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The map label for this gene is hom [H]

Identifier: 55980458

GI number: 55980458

Start: 457462

End: 458460

Strand: Direct

Name: hom [H]

Synonym: TTHA0489

Alternate gene names: 55980458

Gene position: 457462-458460 (Clockwise)

Preceding gene: 55980454

Following gene: 55980459

Centisome position: 24.73

GC content: 71.47

Gene sequence:

>999_bases
ATGGAGGCCTTAAAGATCGCCCTCTTGGGGGGCGGCACCGTGGGGAGCGCCTTCTACAACCTCGTGTTGGAGCGGGCGGA
GGAGCTTTCCGCCTTCGGGGTCGTCCCCCGTTTCCTCGGCGTCTTGGTGCGGGACCCGAGGAAGCCCAGGGCCATCCCCC
AGGAACTTCTTCGCGCCGAGCCCTTTGACCTCCTGGAGGCCGACCTGGTGGTGGAGGCCATGGGGGGGGTGGAGGCCCCC
CTTAGGCTCGTCCTCCCCGCCCTCGAGGCCGGCATCCCCCTCATCACCGCCAACAAGGCCCTCCTCGCCGAGGCCTGGGA
GTCCTTAAGGCCCTTCGCCGAGGAGGGGCTCATCTACCACGAGGCGAGCGTCATGGCGGGCACCCCCGCCCTCTCCTTCC
TGGAGACCCTGAGGGGAAGCGAGCTTCTGGAGCTCCACGGCATCCTGAACGGCACCACCCTCTACATCCTCCAGGAGATG
GAGAAGGGCCGGACCTACGCCGAGGCGCTTCTTGAGGCCCAGCGCCTGGGCTACGCCGAGGCCGACCCCACCTTGGACGT
GGAGGGGATAGACGCCGCCCACAAGCTCACCCTCCTCGCCCGGCTCCTCGTGGACCCCGGCTTCCCCTTCGCCGAGGTGG
AGGCCCAAGGCATCGCCCGCCTCACCCCAGAGGTCCTGCAAAAGGCCGAGGCCCGGGGGGAGCGGGTGCGCCTCGTGGCG
AGCCTCTTCGGGGAAGGGGGGAGGTGGCGGGCGGCGGTGGCCCCAAGGCGCCTTCCCCAGGACCACCCCTTGGCGAGGGC
CCGGGGAAACGCCCTCTGGGTCCGGGCCAGGCCTTTGGGGGAGGCCTTCGTCACGGGGCCTGGGGCGGGGGGCGGGGCCA
CGGCGAGCGGGCTTTTCGCCGACCTCCTCCGCTTCCTCTCCGGGGCCCCGGGGCACCTCCCTGCCCCCCGGGCGAGGCCC
CCTTTGGAGGAGGGAAGCCCCTGGCCGGGGGTAGAATGA

Upstream 100 bases:

>100_bases
GAGGCGGGAGAGGTGGGTCTTGGCCTGGTGCACGGTGAAGGCCTTCACGGACTTAGCTTAGCGAGCTTAGCTAACAAAGC
GCAAGGGGTATAATCCCCCC

Downstream 100 bases:

>100_bases
GGGCGTGCCCCTTCTGGACCTTCTGCGCCCCGTGAGCGATGAGGAGCTCCGCGTCCTTTCCGAGAGAAACCCGGGCTGGC
AGTTTGAGCGCTTGGCCGAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAEPFDLLEADLVVEAMGGVEAP
LRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYHEASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEM
EKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA
SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFADLLRFLSGAPGHLPAPRARP
PLEEGSPWPGVE

Sequences:

>Translated_332_residues
MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAEPFDLLEADLVVEAMGGVEAP
LRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYHEASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEM
EKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA
SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFADLLRFLSGAPGHLPAPRARP
PLEEGSPWPGVE
>Mature_332_residues
MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAEPFDLLEADLVVEAMGGVEAP
LRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYHEASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEM
EKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA
SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFADLLRFLSGAPGHLPAPRARP
PLEEGSPWPGVE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=255, Percent_Identity=31.7647058823529, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=27.1708683473389, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 35492; Mature: 35492

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAE
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PFDLLEADLVVEAMGGVEAPLRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCHHHCCCEEE
EASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEMEKGRTYAEALLEAQRLGYAE
ECHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
ADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCHHHHHHHHHCCHHHHHHH
SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFA
HHHCCCCCEEEECCCCCCCCCCCHHHHCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHH
DLLRFLSGAPGHLPAPRARPPLEEGSPWPGVE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAE
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PFDLLEADLVVEAMGGVEAPLRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCHHHCCCEEE
EASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEMEKGRTYAEALLEAQRLGYAE
ECHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
ADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCHHHHHHHHHCCHHHHHHH
SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFA
HHHCCCCCEEEECCCCCCCCCCCHHHHCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHH
DLLRFLSGAPGHLPAPRARPPLEEGSPWPGVE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]