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The map label for this gene is dapE [H]

Identifier: 55981099

GI number: 55981099

Start: 1072906

End: 1074231

Strand: Reverse

Name: dapE [H]

Synonym: TTHA1130

Alternate gene names: 55981099

Gene position: 1074231-1072906 (Counterclockwise)

Preceding gene: 55981110

Following gene: 55981098

Centisome position: 58.07

GC content: 69.98

Gene sequence:

>1326_bases
ATGGAGGCCTGGATTGCGGAGGCGAAGGCGCTCCTTGCCGCGCTCGTGGCCGTGCCCTCGGTGAGCGCCGAGGGGAGGGC
CCTTCGGGAAGGGGCGGAAAAGGTGGCCGAGGTGCTGGAGGGTCTGGGGCTTCGCGCCGAGCTCCACGAGGGCTACGGTC
CCCCCGTGGTCTTCGCCGAGGGGGGGGAGGGGGAGAGAACCCTCCTCTTCTACAACCACTACGACGTCCAGCCCCCGGAC
CCCCTGGAGCTTTGGGACACGGACCCCTTCGTCCTCGCCGAGCGGGAAGGGGCCTGGTACGCCCGGGGTGCCCACGACGA
CAAGGGGGAGCTCGTGGCCCGCGTGGTGGCCCTGAGGCGCTTCCAAGAGAAGCACGGCTTTCTTCCCCGGGTGAAGTTCG
TGGTGGAGGGGGAGGAGGAGGTGGGAAGCCCCCACCTCGAGGCCTACGTGGCGGACAAGCGGGACCTTTTGAAGGCCGAG
GCCATCCTCTGGGAGGCGGGAGGCGTGGACGCCAAGGGCAGGCCCTACCTCTACGCCGGGCTCAAGGGCATCGTGGCCCT
GGAGCTTAGGGTGCGGACGGCGGCCTTTGACCTCCACTCCTCCTACGGGGCGGTGGTGGAAAACCCCATCTACCGCTTGA
GCCGGGCCCTGGCCTCGCTTCGGGACGAGGAGGGGCGGGTCTTGATCCCGGGCTTCTACGCCAAGGTGCGCCCCCTCACC
CCCTTGGAGATGGAGGTCTTGGCCCAGATCCCGGACGAGTCGGAGGCCCTTCGGGAGGCCTTTGGCGTGAGGGACTTCCT
GGGCGGGGCGAGGAACTTGGACTTCAACCAGCGCCTTTACGCCGAGCCCTGCGTCAACTTCAACGGCTTCCACGCGGGCT
ACGGAGGCCCCGGGTCCAAGACCGTCCTCCCCGCGGAGGCCCGGGCCAAGCTGGACTTCCGCCTGGTGCCGGACCAGGAC
CCGGAGGAGGTGCCGGAGCTCCTTCGGCGCCACCTCGAGGCCCAGGGCTTCCACGACGTGGAGGTGGTGGTCCTGGAGAA
GGGGGAAAGGCCTGCCCGCTCCGACCTCGCCCACCCCTTTGTGGCCCTGGCGCGGCGGGCCTTGGAGGAGGCCTTCGGGG
AGAGGCCCGTCCTCTACCCCAACATGGCGGGCTCGGGGCCCATGCACCCCTTCCTCCACCACCTCAAGGCCCCGGCGGTG
GGCCTCGGGGTGGGCTACCCGGGAAGCCGGGTGCACAGCCCCAACGAGCACATCCGCGTCCGGGACTTTGAGCGGGGGGT
GCAGGCCCTCCTGCGCCTCTTGGAGCTTTTCTTCCTGGGCCGGTAG

Upstream 100 bases:

>100_bases
CCCGTTTCCCTTAGGGTCTCCTCGAGGACCTCCACGGCCCGCTCGTAGGGGGCGCCGTAAAGGACCAGGGAAGGCTCCAC
CATAGTATGCTCAGTCTATC

Downstream 100 bases:

>100_bases
GCCTTACCCTCTTGGCGTATGCGCCTCGTCTTCGGCGAAAAGGACACCCCTTACGAGGAGGCGCGGGTCGTCGTCCTGCC
CGTGCCCTACGACCTCTCCC

Product: ArgE/DapE/Acy1 family peptidase

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MEAWIAEAKALLAALVAVPSVSAEGRALREGAEKVAEVLEGLGLRAELHEGYGPPVVFAEGGEGERTLLFYNHYDVQPPD
PLELWDTDPFVLAEREGAWYARGAHDDKGELVARVVALRRFQEKHGFLPRVKFVVEGEEEVGSPHLEAYVADKRDLLKAE
AILWEAGGVDAKGRPYLYAGLKGIVALELRVRTAAFDLHSSYGAVVENPIYRLSRALASLRDEEGRVLIPGFYAKVRPLT
PLEMEVLAQIPDESEALREAFGVRDFLGGARNLDFNQRLYAEPCVNFNGFHAGYGGPGSKTVLPAEARAKLDFRLVPDQD
PEEVPELLRRHLEAQGFHDVEVVVLEKGERPARSDLAHPFVALARRALEEAFGERPVLYPNMAGSGPMHPFLHHLKAPAV
GLGVGYPGSRVHSPNEHIRVRDFERGVQALLRLLELFFLGR

Sequences:

>Translated_441_residues
MEAWIAEAKALLAALVAVPSVSAEGRALREGAEKVAEVLEGLGLRAELHEGYGPPVVFAEGGEGERTLLFYNHYDVQPPD
PLELWDTDPFVLAEREGAWYARGAHDDKGELVARVVALRRFQEKHGFLPRVKFVVEGEEEVGSPHLEAYVADKRDLLKAE
AILWEAGGVDAKGRPYLYAGLKGIVALELRVRTAAFDLHSSYGAVVENPIYRLSRALASLRDEEGRVLIPGFYAKVRPLT
PLEMEVLAQIPDESEALREAFGVRDFLGGARNLDFNQRLYAEPCVNFNGFHAGYGGPGSKTVLPAEARAKLDFRLVPDQD
PEEVPELLRRHLEAQGFHDVEVVVLEKGERPARSDLAHPFVALARRALEEAFGERPVLYPNMAGSGPMHPFLHHLKAPAV
GLGVGYPGSRVHSPNEHIRVRDFERGVQALLRLLELFFLGR
>Mature_441_residues
MEAWIAEAKALLAALVAVPSVSAEGRALREGAEKVAEVLEGLGLRAELHEGYGPPVVFAEGGEGERTLLFYNHYDVQPPD
PLELWDTDPFVLAEREGAWYARGAHDDKGELVARVVALRRFQEKHGFLPRVKFVVEGEEEVGSPHLEAYVADKRDLLKAE
AILWEAGGVDAKGRPYLYAGLKGIVALELRVRTAAFDLHSSYGAVVENPIYRLSRALASLRDEEGRVLIPGFYAKVRPLT
PLEMEVLAQIPDESEALREAFGVRDFLGGARNLDFNQRLYAEPCVNFNGFHAGYGGPGSKTVLPAEARAKLDFRLVPDQD
PEEVPELLRRHLEAQGFHDVEVVVLEKGERPARSDLAHPFVALARRALEEAFGERPVLYPNMAGSGPMHPFLHHLKAPAV
GLGVGYPGSRVHSPNEHIRVRDFERGVQALLRLLELFFLGR

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI21071039, Length=396, Percent_Identity=30.3030303030303, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI271398239, Length=445, Percent_Identity=30.1123595505618, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI271398277, Length=310, Percent_Identity=28.0645161290323, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788816, Length=235, Percent_Identity=25.9574468085106, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193211059, Length=448, Percent_Identity=29.9107142857143, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17563146, Length=457, Percent_Identity=29.5404814004376, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321159, Length=412, Percent_Identity=29.3689320388349, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319758, Length=402, Percent_Identity=26.1194029850746, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585880, Length=445, Percent_Identity=29.6629213483146, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 48770; Mature: 48770

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAWIAEAKALLAALVAVPSVSAEGRALREGAEKVAEVLEGLGLRAELHEGYGPPVVFAE
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCEEEEE
GGEGERTLLFYNHYDVQPPDPLELWDTDPFVLAEREGAWYARGAHDDKGELVARVVALRR
CCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHH
FQEKHGFLPRVKFVVEGEEEVGSPHLEAYVADKRDLLKAEAILWEAGGVDAKGRPYLYAG
HHHHCCCCCEEEEEEECHHHHCCCHHEEEHHCHHHHHHHHHHEEECCCCCCCCCCEEEEC
LKGIVALELRVRTAAFDLHSSYGAVVENPIYRLSRALASLRDEEGRVLIPGFYAKVRPLT
CCEEEEEEEEEEHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCC
PLEMEVLAQIPDESEALREAFGVRDFLGGARNLDFNQRLYAEPCVNFNGFHAGYGGPGSK
CHHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCCCCCCHHCCCCCCCCEECCCCCCCCC
TVLPAEARAKLDFRLVPDQDPEEVPELLRRHLEAQGFHDVEVVVLEKGERPARSDLAHPF
EEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHCCHH
VALARRALEEAFGERPVLYPNMAGSGPMHPFLHHLKAPAVGLGVGYPGSRVHSPNEHIRV
HHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEE
RDFERGVQALLRLLELFFLGR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAWIAEAKALLAALVAVPSVSAEGRALREGAEKVAEVLEGLGLRAELHEGYGPPVVFAE
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCEEEEE
GGEGERTLLFYNHYDVQPPDPLELWDTDPFVLAEREGAWYARGAHDDKGELVARVVALRR
CCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHHH
FQEKHGFLPRVKFVVEGEEEVGSPHLEAYVADKRDLLKAEAILWEAGGVDAKGRPYLYAG
HHHHCCCCCEEEEEEECHHHHCCCHHEEEHHCHHHHHHHHHHEEECCCCCCCCCCEEEEC
LKGIVALELRVRTAAFDLHSSYGAVVENPIYRLSRALASLRDEEGRVLIPGFYAKVRPLT
CCEEEEEEEEEEHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCC
PLEMEVLAQIPDESEALREAFGVRDFLGGARNLDFNQRLYAEPCVNFNGFHAGYGGPGSK
CHHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCCCCCCHHCCCCCCCCEECCCCCCCCC
TVLPAEARAKLDFRLVPDQDPEEVPELLRRHLEAQGFHDVEVVVLEKGERPARSDLAHPF
EEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHCCHH
VALARRALEEAFGERPVLYPNMAGSGPMHPFLHHLKAPAVGLGVGYPGSRVHSPNEHIRV
HHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEE
RDFERGVQALLRLLELFFLGR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA