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The map label for this gene is pgi

Identifier: 55980246

GI number: 55980246

Start: 264753

End: 266000

Strand: Direct

Name: pgi

Synonym: TTHA0277

Alternate gene names: 55980246

Gene position: 264753-266000 (Clockwise)

Preceding gene: 55980243

Following gene: 55980247

Centisome position: 14.31

GC content: 70.27

Gene sequence:

>1248_bases
ATGCTCCGGCTGGACACCCGCTTTCTCCCGGGCTTCCCCGAGGCCCTAAGCCGGCACGGCCCCCTCCTGGAAGAGGCCCG
CAGGCGCCTCCTCGCCAAGCGGGGGGAGCCGGGGAGCATGCTCGGCTGGATGGACCTCCCCGAGGACACGGAGACCCTGA
GGGAGGTCCGCCGCTACCGGGAGGCGAACCCCTGGGTGGAGGACTTCGTCCTCATCGGCATCGGGGGAAGCGCCCTGGGG
CCCAAGGCCCTCGAGGCCGCCTTCAACGAGAGCGGGGTGCGCTTCCACTACCTGGACCACGTGGAGCCCGAGCCCATCCT
CAGGCTCCTCCGCACCCTGGACCCCAGGAAGACCCTGGTGAACGCCGTCTCCAAGTCGGGGTCCACGGCGGAGACCCTGG
CGGGCCTCGCCGTCTTCCTGAAGTGGCTTAAAGCGCACCTGGGGGAGGACTGGCGGCGGCACCTCGTGGTGACCACCGAC
CCCAAGGAGGGCCCCTTGCGCGCCTTCGCCGAGCGGGAGGGGCTCAAGGCCTTCGCCATCCCCAAGGAGGTGGGCGGGCG
CTTCTCCGCTCTCTCCCCCGTGGGGCTTCTCCCCCTGGCCTTCGCCGGCGCCGACCTGGACGCCCTCCTCATGGGGGCCC
GTAAGGCCAACGAGACCGCCCTCGCCCCCCTCGAGGAGAGCCTGCCCCTAAAGACCGCCCTCCTCCTCCACCTCCACCGC
CACCTCCCCGTCCACGTCTTCATGGTCTACTCGGAGAGGTTAAGCCACCTCCCCAGCTGGTTCGTCCAGCTCCACGACGA
GTCCTTAGGGAAGGTGGACCGCCAGGGCCAAAGGGTGGGCACCACCGCGGTCCCCGCCCTCGGCCCCAAGGACCAGCACG
CCCAGGTCCAGCTCTTCCGGGAAGGCCCTCTGGACAAGCTCCTCGCCCTGGTCATCCCGGAGGCCCCCCTCGAGGACGTG
GAGATCCCGGAGGTGGAGGGCCTCGAGGCCGCCTCCTACCTCTTCGGCAAGACCCTCTTCCAGCTCCTGAAGGCGGAGGC
CGAGGCCACCTACGAGGCCCTGGCCGAGGCGGGGCAGAGGGTCTACGCCCTCTTCCTCCCCGAGGTCTCCCCCTACGCCG
TGGGCTGGCTCATGCAGCACCTCATGTGGCAGACCGCCTTCCTGGGGGAGCTCTGGGAGGTCAACGCCTTTGACCAGCCC
GGGGTGGAGCTGGGCAAGGTTCTCACCCGCAAGCGGCTTGCGGGGTGA

Upstream 100 bases:

>100_bases
CCGAACAAGGCGTACCTCAAAAGGTGCCTCCAAACGGGCGTGGGCTAGGCCTCAGTCTTCCCCGCCAAGGGGGGTTTGGC
AAGGGTGTAAACTGCACTCC

Downstream 100 bases:

>100_bases
CGGGCTTCCCCTCGCCTCGGACAGGGTATACCCTGGCTTTGGAAGCGTGGAAAGCCGCTCGTGATATCCTGAACGAAGGA
GGCGAGGCATGCAACGTTTG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLRLDTRFLPGFPEALSRHGPLLEEARRRLLAKRGEPGSMLGWMDLPEDTETLREVRRYREANPWVEDFVLIGIGGSALG
PKALEAAFNESGVRFHYLDHVEPEPILRLLRTLDPRKTLVNAVSKSGSTAETLAGLAVFLKWLKAHLGEDWRRHLVVTTD
PKEGPLRAFAEREGLKAFAIPKEVGGRFSALSPVGLLPLAFAGADLDALLMGARKANETALAPLEESLPLKTALLLHLHR
HLPVHVFMVYSERLSHLPSWFVQLHDESLGKVDRQGQRVGTTAVPALGPKDQHAQVQLFREGPLDKLLALVIPEAPLEDV
EIPEVEGLEAASYLFGKTLFQLLKAEAEATYEALAEAGQRVYALFLPEVSPYAVGWLMQHLMWQTAFLGELWEVNAFDQP
GVELGKVLTRKRLAG

Sequences:

>Translated_415_residues
MLRLDTRFLPGFPEALSRHGPLLEEARRRLLAKRGEPGSMLGWMDLPEDTETLREVRRYREANPWVEDFVLIGIGGSALG
PKALEAAFNESGVRFHYLDHVEPEPILRLLRTLDPRKTLVNAVSKSGSTAETLAGLAVFLKWLKAHLGEDWRRHLVVTTD
PKEGPLRAFAEREGLKAFAIPKEVGGRFSALSPVGLLPLAFAGADLDALLMGARKANETALAPLEESLPLKTALLLHLHR
HLPVHVFMVYSERLSHLPSWFVQLHDESLGKVDRQGQRVGTTAVPALGPKDQHAQVQLFREGPLDKLLALVIPEAPLEDV
EIPEVEGLEAASYLFGKTLFQLLKAEAEATYEALAEAGQRVYALFLPEVSPYAVGWLMQHLMWQTAFLGELWEVNAFDQP
GVELGKVLTRKRLAG
>Mature_415_residues
MLRLDTRFLPGFPEALSRHGPLLEEARRRLLAKRGEPGSMLGWMDLPEDTETLREVRRYREANPWVEDFVLIGIGGSALG
PKALEAAFNESGVRFHYLDHVEPEPILRLLRTLDPRKTLVNAVSKSGSTAETLAGLAVFLKWLKAHLGEDWRRHLVVTTD
PKEGPLRAFAEREGLKAFAIPKEVGGRFSALSPVGLLPLAFAGADLDALLMGARKANETALAPLEESLPLKTALLLHLHR
HLPVHVFMVYSERLSHLPSWFVQLHDESLGKVDRQGQRVGTTAVPALGPKDQHAQVQLFREGPLDKLLALVIPEAPLEDV
EIPEVEGLEAASYLFGKTLFQLLKAEAEATYEALAEAGQRVYALFLPEVSPYAVGWLMQHLMWQTAFLGELWEVNAFDQP
GVELGKVLTRKRLAG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Escherichia coli, GI1790457, Length=408, Percent_Identity=25.9803921568627, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996703, Length=386, Percent_Identity=27.4611398963731, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71996708, Length=386, Percent_Identity=27.4611398963731, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319673, Length=403, Percent_Identity=26.7990074441687, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24651916, Length=377, Percent_Identity=26.525198938992, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24651914, Length=377, Percent_Identity=26.525198938992, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17737445, Length=377, Percent_Identity=26.525198938992, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_THET8 (Q5SLL6)

Other databases:

- EMBL:   AP008226
- RefSeq:   YP_143543.1
- PDB:   1ZZG
- PDBsum:   1ZZG
- ProteinModelPortal:   Q5SLL6
- SMR:   Q5SLL6
- STRING:   Q5SLL6
- GeneID:   3168044
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0277
- NMPDR:   fig|300852.3.peg.308
- eggNOG:   COG0166
- HOGENOM:   HBG615843
- OMA:   KACAMSA
- ProtClustDB:   CLSK738916
- BioCyc:   TTHE300852:TTHA0277-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 46082; Mature: 46082

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 267-267 ACT_SITE 293-293 ACT_SITE 406-406

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLDTRFLPGFPEALSRHGPLLEEARRRLLAKRGEPGSMLGWMDLPEDTETLREVRRYR
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
EANPWVEDFVLIGIGGSALGPKALEAAFNESGVRFHYLDHVEPEPILRLLRTLDPRKTLV
HCCCCHHHEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHH
NAVSKSGSTAETLAGLAVFLKWLKAHLGEDWRRHLVVTTDPKEGPLRAFAEREGLKAFAI
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCHHHHHHHHCCCEEEEC
PKEVGGRFSALSPVGLLPLAFAGADLDALLMGARKANETALAPLEESLPLKTALLLHLHR
CHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHH
HLPVHVFMVYSERLSHLPSWFVQLHDESLGKVDRQGQRVGTTAVPALGPKDQHAQVQLFR
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEH
EGPLDKLLALVIPEAPLEDVEIPEVEGLEAASYLFGKTLFQLLKAEAEATYEALAEAGQR
HCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VYALFLPEVSPYAVGWLMQHLMWQTAFLGELWEVNAFDQPGVELGKVLTRKRLAG
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRLDTRFLPGFPEALSRHGPLLEEARRRLLAKRGEPGSMLGWMDLPEDTETLREVRRYR
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
EANPWVEDFVLIGIGGSALGPKALEAAFNESGVRFHYLDHVEPEPILRLLRTLDPRKTLV
HCCCCHHHEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCHHHHHH
NAVSKSGSTAETLAGLAVFLKWLKAHLGEDWRRHLVVTTDPKEGPLRAFAEREGLKAFAI
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCHHHHHHHHCCCEEEEC
PKEVGGRFSALSPVGLLPLAFAGADLDALLMGARKANETALAPLEESLPLKTALLLHLHR
CHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHH
HLPVHVFMVYSERLSHLPSWFVQLHDESLGKVDRQGQRVGTTAVPALGPKDQHAQVQLFR
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEH
EGPLDKLLALVIPEAPLEDVEIPEVEGLEAASYLFGKTLFQLLKAEAEATYEALAEAGQR
HCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VYALFLPEVSPYAVGWLMQHLMWQTAFLGELWEVNAFDQPGVELGKVLTRKRLAG
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA