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The map label for this gene is carA

Identifier: 55980249

GI number: 55980249

Start: 268656

End: 269831

Strand: Reverse

Name: carA

Synonym: TTHA0280

Alternate gene names: 55980249

Gene position: 269831-268656 (Counterclockwise)

Preceding gene: 55980250

Following gene: 55980245

Centisome position: 14.59

GC content: 67.01

Gene sequence:

>1176_bases
ATGGCTGGAGTGAAGGAGCGCGCCGTTTTGGTCCTGGAAGACGGGACCGTCTACCACGGTTACGCCTTCGGCGCCCGGGG
GAAGACGGTGGGGGAGGTGGTCTTCAACACCGCCCAGACCGGCTACCAAGAGATCATGACCGATCCCAGCTACCACGGGC
AGATCGTGGTCATGACCTACCCCCACCAGGGCAACTACGGGGTGAACGTCTACGACATGCAGTCCAACCGCCCCTGGGTG
AGGGGCTTTGTGGCCAAGGAGTTCAGCCGCGTGGCCTCCAACCCCCGGGCCCAGCAGACCATCGGGGAGTTCATGGAGTT
CTACGGGGTGGTGGGGATTGAGGGCATAGACACGAGGGCCCTGGTGCGGAAGATCCGGGAAGGCGGGGTGCTGAAGGGGA
CCATCGCCCACGCGAGCCTCTTCGGCGCCCCCGACCACGCCTTCACCCAGGAGGAGCTCGAGGCCCTGCGCCGGGAGGCC
CAGGCCTGGACGGACATTGACGGCCGGGACATGACCCCCGAGGTCTCCACCCCCCTGCCCTACGCCTGGCCCACCCTGAA
GTCGGGGCGGCGCATCGTGGTCATGGACTTCGGCATCAAGCACGCCATCGTGGAGAACCTGGCCGCCCTCGGCTTTGAGG
TCATCGTGGTCCCCGGGAAGACCCCGGCCCACCAGATCATGGCCTTGGAGCCCCACGGCCTCCTCATCTCCAACGGGCCC
GGCGACCCCACCATGCCCCGCTACGCCCACGAGACCATCTGGAAGCTCATGGGGCTTCTGCCCACCTTCGGCATCTGCCT
GGGGCACCAGCTCTTGGCCCTGGCGGCGGGAGGGCGGACCTTCAAGATGAAGTTCGGCCACCGGGGGGCGAACCACCCGG
TGAAGAACCTGCAGACGGGGAAGATTGAGATCACCAGCCAGAACCACGGCTACGCCGTGGACATTGACTCCCTCAAGGAC
TTCCGCCCCACCCACGTGAACCTGAACGACGGGACCCTCGAGGGCATGGCCCACGCCCGCTACCCCGTCTTCTCCGTCCA
GTACCACCCCGAGGCCGCCCCGGGCCCCCACGATGCCCTCTACCTCTTCCGCCGCTTCCTGGAGGAGGTGGAGGCCTTCC
ACGGGGCCACGGGGCTTCCCGTGGAGAAGCAACGGGCGGACCAGCACGGGATTTAA

Upstream 100 bases:

>100_bases
CGGGGGTCCATCCGCCTGGTCTTGCCCAATCCCACCGAGGGGAGATTGGCGTGGACCTTCTAAAGCGCATCCTGAGGCAA
GCGGGGATAGAGGAGGAGGA

Downstream 100 bases:

>100_bases
AGCGCCTGCTCTTTTTTGACGGGGTCAGCTTACCCCGCCCCCCTAGGGAGAGAAGTCCCGGTTGCCCCCGGAGAGGAGGA
GGGCGAGGGTTTGGGGAAGC

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTYPHQGNYGVNVYDMQSNRPWV
RGFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRALVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREA
QAWTDIDGRDMTPEVSTPLPYAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGP
GDPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTGKIEITSQNHGYAVDIDSLKD
FRPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDALYLFRRFLEEVEAFHGATGLPVEKQRADQHGI

Sequences:

>Translated_391_residues
MAGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTYPHQGNYGVNVYDMQSNRPWV
RGFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRALVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREA
QAWTDIDGRDMTPEVSTPLPYAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGP
GDPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTGKIEITSQNHGYAVDIDSLKD
FRPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDALYLFRRFLEEVEAFHGATGLPVEKQRADQHGI
>Mature_390_residues
AGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTYPHQGNYGVNVYDMQSNRPWVR
GFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRALVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREAQ
AWTDIDGRDMTPEVSTPLPYAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGPG
DPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTGKIEITSQNHGYAVDIDSLKDF
RPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDALYLFRRFLEEVEAFHGATGLPVEKQRADQHGI

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI18105007, Length=392, Percent_Identity=40.0510204081633, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI169790915, Length=390, Percent_Identity=34.6153846153846, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI21361331, Length=390, Percent_Identity=34.6153846153846, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1786215, Length=385, Percent_Identity=44.6753246753247, Blast_Score=318, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI193204318, Length=393, Percent_Identity=36.6412213740458, Blast_Score=241, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322331, Length=404, Percent_Identity=36.6336633663366, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6324878, Length=393, Percent_Identity=37.1501272264631, Blast_Score=240, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24642586, Length=385, Percent_Identity=38.7012987012987, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI45555749, Length=385, Percent_Identity=38.7012987012987, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CARA_THET2 (Q72GZ0)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005675.1
- ProteinModelPortal:   Q72GZ0
- SMR:   Q72GZ0
- STRING:   Q72GZ0
- GeneID:   2775932
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0505
- HOGENOM:   HBG286341
- OMA:   FTYPELG
- PhylomeDB:   Q72GZ0
- ProtClustDB:   PRK12564
- BioCyc:   TTHE262724:TT_C1706-MONOMER
- HAMAP:   MF_01209_B
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- PANTHER:   PTHR11405:SF4
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR01368

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase; SSF52021 CP_synthsmall

EC number: =6.3.5.5

Molecular weight: Translated: 43118; Mature: 42987

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 266-266 ACT_SITE 349-349 ACT_SITE 351-351

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTY
CCCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PHQGNYGVNVYDMQSNRPWVRGFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHH
LVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREAQAWTDIDGRDMTPEVSTPLP
HHHHHHHCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
YAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGP
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEEECCC
GDPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
KIEITSQNHGYAVDIDSLKDFRPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDAL
EEEEEECCCCEEEECCCCCCCCCCEEECCCCHHHCHHHCCCCEEEEEECCCCCCCCHHHH
YLFRRFLEEVEAFHGATGLPVEKQRADQHGI
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
AGVKERAVLVLEDGTVYHGYAFGARGKTVGEVVFNTAQTGYQEIMTDPSYHGQIVVMTY
CCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
PHQGNYGVNVYDMQSNRPWVRGFVAKEFSRVASNPRAQQTIGEFMEFYGVVGIEGIDTRA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHH
LVRKIREGGVLKGTIAHASLFGAPDHAFTQEELEALRREAQAWTDIDGRDMTPEVSTPLP
HHHHHHHCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
YAWPTLKSGRRIVVMDFGIKHAIVENLAALGFEVIVVPGKTPAHQIMALEPHGLLISNGP
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEEECCC
GDPTMPRYAHETIWKLMGLLPTFGICLGHQLLALAAGGRTFKMKFGHRGANHPVKNLQTG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
KIEITSQNHGYAVDIDSLKDFRPTHVNLNDGTLEGMAHARYPVFSVQYHPEAAPGPHDAL
EEEEEECCCCEEEECCCCCCCCCCEEECCCCHHHCHHHCCCCEEEEEECCCCCCCCHHHH
YLFRRFLEEVEAFHGATGLPVEKQRADQHGI
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA