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The map label for this gene is hisC [H]

Identifier: 55980397

GI number: 55980397

Start: 403834

End: 404877

Strand: Direct

Name: hisC [H]

Synonym: TTHA0428

Alternate gene names: 55980397

Gene position: 403834-404877 (Clockwise)

Preceding gene: 55980394

Following gene: 55980398

Centisome position: 21.83

GC content: 69.73

Gene sequence:

>1044_bases
ATGCGGGCCTTCAAGGCGCACCTCCGGGGCCTTAGCCCTTACCCCTACAAGAAGGAGGAGGCCCCGGTGAAGTTGGACCA
GAACGAAAGCCCCTTTGACCTCCCCGGGGCGCTTAAGGAGGAGGCCTTGGGGCGCCTTAGGGCCATCCCCTGGAACCGCT
ACCCGGAGATCCACGCCGAAAGCCTGCGGAAGAGGCTTTCCGCCCTTCTGGACTGGCCCGAGGAGGGGATCGTCCTTGCT
CCCGGCTCCAACCTCCTGATCCTCGCCCTGAGCCTGGCGGCGGAGGAGGTCCTGGACCTTAGGCCCTCCTTCCCCCACTA
CGCCCACGCCGCCAAGGTGGCGGGGACGCCCTACCGGGCGGTGCCCCTCGGGGAAGGGTTCTCCCTGGACCTCAAGGCCC
TCCTCGCCGCCTTTAGGGGCGGGGTTCTCTTCCTTCCCAACCCCCACGCCCCCACGGGGGCCCTCTTCCCGGAGGAGGCC
CTTCGGGCCCTGGCGGAAAGGGCCAAGGAGGTGGGGGGGCTTTTGGTGGTGGACGAGGCCTACCGGGAGTTTGCCGGGAC
GGACTTCCGCTTCCTCGCCCGGGAAAACCCCCACGTGGCCCTGCTTCGCACCTTCTCCAAGGCCTTCTCCCTGGGGGGGG
TCCGCGCCGGGTACCTCCTGGGAAGCCCGGAGGTGGCGGGGGTGGTGCGGGAGGTGCTGCCCCCCTTCGTCCTCCCCGCC
CACACCGGGGCCGTCCTGGAGGTGGTCTTGGAAAACCCGGGCTACGTGGAGAAGGTGGTGGAGGAGGTGGTGGCCCAGAG
GGAGCGGGTCTACCGGGAGCTCCTCGCCCACCCCACCTGGCGCCCCTACCCGAGCCGCACCAACTTCCTCCTGGTGCGAA
CCCCCGATGCCGAAGAGGCCTTCCGCCACCTCCTTTCCCAGGGCGTCCTGGTGCGTCGGCAGGACCGCTATCCGGGGCTT
GCGGGGTGCCTCCGGGTGACCGTGGGCCGGAGGGAGGAGATGGACGCCTTCCTTAGGGCGGCCTTCGGGGTGGCCTATGC
GTGA

Upstream 100 bases:

>100_bases
GGCGTTCCGGGCGATCTCGGCCGTCTCCAGGTCCTTCTCCGCCTGGAGGAGCCAGTCCCGGGCCCGGTTCATGCCCTGAG
TTTACCGCTATACTCGGGGC

Downstream 100 bases:

>100_bases
GGCCACGGTGGAAAGGGCCACGGCCGAGACCTGGGTGTGGCTCCGCCTTGGCCTGGACGGGCCCACCGGGGGGAAGGTGG
ACACGGGCCTCCCCTTCCTG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRAFKAHLRGLSPYPYKKEEAPVKLDQNESPFDLPGALKEEALGRLRAIPWNRYPEIHAESLRKRLSALLDWPEEGIVLA
PGSNLLILALSLAAEEVLDLRPSFPHYAHAAKVAGTPYRAVPLGEGFSLDLKALLAAFRGGVLFLPNPHAPTGALFPEEA
LRALAERAKEVGGLLVVDEAYREFAGTDFRFLARENPHVALLRTFSKAFSLGGVRAGYLLGSPEVAGVVREVLPPFVLPA
HTGAVLEVVLENPGYVEKVVEEVVAQRERVYRELLAHPTWRPYPSRTNFLLVRTPDAEEAFRHLLSQGVLVRRQDRYPGL
AGCLRVTVGRREEMDAFLRAAFGVAYA

Sequences:

>Translated_347_residues
MRAFKAHLRGLSPYPYKKEEAPVKLDQNESPFDLPGALKEEALGRLRAIPWNRYPEIHAESLRKRLSALLDWPEEGIVLA
PGSNLLILALSLAAEEVLDLRPSFPHYAHAAKVAGTPYRAVPLGEGFSLDLKALLAAFRGGVLFLPNPHAPTGALFPEEA
LRALAERAKEVGGLLVVDEAYREFAGTDFRFLARENPHVALLRTFSKAFSLGGVRAGYLLGSPEVAGVVREVLPPFVLPA
HTGAVLEVVLENPGYVEKVVEEVVAQRERVYRELLAHPTWRPYPSRTNFLLVRTPDAEEAFRHLLSQGVLVRRQDRYPGL
AGCLRVTVGRREEMDAFLRAAFGVAYA
>Mature_347_residues
MRAFKAHLRGLSPYPYKKEEAPVKLDQNESPFDLPGALKEEALGRLRAIPWNRYPEIHAESLRKRLSALLDWPEEGIVLA
PGSNLLILALSLAAEEVLDLRPSFPHYAHAAKVAGTPYRAVPLGEGFSLDLKALLAAFRGGVLFLPNPHAPTGALFPEEA
LRALAERAKEVGGLLVVDEAYREFAGTDFRFLARENPHVALLRTFSKAFSLGGVRAGYLLGSPEVAGVVREVLPPFVLPA
HTGAVLEVVLENPGYVEKVVEEVVAQRERVYRELLAHPTWRPYPSRTNFLLVRTPDAEEAFRHLLSQGVLVRRQDRYPGL
AGCLRVTVGRREEMDAFLRAAFGVAYA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=350, Percent_Identity=30.2857142857143, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322075, Length=333, Percent_Identity=27.027027027027, Blast_Score=99, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38379; Mature: 38379

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFKAHLRGLSPYPYKKEEAPVKLDQNESPFDLPGALKEEALGRLRAIPWNRYPEIHAE
CCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHH
SLRKRLSALLDWPEEGIVLAPGSNLLILALSLAAEEVLDLRPSFPHYAHAAKVAGTPYRA
HHHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEE
VPLGEGFSLDLKALLAAFRGGVLFLPNPHAPTGALFPEEALRALAERAKEVGGLLVVDEA
EECCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHH
YREFAGTDFRFLARENPHVALLRTFSKAFSLGGVRAGYLLGSPEVAGVVREVLPPFVLPA
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECEEECCHHHHHHHHHHCCCCEECC
HTGAVLEVVLENPGYVEKVVEEVVAQRERVYRELLAHPTWRPYPSRTNFLLVRTPDAEEA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
FRHLLSQGVLVRRQDRYPGLAGCLRVTVGRREEMDAFLRAAFGVAYA
HHHHHHCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAFKAHLRGLSPYPYKKEEAPVKLDQNESPFDLPGALKEEALGRLRAIPWNRYPEIHAE
CCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHH
SLRKRLSALLDWPEEGIVLAPGSNLLILALSLAAEEVLDLRPSFPHYAHAAKVAGTPYRA
HHHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEE
VPLGEGFSLDLKALLAAFRGGVLFLPNPHAPTGALFPEEALRALAERAKEVGGLLVVDEA
EECCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEHHH
YREFAGTDFRFLARENPHVALLRTFSKAFSLGGVRAGYLLGSPEVAGVVREVLPPFVLPA
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECEEECCHHHHHHHHHHCCCCEECC
HTGAVLEVVLENPGYVEKVVEEVVAQRERVYRELLAHPTWRPYPSRTNFLLVRTPDAEEA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHH
FRHLLSQGVLVRRQDRYPGLAGCLRVTVGRREEMDAFLRAAFGVAYA
HHHHHHCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]