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The map label for this gene is argH [H]

Identifier: 55980252

GI number: 55980252

Start: 270819

End: 272207

Strand: Reverse

Name: argH [H]

Synonym: TTHA0283

Alternate gene names: 55980252

Gene position: 272207-270819 (Counterclockwise)

Preceding gene: 55980253

Following gene: 55980251

Centisome position: 14.72

GC content: 68.25

Gene sequence:

>1389_bases
ATGGCGCATAGGACCTGGGGAGGCCGCTTCGGGGAGGGGCCGGATGCCCTTGCGGCCCGCTTCAACGCCTCCCTTGCCTT
TGACCGGGCCCTTTGGCGGGAGGACCTCTGGCAGAACCGGGTCCACGCCCGCATGCTTCACGCCGTGGGCCTCCTGAGCG
CGGAGGAGCTTGAGGCCATCCTCAAGGGGCTGGACCGGATAGAGGAGGAGATTGAGGCGGGCACCTTCCCCTGGCGGGAG
GAGCTTGAGGACGTCCACATGAACCTCGAGGCCCGCCTTACCGAGCTCGTCGGCCCCCCGGGGGGCAAGCTCCACACCGC
CCGTAGCCGCAACGACCAGGTGGCCACGGACCTGAGGCTTTACCTGCGGGGGGCCATAGACGAGCTCCTGGCCCTTCTCC
TTGCGCTCCGGCGGGTCCTGGTGCGGGAGGCCGAGAAGCACCTGGACCCCCTTTATGTCCTTCCCGGCTACACCCACCTG
CAGCGGGCCCAGCCCGTGCTCCTTGCCCACTGGTTCCTCGCCTACTACGAGATGCTTAAGCGGGACGCAGGGCGCCTGGA
GGACGCCAAAGAGCGCCTCAACGAAAGCCCCCTGGGGGCGGCGGCCCTCGCGGGGACGGGCTTCCCCATAGACCGCCACT
TCACCGCCAGGGAGCTTGGCTTCAAGGCCCCCATGCGGAACTCCCTGGACGCGGTGGCCTCCCGGGACTTCGCCCTGGAG
GTCCTTTCCGCCTTGAACATCGGCATGCTCCACCTCTCCCGCATGGCGGAGGAGCTCATCCTCTACAGCACCGAGGAGTT
CGGCTTCGTGGAGGTGCCCGACGCCTTCGCCACCGGGTCTTCCATCATGCCCCAGAAGAAGAACCCGGACATCCTGGAGC
TCATCCGCGCCAAGGCGGGAAGGGTGCTCGGGGCCTTTGTGGGGCTTTCCGCGGTGGTGAAGGGCCTTCCCCTCGCCTAC
AACAAGGACCTCCAGGAGGACAAGGAGCCCCTTTTGGACGCCCTCGCCACCTACAGGGATAGCCTCAGGCTCCTCGCCGC
CCTCCTCCCCGGGCTCAAGTGGCGCCGGGAGAGGATGTGGCGGGCGGCGGAGGGGGGCTACACCCTCGCCACGGAGCTCG
CCGACTATCTGGCGGAAAAGGGGCTTCCCTTCCGGGAGGCCCACCACGTGGTGGGGAGGCTCGTGCGAAGGCTTGTGGAG
GAGGGGCGGGCCCTTAAGGACCTCACCTTGGAAGAACTCCAGGCCCACCACCCCCTCTTCGCCGAGGACGCCCTTCCCCT
CCTCCGCCTGGAGACCGCCATCCATAGGCGCCGCTCCTATGGCGGCACGGCCCCGGAGGCGGTGCGGGAGAGGCTAGAGG
AGGCCAAGAAGGAGGTGGGGCTTGACTGA

Upstream 100 bases:

>100_bases
TTTGACGAGGCAGGGGGCTACGACCAGAAGGACGCCGAGGGCTTCATCAAGATCCAGGCCCTGCGCCTCCGGGTGCGGGC
CCTTGTGGAGAGGGAGGGCC

Downstream 100 bases:

>100_bases
AGTGAGGGGGCTTTCCCTTTCCCCGGTGGTTCTCCCCGAGGTGCGGCGCGAGGCGGGGGTGGAGCTTAGGAAGGCGCGGC
TAGAGGACGTGGACGCCATC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAHRTWGGRFGEGPDALAARFNASLAFDRALWREDLWQNRVHARMLHAVGLLSAEELEAILKGLDRIEEEIEAGTFPWRE
ELEDVHMNLEARLTELVGPPGGKLHTARSRNDQVATDLRLYLRGAIDELLALLLALRRVLVREAEKHLDPLYVLPGYTHL
QRAQPVLLAHWFLAYYEMLKRDAGRLEDAKERLNESPLGAAALAGTGFPIDRHFTARELGFKAPMRNSLDAVASRDFALE
VLSALNIGMLHLSRMAEELILYSTEEFGFVEVPDAFATGSSIMPQKKNPDILELIRAKAGRVLGAFVGLSAVVKGLPLAY
NKDLQEDKEPLLDALATYRDSLRLLAALLPGLKWRRERMWRAAEGGYTLATELADYLAEKGLPFREAHHVVGRLVRRLVE
EGRALKDLTLEELQAHHPLFAEDALPLLRLETAIHRRRSYGGTAPEAVRERLEEAKKEVGLD

Sequences:

>Translated_462_residues
MAHRTWGGRFGEGPDALAARFNASLAFDRALWREDLWQNRVHARMLHAVGLLSAEELEAILKGLDRIEEEIEAGTFPWRE
ELEDVHMNLEARLTELVGPPGGKLHTARSRNDQVATDLRLYLRGAIDELLALLLALRRVLVREAEKHLDPLYVLPGYTHL
QRAQPVLLAHWFLAYYEMLKRDAGRLEDAKERLNESPLGAAALAGTGFPIDRHFTARELGFKAPMRNSLDAVASRDFALE
VLSALNIGMLHLSRMAEELILYSTEEFGFVEVPDAFATGSSIMPQKKNPDILELIRAKAGRVLGAFVGLSAVVKGLPLAY
NKDLQEDKEPLLDALATYRDSLRLLAALLPGLKWRRERMWRAAEGGYTLATELADYLAEKGLPFREAHHVVGRLVRRLVE
EGRALKDLTLEELQAHHPLFAEDALPLLRLETAIHRRRSYGGTAPEAVRERLEEAKKEVGLD
>Mature_461_residues
AHRTWGGRFGEGPDALAARFNASLAFDRALWREDLWQNRVHARMLHAVGLLSAEELEAILKGLDRIEEEIEAGTFPWREE
LEDVHMNLEARLTELVGPPGGKLHTARSRNDQVATDLRLYLRGAIDELLALLLALRRVLVREAEKHLDPLYVLPGYTHLQ
RAQPVLLAHWFLAYYEMLKRDAGRLEDAKERLNESPLGAAALAGTGFPIDRHFTARELGFKAPMRNSLDAVASRDFALEV
LSALNIGMLHLSRMAEELILYSTEEFGFVEVPDAFATGSSIMPQKKNPDILELIRAKAGRVLGAFVGLSAVVKGLPLAYN
KDLQEDKEPLLDALATYRDSLRLLAALLPGLKWRRERMWRAAEGGYTLATELADYLAEKGLPFREAHHVVGRLVRRLVEE
GRALKDLTLEELQAHHPLFAEDALPLLRLETAIHRRRSYGGTAPEAVRERLEEAKKEVGLD

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=453, Percent_Identity=45.916114790287, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303542, Length=453, Percent_Identity=45.916114790287, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303549, Length=453, Percent_Identity=43.7086092715232, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI68303547, Length=453, Percent_Identity=43.2671081677704, Blast_Score=358, Evalue=7e-99,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=50, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17553882, Length=225, Percent_Identity=31.5555555555556, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32565146, Length=218, Percent_Identity=32.1100917431193, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=44.6854663774403, Blast_Score=376, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=456, Percent_Identity=41.2280701754386, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI78706858, Length=456, Percent_Identity=41.2280701754386, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51915; Mature: 51784

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRTWGGRFGEGPDALAARFNASLAFDRALWREDLWQNRVHARMLHAVGLLSAEELEAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LKGLDRIEEEIEAGTFPWREELEDVHMNLEARLTELVGPPGGKLHTARSRNDQVATDLRL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHH
YLRGAIDELLALLLALRRVLVREAEKHLDPLYVLPGYTHLQRAQPVLLAHWFLAYYEMLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHH
RDAGRLEDAKERLNESPLGAAALAGTGFPIDRHFTARELGFKAPMRNSLDAVASRDFALE
HHHCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
VLSALNIGMLHLSRMAEELILYSTEEFGFVEVPDAFATGSSIMPQKKNPDILELIRAKAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHH
RVLGAFVGLSAVVKGLPLAYNKDLQEDKEPLLDALATYRDSLRLLAALLPGLKWRRERMW
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RAAEGGYTLATELADYLAEKGLPFREAHHVVGRLVRRLVEEGRALKDLTLEELQAHHPLF
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
AEDALPLLRLETAIHRRRSYGGTAPEAVRERLEEAKKEVGLD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHRTWGGRFGEGPDALAARFNASLAFDRALWREDLWQNRVHARMLHAVGLLSAEELEAI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LKGLDRIEEEIEAGTFPWREELEDVHMNLEARLTELVGPPGGKLHTARSRNDQVATDLRL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHH
YLRGAIDELLALLLALRRVLVREAEKHLDPLYVLPGYTHLQRAQPVLLAHWFLAYYEMLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHH
RDAGRLEDAKERLNESPLGAAALAGTGFPIDRHFTARELGFKAPMRNSLDAVASRDFALE
HHHCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
VLSALNIGMLHLSRMAEELILYSTEEFGFVEVPDAFATGSSIMPQKKNPDILELIRAKAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHH
RVLGAFVGLSAVVKGLPLAYNKDLQEDKEPLLDALATYRDSLRLLAALLPGLKWRRERMW
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RAAEGGYTLATELADYLAEKGLPFREAHHVVGRLVRRLVEEGRALKDLTLEELQAHHPLF
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
AEDALPLLRLETAIHRRRSYGGTAPEAVRERLEEAKKEVGLD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA