Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 55980401

GI number: 55980401

Start: 407202

End: 408683

Strand: Direct

Name: guaB [H]

Synonym: TTHA0432

Alternate gene names: 55980401

Gene position: 407202-408683 (Clockwise)

Preceding gene: 55980399

Following gene: 55980403

Centisome position: 22.01

GC content: 68.56

Gene sequence:

>1482_bases
ATGGACGAGGGGAAGATCCTCTACGAGGGGCTCACCTTTGACGACGTGTTGCTCCTTCCCGACTACTCCGAGGTCCTGCC
CAAGGAGGTTTCCGTCAGGACGCGGCTCACCAAGCGCCTTTTCCTCAACATCCCCATCCTCTCCGCCGCCATGGACACGG
TGACCGAGGCGGAGATGGCCATCGCCATGGCCCGGGAGGGGGGGCTTGGGGTCATCCACAAGAACCTCTCCATTGAGGCC
CAGGCGGCCATGGTGCGCAAGGTGAAGCGCTCCGAGGCGGGGATGATCCAGGACCCCGTGACCCTCCCCCCCACGGCCAC
CCTGGAGGACGCCGAGCGCCTCATGCGGGAGTACCGCATCGGGGGGCTACCCGTGGTGGACGTGTACGGGAGGCTTCTGG
GCCTGGTGACGAACCGCGACCTCCGCTTTGAGCGGGACCTCAAGCGGCCCGTGACCGAGGTCATGACCCCGGTGGAGCGC
CTCGTCACCGCCCGCCCCGGCACCACCCTGGAGGAGGCGGAGGAGCTCCTCAGGCGGCACAAGGTGGAGAAGCTCCCCCT
GGTGGACGAGTCGGGGAGGCTCAAGGGGCTCATCACCCTGAAGGACATCGTCAAGCGGCGCCAGTACCCGAACGCCGTCA
AGGACGCCCAGGGAAGGCTCCTCGTGGGGGCGGCGGTGGGGGCCTCCAAGGACCTTCCCGAAAGGGCCCAGGCCCTGGTG
GAGGCGGGGGTGGACGTCCTCGTCTTGGACTCCGCCCACGGCCACTCCAAGGGGATCCTGGAGGCCCTCGCCTACCTCAA
GGAGACCTTCGGCGAGAGGGTGGAGGTCATCGCCGGGAACGTGGCCACCCGAGAAGGGGCGAGGGCCCTGGCCGAGCGGG
GGGCGGACGCGGTGAAGGTGGGGATCGGCCCCGGCTCCATCTGCACCACCCGGGTGGTCACGGGGGTGGGGGTGCCCCAG
ATCACGGCCATCCTCGAGGCGGTGGCGGGGGTTAAGGACCTGGACGTGCCCGTGATCGCCGACGGGGGGATCAAGTACAC
GGGGGACGTGGCCAAGGCCATCGCCGCCGGGGCCCACGCGGTGATGCTCGGCAGCATGCTGGCGGGCACGGACGAGGCCC
CGGGGGAGGAGGTCTTAAAGGACGGGCGCCGCTACAAGCTCTACCGGGGCATGGGCTCCCTGGGGGCCATGAAGCAGGGC
TCCGCCGACCGCTACTTCCAGGATCCCGAAAAAGGGGAGACCGAGGCCAAGAAGCTCGTTCCCGAGGGGATTGAGGGAAT
GGTGCCCTACAAAGGCCCCGTGGCCGATGTCCTCTACCAGATCGTGGGGGGCTTGCGGAGCGCCATGGGGTACGTGGGGG
CGCCGGACATTGAGACCTTCCGCAAGAAGGCCCGCTTCGTGCGCATGACCATGGCGGGGCTCATTGAGAGCCACCCCCAC
GACGTGGTGGTGGTCAAGGAGGCCCCCAACTACTCCCGCTAA

Upstream 100 bases:

>100_bases
GCCCACGGGCGCCCCTGTCTTTGCCCGGAGGATACCCGGCCAACATGAGAAATGCGTAACGAGGTGGACCGCCGCCCGGG
GAAGGCTTACCCTAGAGAGT

Downstream 100 bases:

