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The map label for this gene is caaA

Identifier: 55980281

GI number: 55980281

Start: 299755

End: 302130

Strand: Direct

Name: caaA

Synonym: TTHA0312

Alternate gene names: 55980281

Gene position: 299755-302130 (Clockwise)

Preceding gene: 55980280

Following gene: 55980282

Centisome position: 16.21

GC content: 64.56

Gene sequence:

>2376_bases
ATGGCGATCACGGCAAAGCCGAAAGCGGGCGTTTGGGCGGTCCTTTGGGACCTGCTCACTACGGTGGACCACAAGAAGAT
CGGCCTCATGTACACGGCCACGGCCTTCTTCGCCTTCGCCCTGGCGGGGGTCTTCTCCCTCCTCATCCGCACCCAGCTGG
CCGTGCCCAACAACCAGTTCCTCACCGGGGAGCAGTACAACCAGATCCTCACCCTGCACGGGGCCACCATGCTCTTCTTC
TTCATCATCCAGGCCGGGCTCACCGGCTTCGGTAACTTCGTGGTGCCCCTGATGCTGGGGGCGCGGGACGTGGCCCTCCC
CCGGGTGAACGCCTTCAGCTACTGGGCCTTCTTGGGGGCCATCGTCCTCGCCCTCATGAGCTACTTCTTCCCCGGCGGGG
CCCCCAGCGTAGGCTGGACCTTCTACTACCCCTTCTCCGCCCAGTCGGAAAGCGGGGTGGACTTCTACCTGGCGGCCATC
CTCCTTCTGGGCTTCTCCAGCCTCCTTGGTAACGCCAACTTCGTGGCCACCATCTACAACCTCCGGGCCCAGGGGATGAG
CCTCTGGAAGATGCCCATCTACGTCTGGAGCGTCTTCGCCGCCAGCGTCCTCAACCTCTTCTCCCTGGCGGGGCTCACCG
CAGCCACCCTCCTGGTGCTTCTGGAGCGGAAGATCGGCCTCTCCTGGTTCAACCCGGCCGTGGGCGGGGACCCCGTTCTC
TTCCAGCAGTTCTTCTGGTTCTACTCCCACCCCACGGTCTACGTGATGCTCCTCCCCTACCTCGGCATCCTCGCCGAGGT
GGCCTCCACCTTCGCCCGGAAGCCCCTCTTCGGCTACCGGCAGATGGTCTGGGCCCAGATGGGGATCGTGGTCCTGGGGA
CCATGGTCTGGGCCCACCACATGTTCACCGTGGGCGAGTCCACCCTCTTCCAGATCGCCTTCGCCTTCTTCACCGCCCTC
ATCGCCGTGCCCACGGGGGTCAAGCTCTTCAACATCATCGGCACCCTCTGGGGCGGGAAGCTGCAGATGAAGACCCCCCT
CTACTGGGTTTTGGGCTTCATCTTCAACTTCCTCCTCGGGGGGATCACCGGGGTCATGCTCTCCATGACCCCCCTGGACT
ACCAGTTCCACGACTCCTACTTCGTGGTGGCCCACTTCCACAACGTCCTCATGGCGGGCTCCGGCTTCGGGGCCTTCGCC
GGCCTTTACTACTGGTGGCCCAAGATGACGGGCCGGATGTACGACGAGAGGCTGGGCCGGCTCCACTTCTGGCTCTTCCT
CGTGGGCTACCTCCTCACCTTCCTGCCCCAGTACGCCCTGGGCTACCTGGGGATGCCCCGGCGCTACTACACCTACAACG
CCGACATCGCCGGCTGGCCCGAGCTCAACCTCCTCTCCACCATCGGCGCCTACATCCTGGGCCTGGGCGGGCTGGTCTGG
ATCTACACCATGTGGAAAAGCCTCCGCTCCGGCCCCAAGGCCCCCGACAACCCTTGGGGCGGTTACACCCTGGAGTGGCT
CACCGCCTCGCCTCCCAAGGCCCACAACTTTGACGTGAAGCTTCCCACCGAGTTCCCCTCCGAAAGGCCCCTTTACGACT
GGAAGAAGAAGGGGGTGGAGCTCAAGCCCGAGGACCCGGCCCACATCCACCTGCCCAACAGCTCCTTCTGGCCCTTCTAC
TCGGCAGCCACCCTCTTCGCCTTCTTCGTGGCGGTGGCGGCCCTCCCCGTGCCCAACGTCTGGATGTGGGTCTTCCTCGC
CCTCTTCGCCTACGGCCTGGTGCGCTGGGCCCTGGAGGACGAGTACAGCCACCCGGTGGAGCACCACACCGTCACGGGCA
AATCCAACGCCTGGATGGGGATGGCCTGGTTCATCGTTTCCGAGGTGGGCCTCTTCGCCATCCTCATCGCGGGCTACCTC
TACCTGCGCCTCTCCGGGGCGGCCACGCCCCCTGAGGAAAGGCCCGCCCTGTGGCTTGCCCTCCTCAACACCTTCCTCCT
GGTGAGCTCCTCCTTCACCGTGCACTTCGCCCACCACGACCTCCGCCGGGGCCGGTTCAACCCCTTCCGCTTCGGGCTTC
TCGTCACCATCATTCTCGGCGTCCTCTTCTTCCTGGTGCAGTCCTGGGAGTTCTACCAGTTCTACCACCACTCCAGCTGG
CAGGAGAACCTCTGGACCGCGGCCTTCTTCACCATCGTGGGCCTCCACGGCCTGCACGTGGTGATCGGAGGCTTCGGCCT
GATCCTCGCTTACCTCCAGGCCCTAAGGGGCAAGATCACCCTCCATAACCACGGCACCCTCGAGGCCGCCAGCATGTACT
GGCACCTGGTGGACGCCGTCTGGCTGGTGATCGTCACCATCTTCTACGTCTGGTAG

Upstream 100 bases:

>100_bases
CTCCGAGGAGGACCTGGACGCTCTGGTGCGCTACCTGGAGGGGCTCAAGGTGGAGGGGTTTGACTTCGGGGCCCTGCCCA
AGTTCTAAGGGAGGTGCGGG

Downstream 100 bases:

>100_bases
TCAAGAAGGCCGCAAAGCCCCCCGCTTAGGCGGGGGGCTTTGCTATGAAAAGGGAAGGGATGCGGCTTTTGGTGGTGGAC
TTTGACTACTTCTTCCCCGT

Product: cytochrome Caa3 oxidase subunit I

Products: NA

Alternate protein names: Cytochrome c aa(3) subunit 1; A-protein; Cytochrome caa3

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MAITAKPKAGVWAVLWDLLTTVDHKKIGLMYTATAFFAFALAGVFSLLIRTQLAVPNNQFLTGEQYNQILTLHGATMLFF
FIIQAGLTGFGNFVVPLMLGARDVALPRVNAFSYWAFLGAIVLALMSYFFPGGAPSVGWTFYYPFSAQSESGVDFYLAAI
LLLGFSSLLGNANFVATIYNLRAQGMSLWKMPIYVWSVFAASVLNLFSLAGLTAATLLVLLERKIGLSWFNPAVGGDPVL
FQQFFWFYSHPTVYVMLLPYLGILAEVASTFARKPLFGYRQMVWAQMGIVVLGTMVWAHHMFTVGESTLFQIAFAFFTAL
IAVPTGVKLFNIIGTLWGGKLQMKTPLYWVLGFIFNFLLGGITGVMLSMTPLDYQFHDSYFVVAHFHNVLMAGSGFGAFA
GLYYWWPKMTGRMYDERLGRLHFWLFLVGYLLTFLPQYALGYLGMPRRYYTYNADIAGWPELNLLSTIGAYILGLGGLVW
IYTMWKSLRSGPKAPDNPWGGYTLEWLTASPPKAHNFDVKLPTEFPSERPLYDWKKKGVELKPEDPAHIHLPNSSFWPFY
SAATLFAFFVAVAALPVPNVWMWVFLALFAYGLVRWALEDEYSHPVEHHTVTGKSNAWMGMAWFIVSEVGLFAILIAGYL
YLRLSGAATPPEERPALWLALLNTFLLVSSSFTVHFAHHDLRRGRFNPFRFGLLVTIILGVLFFLVQSWEFYQFYHHSSW
QENLWTAAFFTIVGLHGLHVVIGGFGLILAYLQALRGKITLHNHGTLEAASMYWHLVDAVWLVIVTIFYVW

Sequences:

>Translated_791_residues
MAITAKPKAGVWAVLWDLLTTVDHKKIGLMYTATAFFAFALAGVFSLLIRTQLAVPNNQFLTGEQYNQILTLHGATMLFF
FIIQAGLTGFGNFVVPLMLGARDVALPRVNAFSYWAFLGAIVLALMSYFFPGGAPSVGWTFYYPFSAQSESGVDFYLAAI
LLLGFSSLLGNANFVATIYNLRAQGMSLWKMPIYVWSVFAASVLNLFSLAGLTAATLLVLLERKIGLSWFNPAVGGDPVL
FQQFFWFYSHPTVYVMLLPYLGILAEVASTFARKPLFGYRQMVWAQMGIVVLGTMVWAHHMFTVGESTLFQIAFAFFTAL
IAVPTGVKLFNIIGTLWGGKLQMKTPLYWVLGFIFNFLLGGITGVMLSMTPLDYQFHDSYFVVAHFHNVLMAGSGFGAFA
GLYYWWPKMTGRMYDERLGRLHFWLFLVGYLLTFLPQYALGYLGMPRRYYTYNADIAGWPELNLLSTIGAYILGLGGLVW
IYTMWKSLRSGPKAPDNPWGGYTLEWLTASPPKAHNFDVKLPTEFPSERPLYDWKKKGVELKPEDPAHIHLPNSSFWPFY
SAATLFAFFVAVAALPVPNVWMWVFLALFAYGLVRWALEDEYSHPVEHHTVTGKSNAWMGMAWFIVSEVGLFAILIAGYL
YLRLSGAATPPEERPALWLALLNTFLLVSSSFTVHFAHHDLRRGRFNPFRFGLLVTIILGVLFFLVQSWEFYQFYHHSSW
QENLWTAAFFTIVGLHGLHVVIGGFGLILAYLQALRGKITLHNHGTLEAASMYWHLVDAVWLVIVTIFYVW
>Mature_790_residues
AITAKPKAGVWAVLWDLLTTVDHKKIGLMYTATAFFAFALAGVFSLLIRTQLAVPNNQFLTGEQYNQILTLHGATMLFFF
IIQAGLTGFGNFVVPLMLGARDVALPRVNAFSYWAFLGAIVLALMSYFFPGGAPSVGWTFYYPFSAQSESGVDFYLAAIL
LLGFSSLLGNANFVATIYNLRAQGMSLWKMPIYVWSVFAASVLNLFSLAGLTAATLLVLLERKIGLSWFNPAVGGDPVLF
QQFFWFYSHPTVYVMLLPYLGILAEVASTFARKPLFGYRQMVWAQMGIVVLGTMVWAHHMFTVGESTLFQIAFAFFTALI
AVPTGVKLFNIIGTLWGGKLQMKTPLYWVLGFIFNFLLGGITGVMLSMTPLDYQFHDSYFVVAHFHNVLMAGSGFGAFAG
LYYWWPKMTGRMYDERLGRLHFWLFLVGYLLTFLPQYALGYLGMPRRYYTYNADIAGWPELNLLSTIGAYILGLGGLVWI
YTMWKSLRSGPKAPDNPWGGYTLEWLTASPPKAHNFDVKLPTEFPSERPLYDWKKKGVELKPEDPAHIHLPNSSFWPFYS
AATLFAFFVAVAALPVPNVWMWVFLALFAYGLVRWALEDEYSHPVEHHTVTGKSNAWMGMAWFIVSEVGLFAILIAGYLY
LRLSGAATPPEERPALWLALLNTFLLVSSSFTVHFAHHDLRRGRFNPFRFGLLVTIILGVLFFLVQSWEFYQFYHHSSWQ
ENLWTAAFFTIVGLHGLHVVIGGFGLILAYLQALRGKITLHNHGTLEAASMYWHLVDAVWLVIVTIFYVW

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=39.6825396825397, Blast_Score=349, Evalue=7e-96,
Organism=Homo sapiens, GI251831113, Length=192, Percent_Identity=34.375, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1786634, Length=560, Percent_Identity=37.8571428571429, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1786633, Length=192, Percent_Identity=28.6458333333333, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6226519, Length=527, Percent_Identity=38.8994307400379, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=39.937106918239, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6226523, Length=244, Percent_Identity=37.7049180327869, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6226542, Length=191, Percent_Identity=32.4607329842932, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COX13_THET8 (P98005)

Other databases:

- EMBL:   M84341
- EMBL:   AP008226
- PIR:   A46616
- RefSeq:   YP_143578.1
- ProteinModelPortal:   P98005
- STRING:   P98005
- GeneID:   3168081
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0312
- NMPDR:   fig|300852.3.peg.343
- eggNOG:   COG0843
- HOGENOM:   HBG603668
- OMA:   GAPSVGW
- ProtClustDB:   CLSK445695
- BioCyc:   TTHE300852:TTHA0312-MONOMER
- InterPro:   IPR000883
- InterPro:   IPR014241
- InterPro:   IPR000298
- InterPro:   IPR013833
- Gene3D:   G3DSA:1.20.210.10
- Gene3D:   G3DSA:1.20.120.80
- PANTHER:   PTHR10422
- PRINTS:   PR01165
- TIGRFAMs:   TIGR02891

Pfam domain/function: PF00115 COX1; PF00510 COX3; SSF81442 COX1; SSF81452 CytC_oxdse_III

EC number: =1.9.3.1

Molecular weight: Translated: 89215; Mature: 89083

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50855 COX1; PS00077 COX1_CUB; PS50253 COX3

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1295f75c)-; HASH(0x121aa2a8)-; HASH(0x1326d4b8)-; HASH(0x10ebc404)-; HASH(0x130c8a14)-; HASH(0x11e84e40)-; HASH(0x12d4dce0)-; HASH(0x13212700)-; HASH(0xc9e83b0)-; HASH(0x12ab46c4)-; HASH(0xc9e84a0)-; HASH(0x126b30a0)-; HASH(0x12369e0c)-; HASH(0x1315f3f0)-; HASH(0x12d85350)-; HASH(0x11aa36a4)-; HASH(0x1329fc64)-; HASH(0x11c4ab40)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITAKPKAGVWAVLWDLLTTVDHKKIGLMYTATAFFAFALAGVFSLLIRTQLAVPNNQF
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LTGEQYNQILTLHGATMLFFFIIQAGLTGFGNFVVPLMLGARDVALPRVNAFSYWAFLGA
ECCHHHHHEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCCCCHHHHHHHHHH
IVLALMSYFFPGGAPSVGWTFYYPFSAQSESGVDFYLAAILLLGFSSLLGNANFVATIYN
HHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LRAQGMSLWKMPIYVWSVFAASVLNLFSLAGLTAATLLVLLERKIGLSWFNPAVGGDPVL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FQQFFWFYSHPTVYVMLLPYLGILAEVASTFARKPLFGYRQMVWAQMGIVVLGTMVWAHH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
MFTVGESTLFQIAFAFFTALIAVPTGVKLFNIIGTLWGGKLQMKTPLYWVLGFIFNFLLG
HHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
GITGVMLSMTPLDYQFHDSYFVVAHFHNVLMAGSGFGAFAGLYYWWPKMTGRMYDERLGR
HHHHHHHHCCCCCEEECCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHFWLFLVGYLLTFLPQYALGYLGMPRRYYTYNADIAGWPELNLLSTIGAYILGLGGLVW
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
IYTMWKSLRSGPKAPDNPWGGYTLEWLTASPPKAHNFDVKLPTEFPSERPLYDWKKKGVE
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCCCCHHHHCCCC
LKPEDPAHIHLPNSSFWPFYSAATLFAFFVAVAALPVPNVWMWVFLALFAYGLVRWALED
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EYSHPVEHHTVTGKSNAWMGMAWFIVSEVGLFAILIAGYLYLRLSGAATPPEERPALWLA
CCCCCCHHCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHH
LLNTFLLVSSSFTVHFAHHDLRRGRFNPFRFGLLVTIILGVLFFLVQSWEFYQFYHHSSW
HHHHHHHHHCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCH
QENLWTAAFFTIVGLHGLHVVIGGFGLILAYLQALRGKITLHNHGTLEAASMYWHLVDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
WLVIVTIFYVW
HHHHHHHHHCH
>Mature Secondary Structure 
AITAKPKAGVWAVLWDLLTTVDHKKIGLMYTATAFFAFALAGVFSLLIRTQLAVPNNQF
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LTGEQYNQILTLHGATMLFFFIIQAGLTGFGNFVVPLMLGARDVALPRVNAFSYWAFLGA
ECCHHHHHEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCCCCHHHHHHHHHH
IVLALMSYFFPGGAPSVGWTFYYPFSAQSESGVDFYLAAILLLGFSSLLGNANFVATIYN
HHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LRAQGMSLWKMPIYVWSVFAASVLNLFSLAGLTAATLLVLLERKIGLSWFNPAVGGDPVL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FQQFFWFYSHPTVYVMLLPYLGILAEVASTFARKPLFGYRQMVWAQMGIVVLGTMVWAHH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
MFTVGESTLFQIAFAFFTALIAVPTGVKLFNIIGTLWGGKLQMKTPLYWVLGFIFNFLLG
HHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
GITGVMLSMTPLDYQFHDSYFVVAHFHNVLMAGSGFGAFAGLYYWWPKMTGRMYDERLGR
HHHHHHHHCCCCCEEECCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHFWLFLVGYLLTFLPQYALGYLGMPRRYYTYNADIAGWPELNLLSTIGAYILGLGGLVW
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
IYTMWKSLRSGPKAPDNPWGGYTLEWLTASPPKAHNFDVKLPTEFPSERPLYDWKKKGVE
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCCCCHHHHCCCC
LKPEDPAHIHLPNSSFWPFYSAATLFAFFVAVAALPVPNVWMWVFLALFAYGLVRWALED
CCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EYSHPVEHHTVTGKSNAWMGMAWFIVSEVGLFAILIAGYLYLRLSGAATPPEERPALWLA
CCCCCCHHCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHH
LLNTFLLVSSSFTVHFAHHDLRRGRFNPFRFGLLVTIILGVLFFLVQSWEFYQFYHHSSW
HHHHHHHHHCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCH
QENLWTAAFFTIVGLHGLHVVIGGFGLILAYLQALRGKITLHNHGTLEAASMYWHLVDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
WLVIVTIFYVW
HHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8383670; 10338009