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The map label for this gene is accC [H]

Identifier: 55981092

GI number: 55981092

Start: 1067532

End: 1068869

Strand: Reverse

Name: accC [H]

Synonym: TTHA1123

Alternate gene names: 55981092

Gene position: 1068869-1067532 (Counterclockwise)

Preceding gene: 55981093

Following gene: 55981091

Centisome position: 57.78

GC content: 67.94

Gene sequence:

>1338_bases
ATGAAGAAGGTCCTGATCGCCAACCGGGGTGAGATCGCCTTAAGGATCATCCGGGCGGCCCGGGAGCTCGGGATCAAGAC
GGTGGTGGCCCACTCCACCGCCGACGAGAAGAGCCTTCCCGTCCTCCTCGCCGACGAGGCCATCTGCATCGGGCCGCCCC
CCTCGGGGCAGAGCTACCTCAACATCCCCAACATCCTCTCCGCGGCCATCGTCACCGGGGCCGACGCCATCCATCCGGGC
TACGGCTTCCTGGCGGAGAACGCCACCTTCGCCGAGATGTGCCGGGAGCACGGGATCACCTTCATCGGCCCCACCCCGGA
GAACATGAAGGCCCTGGGGGACAAGGCCACGGCGAGGAAGGTGGCCCGGGAGGCGGGGGTGCCCACGGTGCCGGGCACGG
ACGAGCTGAGCAGCGTGGAGGAGGCCAAGCGGGCGGCCCAGGAGATCGGCTACCCCGTGATCCTCAAGGCGAGCGCGGGA
GGCGGGGGCCGGGGCATGCGCGTGGTCCACACGGAGGAGGAGCTGGAGCGGGCGGTGCTCCAGGCCCAGGAGGAGGCCCG
GGCCGCCTTCGGGAACCCCGCCGTCTACCTGGAGAAGTACATTGAGGAGCCCAAGCACATTGAGATCCAGGTCCTGGGGG
ACGGGGAACGGGTGGTCCACCTTTGGGAGCGGGACTGCTCCATCCAGCGCCGCCACCAGAAGCTTCTGGAGGAGGCCCCG
AGCCTCCTCCCCGAGGAGACCCGCCGGGCCATCGCCGAGGCGGCGCGGCGCCTCGCCGAGCGCGTGGGCTACGTGTCGGC
AGGCACGATGGAGTTCCTGGTGGACAAGGAGGGGAACTTCTACTTCATTGAGATGAACACCCGCATCCAGGTGGAGCACC
CCGTTACCGAGATGATCACGGGGATTGACCTGGTCCAGGCCCAGTTCCGCATCGCCCAGGGGGAGAAGCTCTGGCTCAAG
CAGGAGGAGATCCAGGTCCGGGGGCATGCCATAGAGGTCCGGGTGAACGCCGAGGACCCGGAGAAGGGCTTCAGGCCCTC
CATCGGCAAGGTGGAAACCCTCCTCTTCCCCGGGGGGCCCGGGGTGCGGGTGGACAGCCACCTCTACACCGGCTACCAGA
TCCCTCCCCACTACGACAGCCTCATCGCCAAGATCATCGTCTGGGCCCCCACCCGGGAGGAGGCCATAAGGCGCATGGAG
CGGGCCCTCTCCGAGACGGTGATTGAGGGGCCGGGCCTCAAGACCACCATCCCCTTCCACCAGAAGGTCCTCCAGAACGC
CTTCTTCCGCAGGGGGGCCGTGTACACCAACTTCGTGGCCCGGCGGATGGAGATGTAG

Upstream 100 bases:

>100_bases
ACGAGATCGAGTCCGAGGTCTCGGGGATCGTCAAGAAGATCCTGGTGGAGAACGGGGAGCCGGTGGAGTACGGCCAGCCC
CTCTTCCTTATCCAGCCGGT

Downstream 100 bases:

>100_bases
ACTGAGGCCTGTGCGGGTGGACTACGAGATCAGCGAGCAGGCCCTCGAGGCCGTGGTCCTTTGTGCCCTGAAGGGGATAG
AGGGGGTTAGGGCCCTCGAG

Product: acetyl-CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKKVLIANRGEIALRIIRAARELGIKTVVAHSTADEKSLPVLLADEAICIGPPPSGQSYLNIPNILSAAIVTGADAIHPG
YGFLAENATFAEMCREHGITFIGPTPENMKALGDKATARKVAREAGVPTVPGTDELSSVEEAKRAAQEIGYPVILKASAG
GGGRGMRVVHTEEELERAVLQAQEEARAAFGNPAVYLEKYIEEPKHIEIQVLGDGERVVHLWERDCSIQRRHQKLLEEAP
SLLPEETRRAIAEAARRLAERVGYVSAGTMEFLVDKEGNFYFIEMNTRIQVEHPVTEMITGIDLVQAQFRIAQGEKLWLK
QEEIQVRGHAIEVRVNAEDPEKGFRPSIGKVETLLFPGGPGVRVDSHLYTGYQIPPHYDSLIAKIIVWAPTREEAIRRME
RALSETVIEGPGLKTTIPFHQKVLQNAFFRRGAVYTNFVARRMEM

Sequences:

>Translated_445_residues
MKKVLIANRGEIALRIIRAARELGIKTVVAHSTADEKSLPVLLADEAICIGPPPSGQSYLNIPNILSAAIVTGADAIHPG
YGFLAENATFAEMCREHGITFIGPTPENMKALGDKATARKVAREAGVPTVPGTDELSSVEEAKRAAQEIGYPVILKASAG
GGGRGMRVVHTEEELERAVLQAQEEARAAFGNPAVYLEKYIEEPKHIEIQVLGDGERVVHLWERDCSIQRRHQKLLEEAP
SLLPEETRRAIAEAARRLAERVGYVSAGTMEFLVDKEGNFYFIEMNTRIQVEHPVTEMITGIDLVQAQFRIAQGEKLWLK
QEEIQVRGHAIEVRVNAEDPEKGFRPSIGKVETLLFPGGPGVRVDSHLYTGYQIPPHYDSLIAKIIVWAPTREEAIRRME
RALSETVIEGPGLKTTIPFHQKVLQNAFFRRGAVYTNFVARRMEM
>Mature_445_residues
MKKVLIANRGEIALRIIRAARELGIKTVVAHSTADEKSLPVLLADEAICIGPPPSGQSYLNIPNILSAAIVTGADAIHPG
YGFLAENATFAEMCREHGITFIGPTPENMKALGDKATARKVAREAGVPTVPGTDELSSVEEAKRAAQEIGYPVILKASAG
GGGRGMRVVHTEEELERAVLQAQEEARAAFGNPAVYLEKYIEEPKHIEIQVLGDGERVVHLWERDCSIQRRHQKLLEEAP
SLLPEETRRAIAEAARRLAERVGYVSAGTMEFLVDKEGNFYFIEMNTRIQVEHPVTEMITGIDLVQAQFRIAQGEKLWLK
QEEIQVRGHAIEVRVNAEDPEKGFRPSIGKVETLLFPGGPGVRVDSHLYTGYQIPPHYDSLIAKIIVWAPTREEAIRRME
RALSETVIEGPGLKTTIPFHQKVLQNAFFRRGAVYTNFVARRMEM

