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The map label for this gene is paaK [H]

Identifier: 55980935

GI number: 55980935

Start: 910259

End: 911605

Strand: Direct

Name: paaK [H]

Synonym: TTHA0966

Alternate gene names: 55980935

Gene position: 910259-911605 (Clockwise)

Preceding gene: 55980934

Following gene: 55980936

Centisome position: 49.21

GC content: 67.71

Gene sequence:

>1347_bases
GTGATGGGGATGATGTACCAGCCGGAACTGGAAACCTTGCCCCGCGAGAAGCTTAGGGCGCTTCAGGAAGAACGGCTCAA
GCGCCTGGTGGTCTACGTCTACGAGCGGGTCCCCTTCTACCGGAGGCTCCTTGACGAGGCCGGGGTGGACCCCAAAGGGT
TTAGGGGCCTCGAGGACCTCCCCCGGATTCCCTTCACCAAGAAGACGGACCTCCGCGACCACTACCCCTTCGGCCTCTTC
GCCGTGCCGAGGGAGGAGGTGGCCAGGATCCACGCCTCTAGCGGCACCACCGGCAAGCCCACCGTGGTGGGCTACACCAA
AAACGACCTCAAGGTCTTCGCCGAGGTGGTGGCCCGCTCCTTGGCCGCGGCCGGGGCAAGGCCCGGGATGATGCTCCACA
ACGCCTACGGCTACGGCCTCTTCACCGGGGGCCTCGGCCTCCACGGGGGGGCGGAGGCTTTGGGGATGACGGTGGTGCCG
GTCTCCGGGGGGATGACGGAAAGGCAGGTCATGCTCATCCAGGACTTCCGCCCCGAGGTGATCTCCTGCACCCCTTCCTA
CGCCCAGACCCTGGCGGAGGAGTTCAGAAAGCGGGGGGTCTCCCCGGAGGAGCTCTCCCTGGAGTACGCCGTCCTGGGCG
CCGAGCCCTGGACCGAGGCCATCCGCAAGCAGGTGGACGAGGGGCTTGGGGTGAAGAGCACCAACATCTACGGCCTCTCC
GAGATCATCGGCCCCGGGGTTTCCAACGAGTGCGTGGAGGAGCGCCAGGGCAGCCACATCTGGGAGGACCACTTCCTGCC
CGAGGTGGTGGACCCGGACACCGGGGAGCCCCTCCCCGAGGGGAAGGTGGGGGTTCTGGTCTTCACCACCCTCACCAAGG
AGGCCATGCCCCTCCTGCGCTACTGGACCGGGGACCTCACCTTCCTCACCTACGAGGCCTGCACCTGCGGCCGCACCCAC
GTGCGCATGGGGCCCATCCTGGGGCGCACTGACGACATGCTCATCATCCGGGGCGTGAACGTCTACCCCACCCAGGTGGA
GGCGGTGCTTCTGGCCATCCCCGAGGTGGAGCCCTACTACCAGATCGTGGTGCGGCGGGAGGGCACCCTGGACGAGGCCG
AGCTCAAGGTGGAGGTCTCCGAGCCCTTCTTCCGGGAGATCGGCCGGGAGGTCCTCTCCGACGAGGTGGTGGAGGCGGAC
CACCGGCTCCACGCCCTAAGGGAGCGGATCGCCCGCAAGATCAAGGACAACGTCGGCGTCACCCTGAAGGTCACCCTCCT
CCCCCCGGGCCAGGCCCCGAGGAGCGAGGGGGGGAAGCTCAGGCGGGTCCTGGACCTGAGGAAGTAG

Upstream 100 bases:

>100_bases
GAGGTGAACCTCTCCCGGCGCACGGCCACCTACCGGGTGGAGGTGGTCTCCGAAGGCAAGCTCGTGGCCCTCTTCACGGG
AACGGTCTTTCGCTTGGGAG

Downstream 100 bases:

>100_bases
CCATGCGCCCCATCCCCGAAGGCTACGAGGCGGTCTTTGAGACCGTGGTCACCCCGGAGATGACGGTGCGCTTTGAGGAG
CTGGGCCCCGTCCACCCCGT

Product: phenylacetyl-CoA ligase

Products: NA

Alternate protein names: Phenylacetyl-CoA ligase; PA-CoA ligase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MMGMMYQPELETLPREKLRALQEERLKRLVVYVYERVPFYRRLLDEAGVDPKGFRGLEDLPRIPFTKKTDLRDHYPFGLF
AVPREEVARIHASSGTTGKPTVVGYTKNDLKVFAEVVARSLAAAGARPGMMLHNAYGYGLFTGGLGLHGGAEALGMTVVP
VSGGMTERQVMLIQDFRPEVISCTPSYAQTLAEEFRKRGVSPEELSLEYAVLGAEPWTEAIRKQVDEGLGVKSTNIYGLS
EIIGPGVSNECVEERQGSHIWEDHFLPEVVDPDTGEPLPEGKVGVLVFTTLTKEAMPLLRYWTGDLTFLTYEACTCGRTH
VRMGPILGRTDDMLIIRGVNVYPTQVEAVLLAIPEVEPYYQIVVRREGTLDEAELKVEVSEPFFREIGREVLSDEVVEAD
HRLHALRERIARKIKDNVGVTLKVTLLPPGQAPRSEGGKLRRVLDLRK

Sequences:

