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The map label for this gene is hisB [H]

Identifier: 55980398

GI number: 55980398

Start: 404870

End: 405454

Strand: Direct

Name: hisB [H]

Synonym: TTHA0429

Alternate gene names: 55980398

Gene position: 404870-405454 (Clockwise)

Preceding gene: 55980397

Following gene: 55980399

Centisome position: 21.89

GC content: 70.94

Gene sequence:

>585_bases
ATGCGTGAGGCCACGGTGGAAAGGGCCACGGCCGAGACCTGGGTGTGGCTCCGCCTTGGCCTGGACGGGCCCACCGGGGG
GAAGGTGGACACGGGCCTCCCCTTCCTGGACCACATGCTTCTCCAGCTCCAGCGCCACGGCCGCTTCCTCCTGGAGGTGG
AGGCCAGGGGGGACCTCGAGGTGGACGTGCACCACCTGGTGGAGGACGTGGGCATCGCCCTGGGGATGGCCCTGAAGGAG
GCCCTGGGGGACGGGGTGGGGCTGGAGCGCTACGCCGAGGCCTTCGCCCCCATGGACGAGACCCTGGTGCTCTGCGTCTT
GGACCTCTCGGGAAGGCCCCACCTGGAGTTCCGCCCCGAGGCCTGGCCCGTGGTGGGGGAGGCGGGCGGGGTGAACCACT
ACCACCTCCGGGAGTTCCTGCGGGGCCTGGTGAACCACGGGCGGCTCACCCTCCACCTGAGGCTCCTTTCCGGAAGGGAG
GCGCACCACGTGGTGGAGGCGAGCTTTAAGGCTTTGGCCCGGGCCCTCCACAAGGCGACCCGGCGCACGGGGGAGGGGGT
CCCCAGCACCAAAGGGGTGCTTTGA

Upstream 100 bases:

>100_bases
CGGCAGGACCGCTATCCGGGGCTTGCGGGGTGCCTCCGGGTGACCGTGGGCCGGAGGGAGGAGATGGACGCCTTCCTTAG
GGCGGCCTTCGGGGTGGCCT

Downstream 100 bases:

>100_bases
TGCCACCCCATGCTGGCTTGCGCCAGCATGGGGGCCCCGGCAAAAGCTCCCTGAGGGAGCCTCCCCGGGCCAGTCGGACG
AAGGAAACCGGATGATGCCC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLEVDVHHLVEDVGIALGMALKE
ALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPEAWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGRE
AHHVVEASFKALARALHKATRRTGEGVPSTKGVL

Sequences:

>Translated_194_residues
MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLEVDVHHLVEDVGIALGMALKE
ALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPEAWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGRE
AHHVVEASFKALARALHKATRRTGEGVPSTKGVL
>Mature_194_residues
MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLEVDVHHLVEDVGIALGMALKE
ALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPEAWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGRE
AHHVVEASFKALARALHKATRRTGEGVPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=45.5958549222798, Blast_Score=155, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324776, Length=195, Percent_Identity=42.0512820512821, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21392; Mature: 21392

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLE
CCCCHHHHHHHCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
VDVHHLVEDVGIALGMALKEALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEECCC
AWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGREAHHVVEASFKALARALHKAT
CCCEECCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RRTGEGVPSTKGVL
HHCCCCCCCCCCCC
>Mature Secondary Structure
MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLE
CCCCHHHHHHHCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
VDVHHLVEDVGIALGMALKEALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEECCC
AWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGREAHHVVEASFKALARALHKAT
CCCEECCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RRTGEGVPSTKGVL
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA