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The map label for this gene is hisD [H]

Identifier: 55980691

GI number: 55980691

Start: 684200

End: 685438

Strand: Direct

Name: hisD [H]

Synonym: TTHA0722

Alternate gene names: 55980691

Gene position: 684200-685438 (Clockwise)

Preceding gene: 55980690

Following gene: 55980692

Centisome position: 36.99

GC content: 73.85

Gene sequence:

>1239_bases
ATGATCTACGCTGCCGAGGAGGTGCGGGCCCGCTTCGCCCGCCGGGGCCTCTCCTTTGACCCCACGGTGGAGGAGATCGT
GCGGGGCATCCTGGAGGCGGTCCGGGAGGAAGGGGACGAGGCCCTGGACCGGTTCAGCCGGGACCTGGACGGCTACCCGG
TGGAGGAGGTCCCCAAGCGGGCCTGGCGGGAGGCCTACGAGGACTTGGACGAGGACCTCAGGGACGCCCTGGAGACGGCC
CGGGAGCGCATAGAGGCCTTCTACCGGGAGGAGGCCCGGGGCGGCTTCCTCCGGGCCGAGGGGGGCGGGGTGCTGGCCCA
GCTCGTCCGCCCCCTGGAGCGGGTGGGGGTCTACGTCCCCGGGGGAAGCGCCCCCCTCCTCTCCACCCTCCTCATGACCG
TGGTCCCGGCCAAGGTGGCGGGGGTGCGGGAGGTGATCGTGGCGAGCCCCCCCAAGGTCCACCCCGGGGTCCTGGCCGCC
GCCTGGGTGGCGGGGGCCGACCGCCTCTTCGCCATGGGCGGGGCCCAGGCCATCGCCGCCTTGGCCTACGGCACGGGGCG
CGTCCCCCGGGTGGACAAGATCGTGGGGCCGGGGAACCGCTACGTGGTGGCGGCGAAGAGGCTCGTCTACGGCACCGTGG
GCATTGACGGCCTCGCCGGCCCCACGGAGACCATGATCATCGCCGACGGCTCCGCCTCCCCCAGGCTCCTCGCCGCCGAC
CTCCTGGCCCAGGCGGAGCACGGCCCCGACTCCGAGCCCTGGCTCCTCTCCCCGGACCGGGCCCTGTTGGAACGGGTGGA
GGCCGAGCTTTCCTGGCAGCTCCAGGACCTCCCCCGGGCCGAGGTGGCCCGTCAGGCCCTGGAGAAGGGCGGGCTCGTCC
TCACCAAGGACCTGGAGGAGGCCTTCGCCCTCGCCAACCTCTACGCCCCCGAGCACCTCTCCCTCGCCCTCTCGGACCCC
CTTCCCTGGCTGGAGAAGGTGCAGAACGCCGGGGGGGTCTTCCTGGGGGAGGGGAGCCCCGAGGCCTTGGGCGACTACAT
CGCCGGGCCCAGCCACGTCATGCCCACCTCGGGGACGGCCCGCTTCCAGGGGGGGTTGGCGGTGCGGGACTTCCTGAAGG
TGATCCCGGTGGTGGGCCTTTCCGAGGGCGCGGCCCGGGAGCTCGCCAAGAAGGGGGCGCTTTTGGCCCGGGCGGAGGGC
CTCGAGGGCCACGCCCGCTCCCTGGACCTCAGGCGATGA

Upstream 100 bases:

>100_bases
CGTGGCCCAGCAGGTGGGCCGGCACGTCTTTGAGGCGGTCCTCCTGGAGGCGGAAGGCCCCTGAAGCCGTTTCCCGCGCC
GGTATTGGTATAGTGGGGGC

Downstream 100 bases:

>100_bases
GGCTCTTCCACGAACTCTTAGGTCCCCTGGAGCTTCCCGACCGCTTCTCGCGCATCGTCTCCCTGGCCCCGAACCTCACC
GACGCCCTCTTCGCCCTGGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MIYAAEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVEEVPKRAWREAYEDLDEDLRDALETA
RERIEAFYREEARGGFLRAEGGGVLAQLVRPLERVGVYVPGGSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAA
AWVAGADRLFAMGGAQAIAALAYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTVGIDGLAGPTETMIIADGSASPRLLAAD
LLAQAEHGPDSEPWLLSPDRALLERVEAELSWQLQDLPRAEVARQALEKGGLVLTKDLEEAFALANLYAPEHLSLALSDP
LPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSGTARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEG
LEGHARSLDLRR

Sequences:

>Translated_412_residues
MIYAAEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVEEVPKRAWREAYEDLDEDLRDALETA
RERIEAFYREEARGGFLRAEGGGVLAQLVRPLERVGVYVPGGSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAA
AWVAGADRLFAMGGAQAIAALAYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTVGIDGLAGPTETMIIADGSASPRLLAAD
LLAQAEHGPDSEPWLLSPDRALLERVEAELSWQLQDLPRAEVARQALEKGGLVLTKDLEEAFALANLYAPEHLSLALSDP
LPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSGTARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEG
LEGHARSLDLRR
>Mature_412_residues
MIYAAEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVEEVPKRAWREAYEDLDEDLRDALETA
RERIEAFYREEARGGFLRAEGGGVLAQLVRPLERVGVYVPGGSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAA
AWVAGADRLFAMGGAQAIAALAYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTVGIDGLAGPTETMIIADGSASPRLLAAD
LLAQAEHGPDSEPWLLSPDRALLERVEAELSWQLQDLPRAEVARQALEKGGLVLTKDLEEAFALANLYAPEHLSLALSDP
LPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSGTARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEG
LEGHARSLDLRR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=413, Percent_Identity=41.4043583535109, Blast_Score=302, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=36.8674698795181, Blast_Score=268, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44124; Mature: 44124

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYAAEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVEEVPKR
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
AWREAYEDLDEDLRDALETARERIEAFYREEARGGFLRAEGGGVLAQLVRPLERVGVYVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCEECC
GGSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHH
LAYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTVGIDGLAGPTETMIIADGSASPRLLAAD
HHHCCCCCCCHHHHCCCCCCEEEEEHHHHEEECCCCCCCCCCCEEEEECCCCCCHHHHHH
LLAQAEHGPDSEPWLLSPDRALLERVEAELSWQLQDLPRAEVARQALEKGGLVLTKDLEE
HHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEHHHHH
AFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSGTA
HHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCC
RFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLRR
HHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCHHCCCCCCC
>Mature Secondary Structure
MIYAAEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVEEVPKR
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
AWREAYEDLDEDLRDALETARERIEAFYREEARGGFLRAEGGGVLAQLVRPLERVGVYVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCEECC
GGSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHH
LAYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTVGIDGLAGPTETMIIADGSASPRLLAAD
HHHCCCCCCCHHHHCCCCCCEEEEEHHHHEEECCCCCCCCCCCEEEEECCCCCCHHHHHH
LLAQAEHGPDSEPWLLSPDRALLERVEAELSWQLQDLPRAEVARQALEKGGLVLTKDLEE
HHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEHHHHH
AFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSGTA
HHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCC
RFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLRR
HHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA