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The map label for this gene is nqo5

Identifier: 55980055

GI number: 55980055

Start: 84664

End: 85287

Strand: Direct

Name: nqo5

Synonym: TTHA0086

Alternate gene names: 55980055

Gene position: 84664-85287 (Clockwise)

Preceding gene: 55980054

Following gene: 55980056

Centisome position: 4.58

GC content: 66.83

Gene sequence:

>624_bases
ATGCGGCTTGAGCGCGTCCTGGAAGAGGCCCGGGCCAAGGGCTACCCCATAGAGGACAACGGCCTCGGCAACCTCTGGGT
GGTCCTGCCCAGGGAGCGCTTCAAGGAGGAGATGGCCCACTACAAGGCCATGGGGTTCAACTTCCTGGCCGACATCGTGG
GCCTGGACTACCTGACCTACCCGGACCCCCGCCCCGAGCGCTTCGCCGTGGTCTACGAGCTCGTCTCCCTCCCGGGCTGG
AAGGACGGGGACGGGAGCCGCTTCTTCGTGCGGGTCTACGTGCCCGAAGAGGACCCCAGGCTCCCCACGGTCACCGACCT
CTGGGGGAGCGCCAATTTCCTGGAAAGGGAGGTCTACGACCTCTTCGGCATCGTCTTTGAAGGCCACCCCGACCTCCGCA
AGATCCTCACCCCGGAGGACCTCGAGGGCCACCCCCTGCGCAAGGACTACCCCTTGGGCGAGACCCCCACCCTCTTCCGC
GAGGGGCGGTACATCATCCCGGCGGAGTTCCGCGCCGCCCTCACCGGCAAGGACCCCGGCCTCACCTTCTACAAGGGCGG
GAGCCGCAAGGGCTACAGGTCCCTTTGGGCCGACCTGAAGAAGGCCCGGGAGGTTAAAGGATGA

Upstream 100 bases:

>100_bases
GGTGATGCAGCTGCAGAAGAAGGTGCGGGGCCAGGCCTACAACGAGCGGGGAGAGAGGCTTCCCCCGGTGGCGGCCTGGA
AGCGGACGAGGGGGTGAGGT

Downstream 100 bases:

>100_bases
GGGAAGAGTTCCTGGAGGAAATCCCCCTAGACGCCCCCCCGGAGGAGGCCAAGGAGCTCCGCACCGAGGTGATGACCCTG
AACGTGGGCCCGCAGCACCC

Product: NADH-quinone oxidoreductase subunit 5

Products: NA

Alternate protein names: NADH dehydrogenase I chain 5; NDH-1 subunit 5

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTYPDPRPERFAVVYELVSLPGW
KDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYDLFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFR
EGRYIIPAEFRAALTGKDPGLTFYKGGSRKGYRSLWADLKKAREVKG

Sequences:

>Translated_207_residues
MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTYPDPRPERFAVVYELVSLPGW
KDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYDLFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFR
EGRYIIPAEFRAALTGKDPGLTFYKGGSRKGYRSLWADLKKAREVKG
>Mature_207_residues
MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTYPDPRPERFAVVYELVSLPGW
KDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYDLFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFR
EGRYIIPAEFRAALTGKDPGLTFYKGGSRKGYRSLWADLKKAREVKG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG0852

COG function: function code C; NADH:ubiquinone oxidoreductase 27 kD subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 30 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758788, Length=108, Percent_Identity=41.6666666666667, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI145693162, Length=88, Percent_Identity=46.5909090909091, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71990788, Length=111, Percent_Identity=41.4414414414414, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32563621, Length=111, Percent_Identity=41.4414414414414, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24656494, Length=114, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NQO5_THET8 (Q56219)

Other databases:

- EMBL:   U52917
- EMBL:   AP008226
- PIR:   T11900
- RefSeq:   YP_143352.1
- PDB:   2FUG
- PDB:   3I9V
- PDB:   3IAM
- PDB:   3IAS
- PDB:   3M9S
- PDBsum:   2FUG
- PDBsum:   3I9V
- PDBsum:   3IAM
- PDBsum:   3IAS
- PDBsum:   3M9S
- ProteinModelPortal:   Q56219
- SMR:   Q56219
- STRING:   Q56219
- GeneID:   3168317
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0086
- eggNOG:   COG0852
- HOGENOM:   HBG244769
- OMA:   ERECHEM
- ProtClustDB:   CLSK445105
- BioCyc:   TTHE300852:TTHA0086-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01357
- InterPro:   IPR010218
- InterPro:   IPR001268
- InterPro:   IPR020396
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961

Pfam domain/function: PF00329 Complex1_30kDa

EC number: =1.6.99.5

Molecular weight: Translated: 23860; Mature: 23860

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00542 COMPLEX1_30K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTY
CCHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDPRPERFAVVYELVSLPGWKDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHH
LFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFREGRYIIPAEFRAALTGKDPG
HHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEECHHHHEEECCCCCC
LTFYKGGSRKGYRSLWADLKKAREVKG
EEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTY
CCHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDPRPERFAVVYELVSLPGWKDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHH
LFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFREGRYIIPAEFRAALTGKDPG
HHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEECHHHHEEECCCCCC
LTFYKGGSRKGYRSLWADLKKAREVKG
EEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134