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The map label for this gene is zntA [H]

Identifier: 55980675

GI number: 55980675

Start: 669093

End: 671147

Strand: Direct

Name: zntA [H]

Synonym: TTHA0706

Alternate gene names: 55980675

Gene position: 669093-671147 (Clockwise)

Preceding gene: 55980674

Following gene: 55980676

Centisome position: 36.17

GC content: 67.45

Gene sequence:

>2055_bases
ATGAAGGCTCCCAGAGTGCGCGTCTTCCGGGTAGAGGGCATGGACTGCGCCGACTGCGCCTTAAAGGTGGAGAAAGCCCT
TTCCGAGGTGCCTGGAGTGGTGCAGGCCCAGGTCAGCTTTGCCAGCGGAAAGGCCTATCTGCACCTCGAGGTTCCCGGGG
CGGAGAAGGAGGCGGAAAGGGTGGTTTCCGCCCTGGGCTACCGTTTGAAGCCTGAAGGGGACACGACCAGGGGTGTTTTG
GGACCCTGGCGCTGGGCCTTGGTTTCCGGAGGGCTTCTCCTGGCGGCCTTTTTGGCTTCGCTCTTCCTCCCCGGCCTAGC
CCCTTGGGGCTATCGGCTGGCGGCCTTGATAGGGGTTTTCCCCCTGGCTCGTCGTGCGGTGGCTGCGTTCCGGCAAAACC
CCTTCAGCATGCAAACCCTGGTTACGCTGGCTACCCTGGGAGCCATGCTCATCGGGGCGGAGGCCGAGGCGGCGGTGGTG
GTCTTCCTCTTCCTCGTGGGGGAGGTGCTGGAGGCTTATAGCGTGGCCCAGGCCCGCAGGTCCCTTTACGCCCTTTCCGA
GCTTCTTCCCAGGCGGGCCTACCGCCTGAAGGAGGGTGGGGTGGAGGAGGTGCCCCTTAAGGCCTTGAGGGTGGGGGACC
TGGTGAGGGTGCCCCCGGGGGAGCGGGTACCGGCCGACGGGGTGGTGGTGTCTGGACAGGCTTCCGTGGAGGAGGCCGCC
TTCACCGGGGAGCCCTTGCCTAGGCCCAAGGGGATAGGGGACCGGGTTTACGGGGGCAGTCTGGTGCAGGAGGGGAGCTT
GGTGGTAAAGGTGGAGCGCCTTCCCGAGGAGGGCTTCCTGGCGGAGATGGAACGCCTGGCGGAGGAGGCCTTGCTTAAGA
AGAGCCAGGCGGAGCGGGTGGTGGATGCCTTTAGCCGCCGCTACACCCCGGCGGTCCTGGCCCTGGCAGGCTTCGTGGGC
CTGGTCCTTCCCCTTTTCCGGGGGGATTTCCTGGGGCATGTCTACAAGGCCTTGGGCCTTCTCCTCATCGCCTGTCCCTG
CGCTCTGGTGGTGTCGGTGCCTGCGGCCATCGCCGCAGGGGTGGGCCGGGGAGCCAGGGCGGGGGTGCTCTTTAAGAGCG
GGGCGGCCCTGGAGCGCTTGGCTGGGGTTCGCTACGTGGCTTTGGACAAGACGGGAACCCTGACCCTGGGAAAGCCCACG
CTGGTGCGGGTGGTTACCTTTGGGGTTTCGACGGAGGAGGCCTTGGCCCTGGCGAAGGGGGTGGCGGAGGGTTCCTCCCA
CCCCTTAGCCCGGGCGGTGCGGGAGGCTTTGGGCCCCAAGGCCTTGCCCTCGGAGGAGCATCGGGCGGTGCCGGGCCTCG
GGGCCTTCGCTCGGGTGGAGGGGAAGGAGGTGGGTTTGGTGCGGCCCGAGGCCTGGGACCTGCCCCCGGAAGTAGAGGCC
CAGGTGAAGGCCTTGGCGGAGGAAGGCTTCAGCCTTTCCCTCTTGGTTAGGGAGGGGGTTCCCTTGGCCCTCTTGGCCTT
CCAGGATACCCCCCGCCTCGAGGCCCGGGAAGTCTTGGCCGAACTGCGCCGACTGGGCCTTAAGCCCCTCCTGCTTACCG
GCGACCGGGAGACCTCTGCTTTGGCTTTGGGCACGGCCATAGGGCTTTTTCCTGAGGAAATCCGGGCTGGCCTTTCTCCC
GTGGACAAGCTCCGCCTGGTGGAGGAGTTGGCAGGTAGGGGTGGCGTGGCCATGGTGGGGGATGGGGTGAACGACGCCCC
AGCCCTGGCCAGGGCCACGGTAGGGCTTGCCGTGGCCGAGGGCACGGAAGCGGCCCTGCAGAGTGCAGACGTGGGGCTTC
TGAGCCTTGCCGCCTTGCCCCGGGCCTTCCGGCTAAGCCGCCTGACCCTGGGCGTGGTCCGCCAGAACGTGGCCTTGGCG
GTGGGGCTCAAGGGGCTTTTCCTCCTCACCACCTTGGTGGGCCTGACCGGGCTTTGGCCGGCGGTCTTGGCGGACAACGG
CGCTTTGGTCCTGGTGACCCTGAATAGCCTTCGCCTTCTTCGGGCCCGGGTGTGA

Upstream 100 bases:

>100_bases
CGCCTCGCCGACCGGCACGTGGAGGGCCTGTTGGCGGAGGCCCTGGCCCACGCGGAAGAAAACACTTGACCAGTTGCTCA
AATGATGCTACCCTGGGGGC

Downstream 100 bases:

>100_bases
CCTGGCCCTTGACAGGGTCAGGGCCTGGGTCCAGGATGAGGGGCGTGGTCGGCGTCCTAGCCCTACAAGGGGATTTCCGC
GAGCACAAGGAGGCGCTTAA

Product: cation-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MKAPRVRVFRVEGMDCADCALKVEKALSEVPGVVQAQVSFASGKAYLHLEVPGAEKEAERVVSALGYRLKPEGDTTRGVL
GPWRWALVSGGLLLAAFLASLFLPGLAPWGYRLAALIGVFPLARRAVAAFRQNPFSMQTLVTLATLGAMLIGAEAEAAVV
VFLFLVGEVLEAYSVAQARRSLYALSELLPRRAYRLKEGGVEEVPLKALRVGDLVRVPPGERVPADGVVVSGQASVEEAA
FTGEPLPRPKGIGDRVYGGSLVQEGSLVVKVERLPEEGFLAEMERLAEEALLKKSQAERVVDAFSRRYTPAVLALAGFVG
LVLPLFRGDFLGHVYKALGLLLIACPCALVVSVPAAIAAGVGRGARAGVLFKSGAALERLAGVRYVALDKTGTLTLGKPT
LVRVVTFGVSTEEALALAKGVAEGSSHPLARAVREALGPKALPSEEHRAVPGLGAFARVEGKEVGLVRPEAWDLPPEVEA
QVKALAEEGFSLSLLVREGVPLALLAFQDTPRLEAREVLAELRRLGLKPLLLTGDRETSALALGTAIGLFPEEIRAGLSP
VDKLRLVEELAGRGGVAMVGDGVNDAPALARATVGLAVAEGTEAALQSADVGLLSLAALPRAFRLSRLTLGVVRQNVALA
VGLKGLFLLTTLVGLTGLWPAVLADNGALVLVTLNSLRLLRARV

Sequences:

>Translated_684_residues
MKAPRVRVFRVEGMDCADCALKVEKALSEVPGVVQAQVSFASGKAYLHLEVPGAEKEAERVVSALGYRLKPEGDTTRGVL
GPWRWALVSGGLLLAAFLASLFLPGLAPWGYRLAALIGVFPLARRAVAAFRQNPFSMQTLVTLATLGAMLIGAEAEAAVV
VFLFLVGEVLEAYSVAQARRSLYALSELLPRRAYRLKEGGVEEVPLKALRVGDLVRVPPGERVPADGVVVSGQASVEEAA
FTGEPLPRPKGIGDRVYGGSLVQEGSLVVKVERLPEEGFLAEMERLAEEALLKKSQAERVVDAFSRRYTPAVLALAGFVG
LVLPLFRGDFLGHVYKALGLLLIACPCALVVSVPAAIAAGVGRGARAGVLFKSGAALERLAGVRYVALDKTGTLTLGKPT
LVRVVTFGVSTEEALALAKGVAEGSSHPLARAVREALGPKALPSEEHRAVPGLGAFARVEGKEVGLVRPEAWDLPPEVEA
QVKALAEEGFSLSLLVREGVPLALLAFQDTPRLEAREVLAELRRLGLKPLLLTGDRETSALALGTAIGLFPEEIRAGLSP
VDKLRLVEELAGRGGVAMVGDGVNDAPALARATVGLAVAEGTEAALQSADVGLLSLAALPRAFRLSRLTLGVVRQNVALA
VGLKGLFLLTTLVGLTGLWPAVLADNGALVLVTLNSLRLLRARV
>Mature_684_residues
MKAPRVRVFRVEGMDCADCALKVEKALSEVPGVVQAQVSFASGKAYLHLEVPGAEKEAERVVSALGYRLKPEGDTTRGVL
GPWRWALVSGGLLLAAFLASLFLPGLAPWGYRLAALIGVFPLARRAVAAFRQNPFSMQTLVTLATLGAMLIGAEAEAAVV
VFLFLVGEVLEAYSVAQARRSLYALSELLPRRAYRLKEGGVEEVPLKALRVGDLVRVPPGERVPADGVVVSGQASVEEAA
FTGEPLPRPKGIGDRVYGGSLVQEGSLVVKVERLPEEGFLAEMERLAEEALLKKSQAERVVDAFSRRYTPAVLALAGFVG
LVLPLFRGDFLGHVYKALGLLLIACPCALVVSVPAAIAAGVGRGARAGVLFKSGAALERLAGVRYVALDKTGTLTLGKPT
LVRVVTFGVSTEEALALAKGVAEGSSHPLARAVREALGPKALPSEEHRAVPGLGAFARVEGKEVGLVRPEAWDLPPEVEA
QVKALAEEGFSLSLLVREGVPLALLAFQDTPRLEAREVLAELRRLGLKPLLLTGDRETSALALGTAIGLFPEEIRAGLSP
VDKLRLVEELAGRGGVAMVGDGVNDAPALARATVGLAVAEGTEAALQSADVGLLSLAALPRAFRLSRLTLGVVRQNVALA
VGLKGLFLLTTLVGLTGLWPAVLADNGALVLVTLNSLRLLRARV

Specific function: Involved in export of lead, cadmium, zinc and mercury [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=778, Percent_Identity=27.7634961439589, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI115529486, Length=812, Percent_Identity=26.3546798029557, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI55743073, Length=507, Percent_Identity=32.1499013806706, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI48762687, Length=306, Percent_Identity=25.8169934640523, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762689, Length=306, Percent_Identity=25.8169934640523, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762691, Length=306, Percent_Identity=25.8169934640523, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762685, Length=306, Percent_Identity=25.8169934640523, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI83700225, Length=247, Percent_Identity=20.6477732793522, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI22748667, Length=260, Percent_Identity=25, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789879, Length=690, Percent_Identity=41.304347826087, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1786691, Length=715, Percent_Identity=32.4475524475524, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1786914, Length=480, Percent_Identity=30.625, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI2367363, Length=581, Percent_Identity=22.5473321858864, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=572, Percent_Identity=29.1958041958042, Blast_Score=171, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.4074074074074, Blast_Score=213, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6319772, Length=498, Percent_Identity=29.5180722891566, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321430, Length=571, Percent_Identity=27.1453590192644, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325221, Length=576, Percent_Identity=27.0833333333333, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI221329854, Length=558, Percent_Identity=26.5232974910394, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI281366617, Length=250, Percent_Identity=27.2, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24668696, Length=319, Percent_Identity=25.0783699059561, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24668708, Length=250, Percent_Identity=27.2, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668704, Length=250, Percent_Identity=27.2, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161085803, Length=319, Percent_Identity=25.0783699059561, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006404
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 71914; Mature: 71914

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPRVRVFRVEGMDCADCALKVEKALSEVPGVVQAQVSFASGKAYLHLEVPGAEKEAER
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCHHHHHH
VVSALGYRLKPEGDTTRGVLGPWRWALVSGGLLLAAFLASLFLPGLAPWGYRLAALIGVF
HHHHHCCEECCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
PLARRAVAAFRQNPFSMQTLVTLATLGAMLIGAEAEAAVVVFLFLVGEVLEAYSVAQARR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLYALSELLPRRAYRLKEGGVEEVPLKALRVGDLVRVPPGERVPADGVVVSGQASVEEAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCCCCCEEECCCCCHHHHH
FTGEPLPRPKGIGDRVYGGSLVQEGSLVVKVERLPEEGFLAEMERLAEEALLKKSQAERV
CCCCCCCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VDAFSRRYTPAVLALAGFVGLVLPLFRGDFLGHVYKALGLLLIACPCALVVSVPAAIAAG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRGARAGVLFKSGAALERLAGVRYVALDKTGTLTLGKPTLVRVVTFGVSTEEALALAKG
CCCCCCCCEEEECCHHHHHHCCCEEEEECCCCCEEECCCCEEEEEEECCCHHHHHHHHHH
VAEGSSHPLARAVREALGPKALPSEEHRAVPGLGAFARVEGKEVGLVRPEAWDLPPEVEA
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCHHHH
QVKALAEEGFSLSLLVREGVPLALLAFQDTPRLEAREVLAELRRLGLKPLLLTGDRETSA
HHHHHHHCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHH
LALGTAIGLFPEEIRAGLSPVDKLRLVEELAGRGGVAMVGDGVNDAPALARATVGLAVAE
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHEEEC
GTEAALQSADVGLLSLAALPRAFRLSRLTLGVVRQNVALAVGLKGLFLLTTLVGLTGLWP
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AVLADNGALVLVTLNSLRLLRARV
HHHCCCCCEEEEEECHHHHHHHCC
>Mature Secondary Structure
MKAPRVRVFRVEGMDCADCALKVEKALSEVPGVVQAQVSFASGKAYLHLEVPGAEKEAER
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCHHHHHH
VVSALGYRLKPEGDTTRGVLGPWRWALVSGGLLLAAFLASLFLPGLAPWGYRLAALIGVF
HHHHHCCEECCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
PLARRAVAAFRQNPFSMQTLVTLATLGAMLIGAEAEAAVVVFLFLVGEVLEAYSVAQARR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLYALSELLPRRAYRLKEGGVEEVPLKALRVGDLVRVPPGERVPADGVVVSGQASVEEAA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCCCCCEEECCCCCHHHHH
FTGEPLPRPKGIGDRVYGGSLVQEGSLVVKVERLPEEGFLAEMERLAEEALLKKSQAERV
CCCCCCCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VDAFSRRYTPAVLALAGFVGLVLPLFRGDFLGHVYKALGLLLIACPCALVVSVPAAIAAG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRGARAGVLFKSGAALERLAGVRYVALDKTGTLTLGKPTLVRVVTFGVSTEEALALAKG
CCCCCCCCEEEECCHHHHHHCCCEEEEECCCCCEEECCCCEEEEEEECCCHHHHHHHHHH
VAEGSSHPLARAVREALGPKALPSEEHRAVPGLGAFARVEGKEVGLVRPEAWDLPPEVEA
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCHHHH
QVKALAEEGFSLSLLVREGVPLALLAFQDTPRLEAREVLAELRRLGLKPLLLTGDRETSA
HHHHHHHCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHH
LALGTAIGLFPEEIRAGLSPVDKLRLVEELAGRGGVAMVGDGVNDAPALARATVGLAVAE
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHEEEC
GTEAALQSADVGLLSLAALPRAFRLSRLTLGVVRQNVALAVGLKGLFLLTTLVGLTGLWP
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AVLADNGALVLVTLNSLRLLRARV
HHHCCCCCEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 9405611; 9364914; 10660539; 12417201 [H]