>100_bases
TCCCCGAAGAGGCGGCGGAAGGCCTCCGCGCTCCCCTTCTTCCGGGCGGGGCGGTAGACGCCCTCCTTCTCCTCCAAAAG
CCCCTCCGCCACCAGGGCCT

Product: IMP dehydrogenase/GMP reductase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDEGKILYEGLTFDDVLLLPDYSEVLPKEVSVRTRLTKRLFLNIPILSAAMDTVTEAEMAIAMAREGGLGVIHKNLSIEA
QAAMVRKVKRSEAGMIQDPVTLPPTATLEDAERLMREYRIGGLPVVDVYGRLLGLVTNRDLRFERDLKRPVTEVMTPVER
LVTARPGTTLEEAEELLRRHKVEKLPLVDESGRLKGLITLKDIVKRRQYPNAVKDAQGRLLVGAAVGASKDLPERAQALV
EAGVDVLVLDSAHGHSKGILEALAYLKETFGERVEVIAGNVATREGARALAERGADAVKVGIGPGSICTTRVVTGVGVPQ
ITAILEAVAGVKDLDVPVIADGGIKYTGDVAKAIAAGAHAVMLGSMLAGTDEAPGEEVLKDGRRYKLYRGMGSLGAMKQG
SADRYFQDPEKGETEAKKLVPEGIEGMVPYKGPVADVLYQIVGGLRSAMGYVGAPDIETFRKKARFVRMTMAGLIESHPH
DVVVVKEAPNYSR

Sequences:

>Translated_493_residues
MDEGKILYEGLTFDDVLLLPDYSEVLPKEVSVRTRLTKRLFLNIPILSAAMDTVTEAEMAIAMAREGGLGVIHKNLSIEA
QAAMVRKVKRSEAGMIQDPVTLPPTATLEDAERLMREYRIGGLPVVDVYGRLLGLVTNRDLRFERDLKRPVTEVMTPVER
LVTARPGTTLEEAEELLRRHKVEKLPLVDESGRLKGLITLKDIVKRRQYPNAVKDAQGRLLVGAAVGASKDLPERAQALV
EAGVDVLVLDSAHGHSKGILEALAYLKETFGERVEVIAGNVATREGARALAERGADAVKVGIGPGSICTTRVVTGVGVPQ
ITAILEAVAGVKDLDVPVIADGGIKYTGDVAKAIAAGAHAVMLGSMLAGTDEAPGEEVLKDGRRYKLYRGMGSLGAMKQG
SADRYFQDPEKGETEAKKLVPEGIEGMVPYKGPVADVLYQIVGGLRSAMGYVGAPDIETFRKKARFVRMTMAGLIESHPH
DVVVVKEAPNYSR
>Mature_493_residues
MDEGKILYEGLTFDDVLLLPDYSEVLPKEVSVRTRLTKRLFLNIPILSAAMDTVTEAEMAIAMAREGGLGVIHKNLSIEA
QAAMVRKVKRSEAGMIQDPVTLPPTATLEDAERLMREYRIGGLPVVDVYGRLLGLVTNRDLRFERDLKRPVTEVMTPVER
LVTARPGTTLEEAEELLRRHKVEKLPLVDESGRLKGLITLKDIVKRRQYPNAVKDAQGRLLVGAAVGASKDLPERAQALV
EAGVDVLVLDSAHGHSKGILEALAYLKETFGERVEVIAGNVATREGARALAERGADAVKVGIGPGSICTTRVVTGVGVPQ
ITAILEAVAGVKDLDVPVIADGGIKYTGDVAKAIAAGAHAVMLGSMLAGTDEAPGEEVLKDGRRYKLYRGMGSLGAMKQG
SADRYFQDPEKGETEAKKLVPEGIEGMVPYKGPVADVLYQIVGGLRSAMGYVGAPDIETFRKKARFVRMTMAGLIESHPH
DVVVVKEAPNYSR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=484, Percent_Identity=41.3223140495868, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI156616279, Length=484, Percent_Identity=41.3223140495868, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI34328928, Length=484, Percent_Identity=41.3223140495868, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI34328930, Length=484, Percent_Identity=41.3223140495868, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI66933016, Length=487, Percent_Identity=41.4784394250513, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI217035152, Length=478, Percent_Identity=41.2133891213389, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI217035148, Length=484, Percent_Identity=40.2892561983471, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI217035150, Length=484, Percent_Identity=38.4297520661157, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI50541956, Length=271, Percent_Identity=38.3763837638376, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541954, Length=270, Percent_Identity=38.5185185185185, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=270, Percent_Identity=38.5185185185185, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=270, Percent_Identity=38.5185185185185, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=39.4422310756972, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=56.8788501026694, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786293, Length=262, Percent_Identity=37.0229007633588, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=502, Percent_Identity=37.0517928286853, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=40.6175771971496, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=226, Percent_Identity=40.2654867256637, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=488, Percent_Identity=40.5737704918033, Blast_Score=352, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.9590163934426, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=488, Percent_Identity=40.1639344262295, Blast_Score=339, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=340, Percent_Identity=41.4705882352941, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=138, Percent_Identity=34.0579710144928, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=42.9158110882957, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=42.9158110882957, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=42.9213483146067, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53173; Mature: 53173

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEGKILYEGLTFDDVLLLPDYSEVLPKEVSVRTRLTKRLFLNIPILSAAMDTVTEAEMA
CCCCCEEEECCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IAMAREGGLGVIHKNLSIEAQAAMVRKVKRSEAGMIQDPVTLPPTATLEDAERLMREYRI
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGLPVVDVYGRLLGLVTNRDLRFERDLKRPVTEVMTPVERLVTARPGTTLEEAEELLRRH
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KVEKLPLVDESGRLKGLITLKDIVKRRQYPNAVKDAQGRLLVGAAVGASKDLPERAQALV
CHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHH
EAGVDVLVLDSAHGHSKGILEALAYLKETFGERVEVIAGNVATREGARALAERGADAVKV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVTGVGVPQITAILEAVAGVKDLDVPVIADGGIKYTGDVAKAIAAGAHA
ECCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCEEECHHHHHHHHHCHHH
VMLGSMLAGTDEAPGEEVLKDGRRYKLYRGMGSLGAMKQGSADRYFQDPEKGETEAKKLV
HHHHHHHCCCCCCCCHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
PEGIEGMVPYKGPVADVLYQIVGGLRSAMGYVGAPDIETFRKKARFVRMTMAGLIESHPH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVVVKEAPNYSR
CEEEEECCCCCCC
>Mature Secondary Structure
MDEGKILYEGLTFDDVLLLPDYSEVLPKEVSVRTRLTKRLFLNIPILSAAMDTVTEAEMA
CCCCCEEEECCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IAMAREGGLGVIHKNLSIEAQAAMVRKVKRSEAGMIQDPVTLPPTATLEDAERLMREYRI
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGLPVVDVYGRLLGLVTNRDLRFERDLKRPVTEVMTPVERLVTARPGTTLEEAEELLRRH
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
KVEKLPLVDESGRLKGLITLKDIVKRRQYPNAVKDAQGRLLVGAAVGASKDLPERAQALV
CHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCHHHHHHHH
EAGVDVLVLDSAHGHSKGILEALAYLKETFGERVEVIAGNVATREGARALAERGADAVKV
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVTGVGVPQITAILEAVAGVKDLDVPVIADGGIKYTGDVAKAIAAGAHA
ECCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCEEECHHHHHHHHHCHHH
VMLGSMLAGTDEAPGEEVLKDGRRYKLYRGMGSLGAMKQGSADRYFQDPEKGETEAKKLV
HHHHHHHCCCCCCCCHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
PEGIEGMVPYKGPVADVLYQIVGGLRSAMGYVGAPDIETFRKKARFVRMTMAGLIESHPH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVVVKEAPNYSR
CEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]