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=47.8555304740406, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=49.8871331828442, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=49.8871331828442, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=49.6629213483146, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=453, Percent_Identity=48.7858719646799, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI106049295, Length=453, Percent_Identity=48.7858719646799, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI106049292, Length=453, Percent_Identity=48.7858719646799, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=32.5396825396825, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=32.5396825396825, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=32.5396825396825, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=32.5396825396825, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=32.5396825396825, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=33.2007952286282, Blast_Score=245, Evalue=5e-65,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=54.3624161073826, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1786216, Length=234, Percent_Identity=23.0769230769231, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=49.6613995485327, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=454, Percent_Identity=49.3392070484581, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.5113122171946, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.7240704500978, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.7240704500978, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=31.0344827586207, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319685, Length=439, Percent_Identity=44.4191343963554, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=48.3296213808463, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=49.2204899777283, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6323863, Length=451, Percent_Identity=33.7028824833703, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=509, Percent_Identity=31.6306483300589, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322331, Length=306, Percent_Identity=22.5490196078431, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322569, Length=214, Percent_Identity=24.2990654205607, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651757, Length=450, Percent_Identity=46.4444444444444, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=50.1118568232662, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.5882352941176, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=32.9979879275654, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=32.9979879275654, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=32.9979879275654, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=32.9979879275654, Blast_Score=241, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49303; Mature: 49303

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIALRIIRAARELGIKTVVAHSTADEKSLPVLLADEAICIGPPPSGQSYL
CCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCEEEECCCCCCCCCC
NIPNILSAAIVTGADAIHPGYGFLAENATFAEMCREHGITFIGPTPENMKALGDKATARK
CCHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHCCCEEECCCCHHHHHHCCHHHHHH
VAREAGVPTVPGTDELSSVEEAKRAAQEIGYPVILKASAGGGGRGMRVVHTEEELERAVL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHHHH
QAQEEARAAFGNPAVYLEKYIEEPKHIEIQVLGDGERVVHLWERDCSIQRRHQKLLEEAP
HHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCEEEEHHHCCHHHHHHHHHHHHHH
SLLPEETRRAIAEAARRLAERVGYVSAGTMEFLVDKEGNFYFIEMNTRIQVEHPVTEMIT
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCEEEECCCHHHHHH
GIDLVQAQFRIAQGEKLWLKQEEIQVRGHAIEVRVNAEDPEKGFRPSIGKVETLLFPGGP
HHHHHHHHHHHCCCCEEEEEHHHEEECCEEEEEEECCCCCCCCCCCCCCCEEEEEECCCC
GVRVDSHLYTGYQIPPHYDSLIAKIIVWAPTREEAIRRMERALSETVIEGPGLKTTIPFH
CCEECCEEEECCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEECHHH
QKVLQNAFFRRGAVYTNFVARRMEM
HHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKVLIANRGEIALRIIRAARELGIKTVVAHSTADEKSLPVLLADEAICIGPPPSGQSYL
CCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCEEEECCCCCCCCCC
NIPNILSAAIVTGADAIHPGYGFLAENATFAEMCREHGITFIGPTPENMKALGDKATARK
CCHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHCCCEEECCCCHHHHHHCCHHHHHH
VAREAGVPTVPGTDELSSVEEAKRAAQEIGYPVILKASAGGGGRGMRVVHTEEELERAVL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHHHH
QAQEEARAAFGNPAVYLEKYIEEPKHIEIQVLGDGERVVHLWERDCSIQRRHQKLLEEAP
HHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCEEEEHHHCCHHHHHHHHHHHHHH
SLLPEETRRAIAEAARRLAERVGYVSAGTMEFLVDKEGNFYFIEMNTRIQVEHPVTEMIT
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCEEEECCCHHHHHH
GIDLVQAQFRIAQGEKLWLKQEEIQVRGHAIEVRVNAEDPEKGFRPSIGKVETLLFPGGP
HHHHHHHHHHHCCCCEEEEEHHHEEECCEEEEEEECCCCCCCCCCCCCCCEEEEEECCCC
GVRVDSHLYTGYQIPPHYDSLIAKIIVWAPTREEAIRRMERALSETVIEGPGLKTTIPFH
CCEECCEEEECCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEECHHH
QKVLQNAFFRRGAVYTNFVARRMEM
HHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]