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The map label for this gene is siaT [H]

Identifier: 55980737

GI number: 55980737

Start: 734172

End: 735485

Strand: Direct

Name: siaT [H]

Synonym: TTHA0768

Alternate gene names: 55980737

Gene position: 734172-735485 (Clockwise)

Preceding gene: 55980736

Following gene: 55980741

Centisome position: 39.69

GC content: 63.47

Gene sequence:

>1314_bases
ATGCCGATTGAGACCCTCACCTGGCTGATGTTCGGGGCCCTTTTTGTCCTTCTCCTCACCGGCTACCCCCTGGCCTTTTT
GGTCGGGGGGCTTTCCGTGGTCTTCATCGCCTGGCTCTGGAGCCCCGACGCCTTGGCCTTGGTGCCCCAGCGGGTCTGGA
ACAACATGACCCAATACCTCCTCGCCGCCATCCCCCTTTTCATCTTCATGGCCTCCATGCTGGAAAAATCGGGGGTCATA
GAGGAGGTTTTTGACGTGGCCTACAAGTGGCTGGGCCGGATCCCGGGGGGGTTGGCCGTGGCCACGGTGGTGGCCTCCAC
CGTCCTCGCGGCCATGGTGGGGGTTATCGGGGCGGCGGTGGTGACCATGGCCCTGGTGGCCCTCCCTTCCATGCTCCGCC
GGGGCTATAGCCCGGTTTTGGCCGTGGGAACGGTGATGGCTGGGGGGACCTTGGGCATCCTGATTCCCCCCAGCGTCTTG
GCCATCGTCTACGGCTTGGTGGCCAACCAGTCCGTGGGGGAGCTTTACCTGGGCTCGGTTTTCCCTGGGCTGGTCCTTTC
GGGGTTGTACATTCTCTTCTCGGTGGGGTATGCCCTCCTGAACCCCAAGGCGGCCCCCCGCTTGAGCCCGGAGGAAACGC
CCACCTGGTCCGAGCGGTGGCGGGCGCTCCGGTCCATATGGTCCCCTTTGGTCCTTATCTTTTTGGTGCTGGGCACGATC
TTTCTGGGGCTTGCCGCCCCTACGGAGGCCGCGGCCATCGGGGCCTTCGGGGCCATGGTGGTGGCGGCCATCCACCGCCG
TCTTTCCTGGACCATCTTGCGCTTGGCCCTGGAGCAGACGGCGAAGGCGACGGCCATGGTGATGTGGATCGTCTTTGGGG
CCAACGCCTTTGTGGGGTTTTACATCGCCCAAGGGGGGGACCGCTACGTTTCCGAGCTCCTGCTGGGGACGGGACTTTCC
CCCTGGGGCATCCTCCTCCTGATGCAGGGAATCCTCATCGTCTTGGGGATGTTCTTGGACTGGGTGGGGATCCTGCTCTT
GGCGGTGCCCGTCTTTGTGCCGATCATCCGGGACCTGGGGTTTGATCCCTTGTGGTTCGGCGTCCTCTATCTGGTGAACA
TGCAGATCTCTTTCCTAAGTCCACCCTTCGGCTACGCCCTTTTCTACGTGCGGGGTGTGGCCCCTCAGGTCCCTATGGGG
ACGATCTATAAAGCTGCCCTTCCCTTCCTCTTCCTCCAGCTCGTGGGGCTGGCCTTGGTGATGCTTTTCCCGGGGCTGGC
CACCTGGCTTCCGAGCGTGGTGTACGGCCGCTAG

Upstream 100 bases:

>100_bases
TACCCCTTTAAACTGGCCATTCCTTTAGGGGCCCTTCTCCTGCTGATGCAAGGGCTGGTTTTGGCCCTGCGCGAACTCGC
CTTCCTCCTCGGGGGTGCCC

Downstream 100 bases:

>100_bases
CGCCCGGGGAAGGGGGCGAGGACCACCTCCACCGGGAAGACCTGGCCTCCCCGCCGCACCGTGAGCCGGACCCTGTCCCC
CACCCTGTAGCGGCGCACCT

Product: large integral membrane transport protein

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPIETLTWLMFGALFVLLLTGYPLAFLVGGLSVVFIAWLWSPDALALVPQRVWNNMTQYLLAAIPLFIFMASMLEKSGVI
EEVFDVAYKWLGRIPGGLAVATVVASTVLAAMVGVIGAAVVTMALVALPSMLRRGYSPVLAVGTVMAGGTLGILIPPSVL
AIVYGLVANQSVGELYLGSVFPGLVLSGLYILFSVGYALLNPKAAPRLSPEETPTWSERWRALRSIWSPLVLIFLVLGTI
FLGLAAPTEAAAIGAFGAMVVAAIHRRLSWTILRLALEQTAKATAMVMWIVFGANAFVGFYIAQGGDRYVSELLLGTGLS
PWGILLLMQGILIVLGMFLDWVGILLLAVPVFVPIIRDLGFDPLWFGVLYLVNMQISFLSPPFGYALFYVRGVAPQVPMG
TIYKAALPFLFLQLVGLALVMLFPGLATWLPSVVYGR

Sequences:

>Translated_437_residues
MPIETLTWLMFGALFVLLLTGYPLAFLVGGLSVVFIAWLWSPDALALVPQRVWNNMTQYLLAAIPLFIFMASMLEKSGVI
EEVFDVAYKWLGRIPGGLAVATVVASTVLAAMVGVIGAAVVTMALVALPSMLRRGYSPVLAVGTVMAGGTLGILIPPSVL
AIVYGLVANQSVGELYLGSVFPGLVLSGLYILFSVGYALLNPKAAPRLSPEETPTWSERWRALRSIWSPLVLIFLVLGTI
FLGLAAPTEAAAIGAFGAMVVAAIHRRLSWTILRLALEQTAKATAMVMWIVFGANAFVGFYIAQGGDRYVSELLLGTGLS
PWGILLLMQGILIVLGMFLDWVGILLLAVPVFVPIIRDLGFDPLWFGVLYLVNMQISFLSPPFGYALFYVRGVAPQVPMG
TIYKAALPFLFLQLVGLALVMLFPGLATWLPSVVYGR
>Mature_436_residues
PIETLTWLMFGALFVLLLTGYPLAFLVGGLSVVFIAWLWSPDALALVPQRVWNNMTQYLLAAIPLFIFMASMLEKSGVIE
EVFDVAYKWLGRIPGGLAVATVVASTVLAAMVGVIGAAVVTMALVALPSMLRRGYSPVLAVGTVMAGGTLGILIPPSVLA
IVYGLVANQSVGELYLGSVFPGLVLSGLYILFSVGYALLNPKAAPRLSPEETPTWSERWRALRSIWSPLVLIFLVLGTIF
LGLAAPTEAAAIGAFGAMVVAAIHRRLSWTILRLALEQTAKATAMVMWIVFGANAFVGFYIAQGGDRYVSELLLGTGLSP
WGILLLMQGILIVLGMFLDWVGILLLAVPVFVPIIRDLGFDPLWFGVLYLVNMQISFLSPPFGYALFYVRGVAPQVPMGT
IYKAALPFLFLQLVGLALVMLFPGLATWLPSVVYGR

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG4664

COG function: function code Q; TRAP-type mannitol/chloroaromatic compound transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=379, Percent_Identity=29.5514511873351, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 47043; Mature: 46912

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIETLTWLMFGALFVLLLTGYPLAFLVGGLSVVFIAWLWSPDALALVPQRVWNNMTQYL
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LAAIPLFIFMASMLEKSGVIEEVFDVAYKWLGRIPGGLAVATVVASTVLAAMVGVIGAAV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTMALVALPSMLRRGYSPVLAVGTVMAGGTLGILIPPSVLAIVYGLVANQSVGELYLGSV
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHH
FPGLVLSGLYILFSVGYALLNPKAAPRLSPEETPTWSERWRALRSIWSPLVLIFLVLGTI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLGLAAPTEAAAIGAFGAMVVAAIHRRLSWTILRLALEQTAKATAMVMWIVFGANAFVGF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIAQGGDRYVSELLLGTGLSPWGILLLMQGILIVLGMFLDWVGILLLAVPVFVPIIRDLG
HHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDPLWFGVLYLVNMQISFLSPPFGYALFYVRGVAPQVPMGTIYKAALPFLFLQLVGLALV
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MLFPGLATWLPSVVYGR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]