTGGTGGCGAGCCGGGAGGGGGAGCGGGCGGTGGAGG
GCTTCGTGCGCCTTCCCCAGGTCAAGGAGGTCTACGCCAAGGGGAAGGAAAGGGCCACCGTCTTCCTGAAAAACGGCCTC
CAGGTGGACCTCAGGGTGGTCCCCCCCGAAAGCTACGGGGCGGGCCTCCAGTACCTCACGGGGAGCAAGGCCCACTCCAT
CCGCCTTCGCGCCCTCGCCCAGGAGAAGGGCCTGAAGCTTTCCGAGTACGGGGTCTTCCGAGGGGAGAAAAGGATCGCCG
GGGAGACGGAGGAGGAGGTCTACGCCGCCTTGGGCCTCCCCTGGATCCCGCCCCCCCTCCGGGAGGACCAGGGGGAGGTG
GAGGCCGCCCTGGAGGGCAGGCTTCCCAAGCTCCTGGAGCTTCCTCAGGTCAAGGGGGACCTCCAGGTCCACTCCACCTA
CTCCGACGGCCAGAACACCTTGGAGGAGCTCTGGGAAGCGGCCAAGACCATGGGCTACCGCTACCTCGCCGTGACCGACC
ACTCCCCGGCGGTGCGGGTGGCGGGGGGGCCTTCCCCCGAGGAGGCCTTGAAGCGCGTGGGGGAGATCCGCCGCTTCAAC
GAGACCCACGGCCCCCCCTACCTCCTCGCCGGGGCCGAGGTGGACATCCACCCCGACGGGACCCTGGACTACCCGGACTG
GGTCTTAAGGGAGCTGGACCTGGTTTTGGTTTCCGTCCACTCCCGCTTCAACCTCCCCAAGGCCGACCAGACCAAGCGCC
TCCTCAAGGCCCTGGAAAACCCCTTCGTCCACGTCCTCGCCCACCCCACGGCGAGGCTTTTGGGCCGCCGCGCCCCCATT
GAAGCCGACTGGGAGGCCGTCTTCCAGAAGGCCAAGGAAAAGGGCGTGGCGGTGGAGATTGACGGCTACTACGACCGCAT
GGACCTCCCCGACGACCTGGCCCGCATGGCCTACGGGATGGGGCTTTGGATCAGCCTCTCCACCGACGCCCACCAGACCG
ACCACCTCCGCTTCATGGAGCTCGCCGTGGGCACGGCGCAACGGGCCTGGATCGGCCCCGAGCGGGTGCTCAACACCTTG
GACTACGAGGACCTCCTCTCCTGGCTCAAAGCCCGGCGAGGCGTTTAG

Upstream 100 bases:

>100_bases
AGGGGCCTTCCCGCCTCTTTGAGGAGCGCTAACACCTTTTTGCGAAACCGGTCCGGCCTCGGCATAGGGGCTTCGTCCAG
TCTACCCGTATAGTGGGGGT

Downstream 100 bases:

>100_bases
CCTCCATCAGGACCTCCAGGAACATCTCCCGGGTGAGCCTGCCCGTCTGGGTGTTCTGCCGGGAGACGTGGTAGCTCGCG
AGGAGGTGCCTTCCCCCGGG

Product: DNA polymerase beta family protein

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPGVGPDLAEKILEFLRTGKVRK
HEELSRKVPRGVLEVMEVPGVGPKTARLLYEGLGIDSLEKLKAALDRGDLTRLKGFGPKRAERIREGLALAQAAGKRRPL
GAVLSLARSLLEAIRALPGVERAELCGSARRYKDTVGDLDFLVASREGERAVEGFVRLPQVKEVYAKGKERATVFLKNGL
QVDLRVVPPESYGAGLQYLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEVYAALGLPWIPPPLREDQGEV
EAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFN
ETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLGRRAPI
EADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTL
DYEDLLSWLKARRGV

Sequences:

>Translated_575_residues
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPGVGPDLAEKILEFLRTGKVRK
HEELSRKVPRGVLEVMEVPGVGPKTARLLYEGLGIDSLEKLKAALDRGDLTRLKGFGPKRAERIREGLALAQAAGKRRPL
GAVLSLARSLLEAIRALPGVERAELCGSARRYKDTVGDLDFLVASREGERAVEGFVRLPQVKEVYAKGKERATVFLKNGL
QVDLRVVPPESYGAGLQYLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEVYAALGLPWIPPPLREDQGEV
EAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFN
ETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLGRRAPI
EADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTL
DYEDLLSWLKARRGV
>Mature_575_residues
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPGVGPDLAEKILEFLRTGKVRK
HEELSRKVPRGVLEVMEVPGVGPKTARLLYEGLGIDSLEKLKAALDRGDLTRLKGFGPKRAERIREGLALAQAAGKRRPL
GAVLSLARSLLEAIRALPGVERAELCGSARRYKDTVGDLDFLVASREGERAVEGFVRLPQVKEVYAKGKERATVFLKNGL
QVDLRVVPPESYGAGLQYLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEVYAALGLPWIPPPLREDQGEV
EAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFN
ETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLGRRAPI
EADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTL
DYEDLLSWLKARRGV

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI7019491, Length=326, Percent_Identity=29.1411042944785, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI291463287, Length=326, Percent_Identity=29.1411042944785, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4505931, Length=282, Percent_Identity=28.7234042553192, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI291463291, Length=298, Percent_Identity=30.2013422818792, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64110; Mature: 64110

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPG
CCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
VGPDLAEKILEFLRTGKVRKHEELSRKVPRGVLEVMEVPGVGPKTARLLYEGLGIDSLEK
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
LKAALDRGDLTRLKGFGPKRAERIREGLALAQAAGKRRPLGAVLSLARSLLEAIRALPGV
HHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
ERAELCGSARRYKDTVGDLDFLVASREGERAVEGFVRLPQVKEVYAKGKERATVFLKNGL
CHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCC
QVDLRVVPPESYGAGLQYLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEV
EEEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCEEHHCCCCCCCCCCCCCCHHHH
YAALGLPWIPPPLREDQGEVEAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEELWEA
HHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
AKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDG
HHHCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCC
TLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLGRRAPI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHCCCCCC
EADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFME
CCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
LAVGTAQRAWIGPERVLNTLDYEDLLSWLKARRGV
HHHCCHHHHCCCHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPG
CCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
VGPDLAEKILEFLRTGKVRKHEELSRKVPRGVLEVMEVPGVGPKTARLLYEGLGIDSLEK
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
LKAALDRGDLTRLKGFGPKRAERIREGLALAQAAGKRRPLGAVLSLARSLLEAIRALPGV
HHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
ERAELCGSARRYKDTVGDLDFLVASREGERAVEGFVRLPQVKEVYAKGKERATVFLKNGL
CHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCC
QVDLRVVPPESYGAGLQYLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEV
EEEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCEEHHCCCCCCCCCCCCCCHHHH
YAALGLPWIPPPLREDQGEVEAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEELWEA
HHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
AKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDG
HHHCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCC
TLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLGRRAPI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHCCCCCC
EADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFME
CCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
LAVGTAQRAWIGPERVLNTLDYEDLLSWLKARRGV
HHHCCHHHHCCCHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]