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The map label for this gene is fmt [H]

Identifier: 55980289

GI number: 55980289

Start: 308668

End: 309585

Strand: Reverse

Name: fmt [H]

Synonym: TTHA0320

Alternate gene names: 55980289

Gene position: 309585-308668 (Counterclockwise)

Preceding gene: 55980290

Following gene: 55980288

Centisome position: 16.74

GC content: 74.4

Gene sequence:

>918_bases
ATGAGGGTGGCCTTCTTCGGCACCCCCCTCTGGGCCGTCCCCGTGCTGGACGCCCTACGGAAGCGCCACCAGGTGGTCCT
GGTGGTCTCCCAGCCCGACAAGCCCCAGGGCCGGGGCCTGAGGCCCGCCCCGAGCCCCGTGGCCCGCTACGCCGAGGCGG
AGGGGCTTCCCCTTTTGCGCCCGGCTCGGCTTAGGGAGGAGGCCTTCCTCGAGGCCTTGCGCCAGGCCGCGCCCGAGGTG
GCGGTGGTGGCGGCCTACGGGAAGCTCATCCCCAAGGAGGCCTTGGACATCCCCCCACACGGCTTCCTCAACCTCCACCC
CTCCCTCCTCCCCAAGTACCGGGGGGCGGCCCCCGTCCAGCGGGCCCTCCTCGCCGGGGAACGGGAGACCGGGGTCTCCA
TCATGCGCCTGGACGAGGGCCTGGACACCGGCCCCCTCTACGCCGTCTGGCGGACGCCCATCCTGCCGGACGAGGACGCC
GTGGCCCTGGGGAACCGGCTCAGGGACAAGGGGGTGGAGCTCCTTCTTGAGGTGCTGGAGCGCCTCCCGGAGCTCACCCC
CAGGCCCCAGGAAGGGGAGGCCTCCTACGCCCCGCCCCTTTCCAAGGAGGAGGGACGGCTGGACTTCGGGGAGAGCGCCG
AGGCCCTCTACCGCCGCCACCGGGCCGTCCAGCCCTGGCCCGGGAGCTACTTCTTCCACCGGGGCCAGCGGGTCAAGGCC
TTGAGGCTCCGCCCCGAGCCCGGGGAAGGGGAGCCCGGGGTGGTGGCCCGGGTGGGGCCGGAGGGCGTGGTGGTGGGCAC
GGCCTCGGGCCTCCTCCTCCTCCTGGAGGTCCAGCCCGAGGGAAGGCGGGCCATGCCCGCCGCCGACTGGGCCCGGGGCT
ATGGCGTGGCCCCGGGGACCCGGCTCGGCCAGGTATAG

Upstream 100 bases:

>100_bases
TGCCCAAGCCCAAGCGGGAGGCCTTCCTGGAGGCCAACCGGGCGGAGCTCGTCCGCTTCCAGAAGGAGGCCCGGGCCTTG
CTGAAGGAGCTTTCCCAGGG

Downstream 100 bases:

>100_bases
TCAGGTAGATGCGCTTCCTCGTCCTCACGGGCCTCTCCGGGGCGGGCAAGACCACGGCCCGGGGTTTTCTGGAGGACCTC
GGCTACTTCATGGTGGACAA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRVAFFGTPLWAVPVLDALRKRHQVVLVVSQPDKPQGRGLRPAPSPVARYAEAEGLPLLRPARLREEAFLEALRQAAPEV
AVVAAYGKLIPKEALDIPPHGFLNLHPSLLPKYRGAAPVQRALLAGERETGVSIMRLDEGLDTGPLYAVWRTPILPDEDA
VALGNRLRDKGVELLLEVLERLPELTPRPQEGEASYAPPLSKEEGRLDFGESAEALYRRHRAVQPWPGSYFFHRGQRVKA
LRLRPEPGEGEPGVVARVGPEGVVVGTASGLLLLLEVQPEGRRAMPAADWARGYGVAPGTRLGQV

Sequences:

>Translated_305_residues
MRVAFFGTPLWAVPVLDALRKRHQVVLVVSQPDKPQGRGLRPAPSPVARYAEAEGLPLLRPARLREEAFLEALRQAAPEV
AVVAAYGKLIPKEALDIPPHGFLNLHPSLLPKYRGAAPVQRALLAGERETGVSIMRLDEGLDTGPLYAVWRTPILPDEDA
VALGNRLRDKGVELLLEVLERLPELTPRPQEGEASYAPPLSKEEGRLDFGESAEALYRRHRAVQPWPGSYFFHRGQRVKA
LRLRPEPGEGEPGVVARVGPEGVVVGTASGLLLLLEVQPEGRRAMPAADWARGYGVAPGTRLGQV
>Mature_305_residues
MRVAFFGTPLWAVPVLDALRKRHQVVLVVSQPDKPQGRGLRPAPSPVARYAEAEGLPLLRPARLREEAFLEALRQAAPEV
AVVAAYGKLIPKEALDIPPHGFLNLHPSLLPKYRGAAPVQRALLAGERETGVSIMRLDEGLDTGPLYAVWRTPILPDEDA
VALGNRLRDKGVELLLEVLERLPELTPRPQEGEASYAPPLSKEEGRLDFGESAEALYRRHRAVQPWPGSYFFHRGQRVKA
LRLRPEPGEGEPGVVARVGPEGVVVGTASGLLLLLEVQPEGRRAMPAADWARGYGVAPGTRLGQV

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=317, Percent_Identity=29.3375394321767, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI238814322, Length=313, Percent_Identity=29.7124600638978, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=33.0508474576271, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=40.9677419354839, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788589, Length=288, Percent_Identity=30.2083333333333, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI133930964, Length=326, Percent_Identity=27.9141104294479, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=351, Percent_Identity=28.4900284900285, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45550868, Length=304, Percent_Identity=31.9078947368421, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=33.920704845815, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585660, Length=242, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24582400, Length=67, Percent_Identity=46.2686567164179, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33296; Mature: 33296

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAFFGTPLWAVPVLDALRKRHQVVLVVSQPDKPQGRGLRPAPSPVARYAEAEGLPLLR
CEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
PARLREEAFLEALRQAAPEVAVVAAYGKLIPKEALDIPPHGFLNLHPSLLPKYRGAAPVQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHCCCCCCCCEECCHHHHHHCCCCHHHH
RALLAGERETGVSIMRLDEGLDTGPLYAVWRTPILPDEDAVALGNRLRDKGVELLLEVLE
HHHHCCCHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RLPELTPRPQEGEASYAPPLSKEEGRLDFGESAEALYRRHRAVQPWPGSYFFHRGQRVKA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCEEEE
LRLRPEPGEGEPGVVARVGPEGVVVGTASGLLLLLEVQPEGRRAMPAADWARGYGVAPGT
EEECCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCC
RLGQV
CCCCC
>Mature Secondary Structure
MRVAFFGTPLWAVPVLDALRKRHQVVLVVSQPDKPQGRGLRPAPSPVARYAEAEGLPLLR
CEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
PARLREEAFLEALRQAAPEVAVVAAYGKLIPKEALDIPPHGFLNLHPSLLPKYRGAAPVQ
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHCCCCCCCCEECCHHHHHHCCCCHHHH
RALLAGERETGVSIMRLDEGLDTGPLYAVWRTPILPDEDAVALGNRLRDKGVELLLEVLE
HHHHCCCHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RLPELTPRPQEGEASYAPPLSKEEGRLDFGESAEALYRRHRAVQPWPGSYFFHRGQRVKA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCEEEE
LRLRPEPGEGEPGVVARVGPEGVVVGTASGLLLLLEVQPEGRRAMPAADWARGYGVAPGT
EEECCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCC
RLGQV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA