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The map label for this gene is pntAA [H]

Identifier: 55980175

GI number: 55980175

Start: 203137

End: 204264

Strand: Direct

Name: pntAA [H]

Synonym: TTHA0206

Alternate gene names: 55980175

Gene position: 203137-204264 (Clockwise)

Preceding gene: 55980171

Following gene: 55980176

Centisome position: 10.98

GC content: 70.83

Gene sequence:

>1128_bases
ATGGTGACCGTCGCGGTTCCCAAGGAAAGGGCCCCAGGGGAAAGGAGGGTGGCCCTGGTGCCCGAGGTGGTGGCCCGCCT
GGTGAAAGGCGGGGCCCGGGTGCGGGTGGAGCGGGGCGCGGGGGAGGGCGCCTACCACCCCGACGAGGCCTACCAGGAGG
CCGGGGCCGAGGTGGTGGAGCGAGGGGAGCTCCTAAAGGGCGCCCACCTCCTCTTCACCGTCCAGCCGCCCCCGGAGGAC
CTCATCCAGGCCCTGGAGCCGGGGGCCATCGTGGTGGGCTTCGTCCAGCCCCACAAGAACCTGGAGCTGGTGCGGGCCCT
ACAGGCGAAGAAGGCCACGGTGATCGCCATGGAGCTCATCCCCCGCATCACCCGGGCCCAGAGCATGGACGCCCTCTCCA
GCCAGGCCACGGTGGCGGGGTATCTGGCGGCCATCCACGCGGCGAGGCTCTCCCCCCGCTTCTTCCCCATGCTCACCACG
GCGGCGGGCACCATCCGCCCCGCCAAGGTGATGGTCATGGGGGTGGGGGTGGCGGGGCTCATGGCCATCGCCACCGCCAA
GCGCCTCGGGGCCCAGGTCTTCGCCTACGACGTGCGCAAGGCCGCCCTGGAGCAGGCCCTCTCCCTGGGGGCGAAGCCCA
TTGAACTCCCCATCAGCGCCGAAGGGGAGGGGGGCTACGCCCGGGAGCTCACCGAGGAGGAGAAGCGCATCCAGCACGAG
GCCCTCCGCGACCACGTGGCGGGGATGGACGTCCTCATCACCACGGCCCAGGTGCCGGGCCGCCGCGCCCCCATCCTCCT
CACCGAGGACATGGTGGAGCGCCTGAAGCCCGGGACCGTGGTGGTGGACCTGGCCGCCGAGAGCGGGGGCAACTGCGTCC
TCACCAAGCCGGGGGAGGTGGTGGAGGTGAGGGGCGTGCGGGTCTATGGCCCCTTGAACCTGCCGAGCGAGCTTTCCGTC
CACGCCTCGGAGATGTACGCCAAGAACCTCTACAACCTCTCCAGCCTCCTCATAGAGAAAGGCGCGTTCGCCCCCAAGTG
GGAGGACGAGATCGTCCGGGCCGCCCTCCTCATGAAGGAGGGCGAGGTCCTGCACGGGCCCACCAAGGCCCTTCTGGGAG
GTGCGTGA

Upstream 100 bases:

>100_bases
GGAAGCCTTCCGGGAAGCGTCAAAGTAGTGTAGCCCAAGGGAAAACCCGGGGACGGACGCCCCACCCCGCGCTGGTATAC
TTCCCCCGAAGGAGGCGCCT

Downstream 100 bases:

>100_bases
TGGAGTTTAACTTCTGGTCGGCGCTTTACATCTTCGTGCTCACGGCCTTCTTGGGCTACGAGCTCATCACCCGGGTGCCC
GTGATCCTCCACACCCCCTT

Product: nicotinamide nucleotide transhydrogenase subunit alpha 1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVTVAVPKERAPGERRVALVPEVVARLVKGGARVRVERGAGEGAYHPDEAYQEAGAEVVERGELLKGAHLLFTVQPPPED
LIQALEPGAIVVGFVQPHKNLELVRALQAKKATVIAMELIPRITRAQSMDALSSQATVAGYLAAIHAARLSPRFFPMLTT
AAGTIRPAKVMVMGVGVAGLMAIATAKRLGAQVFAYDVRKAALEQALSLGAKPIELPISAEGEGGYARELTEEEKRIQHE
ALRDHVAGMDVLITTAQVPGRRAPILLTEDMVERLKPGTVVVDLAAESGGNCVLTKPGEVVEVRGVRVYGPLNLPSELSV
HASEMYAKNLYNLSSLLIEKGAFAPKWEDEIVRAALLMKEGEVLHGPTKALLGGA

Sequences:

>Translated_375_residues
MVTVAVPKERAPGERRVALVPEVVARLVKGGARVRVERGAGEGAYHPDEAYQEAGAEVVERGELLKGAHLLFTVQPPPED
LIQALEPGAIVVGFVQPHKNLELVRALQAKKATVIAMELIPRITRAQSMDALSSQATVAGYLAAIHAARLSPRFFPMLTT
AAGTIRPAKVMVMGVGVAGLMAIATAKRLGAQVFAYDVRKAALEQALSLGAKPIELPISAEGEGGYARELTEEEKRIQHE
ALRDHVAGMDVLITTAQVPGRRAPILLTEDMVERLKPGTVVVDLAAESGGNCVLTKPGEVVEVRGVRVYGPLNLPSELSV
HASEMYAKNLYNLSSLLIEKGAFAPKWEDEIVRAALLMKEGEVLHGPTKALLGGA
>Mature_375_residues
MVTVAVPKERAPGERRVALVPEVVARLVKGGARVRVERGAGEGAYHPDEAYQEAGAEVVERGELLKGAHLLFTVQPPPED
LIQALEPGAIVVGFVQPHKNLELVRALQAKKATVIAMELIPRITRAQSMDALSSQATVAGYLAAIHAARLSPRFFPMLTT
AAGTIRPAKVMVMGVGVAGLMAIATAKRLGAQVFAYDVRKAALEQALSLGAKPIELPISAEGEGGYARELTEEEKRIQHE
ALRDHVAGMDVLITTAQVPGRRAPILLTEDMVERLKPGTVVVDLAAESGGNCVLTKPGEVVEVRGVRVYGPLNLPSELSV
HASEMYAKNLYNLSSLLIEKGAFAPKWEDEIVRAALLMKEGEVLHGPTKALLGGA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=384, Percent_Identity=40.625, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI122939153, Length=384, Percent_Identity=40.625, Blast_Score=265, Evalue=7e-71,
Organism=Escherichia coli, GI1787887, Length=365, Percent_Identity=42.7397260273973, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17550456, Length=362, Percent_Identity=43.646408839779, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39972; Mature: 39972

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVAVPKERAPGERRVALVPEVVARLVKGGARVRVERGAGEGAYHPDEAYQEAGAEVVE
CEEEECCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
RGELLKGAHLLFTVQPPPEDLIQALEPGAIVVGFVQPHKNLELVRALQAKKATVIAMELI
HHHHCCCCEEEEEECCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PRITRAQSMDALSSQATVAGYLAAIHAARLSPRFFPMLTTAAGTIRPAKVMVMGVGVAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCHHHH
MAIATAKRLGAQVFAYDVRKAALEQALSLGAKPIELPISAEGEGGYARELTEEEKRIQHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ALRDHVAGMDVLITTAQVPGRRAPILLTEDMVERLKPGTVVVDLAAESGGNCVLTKPGEV
HHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCEEEECCCCE
VEVRGVRVYGPLNLPSELSVHASEMYAKNLYNLSSLLIEKGAFAPKWEDEIVRAALLMKE
EEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GEVLHGPTKALLGGA
CCEEECCHHHHCCCC
>Mature Secondary Structure
MVTVAVPKERAPGERRVALVPEVVARLVKGGARVRVERGAGEGAYHPDEAYQEAGAEVVE
CEEEECCCCCCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
RGELLKGAHLLFTVQPPPEDLIQALEPGAIVVGFVQPHKNLELVRALQAKKATVIAMELI
HHHHCCCCEEEEEECCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PRITRAQSMDALSSQATVAGYLAAIHAARLSPRFFPMLTTAAGTIRPAKVMVMGVGVAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCHHHH
MAIATAKRLGAQVFAYDVRKAALEQALSLGAKPIELPISAEGEGGYARELTEEEKRIQHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ALRDHVAGMDVLITTAQVPGRRAPILLTEDMVERLKPGTVVVDLAAESGGNCVLTKPGEV
HHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCEEEECCCCE
VEVRGVRVYGPLNLPSELSVHASEMYAKNLYNLSSLLIEKGAFAPKWEDEIVRAALLMKE
EEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GEVLHGPTKALLGGA
CCEEECCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]