Click here to switch to the map view.

The map label for this gene is patA [H]

Identifier: 55980878

GI number: 55980878

Start: 868153

End: 869397

Strand: Direct

Name: patA [H]

Synonym: TTHA0909

Alternate gene names: 55980878

Gene position: 868153-869397 (Clockwise)

Preceding gene: 55980877

Following gene: 55980879

Centisome position: 46.93

GC content: 69.16

Gene sequence:

>1245_bases
ATGGACTTGGACGCCTTCACCCTCTTTGAGCGGCACATCAACCCAGGCCTCGCCGGGCTTCTCCGCTTCACCGGGCTAGA
CCGGGTGGAGTCCCACGCCGAAGGCCCCTACGTCTGGGACACCCAGGGCAAGCGCTACCTGGACTTCCTAGGCCTCTACG
GCACCCTGAACCTGGGCCACCGCCACCCCAAGGTGGTGGAGGCGGTCAAGCGGCAGCTTGACCGCATGCCCATGTCGGTG
CGGGTCCTGGTCTCGGAGCCCACGGCCAGGCTTGCCGCAAAGCTCGCCGAGATCACCCCGGAGGGCCTGGAGATGGTCTT
CTTCGGCAACTCCGGGGCCGAGGCGGTGGAGGCCGCCATCAAGCTGGCCCGGGCCTACACCGGCAAGCCCGGCATCGTCA
CCACCCAAGGGGGGTTCCACGGCAAGACCATGGGGGCGCTCTCCCTCACCCCCAAGCCCGAGTACCAGGACCCCGCAAGG
CCCCTCCTCCCCGGGGTCAAGGTGGTGCCCTACGGGGACCTAAAGGCCCTGGAGGAGGCCATAGACGAAACGACCGCCGC
CGTGATCGTGGAGCCCATCCAGGGGGAAGGGGGCATCCGGGTGCCCCCCGAGGGGTACCTGAGGGGCGTGCGGGAGCTTA
CCCGGGAAAAGGGCGTCCTCATGATCGCCGACGAGGTGCAGACCGGCCTCGGCCGCACGGGGAAGCTCTTCGGGGTGGAC
TGGGAGGGGGTCTCCCCGGACCTCATGACCCTGGCCAAGGCCCTGGGGGGCGGGGTGATGCCCATCGGGGCCTGCGTGGG
GCGGCGGGAGGTCTTTGAGGTCTTCAAGAATAACCCCCTCTTCCACTCCTCCACCTTCGGGGGGAACCCCCTGGCCGCGG
CCGCCGCCCTTGCGGCCATTGAGGTCACCCTGGAGGAGGACCTCCCGGGGCGGGCCCTGGAGCTCGGCCGCCACCTGATG
GAGGGGCTAAAGGTCCTCAAGGAGGAGCACCCCCACCTCATTGAGGACGTGCGCGGCCGGGGGCTCATGGTGGGCGTGGA
GTTCGCGGACGCCGACATCGGCGCCCTGGTGGTGGCGGAGATGGCGGAGAGGGGCGTCCTCACCGCCTTCGGCCTGAATA
ACCCCAAGGTGGTCCGCCTCGAGCCCCCCCTGATCATCGGCAAGGAGCACGTGGACGAGGCCCTCGCCGTCTTCGCGGAG
GCCCTCAAGGCTACGGAAAAGGCCCTCGAGGGCCTTCTAGGTTGA

Upstream 100 bases:

>100_bases
CTTCACCCGCCACCTCTGCCAGGTGGGGGAGAGGGCGGCCCGCATCCCGGAGGACATCTACCGGGCCTTGAGCGTGCTAC
ACTTAAAGTAGCATTGGGGC

Downstream 100 bases:

>100_bases
AATGCAGGAAACGCTTTTAGAGTTTTTCAAGAAGACGGGGAGGCCGCACCGGCTGGAGGAGATCCTGCACCGGTTCGGCC
TGGAGAAGCGGGAGGCCAAG

Product: ornithine aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGHRHPKVVEAVKRQLDRMPMSV
RVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAIKLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPAR
PLLPGVKVVPYGDLKALEEAIDETTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGKLFGVD
WEGVSPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAIEVTLEEDLPGRALELGRHLM
EGLKVLKEEHPHLIEDVRGRGLMVGVEFADADIGALVVAEMAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAE
ALKATEKALEGLLG

Sequences:

>Translated_414_residues
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGHRHPKVVEAVKRQLDRMPMSV
RVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAIKLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPAR
PLLPGVKVVPYGDLKALEEAIDETTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGKLFGVD
WEGVSPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAIEVTLEEDLPGRALELGRHLM
EGLKVLKEEHPHLIEDVRGRGLMVGVEFADADIGALVVAEMAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAE
ALKATEKALEGLLG
>Mature_414_residues
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGHRHPKVVEAVKRQLDRMPMSV
RVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAIKLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPAR
PLLPGVKVVPYGDLKALEEAIDETTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGKLFGVD
WEGVSPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAIEVTLEEDLPGRALELGRHLM
EGLKVLKEEHPHLIEDVRGRGLMVGVEFADADIGALVVAEMAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAE
ALKATEKALEGLLG

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=381, Percent_Identity=37.7952755905512, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI13994255, Length=414, Percent_Identity=32.1256038647343, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI284507298, Length=305, Percent_Identity=39.672131147541, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=29.7968397291196, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI226442705, Length=443, Percent_Identity=29.3453724604966, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=30.5912596401028, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=28.3980582524272, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI188536080, Length=432, Percent_Identity=26.1574074074074, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI38679950, Length=432, Percent_Identity=26.1574074074074, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI38679946, Length=432, Percent_Identity=26.1574074074074, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI145693181, Length=431, Percent_Identity=45.707656612529, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=38.7862796833773, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=39.0501319261214, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789016, Length=401, Percent_Identity=34.6633416458853, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=38.1909547738693, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=31.4685314685315, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=34.2028985507246, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=373, Percent_Identity=36.9973190348526, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=33.175355450237, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI25144274, Length=264, Percent_Identity=39.7727272727273, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=419, Percent_Identity=28.1622911694511, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=25.9860788863109, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=153, Percent_Identity=31.3725490196078, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=397, Percent_Identity=36.7758186397985, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6324432, Length=384, Percent_Identity=33.59375, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=25.1748251748252, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=317, Percent_Identity=29.0220820189274, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21357415, Length=381, Percent_Identity=35.9580052493438, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI21356575, Length=439, Percent_Identity=33.2574031890661, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161085790, Length=420, Percent_Identity=32.8571428571429, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574759, Length=422, Percent_Identity=32.4644549763033, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281366494, Length=430, Percent_Identity=25.3488372093023, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24667139, Length=430, Percent_Identity=25.3488372093023, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24667143, Length=430, Percent_Identity=25.3488372093023, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 44406; Mature: 44406

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGH
CCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCCEEECCCCCHHHHHHHHHHEECCCC
RHPKVVEAVKRQLDRMPMSVRVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAI
CCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
KLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPARPLLPGVKVVPYGDLKALEEA
HHHHHHCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCHHCCCCEEECCCCHHHHHHH
IDETTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGKLFGVD
HHHHCEEEEEEEECCCCCEECCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEC
WEGVSPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAI
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHH
EVTLEEDLPGRALELGRHLMEGLKVLKEEHPHLIEDVRGRGLMVGVEFADADIGALVVAE
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHH
MAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAEALKATEKALEGLLG
HHHCCCEEEECCCCCEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGH
CCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCCEEECCCCCHHHHHHHHHHEECCCC
RHPKVVEAVKRQLDRMPMSVRVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAI
CCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
KLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPARPLLPGVKVVPYGDLKALEEA
HHHHHHCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCHHCCCCEEECCCCHHHHHHH
IDETTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGKLFGVD
HHHHCEEEEEEEECCCCCEECCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEC
WEGVSPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAI
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHH
EVTLEEDLPGRALELGRHLMEGLKVLKEEHPHLIEDVRGRGLMVGVEFADADIGALVVAE
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECCCCHHHHHHHH
MAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAEALKATEKALEGLLG
HHHCCCEEEECCCCCEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA