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The map label for this gene is gcvT [H]

Identifier: 55980492

GI number: 55980492

Start: 486811

End: 487860

Strand: Direct

Name: gcvT [H]

Synonym: TTHA0523

Alternate gene names: 55980492

Gene position: 486811-487860 (Clockwise)

Preceding gene: 55980491

Following gene: 55980493

Centisome position: 26.32

GC content: 69.81

Gene sequence:

>1050_bases
ATGAAGAAGACCCCCCTTTACGAGGCCCACCTTCGCCTGGGCGCCCGGATGGTGGACTTCGCCGGGTACCTCCTCCCCCT
CCAGTACACCTCCATCGTGGAGGAGCACCTGGCCGTGCGCCGGGCGGTCGGGGTTTTTGACGTGAGCCACATGGGGGAGT
TTCTGGTCCGGGGCAAGGAGGCCCTGGCCTTCCTCCAGTGGGCCACGGCGAACGACGCAGGCAAGCTCAAGGTGGGAAGG
GCCCAGTACTCCATGCTCCCCAACGAGCGGGGCGGGGTGGTGGACGACATCTACCTCTACCGCCTGGGGGAAGAGGAGTA
CCTCATGGTGGTGAACGCCGCCAACATCGCCAAGGACCTCGCCCACCTCCAGGCCTTGGCCAAGGGGTTCAGGGTGGAGC
TTGAGGACGCCTCCGAAAGGACCGCCCTCCTCGCCCTCCAGGGCCCGAAGGCGGCCTCCCTCCTCCAGGGGCTTACCGAT
CTGGACCTTTCCCAGAAGCGCAAGAACGACGTCTTCCCCGCCCGGGTGGCGGGCCGGCCCGCCCGCCTCGCCCGCACGGG
GTACACGGGGGAGGACGGGTTTGAGCTCTTCCTCGCCCCGGAGGACGCCGAGCCCGTCTTTCTGGCCCTGGTGGAGGCCG
GGGCCAAGCCCGCGGGCCTCGGGGCCCGGGACTCCTTGAGGCTCGAGGCGGGCTTCCCCCTCTACGGCCACGAGCTCACC
GAGGAGACCAACCCCCTCTGCACCCCCTGGGCCTGGGTGGTGAAGAAGGAAAAGGCGTTTTTGGGCAAGGAGGCCATGCT
GGCCCAGGCCTGCCGGGAGCGCCTCGTGGGCCTCGTTCTGGAAGGGGGCATCCCCCGGGAGGGCTACCGGGTGCTCTCTG
GGGGCCGCCCCGTGGGCCGGGTGACGAGCGGCGGGTATTCGCCCCTGCTGCAGAGGGGCATCGCCCTCGCCTACGTGGAG
GAAGGGGCGGAGGGGCCTTTCCAGGTGGAGGTCCGGGGCCGGGCGGTCCCCGCCGCCCTTAGCCCCCTCCCCTTTGTGCC
GCTAAAATAG

Upstream 100 bases:

>100_bases
CTTCCCTTTCCCCGCCTGGGCCACCAAGAGGGAGGAGGTCCTGGAGGACAACTCCGCCGAGGCCCTGCGCCGGGAGTTCT
TCAGGTAGGATGGCCTCGCC

Downstream 100 bases:

>100_bases
CGGGGGTTGGGAGGCGCTATGGACATACCCAAGGACCGCTTCTATACCAAGACCCACGAGTGGGCCCTGCCCGAAGGCGA
CACGGTGCTCGTCGGCATCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGKEALAFLQWATANDAGKLKVGR
AQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDLAHLQALAKGFRVELEDASERTALLALQGPKAASLLQGLTD
LDLSQKRKNDVFPARVAGRPARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELT
EETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGRPVGRVTSGGYSPLLQRGIALAYVE
EGAEGPFQVEVRGRAVPAALSPLPFVPLK

Sequences:

>Translated_349_residues
MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGKEALAFLQWATANDAGKLKVGR
AQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDLAHLQALAKGFRVELEDASERTALLALQGPKAASLLQGLTD
LDLSQKRKNDVFPARVAGRPARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELT
EETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGRPVGRVTSGGYSPLLQRGIALAYVE
EGAEGPFQVEVRGRAVPAALSPLPFVPLK
>Mature_349_residues
MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGKEALAFLQWATANDAGKLKVGR
AQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDLAHLQALAKGFRVELEDASERTALLALQGPKAASLLQGLTD
LDLSQKRKNDVFPARVAGRPARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELT
EETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGRPVGRVTSGGYSPLLQRGIALAYVE
EGAEGPFQVEVRGRAVPAALSPLPFVPLK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=35.8695652173913, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI257796258, Length=337, Percent_Identity=36.2017804154303, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=33.1506849315069, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI257796256, Length=312, Percent_Identity=34.2948717948718, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=30.952380952381, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI197927446, Length=345, Percent_Identity=28.4057971014493, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI21361378, Length=345, Percent_Identity=28.4057971014493, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI194306651, Length=367, Percent_Identity=27.2479564032698, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1789272, Length=357, Percent_Identity=41.7366946778711, Blast_Score=234, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=37.027027027027, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI32563613, Length=346, Percent_Identity=25.1445086705202, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71994045, Length=350, Percent_Identity=26.5714285714286, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71994052, Length=350, Percent_Identity=26.5714285714286, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=35.7512953367876, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=36.8279569892473, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20130091, Length=325, Percent_Identity=28, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571104, Length=262, Percent_Identity=27.8625954198473, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 37938; Mature: 37938

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALAFLQWATANDAGKLKVGRAQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDL
HHEEEEEECCCCCCCEEECCHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEHHHHHHHH
AHLQALAKGFRVELEDASERTALLALQGPKAASLLQGLTDLDLSQKRKNDVFPARVAGRP
HHHHHHHHCCEEEECCCCCCEEEEEECCCCHHHHHCCHHCCCHHHHHCCCCCCHHHCCCC
ARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELT
HHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHH
EETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGRPVGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCCCCCC
VTSGGYSPLLQRGIALAYVEEGAEGPFQVEVRGRAVPAALSPLPFVPLK
CCCCCCHHHHHCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKTPLYEAHLRLGARMVDFAGYLLPLQYTSIVEEHLAVRRAVGVFDVSHMGEFLVRGKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALAFLQWATANDAGKLKVGRAQYSMLPNERGGVVDDIYLYRLGEEEYLMVVNAANIAKDL
HHEEEEEECCCCCCCEEECCHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEHHHHHHHH
AHLQALAKGFRVELEDASERTALLALQGPKAASLLQGLTDLDLSQKRKNDVFPARVAGRP
HHHHHHHHCCEEEECCCCCCEEEEEECCCCHHHHHCCHHCCCHHHHHCCCCCCHHHCCCC
ARLARTGYTGEDGFELFLAPEDAEPVFLALVEAGAKPAGLGARDSLRLEAGFPLYGHELT
HHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHH
EETNPLCTPWAWVVKKEKAFLGKEAMLAQACRERLVGLVLEGGIPREGYRVLSGGRPVGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCCCCCC
VTSGGYSPLLQRGIALAYVEEGAEGPFQVEVRGRAVPAALSPLPFVPLK
CCCCCCHHHHHCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA