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The map label for this gene is nanK [H]

Identifier: 55980268

GI number: 55980268

Start: 288535

End: 289443

Strand: Direct

Name: nanK [H]

Synonym: TTHA0299

Alternate gene names: 55980268

Gene position: 288535-289443 (Clockwise)

Preceding gene: 55980267

Following gene: 55980269

Centisome position: 15.6

GC content: 74.7

Gene sequence:

>909_bases
GTGAAGGTGGTGGGCCTGGACCTGGGCGGCACCAAGATCGCCGCCGGCGTCTTTGACGGAAAGAGGCTCCTCTCCAAGGT
GGTCGTCCCCACGCCCAAGGAGGGCGGGGAGCGGGTGGCCGAGGCCCTGGCCGAGGCCGCGGAGCGGGCGGAGAGGGAGG
CGGGGGTCCGGGGGGAGGCCATCGGCCTGGGGACGCCCGGCCCCCTGGACTTCCGCCGCGGGGTGATCCGCTTCGCCCCC
AACATCCCGGGGGTCCAGGACTTCCCCATCCGCCGGATCCTGGAGGAGGCCACGGGGAGGCCCGTCTTCCTGGAAAACGA
CGCCAACGCCGCCGCTTTGGCCGAGCACCACCTGGGGGCGGCCCAGGGAGAGGAGAGCTCCCTCTACCTCACCGTCTCCA
CGGGGATCGGGGGCGGGGTGGTCCTGGGGGGAAGGGTGCTCCGGGGGGAGCGAGGGCAGGGCGGGGAGCTCGGCCACCTG
ACCCTCCTCCCCGGGGGGCCCGCCTGCGGCTGCGGACTGGAGGGCTGCCTCGAGGCCCTGGCCGCGGGCCGCGCCCTGGA
GCGGGACGCCACCTACGCCTTCCAGCGCCCCGTGGACACGCGGGAGCTCTTCCGCCTCTTCCAGGCAGGGGACCCCAAGG
CGGAGCGCCTCGTCCTCCAGGCCGCCCGGTACGTGGGCATCGGCCTCGCCAGCCTGGTGAAGGCCTTTGACCCCGGGGTG
GTGGTCCTGGGGGGCGGGGTGGCCCTGAACGCCCCCGAGGGGTACTGGGAGGCCCTCCTCGAGGCCTACCGCCGCTACCT
CCAAGGCTGGGAGGCCCCCCCCTTGCGGAGGGCCCGCCTGGGAGCCGAGGCCGGGCTTCTGGGCGCGGCCCTCACCGCCT
ACCTGGAGGTGAAGGATGGAAGCGGGTAA

Upstream 100 bases:

>100_bases
TGCCCGAGGCGGCCACGGGCACCTACATGGGGGACGTGGCCCTGTACGTGCCCGAGGAGGTCCTGGGCGAGGCCGAGGCC
CTTTTGCGGGAGGACGTGCC

Downstream 100 bases:

>100_bases
GGTCCTGGTCTACGCCGGTGCCTTCCTTCTCCTCCTCGGGCTCCTCCTCCTCTACTTCCCCAAGCTCTTCGCCTGGTTCG
GCCACCTGCCCGGGGACATC

Product: glucokinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKVVGLDLGGTKIAAGVFDGKRLLSKVVVPTPKEGGERVAEALAEAAERAEREAGVRGEAIGLGTPGPLDFRRGVIRFAP
NIPGVQDFPIRRILEEATGRPVFLENDANAAALAEHHLGAAQGEESSLYLTVSTGIGGGVVLGGRVLRGERGQGGELGHL
TLLPGGPACGCGLEGCLEALAAGRALERDATYAFQRPVDTRELFRLFQAGDPKAERLVLQAARYVGIGLASLVKAFDPGV
VVLGGGVALNAPEGYWEALLEAYRRYLQGWEAPPLRRARLGAEAGLLGAALTAYLEVKDGSG

Sequences:

>Translated_302_residues
MKVVGLDLGGTKIAAGVFDGKRLLSKVVVPTPKEGGERVAEALAEAAERAEREAGVRGEAIGLGTPGPLDFRRGVIRFAP
NIPGVQDFPIRRILEEATGRPVFLENDANAAALAEHHLGAAQGEESSLYLTVSTGIGGGVVLGGRVLRGERGQGGELGHL
TLLPGGPACGCGLEGCLEALAAGRALERDATYAFQRPVDTRELFRLFQAGDPKAERLVLQAARYVGIGLASLVKAFDPGV
VVLGGGVALNAPEGYWEALLEAYRRYLQGWEAPPLRRARLGAEAGLLGAALTAYLEVKDGSG
>Mature_302_residues
MKVVGLDLGGTKIAAGVFDGKRLLSKVVVPTPKEGGERVAEALAEAAERAEREAGVRGEAIGLGTPGPLDFRRGVIRFAP
NIPGVQDFPIRRILEEATGRPVFLENDANAAALAEHHLGAAQGEESSLYLTVSTGIGGGVVLGGRVLRGERGQGGELGHL
TLLPGGPACGCGLEGCLEALAAGRALERDATYAFQRPVDTRELFRLFQAGDPKAERLVLQAARYVGIGLASLVKAFDPGV
VVLGGGVALNAPEGYWEALLEAYRRYLQGWEAPPLRRARLGAEAGLLGAALTAYLEVKDGSG

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=266, Percent_Identity=29.6992481203008, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI298566325, Length=266, Percent_Identity=29.6992481203008, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI190014632, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4885285, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1787363, Length=311, Percent_Identity=31.8327974276527, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI87081733, Length=301, Percent_Identity=31.8936877076412, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786891, Length=316, Percent_Identity=29.4303797468354, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082230, Length=268, Percent_Identity=35.0746268656716, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787878, Length=242, Percent_Identity=25.2066115702479, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082127, Length=195, Percent_Identity=28.7179487179487, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790522, Length=282, Percent_Identity=28.3687943262411, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.60 [H]

Molecular weight: Translated: 31479; Mature: 31479

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVGLDLGGTKIAAGVFDGKRLLSKVVVPTPKEGGERVAEALAEAAERAEREAGVRGEA
CEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IGLGTPGPLDFRRGVIRFAPNIPGVQDFPIRRILEEATGRPVFLENDANAAALAEHHLGA
EECCCCCCHHHHCCHHEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCC
AQGEESSLYLTVSTGIGGGVVLGGRVLRGERGQGGELGHLTLLPGGPACGCGLEGCLEAL
CCCCCCEEEEEEECCCCCCEEECCEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
AAGRALERDATYAFQRPVDTRELFRLFQAGDPKAERLVLQAARYVGIGLASLVKAFDPGV
HCCCHHHHCCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VVLGGGVALNAPEGYWEALLEAYRRYLQGWEAPPLRRARLGAEAGLLGAALTAYLEVKDG
EEEECCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHEEEEEEECC
SG
CC
>Mature Secondary Structure
MKVVGLDLGGTKIAAGVFDGKRLLSKVVVPTPKEGGERVAEALAEAAERAEREAGVRGEA
CEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IGLGTPGPLDFRRGVIRFAPNIPGVQDFPIRRILEEATGRPVFLENDANAAALAEHHLGA
EECCCCCCHHHHCCHHEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCC
AQGEESSLYLTVSTGIGGGVVLGGRVLRGERGQGGELGHLTLLPGGPACGCGLEGCLEAL
CCCCCCEEEEEEECCCCCCEEECCEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
AAGRALERDATYAFQRPVDTRELFRLFQAGDPKAERLVLQAARYVGIGLASLVKAFDPGV
HCCCHHHHCCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VVLGGGVALNAPEGYWEALLEAYRRYLQGWEAPPLRRARLGAEAGLLGAALTAYLEVKDG
EEEECCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHEEEEEEECC
SG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA