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The map label for this gene is hemC

Identifier: 55980314

GI number: 55980314

Start: 326557

End: 327462

Strand: Reverse

Name: hemC

Synonym: TTHA0345

Alternate gene names: 55980314

Gene position: 327462-326557 (Counterclockwise)

Preceding gene: 55980315

Following gene: 55980313

Centisome position: 17.7

GC content: 71.52

Gene sequence:

>906_bases
ATGCGCGTCGTCGTGGTGGGAACCCGGGGGAGCGCCCTGGCCCTGGCCCAGACCCGCTTCGTGGTGGAGAGGCTCAAGGA
GACCTGGCCCGAGACGGAGTTCAAGATCCGCACGATTAAGACCCGGGGGGACCAGGGGGCGAGCCCGAGGGAGGAGGCCA
TCTTCGTCAAGGAGATCCAGGAGGCCCTGCTCTCCCGGGAGATTGACATCGCCGTTCACTCCCTCAAGGACCTGCCCACC
GAGTCGCCCCGGGGGCTCAAGATCGCCTCCGTGCCCCGGCGGCAGGACCCCCGGGACGTCTTCCTGGGCAAGGCGGCCAA
GCGCCTCAAGGACCTCCCCCCGGGGGCGGTGGTGGGGACGAGCTCCGTGCGCCGCAAGGCCCAGATCCTCGCCCTGAGGC
CGGACCTCGTGGTGCGGGACCTCCGGGGCAACGTGGACACCCGGCTCGCCGCTTTGGGCAACGGGGAGTACGACGGCATC
GTCCTCGCGGCGGCGGGGCTCATCCGCCTGGACCTCAGGAACCGCATTGACGAGTTCCTGGACCCCGGCGAGGTGCTCCC
CGCCCCCGGCCAGGGGGCCTTGGCCCTGGAGGTGCGGGAAGGGGACGACCTGGCCGAGGAGCTCTGCTACGCCCTGCACC
ACCCCCCCTCCTACCACCGGGTCCGGGCGGAGCGGGCTTTCCTTAGGGGCCTTGGGGCCGGGTGCCTGGCCCCCGTGGGG
GCCCTCGCCCACGTGGAGGAGGACGGGACGCTGCGGCTTGAGGGGGTCCTCCTCACCCCGGACGGGAAGAGCTTCATCCG
GGCGGAGATTGAGGGGGATGTTTCCGAGGCCGAGGAACTGGGGCTGGACCTGGCCCGGGACGTCCTGGAGCAGGGCGGGC
GGGAGATCCTCGCCCAAATCCGATAG

Upstream 100 bases:

>100_bases
CGAGGCCACCCCCGAGGAACTCCTGCACGGCCACGCCCACTAAGGGCGCAGAAAGGGCAGGGCCCCGGCCTTCGCCGGGG
CTTTTGTAGTATGGGGTGGT

Downstream 100 bases:

>100_bases
GTTTACTGGAGTTTTGCTCCCCCGTGGGGTATAGTGGGGGTGATGGCGCTGAAGCGTCTTACCCGCCAGCGCAAGGCCAT
CCTCGAGGTGGTGCGGCAGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQEALLSREIDIAVHSLKDLPT
ESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGTSSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGI
VLAAAGLIRLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVG
ALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQIR

Sequences:

>Translated_301_residues
MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQEALLSREIDIAVHSLKDLPT
ESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGTSSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGI
VLAAAGLIRLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVG
ALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQIR
>Mature_301_residues
MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQEALLSREIDIAVHSLKDLPT
ESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGTSSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGI
VLAAAGLIRLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVG
ALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQIR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=335, Percent_Identity=38.8059701492537, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI66933009, Length=335, Percent_Identity=38.8059701492537, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI48994974, Length=304, Percent_Identity=44.4078947368421, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319996, Length=315, Percent_Identity=34.6031746031746, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI20130425, Length=318, Percent_Identity=37.4213836477987, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_THET2 (Q72H57)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005607.1
- ProteinModelPortal:   Q72H57
- SMR:   Q72H57
- STRING:   Q72H57
- GeneID:   2775906
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q72H57
- ProtClustDB:   PRK00072
- BioCyc:   TTHE262724:TT_C1638-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 32822; Mature: 32822

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQ
CEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
EALLSREIDIAVHSLKDLPTESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGT
HHHHHCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEECC
SSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGIVLAAAGLIRLDLRNRIDEFL
HHHHHHHHEEEECCCHHHHHHCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHC
DPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVG
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQI
HHHEECCCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHHCHHHHHHHHHHCCHHHHHHC
R
C
>Mature Secondary Structure
MRVVVVGTRGSALALAQTRFVVERLKETWPETEFKIRTIKTRGDQGASPREEAIFVKEIQ
CEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
EALLSREIDIAVHSLKDLPTESPRGLKIASVPRRQDPRDVFLGKAAKRLKDLPPGAVVGT
HHHHHCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEECC
SSVRRKAQILALRPDLVVRDLRGNVDTRLAALGNGEYDGIVLAAAGLIRLDLRNRIDEFL
HHHHHHHHEEEECCCHHHHHHCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHC
DPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFLRGLGAGCLAPVG
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVSEAEELGLDLARDVLEQGGREILAQI
HHHEECCCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHHCHHHHHHHHHHCCHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA