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The map label for this gene is ybdR [H]

Identifier: 55980369

GI number: 55980369

Start: 379402

End: 380436

Strand: Reverse

Name: ybdR [H]

Synonym: TTHA0400

Alternate gene names: 55980369

Gene position: 380436-379402 (Counterclockwise)

Preceding gene: 55980370

Following gene: 55980368

Centisome position: 20.57

GC content: 71.88

Gene sequence:

>1035_bases
ATGAGGGCCGTGGTCTACAAGGGGCCCTTCCAGGTGGCGGTGGAGGAGGTTCCGGAACCCAGGTTGGAAGCGGACACGGA
CGCCCTCCTCGAGGTGGAGCTTTCCGCCATCTGCGGCTCCGACCTCCACATCTACCACGGCAAGATCGCCGGGGTCCTGC
CGGGGACGGTCCTCGGGCACGAGTTCGTGGGGCGCATCGTGGAGAAGGGCCCCCTGGTGCCCTTCCCCGTGGGGGAGCGG
GTGGTGGGAAGCTTCCAGGTGGCCTGCGGGGAGTGCCCTGCCTGCCGCAAGGGCCAGTTCTTCGCCTGCTCAAGGGGCGG
GGTCTTCGGCTTCGGCCTCGCCCTGGGCAACCTCCCGGGGGCCCAGGCGGAGAGGGTGCGGGTGCCCTTCGCCCGGCACA
CCCTCTTCCCCATCGGGGACCTCCCCGCCGAGGAGGCCATCCTCGCCGGGGACATCCTCACCACGGCCTACGGGGGGGTG
AGGCCCTTCCTCACCCCCGGCATGAGCGTGGCCGTGGTGGGCTCGGGGCCCGTGGGCCTCATGGCCCAGATGGTGGCCCA
CGCCCTGGGGGCAGGGCAGGTCTATGCCATAGACCCGGAGGAAGCCCGCCTAGAGAAGGCCAAGGCCCTGGGAAGCCTCC
CCATCCACCCCAAGGCGGAGGACCCCGTGGCCCGGGTGCGCCGGGAGACCGAGGGCCTGGGGGCGGATTTGGTGGTGGAG
GCGGTGGGCGGGGACGGGGAGGCCCTGAAGCTCGCCCTGCGCCTCGCGGGCCCGGGGGGCGTGGTCTCCAGCCTTGGGGT
GCCCACGGCGGAAAGGCTGGACTACCCCTGGCTTCCCGCCTTCAGCCGGGGGATCACCCTAAGGAGTGCCCTCGCCAACG
TCCCCCGCTGGATCGGCGAGGTCCTCGCCCTGCAGAAGGCGGGCAGGCTCAAGGGGAGCTTCGTCTTCAGCCACCGCCTC
CCCCTGGAGGAGGCCCCCGAAGGCTACCGCCTCTTCCACGAGCGGAAGGCCACCAAGGTCGCCCTCGTGCCCTGA

Upstream 100 bases:

>100_bases
TCATGCGGGGACTTTTGGAGCTCAAGAAGGGCACCATCGCCGCCCTCGCCCCTTACGCCCAGGCGGCCCAGGAGCTCGTC
AAAGTGGCCCGGGAGGTGGC

Downstream 100 bases:

>100_bases
GGCTTCTTTGTCCGCTGACTCCTTCATTCTACCACGGCTTGCTCCCTTGCAAAGGGGTATGCAAAAAGCCGCGGGCCTTA
CGGGGTTTTCCGGCGGCGCG

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRAVVYKGPFQVAVEEVPEPRLEADTDALLEVELSAICGSDLHIYHGKIAGVLPGTVLGHEFVGRIVEKGPLVPFPVGER
VVGSFQVACGECPACRKGQFFACSRGGVFGFGLALGNLPGAQAERVRVPFARHTLFPIGDLPAEEAILAGDILTTAYGGV
RPFLTPGMSVAVVGSGPVGLMAQMVAHALGAGQVYAIDPEEARLEKAKALGSLPIHPKAEDPVARVRRETEGLGADLVVE
AVGGDGEALKLALRLAGPGGVVSSLGVPTAERLDYPWLPAFSRGITLRSALANVPRWIGEVLALQKAGRLKGSFVFSHRL
PLEEAPEGYRLFHERKATKVALVP

Sequences:

>Translated_344_residues
MRAVVYKGPFQVAVEEVPEPRLEADTDALLEVELSAICGSDLHIYHGKIAGVLPGTVLGHEFVGRIVEKGPLVPFPVGER
VVGSFQVACGECPACRKGQFFACSRGGVFGFGLALGNLPGAQAERVRVPFARHTLFPIGDLPAEEAILAGDILTTAYGGV
RPFLTPGMSVAVVGSGPVGLMAQMVAHALGAGQVYAIDPEEARLEKAKALGSLPIHPKAEDPVARVRRETEGLGADLVVE
AVGGDGEALKLALRLAGPGGVVSSLGVPTAERLDYPWLPAFSRGITLRSALANVPRWIGEVLALQKAGRLKGSFVFSHRL
PLEEAPEGYRLFHERKATKVALVP
>Mature_344_residues
MRAVVYKGPFQVAVEEVPEPRLEADTDALLEVELSAICGSDLHIYHGKIAGVLPGTVLGHEFVGRIVEKGPLVPFPVGER
VVGSFQVACGECPACRKGQFFACSRGGVFGFGLALGNLPGAQAERVRVPFARHTLFPIGDLPAEEAILAGDILTTAYGGV
RPFLTPGMSVAVVGSGPVGLMAQMVAHALGAGQVYAIDPEEARLEKAKALGSLPIHPKAEDPVARVRRETEGLGADLVVE
AVGGDGEALKLALRLAGPGGVVSSLGVPTAERLDYPWLPAFSRGITLRSALANVPRWIGEVLALQKAGRLKGSFVFSHRL
PLEEAPEGYRLFHERKATKVALVP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=24.8663101604278, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=25.5494505494505, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=25.5494505494505, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=25.201072386059, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=358, Percent_Identity=25.4189944134078, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=35.8247422680412, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=28.9473684210526, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=27.9279279279279, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=26.4437689969605, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=28.4883720930233, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787863, Length=345, Percent_Identity=26.9565217391304, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=25.7396449704142, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=211, Percent_Identity=30.3317535545024, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=27.0114942528736, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=331, Percent_Identity=25.0755287009063, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=248, Percent_Identity=28.6290322580645, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=25.7971014492754, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=345, Percent_Identity=25.7971014492754, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=27.8985507246377, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=318, Percent_Identity=27.6729559748428, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=337, Percent_Identity=25.8160237388724, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=26.5486725663717, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 36236; Mature: 36236

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVYKGPFQVAVEEVPEPRLEADTDALLEVELSAICGSDLHIYHGKIAGVLPGTVLGH
CCEEEECCCHHHHHHHCCCCCCCCCCCHHEEEEEHHHCCCCEEEEECEECCCCCCHHHHH
EFVGRIVEKGPLVPFPVGERVVGSFQVACGECPACRKGQFFACSRGGVFGFGLALGNLPG
HHHHHHHHCCCCCCCCCCCHHHHHEEEECCCCCCCCCCCEEEECCCCEEEEHHHHCCCCC
AQAERVRVPFARHTLFPIGDLPAEEAILAGDILTTAYGGVRPFLTPGMSVAVVGSGPVGL
CCCCEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
MAQMVAHALGAGQVYAIDPEEARLEKAKALGSLPIHPKAEDPVARVRRETEGLGADLVVE
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
AVGGDGEALKLALRLAGPGGVVSSLGVPTAERLDYPWLPAFSRGITLRSALANVPRWIGE
ECCCCCCEEEEEEEECCCCCHHHHCCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHH
VLALQKAGRLKGSFVFSHRLPLEEAPEGYRLFHERKATKVALVP
HHHHHHCCCCCCEEEEEECCCHHHCCCHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MRAVVYKGPFQVAVEEVPEPRLEADTDALLEVELSAICGSDLHIYHGKIAGVLPGTVLGH
CCEEEECCCHHHHHHHCCCCCCCCCCCHHEEEEEHHHCCCCEEEEECEECCCCCCHHHHH
EFVGRIVEKGPLVPFPVGERVVGSFQVACGECPACRKGQFFACSRGGVFGFGLALGNLPG
HHHHHHHHCCCCCCCCCCCHHHHHEEEECCCCCCCCCCCEEEECCCCEEEEHHHHCCCCC
AQAERVRVPFARHTLFPIGDLPAEEAILAGDILTTAYGGVRPFLTPGMSVAVVGSGPVGL
CCCCEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
MAQMVAHALGAGQVYAIDPEEARLEKAKALGSLPIHPKAEDPVARVRRETEGLGADLVVE
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEE
AVGGDGEALKLALRLAGPGGVVSSLGVPTAERLDYPWLPAFSRGITLRSALANVPRWIGE
ECCCCCCEEEEEEEECCCCCHHHHCCCCCHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHH
VLALQKAGRLKGSFVFSHRLPLEEAPEGYRLFHERKATKVALVP
HHHHHHCCCCCCEEEEEECCCHHHCCCHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]