Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 55980879

GI number: 55980879

Start: 869399

End: 871633

Strand: Direct

Name: rnr [H]

Synonym: TTHA0910

Alternate gene names: 55980879

Gene position: 869399-871633 (Clockwise)

Preceding gene: 55980878

Following gene: 55980895

Centisome position: 47.0

GC content: 68.72

Gene sequence:

>2235_bases
ATGCAGGAAACGCTTTTAGAGTTTTTCAAGAAGACGGGGAGGCCGCACCGGCTGGAGGAGATCCTGCACCGGTTCGGCCT
GGAGAAGCGGGAGGCCAAGGCCCACCTTAAGGCCTTGGTGGCGCGGGGGCTTCTGGAGAAGAAGGGAAGCCGGTACTTCC
TGGCCAACCGGGTCCAGGGGCCCTTAAGCCTCCATCGGGACGGGTACGGCTTCGTCCGCCTCCCCGAGGGGGACCTCTTC
GTCCCCCCGGGGTACACGGGGGACGCCTGGCCGGGCGACCTGGTGGAGGCCCGCGTCATGCCCCCGGGCCGGGACGGAAG
GCCTTGGGGGGTGGTGGAGCGGGTCCTCAAGCGGGCGCGGGAGCGGCTCGTGGGGACCCTGGACTTCCGGAAAGGCCGCG
CCCTGCTCCTCCCCGACGAGCCCAACCTCCCGGAGCTTCCCCTCGCCCCCGAGGGGCTTGAGGGCCTGAAGCGGGGAAGC
CGCATCGTGGTCCAGGTCCACTACGGCAAGCGCCCCTACGGGACCTTCCTTGCGTACCTGGGGGAGGGGGAGGCCCCCGA
GACGGAGACGGAGGCCGTCATCGCCAAGTACGGCCTCCGCGCCGAGTTCCCCGAGGAGGTCCTGAAGGAGGCGGAGGCCA
TCCCCTTGGAGATCCCCGAGGCGGAGCTTAGGCGGCGGGAGGACTTCAGGGGCCTTCGGGTCTTCACCATAGACGGGGTG
GACGCCAAGGACTTTGACGACGCCATCCACGTGGAGCGTCTGCCTGGGGGCTACCGCATCGGGGTCCACATCGCCGACGT
CTCCCACTACGTCAAGGAGGGAAGCCTCTTGGACCAGGAGGCCTTCCTCCGGGGCACCAGCGTCTACCTCCCGGGGCGGG
TCCTCCCCATGCTTCCCGAAAGGCTTTCCAATGGGGTCTGCTCCTTGAGGCCGGGGGAGGACCGCTTGGTCCTCTCCGTG
CTCGTGGACCTCACGGAGGACCTAAAGGTCAAGCGGGTCCGCTTCCGGGAAGGGGTCATCCGGAGCGTCGCCCGCCTCAC
CTACACCGAGGTGGAGGCCTTCGCCGAGGGCTTCGGCCTTCCCGAGGAGCACGCCTTCCTGGCGGAGGACTTGCGCCTCC
TTTTGGACCTCACGCAGAGGATGCGGGAGAAGCGCCTAAAGGAGGGCGCCTTGGACTTCGCCTTCCCCGAGGTGAAGGTG
GAGGTGGGGGAGGAGGGGGAGCTTCACCTCATCCCCCAGGCGGAGCCCAAGGCCAGAAGCCTCATTGAGGAGCTGATGCT
CCTCGCCAACCGGCTGGTGGCGGAGTACCTGGTGCAAAAGGGCCTCCCCGGCCTCTTCCGCGTCCACGAGGAGCCGGTCC
AGGACGCCTACGAGAAGCTCCGCCAGGCCCTGGCCCGCCTGGGCTATACCCTCCCCCCCAAGCTTTCCGGCCACGCCCTG
CAAAAGGCCCTCCTCGCCTCGCGGGGCCGCCCGGAGGAGCCCGTGGTGGCCTACCTCGTCCTCCGCTCCTTGCGCCTGGC
CCGCTACGCCCCGGAGAACCTGGGCCACTTCGGCCTCGCCATGGAGCACTACCTGCACTTCACGAGCCCCATCCGCCGCT
ACCCGGACCTGGTGGTCCACCGGGTGCTGAAGGCCGCCTTGCGCCGGACCCTCACCCCGGCGCGGAAGGCGCGGTGGCAA
GAGGCCTTTCCCGCCATCGCCGAGCACGCTTCGGAGATGGAAAGGAAGGCGGAAGCCGCCGAGAGGGAGCTCACCAAGTA
CTACATGGCCAAGTGGGCCGAGCTCCACGTGGGGGAGCGCTTCTTGGGGAAGGTCACCGGGGTGGCGAACTTCGGGGCCT
TCGTCACTTTGCCCAACGGGGTGGAGGGGCTGGTGCGCCTCGAGGCCCTGGGGCCCTACACCTACAGCGAGGAGGCTATG
GCCCTCCTCGGCCCCAAAGGGCGGAGGATCCGCCTCGGGGACGAGATGGAGGTGCGGATCGCCGGGGCCAACCCGAGGCT
TAGGCAGGTGGACCTCCTCCCCGTGGAGGAGGCGCCCAAGAAGACCAAGAACAGGAAGGAAAAGGCTAAGGAGGTGGAGA
TGCGCAAAGTGGTAGGACCCCCCAAGGACCGGGCCCGGGACACCCGTCCCGAGCGGGCCACGGTGAACACCATCTACTTC
GGCGAGTGGACCCCCAAGGAGCCCGAGGAGCCCCGCCCGGAGAGGACCCGGGCCCGCAAAAAGCGGCGCCGCTAA

Upstream 100 bases:

>100_bases
CCCCTGATCATCGGCAAGGAGCACGTGGACGAGGCCCTCGCCGTCTTCGCGGAGGCCCTCAAGGCTACGGAAAAGGCCCT
CGAGGGCCTTCTAGGTTGAA

Downstream 100 bases:

>100_bases
GGCTTCCGCAAGCCCCTGGGGGGGCTGGCAGCGCTCCAGGCCCAGCGCCTGGAGGCTGCCCTCTTGGGACGGGGGCGCTG
CGCCCCCTTTTACTTCTGGC

Product: exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MQETLLEFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVARGLLEKKGSRYFLANRVQGPLSLHRDGYGFVRLPEGDLF
VPPGYTGDAWPGDLVEARVMPPGRDGRPWGVVERVLKRARERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGS
RIVVQVHYGKRPYGTFLAYLGEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGV
DAKDFDDAIHVERLPGGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPERLSNGVCSLRPGEDRLVLSV
LVDLTEDLKVKRVRFREGVIRSVARLTYTEVEAFAEGFGLPEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFAFPEVKV
EVGEEGELHLIPQAEPKARSLIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHAL
QKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVHRVLKAALRRTLTPARKARWQ
EAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGERFLGKVTGVANFGAFVTLPNGVEGLVRLEALGPYTYSEEAM
ALLGPKGRRIRLGDEMEVRIAGANPRLRQVDLLPVEEAPKKTKNRKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYF
GEWTPKEPEEPRPERTRARKKRRR

Sequences:

>Translated_744_residues
MQETLLEFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVARGLLEKKGSRYFLANRVQGPLSLHRDGYGFVRLPEGDLF
VPPGYTGDAWPGDLVEARVMPPGRDGRPWGVVERVLKRARERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGS
RIVVQVHYGKRPYGTFLAYLGEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGV
DAKDFDDAIHVERLPGGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPERLSNGVCSLRPGEDRLVLSV
LVDLTEDLKVKRVRFREGVIRSVARLTYTEVEAFAEGFGLPEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFAFPEVKV
EVGEEGELHLIPQAEPKARSLIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHAL
QKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVHRVLKAALRRTLTPARKARWQ
EAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGERFLGKVTGVANFGAFVTLPNGVEGLVRLEALGPYTYSEEAM
ALLGPKGRRIRLGDEMEVRIAGANPRLRQVDLLPVEEAPKKTKNRKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYF
GEWTPKEPEEPRPERTRARKKRRR
>Mature_744_residues
MQETLLEFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVARGLLEKKGSRYFLANRVQGPLSLHRDGYGFVRLPEGDLF
VPPGYTGDAWPGDLVEARVMPPGRDGRPWGVVERVLKRARERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGS
RIVVQVHYGKRPYGTFLAYLGEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGV
DAKDFDDAIHVERLPGGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPERLSNGVCSLRPGEDRLVLSV
LVDLTEDLKVKRVRFREGVIRSVARLTYTEVEAFAEGFGLPEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFAFPEVKV
EVGEEGELHLIPQAEPKARSLIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHAL
QKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVHRVLKAALRRTLTPARKARWQ
EAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGERFLGKVTGVANFGAFVTLPNGVEGLVRLEALGPYTYSEEAM
ALLGPKGRRIRLGDEMEVRIAGANPRLRQVDLLPVEEAPKKTKNRKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYF
GEWTPKEPEEPRPERTRARKKRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=470, Percent_Identity=31.063829787234, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI190014625, Length=470, Percent_Identity=31.063829787234, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI134288890, Length=409, Percent_Identity=33.9853300733496, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI219521928, Length=565, Percent_Identity=27.9646017699115, Blast_Score=177, Evalue=5e-44,
Organism=Homo sapiens, GI19115966, Length=565, Percent_Identity=27.9646017699115, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI156105695, Length=369, Percent_Identity=27.6422764227642, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI156105693, Length=369, Percent_Identity=27.9132791327913, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI87082383, Length=718, Percent_Identity=34.1225626740947, Blast_Score=334, Evalue=1e-92,
Organism=Escherichia coli, GI1787542, Length=649, Percent_Identity=28.6594761171032, Blast_Score=164, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI212645896, Length=528, Percent_Identity=31.4393939393939, Blast_Score=212, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17553506, Length=418, Percent_Identity=34.688995215311, Blast_Score=204, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324552, Length=516, Percent_Identity=34.1085271317829, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323943, Length=428, Percent_Identity=26.4018691588785, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320499, Length=404, Percent_Identity=25, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24649634, Length=463, Percent_Identity=31.9654427645788, Blast_Score=207, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24654592, Length=444, Percent_Identity=31.3063063063063, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI19922976, Length=444, Percent_Identity=31.3063063063063, Blast_Score=182, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24654597, Length=444, Percent_Identity=31.3063063063063, Blast_Score=182, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84450; Mature: 84450

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETLLEFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVARGLLEKKGSRYFLANRVQG
CHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
PLSLHRDGYGFVRLPEGDLFVPPGYTGDAWPGDLVEARVMPPGRDGRPWGVVERVLKRAR
CHHCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHHH
ERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGSRIVVQVHYGKRPYGTFLAYL
HHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHH
GEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGV
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCC
DAKDFDDAIHVERLPGGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPE
CCCCCCCCHHHEECCCCEEEEEEEHHHHHHHHCCCCCCHHHHHCCCCEECCCCHHHHHHH
RLSNGVCSLRPGEDRLVLSVLVDLTEDLKVKRVRFREGVIRSVARLTYTEVEAFAEGFGL
HHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFAFPEVKVEVGEEGELHLIPQAEPKARS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHH
LIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVH
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVLKAALRRTLTPARKARWQEAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGER
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGKVTGVANFGAFVTLPNGVEGLVRLEALGPYTYSEEAMALLGPKGRRIRLGDEMEVRI
HHHHHHHHHHCCCEEECCCCCCHHEEEHHCCCCCCCCCHHHHCCCCCCEEEECCCEEEEE
AGANPRLRQVDLLPVEEAPKKTKNRKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYF
ECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEE
GEWTPKEPEEPRPERTRARKKRRR
CCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQETLLEFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVARGLLEKKGSRYFLANRVQG
CHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
PLSLHRDGYGFVRLPEGDLFVPPGYTGDAWPGDLVEARVMPPGRDGRPWGVVERVLKRAR
CHHCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHHH
ERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGSRIVVQVHYGKRPYGTFLAYL
HHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCHHHHHHHH
GEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGV
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCC
DAKDFDDAIHVERLPGGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPE
CCCCCCCCHHHEECCCCEEEEEEEHHHHHHHHCCCCCCHHHHHCCCCEECCCCHHHHHHH
RLSNGVCSLRPGEDRLVLSVLVDLTEDLKVKRVRFREGVIRSVARLTYTEVEAFAEGFGL
HHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFAFPEVKVEVGEEGELHLIPQAEPKARS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHH
LIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHAL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
QKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVH
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVLKAALRRTLTPARKARWQEAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGER
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGKVTGVANFGAFVTLPNGVEGLVRLEALGPYTYSEEAMALLGPKGRRIRLGDEMEVRI
HHHHHHHHHHCCCEEECCCCCCHHEEEHHCCCCCCCCCHHHHCCCCCCEEEECCCEEEEE
AGANPRLRQVDLLPVEEAPKKTKNRKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYF
ECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEE
GEWTPKEPEEPRPERTRARKKRRR
CCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]