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The map label for this gene is proC [H]

Identifier: 55980821

GI number: 55980821

Start: 814933

End: 815718

Strand: Direct

Name: proC [H]

Synonym: TTHA0852

Alternate gene names: 55980821

Gene position: 814933-815718 (Clockwise)

Preceding gene: 55980820

Following gene: 55980822

Centisome position: 44.06

GC content: 72.9

Gene sequence:

>786_bases
ATGAGGCTGGCCTTCGTGGGTCTCGGCAAGATGGGCCGGAGCATCCTCAAGGGGGCTCTGGAGCGGGGCTTCTTGCGCCC
GGAGGAGGTGGGGGTCTTGGGGCGGACGCCCGAGCGGAGCCGGGAGCTCGCCGAGCCTTTCGGCGTCCGCCCCTTGACGC
GGGCGGACCTGGGCATGGCCGAGCGCGTCCTGATCGCGGTCCAGCCCCGGGACTTCCCCGCCCTGGCCCCGGAGATCGCC
CACCACCGCCTGGGCTACATCTCCATCATGGCGGGGATCTCCACCTCGGTCCTCGCCCGCAGGCTGGACAACCGCCGCGT
GGTCCGGGCCATGCCCAACCTGGCGGTGGCCATCGGGGAGAGCTCCACCGCCCTCACCGCCCTAAAGGAGGCCAGGGAGG
CGGAAGACCTCGCCTTCGCCCGGGCCCTTTTCGCCACGGTGGGGGACGTGTACGAGATCCCCGAGCACCTCTTTGACGCC
TTCACCGGCATGTCCGCCTCCGCCCCCGCCTATTTGGCGGTGGTGGCCGAGGCCTTGGCGGACGCGGGGGTGAAGATGGG
CATGCCCCGGGCCCTGGCCCTCCGCCTCGCCGCGGACGCCCTGGCGGCCACGGGGGAGCTTCTCAAGGGCAGGCACCCCG
CCCAGGTCAAGGACGAGGTGGCGAGCCCGGGGGGAACCACCATCCACGGCCTCCACGCCCTCGAGGCCCGGGCGGTGCGG
GCGGCCTTTTACGAGGCGGTGGAGGCGGCCACCCAGAGGGGGCACGAGCTCGGCGAGTCGGAGTGA

Upstream 100 bases:

>100_bases
CCTTCCCCGTCCTCGCCCGGGGGCTTGGGGTCTACGTGGACCCGAGGGGAGGGCTGGACGGCTTCTACTACGCCAAGCTG
CGGAGGGTAAACTCTCAGGC

Downstream 100 bases:

>100_bases
GGCCACCCCATGCGGGCTTGCGCCCGCATGGGGGCCCCGGCAGAAGGCTTGGGTGGGGATTTTGGGCGGCAGGAGGGCGA
ACAAAGCGGGAAAGAAGGGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMAERVLIAVQPRDFPALAPEIA
HHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVAIGESSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDA
FTGMSASAPAYLAVVAEALADAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVR
AAFYEAVEAATQRGHELGESE

Sequences:

>Translated_261_residues
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMAERVLIAVQPRDFPALAPEIA
HHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVAIGESSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDA
FTGMSASAPAYLAVVAEALADAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVR
AAFYEAVEAATQRGHELGESE
>Mature_261_residues
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMAERVLIAVQPRDFPALAPEIA
HHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVAIGESSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDA
FTGMSASAPAYLAVVAEALADAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVR
AAFYEAVEAATQRGHELGESE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=37.0786516853933, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=34.6863468634686, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=34.6863468634686, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=34.5588235294118, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=32.9588014981273, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=274, Percent_Identity=34.6715328467153, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=33.4519572953737, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320861, Length=177, Percent_Identity=29.9435028248588, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=33.4519572953737, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=32.5757575757576, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=39.0532544378698, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27763; Mature: 27763

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMA
CEEEEECHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHCHH
ERVLIAVQPRDFPALAPEIAHHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVAIGE
HEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEECC
SSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDAFTGMSASAPAYLAVVAEALA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVR
HCCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHH
AAFYEAVEAATQRGHELGESE
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMA
CEEEEECHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHCHH
ERVLIAVQPRDFPALAPEIAHHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVAIGE
HEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEECC
SSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDAFTGMSASAPAYLAVVAEALA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVR
HCCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHHHHHHHHHHH
AAFYEAVEAATQRGHELGESE
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123043 [H]