>Translated_448_residues
MMGMMYQPELETLPREKLRALQEERLKRLVVYVYERVPFYRRLLDEAGVDPKGFRGLEDLPRIPFTKKTDLRDHYPFGLF
AVPREEVARIHASSGTTGKPTVVGYTKNDLKVFAEVVARSLAAAGARPGMMLHNAYGYGLFTGGLGLHGGAEALGMTVVP
VSGGMTERQVMLIQDFRPEVISCTPSYAQTLAEEFRKRGVSPEELSLEYAVLGAEPWTEAIRKQVDEGLGVKSTNIYGLS
EIIGPGVSNECVEERQGSHIWEDHFLPEVVDPDTGEPLPEGKVGVLVFTTLTKEAMPLLRYWTGDLTFLTYEACTCGRTH
VRMGPILGRTDDMLIIRGVNVYPTQVEAVLLAIPEVEPYYQIVVRREGTLDEAELKVEVSEPFFREIGREVLSDEVVEAD
HRLHALRERIARKIKDNVGVTLKVTLLPPGQAPRSEGGKLRRVLDLRK
>Mature_448_residues
MMGMMYQPELETLPREKLRALQEERLKRLVVYVYERVPFYRRLLDEAGVDPKGFRGLEDLPRIPFTKKTDLRDHYPFGLF
AVPREEVARIHASSGTTGKPTVVGYTKNDLKVFAEVVARSLAAAGARPGMMLHNAYGYGLFTGGLGLHGGAEALGMTVVP
VSGGMTERQVMLIQDFRPEVISCTPSYAQTLAEEFRKRGVSPEELSLEYAVLGAEPWTEAIRKQVDEGLGVKSTNIYGLS
EIIGPGVSNECVEERQGSHIWEDHFLPEVVDPDTGEPLPEGKVGVLVFTTLTKEAMPLLRYWTGDLTFLTYEACTCGRTH
VRMGPILGRTDDMLIIRGVNVYPTQVEAVLLAIPEVEPYYQIVVRREGTLDEAELKVEVSEPFFREIGREVLSDEVVEAD
HRLHALRERIARKIKDNVGVTLKVTLLPPGQAPRSEGGKLRRVLDLRK

Specific function: Catalyzes the activation of phenylacetic acid to phenylacetyl-CoA [H]

COG id: COG1541

COG function: function code H; Coenzyme F390 synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787664, Length=440, Percent_Identity=52.5, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011880 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.30 [H]

Molecular weight: Translated: 50045; Mature: 50045

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGMMYQPELETLPREKLRALQEERLKRLVVYVYERVPFYRRLLDEAGVDPKGFRGLEDL
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHC
PRIPFTKKTDLRDHYPFGLFAVPREEVARIHASSGTTGKPTVVGYTKNDLKVFAEVVARS
CCCCCCCCCCCCCCCCCCEEECCHHHHHHEECCCCCCCCCEEEEECCHHHHHHHHHHHHH
LAAAGARPGMMLHNAYGYGLFTGGLGLHGGAEALGMTVVPVSGGMTERQVMLIQDFRPEV
HHHCCCCCCEEEECCCCCEEEECCCCCCCCCHHHCEEEEECCCCCCCCEEEEEECCCCCE
ISCTPSYAQTLAEEFRKRGVSPEELSLEYAVLGAEPWTEAIRKQVDEGLGVKSTNIYGLS
EECCHHHHHHHHHHHHHCCCCHHHCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHH
EIIGPGVSNECVEERQGSHIWEDHFLPEVVDPDTGEPLPEGKVGVLVFTTLTKEAMPLLR
HHHCCCCCHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
YWTGDLTFLTYEACTCGRTHVRMGPILGRTDDMLIIRGVNVYPTQVEAVLLAIPEVEPYY
HHCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHEEEEEECCCCCCEE
QIVVRREGTLDEAELKVEVSEPFFREIGREVLSDEVVEADHRLHALRERIARKIKDNVGV
EEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLKVTLLPPGQAPRSEGGKLRRVLDLRK
EEEEEEECCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MMGMMYQPELETLPREKLRALQEERLKRLVVYVYERVPFYRRLLDEAGVDPKGFRGLEDL
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHC
PRIPFTKKTDLRDHYPFGLFAVPREEVARIHASSGTTGKPTVVGYTKNDLKVFAEVVARS
CCCCCCCCCCCCCCCCCCEEECCHHHHHHEECCCCCCCCCEEEEECCHHHHHHHHHHHHH
LAAAGARPGMMLHNAYGYGLFTGGLGLHGGAEALGMTVVPVSGGMTERQVMLIQDFRPEV
HHHCCCCCCEEEECCCCCEEEECCCCCCCCCHHHCEEEEECCCCCCCCEEEEEECCCCCE
ISCTPSYAQTLAEEFRKRGVSPEELSLEYAVLGAEPWTEAIRKQVDEGLGVKSTNIYGLS
EECCHHHHHHHHHHHHHCCCCHHHCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHH
EIIGPGVSNECVEERQGSHIWEDHFLPEVVDPDTGEPLPEGKVGVLVFTTLTKEAMPLLR
HHHCCCCCHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
YWTGDLTFLTYEACTCGRTHVRMGPILGRTDDMLIIRGVNVYPTQVEAVLLAIPEVEPYY
HHCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHEEEEEECCCCCCEE
QIVVRREGTLDEAELKVEVSEPFFREIGREVLSDEVVEADHRLHALRERIARKIKDNVGV
EEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLKVTLLPPGQAPRSEGGKLRRVLDLRK
EEEEEEECCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]